EKS-MAM-00189
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00189
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/CASK542.13.6E-16312276265
StatusUnreviewed
Ensembl ProteinENSMMUP00000029724
UniProt AccessionF7BKQ5;
Protein Name
Protein Synonyms/Alias
Gene NameCASK
Gene Synonyms/Alias CASK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000022578ENSMMUP00000029727ENSMMUT00000031773
ENSMMUG00000022578ENSMMUP00000029724ENSMMUT00000031770
ENSMMUG00000022578ENSMMUP00000041117ENSMMUT00000048078
OrganismMacaca mulatta
Functional Description
Protein Length897
Protein Sequence
(FASTA)
MADDDVLFED VYELCEVIGK GPFSVVRRCI NRETGQQFAV KIVDVAKFTS SPGLSTEDLK 60
REASICHMLK HPHIVELLET YSSDGMLYMV FEFMDGADLC FEIVKRADAG FVYSEAVASH 120
YMRQILEALR YCHDNNIIHR DVKPHCVLLA SKENSAPVKL GGFGVAIQLG ESGLVAGGRV 180
GTPHFMAPEV VKREPYGKPV DVWGCGVILF ILLSGCLPFY GTKERLFEGI IKGKYKMNPR 240
QWSHISESAK DLVRRMLMLD PAERITVYEA LNHPWLKERD RYAYKIHLPE TVEQLRKFNA 300
RRKLKGAVLA AVSSHKFNSF YGDPPEELPD FSEDPTSSGA VSQVLDSLEE IHALTDCSEK 360
DLDFLHSVFQ DQHLHTLLDL YDKINTKSSP QIRNPPSDAV QRAKEVLEEI SCYPENNDAK 420
ELKRILTQPH FMALLQTHDV VAHEVYSDEA LRVTPPPTSP YLNGDSPESA NGDMDMENVT 480
RVRLVQFQKN TDEPMGITLK MNELNHCIVA RIMHGGMIHR QGTLHVGDEI REINGISVAN 540
QTVEQLQKML REMRGSITFK IVPSYRTQSS SCEDLPSTTQ PKGRQIYVRA QFEYDPAKDD 600
LIPCKEAGIR FRVGDIIQII SKDDHNWWQG KLENSKNGTA GLIPSPELQE WRVACIAMEK 660
TKQEQQASCT WFGKKKKQYK DKYLAKHNAV FDQLDLVTYE EVVKLPAFKR KTLVLLGAHG 720
VGRRHIKNTL ITKHPDRFAY PIPHTTRPPK KDEENGKNYY FVSHDQMMQD ISNNEYLEYG 780
SHEDAMYGTK LETIRKIHEQ GLIAILDVEP QALKVLRTAE FAPFVVFIAA PTITPGLNED 840
ESLQRLQKES DILQRTYAHY FDLTIINNEI DETIRHLEEA VELVCTAPQW VPVSWVY 897
Nucleotide Sequence
(FASTA)
ATGGCCGACG ACGACGTGCT GTTCGAGGAT GTGTACGAGC TGTGCGAGGT GATCGGAAAG 60
GGTCCCTTCA GTGTTGTACG ACGATGTATC AACAGAGAAA CTGGGCAACA ATTTGCTGTA 120
AAAATTGTTG ATGTAGCCAA GTTCACATCA AGTCCAGGGT TAAGTACAGA AGATCTAAAG 180
CGGGAAGCCA GTATCTGTCA TATGCTGAAA CATCCACACA TTGTAGAGTT ATTGGAGACA 240
TATAGCTCAG ATGGAATGCT TTACATGGTT TTCGAATTTA TGGATGGAGC AGATCTGTGT 300
TTTGAAATCG TAAAGCGAGC GGATGCTGGT TTTGTGTACA GTGAAGCTGT AGCCAGCCAT 360
TATATGAGAC AGATACTGGA AGCTCTACGC TACTGCCATG ATAATAACAT AATTCACAGG 420
GATGTGAAGC CCCACTGTGT TCTCCTCGCC TCAAAAGAAA ACTCGGCACC TGTTAAACTT 480
GGAGGCTTTG GGGTAGCTAT TCAATTAGGG GAGTCTGGAC TTGTAGCTGG AGGACGTGTT 540
GGAACACCTC ATTTTATGGC ACCAGAAGTG GTCAAAAGAG AGCCTTACGG AAAGCCTGTA 600
GACGTCTGGG GGTGCGGTGT GATCCTTTTT ATCCTGCTCA GTGGTTGTTT GCCTTTTTAC 660
GGAACCAAGG AAAGATTGTT TGAAGGCATT ATTAAAGGAA AATATAAGAT GAATCCAAGG 720
CAGTGGAGCC ATATCTCTGA AAGTGCCAAA GACCTAGTAC GTCGCATGCT GATGCTGGAT 780
CCAGCTGAAA GGATCACTGT TTATGAAGCA CTGAATCACC CATGGCTTAA GGAGCGGGAT 840
CGTTATGCCT ACAAGATTCA TCTTCCAGAA ACAGTAGAGC AGCTGAGGAA ATTCAATGCA 900
AGGAGGAAAC TAAAGGGTGC AGTACTAGCC GCTGTGTCAA GTCACAAATT CAACTCATTC 960
TATGGGGATC CCCCTGAAGA GTTGCCAGAT TTCTCCGAAG ACCCTACCTC CTCAGGAGCA 1020
