EKS-MAM-00234
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00234
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/MAPKAPK431.22.4E-12966327262
StatusUnreviewed
Ensembl ProteinENSMMUP00000031021
UniProt AccessionF7HHY8;
Protein Name
Protein Synonyms/Alias
Gene NameMAPKAPK2
Gene Synonyms/Alias MAPKAPK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000023567ENSMMUP00000031021ENSMMUT00000033150
ENSMMUG00000023567ENSMMUP00000031020ENSMMUT00000033149
OrganismMacaca mulatta
Functional Description
Protein Length372
Protein Sequence
(FASTA)
MLSNSQGQSP PVPFPAPAPP PQPPAPAPAP PHPPAQPPPP PPQQFPQFHV KSGLQIKKNA 60
IIDDYKVTSQ VLGLGINGKV LQIFNKRTQE KLALKMLQDC PKARREVELH WRASQCPHIV 120
RIVDVYENLY AGRKCLLIVM ECLDGGELFS RIQDRGDQAF TEREASEIMK SIGEAIQYLH 180
SINIAHRDVK PENLLYTSKR PNAILKLTDF GFAKETTSHN SLTTPCYTPY YVAPEVLGPE 240
KYDKSCDMWS LGVIMYILLC GYPPFYSNHG LAISPGMKTR IRMGQYEFPN PEWSEVSEEV 300
KMLIRNLLKT EPTQRMTITE FMNHPWIMQS TKVPQTPLHT SRVLKEDKER WEDVKGCLHY 360
KNSNQATWLT RL 372
Nucleotide Sequence
(FASTA)
ATGCTGTCCA ACTCCCAGGG CCAGAGCCCG CCGGTGCCCT TCCCCGCCCC GGCCCCGCCG 60
CCGCAGCCCC CCGCCCCTGC CCCTGCCCCG CCGCACCCCC CGGCGCAGCC GCCGCCGCCG 120
CCCCCGCAGC AGTTCCCGCA GTTCCATGTC AAGTCCGGCC TGCAGATCAA GAAGAACGCC 180
ATCATCGATG ACTACAAGGT CACCAGCCAG GTCCTGGGGC TGGGCATCAA CGGGAAAGTT 240
TTGCAGATCT TCAACAAGAG GACCCAGGAG AAATTAGCCC TCAAAATGCT TCAGGACTGC 300
CCCAAGGCCC GCAGGGAGGT GGAGCTGCAC TGGCGGGCCT CCCAGTGCCC GCACATCGTA 360
CGGATCGTGG ATGTGTACGA GAATCTGTAC GCAGGGAGGA AGTGCCTGCT GATTGTCATG 420
GAATGTTTGG ACGGTGGAGA ACTCTTTAGC CGAATCCAGG ACCGAGGAGA CCAGGCGTTC 480
ACAGAAAGAG AGGCATCCGA AATCATGAAG AGCATCGGTG AGGCCATCCA GTATCTGCAC 540
TCAATCAACA TTGCCCATCG GGATGTCAAG CCTGAGAATC TCTTATACAC CTCCAAAAGG 600
CCCAACGCCA TCCTGAAACT CACTGACTTT GGCTTTGCCA AGGAAACCAC CAGCCACAAC 660
TCTTTGACCA CTCCTTGTTA TACGCCATAC TATGTGGCTC CAGAAGTGCT GGGTCCAGAG 720
AAGTATGACA AGTCCTGTGA CATGTGGTCC CTGGGTGTCA TCATGTACAT CCTGCTGTGT 780
GGGTATCCCC CCTTCTACTC CAACCACGGC CTTGCCATCT CTCCGGGCAT GAAGACTCGC 840
ATCCGAATGG GCCAGTATGA ATTTCCCAAC CCAGAATGGT CAGAAGTATC AGAGGAAGTG 900
AAGATGCTCA TTCGGAACCT GCTGAAAACA GAGCCCACCC AGAGAATGAC CATCACCGAG 960
TTTATGAACC ACCCCTGGAT CATGCAATCG ACGAAGGTCC CTCAAACCCC ACTGCACACC 1020
AGCCGGGTCC TGAAGGAGGA CAAGGAGCGG TGGGAGGATG TCAAGGGGTG TCTTCATTAC 1080
AAGAACAGCA ACCAGGCCAC TTGGCTGACT AGGTTGTGA 1119
Domain Profile
S: 1     klteevlGeGisgkvlecvkkktgekyalkilkdrkkvrrevelhvqasghknivelidv  60
         k+t++vlG Gi+gkvl++++k+t+ek alk+l+d++k+rrevelh++as++++iv+++dv
Q: 66    KVTSQVLGLGINGKVLQIFNKRTQEKLALKMLQDCPKARREVELHWRASQCPHIVRIVDV  125
         5799********************************************************
