EPS-MAM-00007

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MAM-00007

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	152.6	1.2E-44	133	278	146

Status

Unreviewed

Ensembl Protein

ENSMMUP00000030896

UniProt Accession

F7EZU7;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP27

Gene Synonyms/Alias

DUSP27;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000023467	ENSMMUP00000030896	ENSMMUT00000033017

Organism

Macaca mulatta

Functional Description

Protein Length

1164

Protein Sequence
(FASTA)

MATSKDPEEE QVVPSEEDEA NVRAVQAHYL RSPSPSQCSM VSDAETESIF MEPIHLSSAI 60

AAKQIINEEL KPRGVRADAE CPGMLESAEQ LLVEDLYNRV REKMDDTSLY NTPCVLDLQR 120

ALVQDRQEAP WNEVDEVWPN VFIAEKSVAV NKGRLKRLGI THILNAAHGT GVYTGPEFYT 180

GLEIQYLGVE VDDFPEVDIS QHFRKAAEFL DEALLTYRGK VLVSSEMGIS RSAVLVVAYL 240

MIFHNMAILE ALMTVRKKRA IYPNDGFLKQ LRELNEKLME EREEDYGREG ESAEAEEGEG 300

MGSMLGARVH ALTVEEEDDS ASHLSGSSLG KASQASKPLT LIDNEEEEKL YEEWKKGQGL 360

PSGKVSQGGG GRRSASSGQG GEQLEDEDED EDVERIIQEW QSRNERYQAE GHRRWGREEE 420

EEEESDAGSS VGRRRRTLSE SSAWESVSSH DIWVLKQQLE LNRPDHSRRR RSDSMSSDST 480

WDAWNERLLE IEKEASRRYH AKSKREEAAD RSSEAGSRVR EDDEESLGSE ASSFYNFCSR 540

NKDKLTALER WKIKRIQFGF HKKDLEAGDS SSEPGAEEAV GEKKNPSDIS LTAYQAWKLK 600

HQKKVGSENR EEVVELSKGE DSALAKKRQR RLELLERSRQ TLEESQSMAS WEADSSTASG 660

SIPLSAFWSA APSVSADGDT ASVLSTQSHR SHLSQAASNI AGCSTSNPIT PLPNLPVGPG 720

DTISIASIQN WIANVVSETL AQKQNEMLLL SRSPSVASMK AVPAASCLGD DQVSMLSGQS 780

SSSLGGCLLP QSQARLSSDM QSVLSCNTTL SSPPESSRSK VRGTSKPIYS LFADNVDLKE 840

LGRKEKEMQM ELREKMSEYK MEKLASDNKR SSLFKKKKVK EDEDDGVGDG DEDTDSAIGS 900

FRYSSRSSSQ KPETDTSSSL AVCDHYASGS RVGKEMDSSI NKWLSGLRTE EKPPFQSDWS 960

GSSRGKYTRS SLLRETESKS SSYKFSKSQS EEQDTSSYHE ANGNSIRSTS RFSSSSTREG 1020

REMHKFSRST YSETSSSREE SSPEPYFFCR TPEPSEREES PESQQPNWAR SRDWEDVEES 1080

SKSDFSEFGA KRKFTQSFMR SEEEGEKERM ENREEGRFAS GRQSQYRRST DREEEEEMDD 1140

EAIIAAWRRR QEETRTKLPR RRED 1164

Nucleotide Sequence
(FASTA)

