EKS-MAM-00159

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00159

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	463.9	2.4E-139	417	673	257

Status

Unreviewed

Ensembl Protein

ENSMMUP00000029118

UniProt Accession

F7H7W3;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA1

Gene Synonyms/Alias

RPS6KA1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000022111	ENSMMUP00000029117	ENSMMUT00000031108
ENSMMUG00000022111	ENSMMUP00000029115	ENSMMUT00000031106
ENSMMUG00000022111	ENSMMUP00000029118	ENSMMUT00000031109
ENSMMUG00000022111	ENSMMUP00000040495	ENSMMUT00000047462

Organism

Macaca mulatta

Functional Description

Protein Length

733

Protein Sequence
(FASTA)

MPLAQKEPWP LMELVPLDPE NGQTSGEEAG LQPSKDEGVL KEISITHHVK AGSEKADPSH 60

FELLKVLGQG SFGKVFLVRK VTRPDSGHLY AMKVLKKATL KVRDRVRTKM ERDILADVNH 120

PFVVKLHYAF QTEGKLYLIL DFLRGGDLFT RLSKEVMFTE EDVKFYLAEL ALGLDHLHSL 180

GIIYRDLKPE NILLDEEGHI KLTDFGLSKE AIDHEKKAYS FCGTVEYMAP EVVNRQGHSH 240

SADWWSYGVL MFEMLTGSLP FQGKDRKETM TLILKAKLGM PQFLSTEAQS LLRALFKRNP 300

ANRLGSGPDG AEEIKRHVFY STIDWNKLYR REIKPPFKPA VAQPDDTFYF DTEFTSRTPN 360

DSPGIPPSAG AHQLFRGFSF VATGLMEDDG KPRAPQAPLH SVVQQLHGKN LVFSDGYVVK 420

ETIGVGSYSV CKRCVHKATN MEYAVKVIDK SKRDPSEEIE ILLRYGQHPN IITLKDAFSE 480

DVLAYQGTKL MRGELLDKIL RQKFFSEREA SFVLHTIGKT VEYLHSQGVV HRDLKPSNIL 540

YVDESGNPEC LRICDFGFAK QLRAENGLLM TPCYTANFVA PEVLKRQGYD EGCDIWSLGI 600

LLYTMLAGYT PFANGPSDTP EEILTRIGSG KFTLSGGNWN TVSETAKDLV SKMLHVDPHQ 660

RLTAKQVLQH PWVTQKDKLP QSQLSHQDLQ LVKGAMAATY SALNSSKPTP QLKPIESSIL 720

AQRRVRKLPS TTL 733

Nucleotide Sequence
(FASTA)

