EKS-MAM-00145

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00145

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	555.4	3.0E-167	387	663	277

Status

Unreviewed

Ensembl Protein

ENSMMUP00000029573

UniProt Accession

F7A4U3;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR1

Gene Synonyms/Alias

FGFR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000022478	ENSMMUP00000032144	ENSMMUT00000039061
ENSMMUG00000022478	ENSMMUP00000029573	ENSMMUT00000031612
ENSMMUG00000022478	ENSMMUP00000029572	ENSMMUT00000031611
ENSMMUG00000022478	ENSMMUP00000029571	ENSMMUT00000031610

Organism

Macaca mulatta

Functional Description

Protein Length

731

Protein Sequence
(FASTA)

MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ DALPSSEDDD DDDDSSSEEK ETDNTKPNRM 60

PVAPYWTSPE KMEKKLHAVP AAKTVKFKCP SSGTPNPTLR WLKNGKEFKP DHRIGGYKVR 120

YATWSIIMDS VVPSDKGNYT CIVENEYGSI NHTYQLDVVE RSPHRPILQA GLPANKTVAL 180

GSNVEFMCKV YSDPQPHIQW LKHIEVNGSK IGPDNLPYVQ ILKTAGVNTT DKEMEVLHLR 240

NVSFEDAGEY TCLAGNSIGL SHHSAWLTVL EALEERPAVM TSPLYLEIII YCTGAFLISC 300

MVGSVIVYKM KSGTKKSDFH SQMAVHKLAK SIPLRRQVSA DSSASMNSGV LLVRPSRLSS 360

SGTPMLAGVS EYELPEDPRW ELPRDRLVLG KPLGEGCFGQ VVLAEAIGLD KDKPNRVTKV 420

AVKMLKSDAT EKDLSDLISE MEMMKMIGKH KNIINLLGAC TQDGPLYVIV EYASKGNLRE 480

YLQARRPPGL EYCYNPSHNP EEQLSSKDLV SCAYQVARGM EYLASKKCIH RDLAARNVLV 540

TEDNVMKIAD FGLARDIHHI DYYKKTTNGR LPVKWMAPEA LFDRIYTHQS DVWSFGVLLW 600

EIFTLGGSPY PGVPVEELFK LLKEGHRMDK PSNCTNELYM MMRDCWHAVP SQRPTFKQLV 660

EDLDRIVALT SNQEYLDLSM PLDQYSPSFP DTRSSTCSSG EDSVFSHEPL PEEPCLPRHP 720

AQLANGGLKR R 731

Nucleotide Sequence
(FASTA)

