EKS-MAM-00257

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00257

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	251.0	1.9E-74	49	309	261

Status

Unreviewed

Ensembl Protein

ENSMMUP00000029217

UniProt Accession

F6ZGN9;

Protein Name

Protein Synonyms/Alias

Serine/threonine-protein kinase 11; Serine/threonine-protein kinase STK11;

Gene Name

STK11

Gene Synonyms/Alias

STK11; EGK_09836;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000022198	ENSMMUP00000032018	ENSMMUT00000025815
ENSMMUG00000022198	ENSMMUP00000029217	ENSMMUT00000031218

Organism

Macaca mulatta

Functional Description

Protein Length

433

Protein Sequence
(FASTA)

MEVVDPQQLG MFTEGELMSV GMDTFIHRID STEVIYQPRR KRAKLIGKYL MGDLLGEGSY 60

GKVKEVLDSE TLCRRAVKIL KKKKLRRIPN GEANVKKEIQ LLRRLRHKNV IQLVDVLYNE 120

EKQKMYMVME YCVCGMQEML DSVPEKRFPV CQAHGYFCQL IDGLEYLHSQ GIVHKDIKPG 180

NLLLTTGGTL KISDLGVAEA LHPFAADDTC RTSQGSPAFQ PPEIANGLDT FSGFKVDIWS 240

AGVTLYNITT GLYPFEGDNI YKLFENIGKG SYAIPGDCGP PLSDLLKGML EYEPAKRFSI 300

RQIRQHSWFR KKHPPAEAPV PIPPSPDTKD RWRSMTVVPY LEDLHGADED EDLFDIEDDI 360

IYTQDFTVPG QVPEEEASQN GQSRGLPKAV CMNGTEAAQL STKSKAEGRA PNPARKACSA 420

SSKIRRLSAC KQQ 433

Nucleotide Sequence
(FASTA)

ATGGAGGTGG TGGACCCGCA GCAGCTGGGC ATGTTCACGG AGGGCGAGCT GATGTCGGTG 60

GGCATGGACA CGTTCATCCA CCGCATCGAC TCCACCGAGG TCATCTACCA GCCGCGCCGC 120

AAGCGGGCCA AGCTCATCGG CAAGTACCTG ATGGGGGACC TGCTGGGGGA AGGCTCTTAC 180

GGCAAGGTGA AGGAGGTGCT GGACTCGGAG ACGCTGTGCA GGAGGGCCGT CAAGATCCTC 240

AAGAAGAAGA AGTTACGAAG GATCCCCAAC GGGGAGGCCA ACGTGAAAAA GGAAATTCAA 300

CTACTGAGGA GGTTACGGCA CAAAAATGTC ATCCAGCTGG TGGACGTGTT ATACAACGAA 360

GAGAAGCAGA AAATGTATAT GGTGATGGAG TACTGCGTGT GTGGCATGCA GGAGATGCTG 420

GACAGCGTGC CAGAGAAGCG TTTCCCGGTG TGCCAGGCCC ACGGGTACTT CTGTCAGCTG 480

ATTGACGGCC TGGAGTACCT GCACAGCCAG GGCATCGTGC ACAAGGATAT CAAGCCCGGG 540

AACCTGCTGC TCACCACCGG GGGCACCCTC AAAATTTCCG ACCTGGGCGT GGCCGAGGCA 600

CTGCACCCGT TCGCGGCGGA CGACACCTGC CGGACCAGCC AGGGCTCCCC GGCTTTCCAG 660

CCACCCGAGA TTGCCAACGG CCTGGACACC TTCTCCGGCT TCAAGGTGGA CATCTGGTCA 720

GCTGGGGTCA CCCTCTACAA CATCACCACG GGTCTGTACC CCTTCGAAGG GGACAACATC 780

TACAAGCTGT TTGAGAACAT TGGGAAGGGG AGCTACGCCA TCCCGGGTGA CTGTGGCCCC 840

CCGCTCTCCG ACCTGCTGAA AGGGATGCTT GAGTACGAGC CGGCCAAGAG GTTCTCCATC 900

CGGCAGATCC GGCAGCACAG CTGGTTCCGG AAGAAACACC CTCCGGCCGA GGCGCCGGTG 960

CCCATCCCGC CGAGCCCGGA CACCAAGGAC CGGTGGCGCA GCATGACTGT GGTGCCGTAC 1020

TTGGAGGACC TGCACGGTGC GGACGAGGAT GAGGACCTCT TTGACATCGA GGACGACATC 1080

ATCTACACTC AGGACTTCAC GGTGCCCGGA CAGGTCCCAG AAGAGGAGGC CAGTCAGAAT 1140

GGACAGAGCC GGGGCCTCCC CAAGGCCGTG TGTATGAACG GCACGGAGGC GGCGCAGCTG 1200

AGCACCAAAT CCAAGGCGGA GGGCAGGGCC CCCAACCCCG CCCGCAAGGC CTGCTCCGCC 1260

AGCAGCAAGA TCCGCCGGCT GTCGGCCTGC AAGCAGCAGT GA 1302

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl..seeslekikrEieilkklkhp  58

         y +++ lGegs+gkVk++ ++et  + avKi+kkkkl    +   ++k+Ei++l++l+h+

Q: 49    YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLrrIPNGEANVKKEIQLLRRLRHK  108

         778999******************************965334567***************

S: 59    niikllevi..etkkklylvleyasgg..eLfdyieekgrlkekearklfkqlvsavkYl  114

         n+i+l++v+  e+k+k+y+v+ey+  g  e++d +  ++r++  +a+ +f ql+++++Yl

Q: 109   NVIQLVDVLynEEKQKMYMVMEYCVCGmqEMLDSV-PEKRFPVCQAHGYFCQLIDGLEYL  167

         ********9888999********998888*****6.8899********************

S: 115   hskgivHrDlKpeNllldkkenikiaDFGlan...lfkegklletfcGsppYaaPellkg  171

         hs+givH+D+Kp Nlll++ +++ki+D+G+a+    f  +++++t++Gsp++++Pe+ +g

Q: 168   HSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEalhPFAADDTCRTSQGSPAFQPPEIANG  227

         *******************************955556778******************99

S: 172   .kkYegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlr  230

          ++++g kvD+Ws+Gv+Ly++ tg +Pf+++n+ +l+e+i kg++ ip  + + l++Ll+

Q: 228   lDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLK  287

         899*********************************************************

S: 231   klLvvdpekRatieeilkhewl  252

          +L+ +p+kR++i++i++h+w+

Q: 288   GMLEYEPAKRFSIRQIRQHSWF  309

         *********************7

Domain Sequence
(FASTA)

YLMGDLLGEG SYGKVKEVLD SETLCRRAVK ILKKKKLRRI PNGEANVKKE IQLLRRLRHK 60

NVIQLVDVLY NEEKQKMYMV MEYCVCGMQE MLDSVPEKRF PVCQAHGYFC QLIDGLEYLH 120

SQGIVHKDIK PGNLLLTTGG TLKISDLGVA EALHPFAADD TCRTSQGSPA FQPPEIANGL 180

DTFSGFKVDI WSAGVTLYNI TTGLYPFEGD NIYKLFENIG KGSYAIPGDC GPPLSDLLKG 240

MLEYEPAKRF SIRQIRQHSW F 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

mcc:705686

;

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013