S: 61    fensfedekrlllvlekleGGellsriqer..kaftekeasevvkdiasalkflhsknia  118
         +en ++++k+ll+v+e+l+GGel+sriq+r  +afte+ease++k+i++a+++lhs nia
Q: 126   YENLYAGRKCLLIVMECLDGGELFSRIQDRgdQAFTEREASEIMKSIGEAIQYLHSINIA  185
         *******************************9****************************
S: 119   hrDlkpenlLyeskeknapvklcDfglaketeeeeelktpcltaeyvaPevleaekeeal  178
         hrD+kpenlLy+sk+ na++kl+Dfg+aket+++++l+tpc+t++yvaPevl++ek    
Q: 186   HRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK----  241
         ********************************************************....
S: 179   lydksCDlWslGvilyillcGypPfyskkgraiskklkeriqegkyefPeeeWsevseea  238
          ydksCD+WslGvi+yillcGypPfys++g ais+++k+ri++g+yefP++eWsevsee+
Q: 242   -YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEV  300
         .***********************************************************
S: 239   kdlirklLkrdpkerltieevlnhpwv  265
         k+lir+lLk++p++r+ti+e++nhpw+
Q: 301   KMLIRNLLKTEPTQRMTITEFMNHPWI  327
         **************************8
Domain Sequence
(FASTA)
KVTSQVLGLG INGKVLQIFN KRTQEKLALK MLQDCPKARR EVELHWRASQ CPHIVRIVDV 60
YENLYAGRKC LLIVMECLDG GELFSRIQDR GDQAFTEREA SEIMKSIGEA IQYLHSINIA 120
HRDVKPENLL YTSKRPNAIL KLTDFGFAKE TTSHNSLTTP CYTPYYVAPE VLGPEKYDKS 180
CDMWSLGVIM YILLCGYPPF YSNHGLAISP GMKTRIRMGQ YEFPNPEWSE VSEEVKMLIR 240
NLLKTEPTQR MTITEFMNHP WI 262
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00214
EKS-ANC-00225
EKS-CAJ-00241
EKS-CAF-00242
EKS-DAR-00545
EKS-EQC-00227
EKS-FEC-00222
EKS-GAM-00136
EKS-GAG-00195
EKS-GAA-00284
EKS-GOG-00233
EKS-HOS-00239
EKS-ICT-00223
EKS-LAC-00247
EKS-LOA-00232
EKS-MEG-00180
EKS-MIM-00006
EKS-MOD-00236
EKS-MUM-00237
EKS-MUP-00235
EKS-MYL-00235
EKS-NOL-00216
EKS-OCP-00011
EKS-ORN-00300
EKS-ORA-00204
EKS-ORC-00211
EKS-ORL-00281
EKS-OTG-00238
EKS-PAT-00222
EKS-PES-00210
EKS-POA-00225
EKS-PRC-00011
EKS-RAN-00234
EKS-SAH-00219
EKS-SUS-00202
EKS-TAR-00296
EKS-XET-00307
EKS-XIM-00292
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0070935; P:3'-UTR-mediated mRNA stabilization
GO:0035924; P:cellular response to vascular endothelial growth factor stimulus
GO:0031572; P:G2/M transition DNA damage checkpoint
GO:0006954; P:inflammatory response
GO:0048839; P:inner ear development
GO:0044351; P:macropinocytosis
GO:0018105; P:peptidyl-serine phosphorylation
GO:0032675; P:regulation of interleukin-6 production
GO:0032680; P:regulation of tumor necrosis factor production
GO:0032496; P:response to lipopolysaccharide
GO:0002224; P:toll-like receptor signaling pathway
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
KEGG
mcc:695044;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013