ATGGCGACCA GCAAGGACCC AGAGGAGGAG CAGGTAGTCC CAAGTGAGGA GGATGAAGCC 60

AACGTGAGGG CGGTGCAGGC CCACTACCTC CGGAGCCCCT CCCCTAGCCA GTGTTCGATG 120

GTCTCAGATG CAGAAACAGA AAGCATTTTC ATGGAACCCA TTCACCTCTC CTCAGCCATT 180

GCAGCCAAAC AGATCATCAA TGAAGAACTC AAGCCACGGG GGGTCAGAGC AGACGCAGAG 240

TGTCCAGGCA TGCTGGAGTC TGCTGAACAG CTGCTGGTGG AGGACCTGTA CAACCGCGTC 300

AGGGAGAAGA TGGACGACAC CAGCCTCTAT AATACGCCCT GCGTCCTGGA CCTACAGCGG 360

GCTCTGGTTC AGGATCGCCA AGAGGCTCCC TGGAATGAGG TGGATGAGGT CTGGCCCAAT 420

GTCTTCATAG CTGAGAAGAG TGTGGCTGTG AACAAGGGGA GGCTGAAGAG GCTGGGAATC 480

ACCCACATTC TGAATGCTGC GCATGGCACT GGCGTTTACA CTGGCCCCGA ATTCTACACT 540

GGCCTGGAGA TCCAGTACCT GGGTGTGGAG GTGGATGATT TTCCTGAGGT GGACATTTCC 600

CAGCATTTCC GGAAGGCGGC TGAGTTCCTC GATGAGGCGC TGCTCACTTA CAGAGGGAAA 660

GTCCTGGTCA GCAGCGAAAT GGGCATCAGC CGGTCAGCAG TTCTAGTGGT CGCCTACCTG 720

ATGATCTTCC ACAATATGGC CATCCTGGAG GCGTTGATGA CTGTGCGTAA GAAGCGGGCC 780

ATCTACCCCA ACGACGGCTT CCTGAAGCAG CTGCGGGAGC TCAACGAGAA GCTGATGGAG 840

GAGAGAGAAG AGGACTACGG CAGGGAGGGG GAATCAGCTG AGGCTGAGGA GGGCGAGGGC 900

ATGGGGAGCA TGCTCGGGGC CAGAGTGCAC GCCCTGACGG TGGAGGAGGA GGACGACAGC 960

GCCAGCCACC TGAGTGGCTC CTCCCTGGGG AAGGCCAGCC AGGCCTCCAA GCCCCTCACC 1020

CTCATTGACA ACGAGGAGGA GGAGAAACTG TACGAGGAGT GGAAGAAGGG GCAGGGCCTC 1080

CCCTCGGGCA AGGTCTCCCA GGGTGGAGGT GGCCGGCGCT CAGCCTCTTC TGGCCAGGGT 1140

GGGGAGCAGC TCGAGGACGA GGACGAGGAC GAGGACGTGG AGAGAATCAT CCAGGAGTGG 1200

CAGAGCCGAA ACGAGAGGTA TCAAGCAGAA GGGCACCGGA GGTGGGGAAG GGAGGAGGAA 1260

GAAGAGGAGG AGAGCGACGC TGGCTCCTCC GTAGGGAGGC GGCGGCGCAC CCTGAGCGAG 1320

AGCAGCGCCT GGGAGAGCGT GAGCAGCCAC GACATCTGGG TCCTGAAGCA GCAGCTGGAG 1380

CTGAACCGGC CAGACCACAG CAGGAGGCGC CGCTCAGACT CGATGTCCTC GGATAGCACC 1440

TGGGACGCGT GGAACGAGAG GCTGCTGGAG ATTGAGAAGG AGGCTTCCCG GAGGTACCAT 1500

GCTAAGAGCA AGAGAGAGGA GGCGGCAGAC AGGAGCTCAG AGGCAGGGAG CAGGGTGCGG 1560

GAGGATGACG AGGAGAGCTT GGGCTCTGAG GCCAGCTCCT TCTACAACTT CTGCAGCAGG 1620

AACAAGGACA AGCTCACTGC CCTGGAAAGA TGGAAGATCA AGAGAATCCA GTTTGGATTT 1680

CACAAGAAAG ACTTGGAAGC AGGAGACAGC AGCAGTGAGC CCGGTGCAGA GGAAGCAGTG 1740

GGGGAGAAGA AGAACCCCTC CGACATCAGC CTGACAGCCT ACCAGGCCTG GAAGCTGAAA 1800

CACCAGAAGA AGGTGGGCAG TGAGAACAGG GAGGAGGTGG TGGAGCTCAG CAAGGGGGAG 1860

GACTCGGCCT TGGCTAAGAA GAGGCAACGG AGGCTGGAGC TGCTGGAGAG AAGCCGGCAG 1920

ACGCTGGAGG AGAGCCAGTC TATGGCAAGC TGGGAGGCGG ACAGCTCCAC GGCCAGCGGG 1980

AGCATTCCCC TGTCTGCGTT CTGGTCTGCA GCCCCCTCAG TCAGTGCTGA TGGGGACACG 2040

GCGTCAGTAC TGAGCACCCA GAGCCACCGC TCCCACCTGT CTCAGGCTGC AAGCAACATA 2100

GCGGGGTGTT CAACCTCCAA TCCCATCACA CCCCTGCCTA ACCTGCCAGT GGGGCCTGGA 2160

GACACCATTT CCATTGCCAG TATCCAGAAC TGGATTGCCA ATGTAGTCAG CGAGACCCTT 2220

GCTCAGAAGC AAAATGAAAT GCTGCTGTTG TCCCGCTCCC CGTCTGTTGC AAGCATGAAG 2280

