EPS-MAM-00019

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MAM-00019

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	289.4	5.5E-86	23	293	271

Status

Unreviewed

Ensembl Protein

ENSMMUP00000029304

UniProt Accession

F6XPC8;

Protein Name

Protein Synonyms/Alias

Protein phosphatase 1B isoform 1;

Gene Name

PPM1B

Gene Synonyms/Alias

PPM1B; EGK_05287;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000022261	ENSMMUP00000029304	ENSMMUT00000031316
ENSMMUG00000022261	ENSMMUP00000029303	ENSMMUT00000031315

Organism

Macaca mulatta

Functional Description

Protein Length

431

Protein Sequence
(FASTA)

MGAFLDKPKT EKHNAHGAGN GLRYGLSSMQ GWRVEMEDAH TAVVGIPHGL EDWSFFAVYD 60

GHAGSRVANY CSTHLLEHIT TNEDFRAAGK SGSALELSVE NVKNGIRTGF LKIDEYMRNF 120

SDLRNGMDRS GSTAVGVMIS PKHIYFINCG DSRAVLYRNG QVCFSTQDHK PCNPREKERI 180

QNAGGSVMIQ RVNGSLAVSR ALGDYDYKCV DGKGPTEQLV SPEPEVYEIL RAEEDEFIIL 240

ACDGIWDVMS NEELCEFVKS RLEVSDDLEN VCNWVVDTCL HKGSRDNMSI VLVCFSNAPK 300

VSDEAVKKDS ELDKHLESRV EEIMEKSGEE GMPDLAHVMR ILSAENIPNL PPGGGLAGKR 360

NVIEAVYSRL NPHRESDGMA VLGTSICKPA ESSGDKKGSG WQTFQAPRST RTKRLLCKPE 420

RKINPALYNY S 431

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TTTTGGATAA ACCCAAAACT GAAAAACATA ATGCTCATGG TGCTGGGAAT 60

GGTTTACGTT ATGGCCTGAG CAGCATGCAA GGATGGAGAG TGGAAATGGA AGATGCACAC 120

ACAGCTGTTG TAGGTATTCC TCACGGCTTG GAAGACTGGT CATTTTTTGC AGTTTATGAT 180

GGTCATGCTG GATCCCGAGT GGCAAATTAC TGCTCAACAC ATTTATTAGA ACACATCACT 240

ACTAACGAAG ACTTTAGGGC AGCTGGAAAA TCAGGATCTG CTCTTGAGCT TTCAGTGGAA 300

AATGTTAAGA ATGGTATCAG AACTGGATTT TTGAAAATTG ATGAATACAT GCGTAACTTT 360

TCAGACCTCA GAAATGGGAT GGACAGGAGT GGTTCAACTG CAGTGGGAGT TATGATTTCA 420

CCTAAGCATA TCTACTTTAT CAACTGTGGT GATTCACGTG CTGTTCTGTA TAGGAATGGA 480

CAAGTCTGCT TTTCTACCCA GGATCACAAA CCTTGCAATC CAAGGGAAAA GGAGCGAATC 540

CAAAATGCAG GAGGCAGCGT GATGATACAG CGTGTTAATG GTTCATTAGC AGTGTCTCGT 600

GCTCTGGGGG ACTATGATTA CAAGTGTGTT GATGGCAAGG GCCCGACAGA ACAACTTGTT 660

TCTCCAGAGC CTGAGGTTTA TGAAATTTTA AGAGCAGAAG AGGATGAATT TATCATCTTG 720

GCTTGTGATG GGATCTGGGA TGTTATGAGT AATGAGGAAC TCTGTGAATT TGTTAAATCT 780

AGGCTTGAGG TATCTGATGA CCTGGAAAAT GTGTGCAATT GGGTAGTGGA CACTTGTTTA 840

CATAAGGGAA GTCGAGATAA CATGAGTATT GTACTAGTTT GCTTTTCAAA TGCTCCCAAG 900

GTCTCAGATG AAGCGGTGAA AAAAGATTCA GAGTTGGATA AGCACTTGGA ATCACGGGTT 960

GAAGAGATTA TGGAGAAGTC TGGCGAGGAA GGAATGCCTG ATCTTGCCCA TGTCATGCGC 1020

ATCTTGTCTG CAGAAAATAT CCCAAATTTG CCTCCTGGGG GAGGTCTTGC TGGCAAGCGC 1080

AATGTAATTG AAGCTGTTTA TAGTAGACTG AATCCACATA GAGAAAGTGA TGGGATGGCA 1140

GTCTTGGGCA CATCCATTTG TAAACCTGCT GAGAGCTCTG GTGACAAGAA AGGCAGTGGC 1200

TGGCAGACCT TCCAAGCACC CAGAAGCACA CGGACAAAAA GGTTGCTTTG TAAACCCGAA 1260

CGAAAAATAA ACCCAGCATT ATATAATTAT AGT 1293

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++    + +d ++ff+vyDGh+gs+va++cs++l e++

Q: 23    RYGLSSMQGWRVEMEDAHTAVVGIPH--GLED-WSFFAVYDGHAGSRVANYCSTHLLEHI  79

         69****************98555444..4434.***************************

S: 62    aeele.........sseseerkvkkalakaFlstdeelkvleeksldidksGstavvali  112

         +++ +         + e + ++vk+ ++++Fl++de ++++++ ++ +d+sGstav ++i

Q: 80    TTNEDfraagksgsALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMI  139

         ***99********99999******************************************

S: 113   kdsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvL  172

         +++++y++n+GdSravL rng+++  ++dHkp +++E+eRi++aggsv+ +   Rv+G+L

Q: 140   SPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQ---RVNGSL  196

         ***************************************************...******

S: 173   avsRalGdlylk.........pyvtpePevtshrltsedefliLasDGlwdvvsneeavs  223

         avsRalGd+++k         ++v+pePev+++ + +edef+iLa+DG+wdv+snee+++

Q: 197   AVSRALGDYDYKcvdgkgpteQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCE  256

         ************************************************************

S: 224   lvrdvlekkeaeqeaakkLvklalargskdnvsaivv  260

         +v+++le +++++++++ +v+++l++gs+dn+s+++v

Q: 257   FVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLV  293

         ********************************98875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VVGIPHGLED WSFFAVYDGH AGSRVANYCS THLLEHITTN 60

EDFRAAGKSG SALELSVENV KNGIRTGFLK IDEYMRNFSD LRNGMDRSGS TAVGVMISPK 120

HIYFINCGDS RAVLYRNGQV CFSTQDHKPC NPREKERIQN AGGSVMIQRV NGSLAVSRAL 180

GDYDYKCVDG KGPTEQLVSP EPEVYEILRA EEDEFIILAC DGIWDVMSNE ELCEFVKSRL 240

EVSDDLENVC NWVVDTCLHK GSRDNMSIVL V 271

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation

KEGG

mcc:713918

;

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013