GTCTCACAGG TGCTGGACAG CCTGGAAGAG ATTCACGCAC TTACAGACTG CAGTGAAAAG 1080
GACCTAGATT TTCTACACAG TGTTTTCCAG GATCAGCATC TTCACACACT ACTAGATCTG 1140
TATGACAAAA TAAACACAAA GTCTTCACCA CAAATCAGGA ATCCTCCAAG TGATGCAGTA 1200
CAGAGAGCCA AAGAGGTATT GGAAGAAATT TCATGTTATC CTGAGAATAA CGACGCAAAG 1260
GAACTAAAGC GTATTTTAAC ACAACCTCAT TTCATGGCCT TACTTCAGAC ACACGACGTA 1320
GTGGCACATG AAGTTTACAG TGATGAAGCA TTGAGGGTCA CACCTCCTCC CACCTCTCCC 1380
TACTTAAACG GCGATTCTCC AGAAAGTGCT AACGGAGACA TGGATATGGA GAATGTGACC 1440
AGAGTTCGGC TGGTACAGTT CCAAAAGAAC ACAGATGAAC CAATGGGAAT CACTTTAAAA 1500
ATGAATGAAC TAAATCATTG TATTGTTGCA AGAATTATGC ATGGGGGCAT GATTCACAGG 1560
CAAGGTACAC TTCACGTTGG TGATGAAATT CGAGAAATCA ATGGCATCAG TGTGGCCAAC 1620
CAAACAGTGG AACAGCTGCA AAAAATGCTT AGGGAAATGC GGGGGAGTAT TACCTTCAAG 1680
ATTGTGCCAA GTTACCGTAC TCAGTCTTCA TCCTGTGAGG ACTTGCCATC AACTACCCAA 1740
CCAAAAGGAC GACAGATCTA TGTAAGAGCA CAATTTGAAT ATGATCCAGC CAAGGATGAC 1800
CTCATCCCCT GCAAAGAAGC TGGCATTCGA TTCAGAGTTG GTGACATCAT CCAGATTATT 1860
AGTAAGGATG ATCATAATTG GTGGCAGGGT AAACTGGAAA ACTCCAAAAA TGGAACCGCG 1920
GGTCTCATTC CTTCTCCTGA ACTTCAGGAA TGGCGAGTAG CTTGCATTGC CATGGAGAAG 1980
ACCAAACAGG AGCAGCAGGC CAGCTGTACT TGGTTTGGCA AGAAAAAGAA GCAGTACAAA 2040
GATAAATATT TGGCAAAGCA CAATGCAGTG TTTGATCAAT TAGATCTTGT CACATATGAA 2100
GAAGTAGTAA AACTGCCAGC ATTCAAAAGG AAAACACTAG TCTTATTAGG CGCACATGGT 2160
GTTGGGAGAA GACACATAAA AAACACTCTC ATCACAAAGC ACCCAGACCG GTTTGCGTAC 2220
CCTATTCCAC ACACAACCAG ACCTCCAAAG AAAGATGAAG AAAATGGAAA GAATTATTAC 2280
TTTGTATCTC ATGACCAAAT GATGCAAGAC ATCTCTAATA ACGAGTACTT GGAGTACGGC 2340
AGCCACGAGG ATGCAATGTA TGGGACAAAA CTGGAGACCA TCCGGAAGAT CCACGAGCAG 2400
GGGCTGATTG CAATACTGGA CGTGGAGCCT CAGGCACTGA AGGTCCTGAG AACTGCAGAG 2460
TTTGCTCCTT TTGTTGTTTT CATTGCTGCA CCAACTATTA CTCCAGGTTT AAATGAGGAT 2520
GAATCTCTTC AGCGTCTGCA GAAGGAGTCT GACATCTTAC AGAGAACATA TGCACACTAC 2580
TTCGATCTCA CAATTATCAA CAATGAAATT GATGAGACAA TCAGACATCT GGAGGAAGCT 2640
GTTGAGCTCG TGTGCACAGC CCCACAGTGG GTCCCTGTCT CCTGGGTCTA TTAG 2694
Domain Profile
S: 1     yelcevigkGpfsvvrriihresnqkfavkivdvakftsspGlstedlkreasichmlkh  60
         yelcevigkGpfsvvrr+i+re++q+favkivdvakftsspGlstedlkreasichmlkh
Q: 12    YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH  71
         89**********************************************************
S: 61    pyivelletyssegmlylvfefmeGadlcfeivkrasaGfvyseavashymrqilealry  120
         p+ivelletyss+gmly+vfefm+Gadlcfeivkra+aGfvyseavashymrqilealry
Q: 72    PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRY  131
         ************************************************************
S: 121   chdnkivhrdvrphcvllaskdnsapvklgGfGvaiqlseisglvagGrvGvphfmapev  180
         chdn+i+hrdv+phcvllask+nsapvklgGfGvaiql+e sglvagGrvG+phfmapev
Q: 132   CHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGE-SGLVAGGRVGTPHFMAPEV  190
