EKS-MAM-00210

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00210

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	519.9	2.3E-156	4	287	284

Status

Unreviewed

Ensembl Protein

ENSMMUP00000030571

UniProt Accession

F7E6W9;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL2

Gene Synonyms/Alias

CDKL2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000023227	ENSMMUP00000030571	ENSMMUT00000032671

Organism

Macaca mulatta

Functional Description

Protein Length

493

Protein Sequence
(FASTA)

MEKYENLGLV GEGSYGMVVK CRNKDTGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH 60

ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDY QVVQKYLFQI INGIGFCHSH 120

NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG 180

KAVDVWAIGC LVTEMFMGEP LFPGDSDIDQ LYHIMMCLGN LIPRHQELFY KNPVFAGVRL 240

PEIKEREPLE RRYPKLSEVV IDLAKKCLHI DPDKRPFCSE LLHHDFFQMD GFAERFSQEL 300

QLKVQKDARN ISLSKKSQNR KKEKEKDDSL GEERKTLVVQ DTNADPKIKD CKLFKIKGSK 360

IDGEKAEKGN RASNASCLHD SRTSHIKIVP STSLKDCSNV SVDHTRNPGV AIPPLMHNLS 420

AVAPGINSGM GTATLPIQSY RVDEKTKKCS IPFVKPNRHS PSGIYNINVT TLVSGPPLSD 480

DSGADLPQME HQH 493

Nucleotide Sequence
(FASTA)

ATGGAAAAAT ATGAAAACCT GGGATTGGTT GGAGAAGGGA GTTATGGAAT GGTGGTGAAG 60

TGTAGGAATA AAGATACTGG AAGAATTGTG GCCATAAAGA AGTTCTTAGA AAGTGACGAT 120

GACAAAATGG TTAAAAAGAT TGCAATGCGA GAAATCAAGT TACTAAAGCA ACTGAGGCAT 180

GAAAACTTGG TGAATCTCTT GGAAGTGTGT AAGAAAAAAA AACGATGGTA CCTAGTCTTT 240

GAATTTGTTG ACCACACAAT TCTTGACGAC TTGGAGCTCT TTCCAAATGG ACTAGACTAC 300

CAAGTAGTTC AAAAGTATTT GTTTCAGATT ATTAATGGAA TTGGATTTTG TCACAGTCAC 360

AATATCATAC ACAGAGATAT AAAGCCAGAG AATATATTAG TCTCCCAGTC TGGCGTTGTC 420

AAGCTATGCG ATTTTGGATT TGCGCGAACA TTGGCAGCTC CTGGGGAGGT TTATACTGAT 480

TATGTGGCAA CCCGATGGTA CAGAGCTCCA GAACTATTGG TTGGTGACGT CAAGTATGGC 540

AAGGCTGTTG ATGTGTGGGC CATTGGTTGT CTGGTAACTG AAATGTTCAT GGGGGAACCC 600

CTATTTCCTG GAGATTCTGA TATTGATCAG CTATATCATA TTATGATGTG TTTAGGTAAT 660

CTAATTCCAA GACATCAGGA GCTTTTTTAT AAAAATCCCG TGTTTGCTGG AGTAAGGTTG 720

CCTGAAATCA AGGAAAGAGA ACCTCTTGAA AGACGCTATC CTAAGCTCTC TGAAGTGGTG 780

ATAGATTTAG CAAAGAAATG CTTACATATT GACCCTGACA AAAGACCCTT CTGTTCTGAG 840

CTCCTACACC ATGATTTCTT TCAAATGGAT GGATTTGCTG AGAGGTTTTC CCAAGAACTA 900

CAGTTAAAAG TACAGAAAGA TGCCAGAAAT ATTTCTTTAT CTAAAAAATC CCAGAACAGA 960

AAGAAGGAAA AAGAAAAAGA TGATTCCTTA GGTGAAGAAA GAAAAACACT TGTGGTACAG 1020

GATACCAATG CTGATCCCAA AATTAAGGAT TGTAAACTAT TTAAAATAAA AGGCTCAAAA 1080

ATTGATGGAG AAAAAGCTGA AAAAGGCAAT AGAGCTTCAA ATGCCAGCTG TCTCCATGAC 1140

AGTAGGACAA GCCACATCAA AATAGTGCCT TCAACAAGCC TCAAAGACTG CAGCAATGTC 1200

AGTGTGGACC ACACAAGGAA TCCAGGCGTG GCAATTCCCC CGCTTATGCA CAATCTTTCT 1260

GCAGTTGCTC CCGGTATTAA TTCTGGAATG GGAACTGCGA CTCTACCAAT TCAGAGTTAC 1320

AGAGTGGATG AGAAAACTAA GAAGTGTTCT ATTCCATTTG TTAAACCGAA CAGACATTCC 1380

CCATCAGGCA TTTATAACAT TAATGTGACC ACATTAGTAT CAGGACCTCC CCTGTCAGAT 1440

GATTCAGGGG CTGATTTGCC TCAAATGGAA CACCAGCACT GA 1482

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         ye+lg vGeGsyG+v+kcrnkdtg+ivaikkfles+ddk+vkkia+reikllkql+henl

Q: 4     YENLGLVGEGSYGMVVKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENL  63

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnllev+++kk++ylvfe+vd+t+ld+le +pnG+++++v+k+l+qi+++i fch++nii

Q: 64    VNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNII  123

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrdikpenil+s+sgvvklcdfGfar+laapg+vytdyvatrwyrapellvgd+kyGk+v

Q: 124   HRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAV  183

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         dvwaiGcl++e+++Geplfpg+sd+dqly+i+++lG+liprhq++f+kn+vfaGv+lpe+

Q: 184   DVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFYKNPVFAGVRLPEI  243

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         +++e+le++ypkl+ev++dl+kkcl++dp++r +c+ell+h++f

Q: 244   KEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCSELLHHDFF  287

         ******************************************98

Domain Sequence
(FASTA)

YENLGLVGEG SYGMVVKCRN KDTGRIVAIK KFLESDDDKM VKKIAMREIK LLKQLRHENL 60

VNLLEVCKKK KRWYLVFEFV DHTILDDLEL FPNGLDYQVV QKYLFQIING IGFCHSHNII 120

HRDIKPENIL VSQSGVVKLC DFGFARTLAA PGEVYTDYVA TRWYRAPELL VGDVKYGKAV 180

DVWAIGCLVT EMFMGEPLFP GDSDIDQLYH IMMCLGNLIP RHQELFYKNP VFAGVRLPEI 240

KEREPLERRY PKLSEVVIDL AKKCLHIDPD KRPFCSELLH HDFF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013