ATGCCGCTCG CCCAGAAGGA GCCCTGGCCG CTCATGGAGC TAGTGCCTCT GGACCCGGAG 60

AATGGACAGA CTTCAGGGGA AGAAGCTGGA CTTCAGCCAT CCAAGGATGA GGGCGTCCTC 120

AAGGAGATCT CCATCACGCA CCACGTCAAG GCTGGCTCTG AGAAGGCTGA TCCATCCCAT 180

TTCGAGCTCC TCAAGGTTCT GGGCCAGGGA TCGTTTGGCA AAGTCTTCCT GGTACGGAAA 240

GTCACCCGGC CTGACAGTGG GCACCTGTAT GCTATGAAGG TGCTGAAGAA GGCGACGCTG 300

AAAGTACGTG ACCGTGTCCG GACCAAGATG GAGAGAGACA TCCTGGCTGA TGTAAACCAC 360

CCATTCGTGG TGAAGCTGCA CTATGCCTTC CAGACCGAGG GCAAGCTGTA TCTCATTCTG 420

GACTTCCTGC GTGGTGGGGA CCTCTTCACA CGGCTCTCAA AAGAGGTGAT GTTCACGGAG 480

GAGGATGTGA AGTTTTACCT GGCCGAGCTA GCTCTGGGCC TGGATCACCT GCACAGCCTG 540

GGTATCATTT ACAGAGACCT CAAGCCTGAG AACATCCTTC TGGATGAGGA GGGCCACATC 600

AAACTCACTG ACTTTGGCCT GAGCAAGGAG GCCATTGACC ACGAGAAGAA GGCCTACTCC 660

TTCTGCGGGA CAGTGGAGTA CATGGCCCCC GAGGTCGTCA ACCGCCAGGG CCACTCCCAC 720

AGTGCGGATT GGTGGTCCTA TGGGGTGTTG ATGTTTGAGA TGCTGACGGG CTCCCTGCCC 780

TTCCAGGGGA AGGACCGGAA GGAAACCATG ACATTGATTC TGAAGGCGAA GCTAGGCATG 840

CCCCAGTTTC TGAGCACCGA AGCCCAGAGC CTCTTGCGGG CCCTGTTCAA GCGGAATCCT 900

GCCAACCGGC TCGGCTCTGG CCCTGATGGG GCAGAGGAAA TCAAGCGGCA TGTCTTCTAC 960

TCCACCATTG ACTGGAATAA GCTATACCGT CGTGAGATCA AGCCACCCTT CAAGCCAGCA 1020

GTGGCTCAGC CTGATGACAC CTTCTACTTT GACACTGAGT TCACGTCCCG CACACCCAAT 1080

GATTCCCCAG GCATCCCCCC TAGCGCTGGG GCCCATCAGC TGTTCCGGGG CTTCAGCTTC 1140

GTGGCCACTG GCCTGATGGA GGACGACGGC AAGCCTCGCG CCCCGCAGGC ACCCCTGCAC 1200

TCGGTGGTAC AGCAACTCCA TGGGAAGAAC CTGGTTTTTA GCGACGGCTA CGTGGTAAAG 1260

GAGACGATTG GTGTGGGCTC CTACTCTGTG TGCAAGCGCT GTGTCCACAA GGCCACCAAC 1320

ATGGAGTATG CTGTCAAGGT CATTGATAAG AGCAAGCGGG ATCCTTCAGA AGAGATTGAG 1380

ATTCTTCTGC GGTACGGCCA GCACCCCAAC ATCATTACTC TGAAAGATGC ATTTTCTGAG 1440

GACGTTCTTG CCTATCAGGG GACCAAGCTG ATGCGGGGCG AGCTGCTGGA CAAGATCCTG 1500

CGGCAGAAGT TCTTCTCGGA GCGGGAGGCC AGCTTCGTCC TGCACACCAT CGGCAAAACT 1560

GTGGAGTATC TGCACTCACA GGGGGTTGTG CACAGGGACC TGAAGCCCAG CAACATCCTG 1620

TATGTGGACG AGTCCGGGAA TCCCGAGTGC CTGCGCATCT GTGACTTTGG TTTTGCCAAA 1680

CAGCTGCGGG CTGAGAATGG GCTCCTCATG ACACCTTGCT ACACAGCCAA CTTCGTGGCG 1740

CCGGAGGTGC TGAAGCGCCA GGGTTATGAT GAAGGCTGTG ACATCTGGAG CCTGGGCATT 1800

CTGCTCTACA CCATGCTGGC GGGGTACACT CCATTTGCCA ACGGTCCCAG TGACACACCA 1860

GAGGAAATCC TAACCCGGAT CGGCAGTGGG AAGTTTACCC TCAGTGGGGG AAACTGGAAC 1920

ACAGTTTCAG AGACAGCCAA AGACCTGGTG TCCAAGATGC TACACGTGGA TCCACACCAG 1980

CGCCTCACAG CTAAGCAGGT TCTGCAGCAT CCATGGGTCA CCCAGAAAGA CAAGCTTCCC 2040

CAAAGCCAGC TGTCCCACCA GGACCTACAG CTTGTGAAGG GAGCCATGGC TGCCACATAC 2100

TCGGCACTCA ACAGCTCCAA GCCCACCCCC CAGCTGAAGC CCATCGAGTC ATCCATCCTG 2160

GCCCAGCGGC GAGTGAGGAA GTTGCCATCC ACCACCCTGT GA 2202

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         y+vke++GvGsysvckrcvhkatn+e+avk+idkskrd+seeieillry+qhpni+tlkd

Q: 417   YVVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKD  476

         689*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

          + ++  +y  ++l++ Gelld+i+++kffsereas +l+t+ k+veylh+qGvvhrdlk

Q: 477   AFSEDVLAYQGTKLMR-GELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLK  535

         ***************9.59*****************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvdes+n+e+++i+dfGfak++raengll+tpcyt+nfvapevlkrqGyde+cd+

Q: 536   PSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDI  595

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslG+llytmlaGy+pfangp+dt+eeil++i++Gkf+lsG++w++vse+akdlvsk+l+

Q: 596   WSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLH  655

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++q+l+h+w+

Q: 656   VDPHQRLTAKQVLQHPWV  673

         *****************7

Domain Sequence
(FASTA)

YVVKETIGVG SYSVCKRCVH KATNMEYAVK VIDKSKRDPS EEIEILLRYG QHPNIITLKD 60

AFSEDVLAYQ GTKLMRGELL DKILRQKFFS EREASFVLHT IGKTVEYLHS QGVVHRDLKP 120

SNILYVDESG NPECLRICDF GFAKQLRAEN GLLMTPCYTA NFVAPEVLKR QGYDEGCDIW 180

SLGILLYTML AGYTPFANGP SDTPEEILTR IGSGKFTLSG GNWNTVSETA KDLVSKMLHV 240

DPHQRLTAKQ VLQHPWV 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005819	; C:spindle
GO:0005524	; F:ATP binding
GO:0043027	; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0043066	; P:negative regulation of apoptotic process
GO:2000491	; P:positive regulation of hepatic stellate cell activation
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013