EKS-MAM-00273
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00273
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK439.11.7E-131111431321
StatusUnreviewed
Ensembl ProteinENSMMUP00000029924
UniProt AccessionF7GIB5;
Protein Name
Protein Synonyms/Alias Dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform a;
Gene NameDYRK1B
Gene Synonyms/Alias DYRK1B;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000022726ENSMMUP00000029925ENSMMUT00000031982
ENSMMUG00000022726ENSMMUP00000029924ENSMMUT00000031981
OrganismMacaca mulatta
Functional Description
Protein Length629
Protein Sequence
(FASTA)
MAIPPGHGPF SGFPGPQEHT QVLPDVRLLP RRLPLAFRDA TSAPLRKLSV DLIKTYKHIN 60
EVYYAKKKRR AQQVPPQDSS TKKEKKVLNH GYDDDNHDYI VRSGERWLER YEIDSLIGKG 120
SFGQVVKAYD HQTQELVAIK IIKNKKAFLN QAQIELRLLE LMNQHDTEMK YYIVHLKRHF 180
MFRNHLCLVF ELLSYNLYDL LRNTHFRGVS LNLTRKLAQQ LCTALLFLAT PELSIIHCDL 240
KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY DLAIDMWSLG 300
CILVEMHTGE PLFSGSNEVD QMNRIVEVLG IPPAAMLDQA PKARKYFERL PGGGWTLRRT 360
KELRKDYQGP GTRRLQEVLG VQTGGPGGRR AGEPGHSPAD YLRFQDLVLR MLEYEPAARI 420
SPLGALQHGF FRRTADEATN TGPAGSSAST SPAPLDTCPS SSTASSISSS GGSSGSSSDN 480
RTYRYSNRYC GGPGPPITDC EMNSPQVPPS QPLRPWAGGD VPHKTHQAPA SASSLPGTGA 540
QLPPQPRYLG RPPSPTSPPP PELMDVSLVG GPADCSPPHP APAPQHPAAS ALRTRMTGGR 600
PPLPPPDDPA TLGPHLGLRG VPQSTAASS 629
Nucleotide Sequence
(FASTA)
ATGGCCATCC CACCGGGCCA TGGTCCCTTC TCTGGCTTCC CAGGGCCCCA GGAGCACACG 60
CAGGTATTGC CTGATGTGCG GCTACTGCCT CGGAGGCTGC CCCTGGCCTT CCGAGATGCA 120
ACCTCAGCCC CGCTGCGTAA GCTCTCTGTG GACCTCATCA AGACCTACAA GCACATCAAT 180
GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAGCAGG TGCCACCCCA GGATTCGAGC 240
ACCAAGAAGG AGAAGAAGGT CCTGAACCAT GGTTATGATG ACGACAACCA TGACTACATC 300
GTGCGCAGTG GCGAGCGCTG GCTGGAGCGC TATGAGATTG ACTCGCTCAT TGGCAAAGGC 360
TCCTTTGGCC AGGTGGTGAA AGCCTATGAC CATCAGACCC AGGAGCTTGT GGCCATCAAG 420
ATCATCAAGA ACAAAAAGGC CTTCCTGAAC CAGGCCCAGA TTGAGCTGCG GCTGCTGGAG 480
CTGATGAACC AGCATGACAC CGAGATGAAG TACTACATAG TGCACCTGAA GCGGCACTTC 540
ATGTTCCGGA ACCACCTGTG CCTGGTGTTC GAGCTGCTGT CCTACAACCT GTACGACCTC 600
CTGCGCAACA CCCACTTCCG CGGCGTCTCG CTGAACCTGA CCCGGAAGCT GGCGCAGCAG 660
CTCTGCACGG CACTGCTCTT TCTGGCCACG CCTGAGCTCA GCATCATTCA CTGCGACCTC 720
AAGCCCGAAA ACATCTTGCT CTGCAACCCC AAGCGCAGCG CCATCAAGAT AGTGGACTTC 780
GGCAGTTCCT GCCAGCTTGG CCAGAGGATC TACCAGTATA TCCAGAGCCG CTTCTACCGC 840
TCGCCTGAGG TGCTCCTGGG CACACCCTAC GACCTGGCCA TTGACATGTG GTCCCTGGGC 900
TGCATCCTTG TGGAGATGCA CACCGGAGAG CCCCTCTTCA GTGGCTCCAA TGAGGTGGAC 960
CAGATGAACC GCATTGTGGA GGTGCTGGGC ATCCCGCCGG CTGCCATGCT GGACCAGGCG 1020
CCCAAGGCTC GCAAGTACTT TGAACGGCTG CCTGGGGGTG GCTGGACCCT ACGAAGGACA 1080
AAAGAACTCA GGAAGGATTA CCAGGGCCCC GGGACACGGC GGCTGCAGGA GGTGCTGGGC 1140
GTGCAGACGG GCGGGCCCGG GGGCCGGCGG GCGGGGGAGC CGGGCCACAG CCCCGCCGAC 1200
TACCTCCGCT TCCAGGACCT GGTGCTGCGC ATGCTGGAGT ATGAGCCCGC CGCCCGCATC 1260
AGCCCCCTGG GGGCTCTGCA GCACGGCTTC TTCCGCCGCA CGGCCGACGA GGCCACCAAC 1320
ACGGGCCCGG CAGGCAGCAG TGCCTCCACC TCGCCCGCGC CTCTCGACAC CTGCCCCTCT 1380
TCCAGCACCG CCAGCTCCAT CTCCAGTTCT GGAGGCTCCA GTGGCTCCTC CAGTGACAAC 1440