ATGTGGAGCT GGAAGTGCCT CCTCTTCTGG GCTGTGCTGG TCACAGCCAC GCTCTGCACC 60

GCTAGGCCGT CCCCGACCTT GCCTGAACAA GATGCTCTCC CCTCCTCAGA GGATGATGAT 120

GATGATGATG ACTCCTCTTC AGAGGAGAAA GAGACAGATA ACACCAAACC AAACCGTATG 180

CCCGTAGCTC CATATTGGAC ATCCCCAGAA AAGATGGAAA AGAAATTGCA TGCGGTGCCA 240

GCTGCCAAGA CAGTGAAGTT CAAATGCCCT TCCAGTGGGA CCCCAAACCC CACACTGCGC 300

TGGTTGAAAA ATGGCAAAGA ATTCAAACCT GACCACAGGA TTGGAGGCTA CAAGGTCCGT 360

TATGCCACCT GGAGCATCAT AATGGACTCC GTGGTGCCCT CTGACAAGGG CAACTACACC 420

TGCATTGTGG AGAATGAGTA TGGCAGCATC AACCACACCT ACCAGCTGGA TGTCGTGGAG 480

CGGTCCCCTC ACCGGCCCAT CCTGCAAGCA GGGTTGCCCG CCAACAAGAC AGTGGCCCTG 540

GGTAGCAACG TGGAGTTCAT GTGTAAGGTG TACAGTGACC CACAGCCGCA TATCCAGTGG 600

CTAAAGCACA TCGAGGTGAA CGGGAGCAAG ATTGGTCCAG ACAACCTGCC TTATGTCCAG 660

ATCTTGAAGA CTGCTGGAGT TAATACCACC GACAAAGAGA TGGAGGTGCT TCACTTAAGA 720

AATGTCTCCT TTGAGGACGC AGGGGAGTAT ACGTGCTTGG CGGGTAACTC TATCGGACTC 780

TCCCATCACT CTGCATGGTT GACCGTTCTG GAAGCTCTGG AAGAGAGGCC GGCGGTGATG 840

ACCTCGCCCC TGTACCTGGA GATCATCATC TATTGCACAG GGGCCTTCCT CATCTCCTGC 900

ATGGTAGGGT CGGTCATCGT CTACAAGATG AAGAGTGGCA CCAAGAAGAG CGACTTCCAC 960

AGCCAGATGG CTGTGCACAA GCTGGCCAAG AGCATCCCTC TGCGCAGACA GGTGTCTGCT 1020

GACTCCAGTG CGTCCATGAA CTCTGGGGTT CTTCTGGTTC GGCCATCACG GCTCTCCTCC 1080

AGTGGGACTC CCATGCTAGC AGGGGTCTCC GAGTATGAGC TTCCTGAAGA CCCTCGCTGG 1140

GAGCTGCCTC GGGACAGACT GGTCTTAGGC AAACCCCTGG GAGAGGGCTG CTTTGGGCAG 1200

GTGGTGTTGG CAGAGGCCAT CGGGTTGGAC AAGGACAAAC CCAACCGTGT GACCAAAGTG 1260

GCTGTGAAGA TGTTGAAGTC GGACGCAACA GAGAAAGACT TGTCAGACCT GATCTCAGAA 1320

ATGGAGATGA TGAAGATGAT CGGGAAGCAT AAGAATATCA TCAACCTGCT GGGGGCCTGC 1380

ACGCAGGACG GTCCCTTGTA TGTCATCGTG GAGTATGCCT CCAAGGGCAA CCTGCGGGAG 1440

TACCTGCAGG CCCGGAGGCC CCCGGGGCTG GAATACTGCT ACAACCCCAG CCACAACCCA 1500

GAGGAGCAGC TCTCCTCCAA GGACCTGGTG TCCTGCGCCT ATCAGGTGGC CCGAGGCATG 1560

GAGTATCTGG CCTCCAAGAA GTGCATACAC CGAGACCTGG CCGCCAGGAA TGTCCTGGTG 1620

ACAGAGGACA ATGTGATGAA GATAGCAGAC TTTGGCCTCG CACGGGACAT TCACCACATC 1680

GACTACTATA AAAAGACAAC CAACGGTCGA CTGCCTGTGA AGTGGATGGC GCCCGAGGCA 1740

TTGTTTGACC GGATCTACAC CCACCAGAGT GATGTGTGGT CTTTCGGGGT GCTTCTGTGG 1800

GAGATCTTCA CTCTGGGCGG CTCCCCATAC CCTGGTGTGC CTGTGGAGGA GCTTTTCAAG 1860

CTGCTGAAGG AGGGTCACCG CATGGACAAG CCCAGTAACT GCACCAACGA GCTGTACATG 1920

ATGATGCGGG ACTGCTGGCA TGCAGTGCCC TCACAGAGAC CCACCTTCAA GCAGCTGGTG 1980

GAAGACCTGG ACCGCATCGT GGCCTTGACC TCCAACCAGG AGTACCTGGA CCTGTCCATG 2040

CCCCTGGACC AGTACTCCCC GAGCTTTCCC GACACCCGGA GCTCTACATG CTCCTCAGGG 2100

GAGGATTCCG TCTTCTCTCA TGAGCCGCTG CCCGAGGAGC CCTGCCTGCC CCGACACCCA 2160

GCCCAGCTTG CCAATGGCGG ACTCAAACGC CGCTGA 2196

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 387   LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  446

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+++eeql++

Q: 447   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS  506

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 507   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  566

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 567   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  626

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl

Q: 627   RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  663

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP SHNPEEQLSS 120

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPSNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008201	; F:heparin binding
GO:0001525	; P:angiogenesis
GO:0060117	; P:auditory receptor cell development
GO:0060445	; P:branching involved in salivary gland morphogenesis
GO:0048469	; P:cell maturation
GO:0002062	; P:chondrocyte differentiation
GO:0030326	; P:embryonic limb morphogenesis
GO:0035607	; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0001701	; P:in utero embryonic development
GO:0042472	; P:inner ear morphogenesis
GO:0060484	; P:lung-associated mesenchyme development
GO:0048762	; P:mesenchymal cell differentiation
GO:0030901	; P:midbrain development
GO:0042474	; P:middle ear morphogenesis
GO:0043066	; P:negative regulation of apoptotic process
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0001759	; P:organ induction
GO:0042473	; P:outer ear morphogenesis
GO:0048339	; P:paraxial mesoderm development
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0060045	; P:positive regulation of cardiac muscle cell proliferation
GO:0045787	; P:positive regulation of cell cycle
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0090080	; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0045666	; P:positive regulation of neuron differentiation
GO:0010976	; P:positive regulation of neuron projection development
GO:0010863	; P:positive regulation of phospholipase C activity
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0048378	; P:regulation of lateral mesodermal cell fate specification
GO:0007605	; P:sensory perception of sound
GO:0001657	; P:ureteric bud development
GO:0021847	; P:ventricular zone neuroblast division

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 2.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013