GCAGTACCAG CGGCCAGTTG CCTGGGGGAT GACCAAGTCT CCATGCTCAG TGGACAAAGC 2340

AGCTCCTCCT TGGGTGGCTG CCTGTTGCCT CAGAGCCAGG CAAGACTCAG CTCTGACATG 2400

CAGTCTGTGC TGTCCTGCAA CACCACACTG AGCTCGCCCC CTGAAAGTTC CAGGAGCAAA 2460

GTGAGGGGGA CCAGCAAGCC CATCTACAGC CTCTTTGCTG ACAATGTGGA CCTGAAGGAA 2520

CTTGGCCGGA AGGAAAAGGA GATGCAGATG GAGCTTAGGG AGAAGATGTC TGAGTACAAA 2580

ATGGAAAAGC TGGCCTCAGA CAACAAACGC AGCTCCCTCT TCAAGAAGAA GAAGGTCAAG 2640

GAAGATGAGG ATGATGGTGT GGGTGATGGG GATGAGGACA CTGACAGCGC CATAGGGAGC 2700

TTCCGGTATT CTTCCCGCAG TAGTTCCCAG AAACCTGAAA CAGACACATC CTCCTCCCTG 2760

GCTGTCTGTG ATCACTATGC AAGTGGCAGC AGAGTTGGCA AAGAGATGGA TAGCAGTATT 2820

AATAAGTGGC TCAGTGGCCT CAGGACAGAG GAAAAACCTC CTTTCCAAAG TGACTGGTCT 2880

GGAAGTTCCA GGGGGAAGTA CACCAGATCA TCCCTGCTCA GGGAGACAGA GTCTAAATCC 2940

TCCAGTTACA AGTTTTCCAA ATCCCAGTCA GAGGAACAGG ACACCTCCTC CTACCACGAG 3000

GCAAATGGCA ACTCTATAAG AAGCACTTCA CGGTTCTCGT CTTCCTCCAC CAGGGAGGGC 3060

AGAGAGATGC ACAAGTTCTC CAGGTCCACG TACAGCGAGA CCTCAAGTTC CCGAGAGGAG 3120

AGCAGCCCAG AGCCCTACTT CTTCTGCCGG ACCCCAGAGC CCTCAGAAAG GGAAGAGTCC 3180

CCAGAGTCAC AGCAACCAAA TTGGGCCAGG TCCAGAGACT GGGAAGATGT GGAAGAATCA 3240

TCCAAGTCAG ACTTCTCTGA ATTTGGAGCC AAGAGGAAAT TCACCCAGAG CTTTATGAGG 3300

TCTGAAGAAG AGGGAGAGAA AGAGAGGATG GAAAACAGAG AAGAAGGGAG GTTTGCATCT 3360

GGACGGCAGT CCCAGTATCG AAGAAGCACT GACAGAGAGG AAGAGGAAGA AATGGACGAT 3420

GAAGCCATCA TTGCTGCTTG GAGACGTCGG CAAGAAGAAA CCAGGACCAA GCTGCCGAGA 3480

AGGAGGGAGG ACTGA 3495

Domain Profile

S: 1     evteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipv  60

         ev+e++p+++++++ +a+++  L++lgit+++na++++    ++Pe+++  +i+y++++v

Q: 133   EVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGV-YTGPEFYTGLEIQYLGVEV  191

         69**********************************8765.79*****************

S: 61    dDsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdA  119

         dD ++ d++q+f++aaef+dea  + +gkvlv +++G+sRSa+lv+aYLm+++++++ +A

Q: 192   DDFPEVDISQHFRKAAEFLDEAlLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEA  251

         **********************8999**********************************

S: 120   ieavkrkrpsiepnegfleQLlelekkl  147

         +++v++kr +i+pn+gfl+QL+el++kl

Q: 252   LMTVRKKR-AIYPNDGFLKQLRELNEKL  278

         ********.***************9987

Domain Sequence
(FASTA)

EVDEVWPNVF IAEKSVAVNK GRLKRLGITH ILNAAHGTGV YTGPEFYTGL EIQYLGVEVD 60

DFPEVDISQH FRKAAEFLDE ALLTYRGKVL VSSEMGISRS AVLVVAYLMI FHNMAILEAL 120

MTVRKKRAIY PNDGFLKQLR ELNEKL 146

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

mcc:697299

;

InterPros

IPR020417	; Atypical_DUSP.
IPR020405	; Atypical_DUSP_famA.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

PR01908	; ADSPHPHTASE.
PR01909	; ADSPHPHTASEA.

Created Date

20-Feb-2013