CGGACCTATC GCTACAGCAA CCGATATTGT GGGGGCCCTG GGCCCCCTAT CACAGACTGT 1500
GAGATGAACA GCCCCCAGGT CCCACCCTCC CAGCCACTGC GGCCCTGGGC AGGGGGTGAT 1560
GTGCCCCACA AGACACATCA AGCCCCGGCC TCTGCCTCAT CACTGCCTGG GACCGGGGCC 1620
CAGTTACCCC CCCAGCCCCG ATACCTTGGT CGTCCCCCAT CACCAACCTC ACCACCGCCT 1680
CCGGAGCTGA TGGATGTGAG CCTGGTGGGC GGGCCTGCTG ACTGCTCCCC ACCTCACCCA 1740
GCGCCTGCCC CCCAGCACCC GGCTGCCTCA GCCCTCCGGA CTCGGATGAC GGGAGGTCGT 1800
CCACCCCTCC CGCCTCCTGA TGACCCTGCC ACTCTGGGGC CTCACCTGGG CCTCCGTGGT 1860
GTACCCCAGA GCACGGCAGC CAGCTCATGA 1890
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         ye++++igkGsfgqVvka+d++t+e vaikiiknkk+f++qaq+E+++Le +n++d+e+k
Q: 111   YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK  170
         9***********************************************************
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119
         y++v+l+++f+frnhlclvfells+nLy+ll++++f+g+sl+l+rklaqq+++aL +L+ 
Q: 171   YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAt  230
         **********************************************************99
S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++
Q: 231   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGTP  289
         99*************************************.********************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238
         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq++ ivevlg+pp+ +l++a ka+k+f++
Q: 290   YDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFER  349
         ************************************************************
S: 239   keapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.f  288
              ++l+++          ++r+ ++vl+v++ +     p+ +++ge+ ++ +d+l f
Q: 350   LPGGGWTLRRTkelrkdyqgPGTRRLQEVLGVQTGG-----PGGRRAGEPGHSPADYLrF  404
         ********9997888888777778888888887777.....99*****************
S: 289   kdllkrmleldpakRitpkealkhpfv  315
         +dl+ rmle++pa+Ri+p  al+h f+
Q: 405   QDLVLRMLEYEPAARISPLGALQHGFF  431
         *************************97
Domain Sequence
(FASTA)
YEIDSLIGKG SFGQVVKAYD HQTQELVAIK IIKNKKAFLN QAQIELRLLE LMNQHDTEMK 60
YYIVHLKRHF MFRNHLCLVF ELLSYNLYDL LRNTHFRGVS LNLTRKLAQQ LCTALLFLAT 120
PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY 180
DLAIDMWSLG CILVEMHTGE PLFSGSNEVD QMNRIVEVLG IPPAAMLDQA PKARKYFERL 240
PGGGWTLRRT KELRKDYQGP GTRRLQEVLG VQTGGPGGRR AGEPGHSPAD YLRFQDLVLR 300
MLEYEPAARI SPLGALQHGF F 321
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00254
EKS-ANC-00260
EKS-BOT-00271
EKS-CAJ-00277
EKS-CAF-00279
EKS-CAP-00306
EKS-DIO-00022
EKS-EQC-00266
EKS-FEC-00257
EKS-HOS-00277
EKS-ICT-00254
EKS-LOA-00282
EKS-MOD-00268
EKS-MUM-00302
EKS-MUP-00270
EKS-MYL-00273
EKS-NOL-00251
EKS-OTG-00277
EKS-PAT-00257
EKS-PES-00242
EKS-POA-00262
EKS-PRC-00022
EKS-RAN-00288
EKS-SUS-00233
EKS-SAC-00053
EKS-SCP-00047
Gene Ontology
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0003713; F:transcription coactivator activity
GO:0007520; P:myoblast fusion
GO:0045893; P:positive regulation of transcription, DNA-dependent
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013