         ****************************************.*******************
S: 181   vkrerygksvdvwgaGvvlfillsGrlpflGskerlfesiikgklkldarewssisesak  240
         vkre+ygk+vdvwg+Gv+lfillsG+lpf+G+kerlfe+iikgk+k+++r+ws+isesak
Q: 191   VKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAK  250
         ************************************************************
S: 241   dlvrrmlaadpakrisvkealnhewl  266
         dlvrrml++dpa+ri+v+ealnh+wl
Q: 251   DLVRRMLMLDPAERITVYEALNHPWL  276
         *************************7
Domain Sequence
(FASTA)
YELCEVIGKG PFSVVRRCIN RETGQQFAVK IVDVAKFTSS PGLSTEDLKR EASICHMLKH 60
PHIVELLETY SSDGMLYMVF EFMDGADLCF EIVKRADAGF VYSEAVASHY MRQILEALRY 120
CHDNNIIHRD VKPHCVLLAS KENSAPVKLG GFGVAIQLGE SGLVAGGRVG TPHFMAPEVV 180
KREPYGKPVD VWGCGVILFI LLSGCLPFYG TKERLFEGII KGKYKMNPRQ WSHISESAKD 240
LVRRMLMLDP AERITVYEAL NHPWL 265
KeywordComplete proteome; Reference proteome; SH3 domain.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00177
EKS-ANC-00182
EKS-BOT-00189
EKS-CAE-00177
EKS-CAJ-00196
EKS-CAF-00195
EKS-CAP-00214
EKS-CII-00122
EKS-CIS-00227
EKS-DAR-00489
EKS-DRM-00100
EKS-EQC-00184
EKS-FEC-00177
EKS-GAM-00106
EKS-GAG-00161
EKS-GAA-00233
EKS-GOG-00185
EKS-HOS-00194
EKS-LAC-00199
EKS-LOA-00185
EKS-MEG-00146
EKS-MOD-00187
EKS-MUM-00191
EKS-MUP-00191
EKS-MYL-00194
EKS-NOL-00178
EKS-ORN-00240
EKS-ORA-00167
EKS-ORC-00172
EKS-ORL-00225
EKS-OTG-00195
EKS-PAT-00179
EKS-PES-00164
EKS-POA-00183
EKS-SAH-00181
EKS-SUS-00162
EKS-TAG-00214
EKS-TAR-00246
EKS-TEN-00240
EKS-XET-00219
EKS-XIM-00236
Gene Ontology
GO:0005604; C:basement membrane
GO:0016323; C:basolateral plasma membrane
GO:0005911; C:cell-cell junction
GO:0005829; C:cytosol
GO:0005652; C:nuclear lamina
GO:0016363; C:nuclear matrix
GO:0005730; C:nucleolus
GO:0045202; C:synapse
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0070509; P:calcium ion import
GO:0001953; P:negative regulation of cell-matrix adhesion
GO:0090288; P:negative regulation of cellular response to growth factor stimulus
GO:0010839; P:negative regulation of keratinocyte proliferation
GO:0061045; P:negative regulation of wound healing
GO:0090280; P:positive regulation of calcium ion import
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR008144; Guanylate_kin.
IPR008145; Guanylate_kin/L-typ_Ca_channel.
IPR020590; Guanylate_kinase_CS.
IPR011009; Kinase-like_dom.
IPR004172; L27.
IPR014775; L27_C.
IPR001478; PDZ.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR011511; SH3_2.
IPR001452; SH3_domain.
Pfam
PF00625; Guanylate_kin; 1.
PF02828; L27; 2.
PF00595; PDZ; 1.
PF00069; Pkinase; 1.
PF07653; SH3_2; 1.
SMARTs
SM00072; GuKc; 1.
SM00569; L27; 2.
SM00228; PDZ; 1.
SM00220; S_TKc; 1.
SM00326; SH3; 1.
Prosites
PS00856; GUANYLATE_KINASE_1; 1.
PS50052; GUANYLATE_KINASE_2; 1.
PS51022; L27; 2.
PS50106; PDZ; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50002; SH3; 1.
Prints
Created Date20-Feb-2013