EKS-MAM-00244

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00244

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	340.1	1.3E-101	18	270	253

Status

Unreviewed

Ensembl Protein

ENSMMUP00000031353

UniProt Accession

F7HR74;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKAA1

Gene Synonyms/Alias

PRKAA1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000023806	ENSMMUP00000031354	ENSMMUT00000033500
ENSMMUG00000023806	ENSMMUP00000031353	ENSMMUT00000033499
ENSMMUG00000023806	ENSMMUP00000031352	ENSMMUT00000033498

Organism

Macaca mulatta

Functional Description

Protein Length

550

Protein Sequence
(FASTA)

MATAEKQKHD GRVKIGHYIL GDTLGVGTFG KVKVGKHELT GHKVAVKILN RQKIRSLDVV 60

GKIRREIQNL KLFRHPHIIK LYQVISTPSD IFMVMEYVSG GELFDYICKN GRLDEKESRR 120

LFQQILSGVD YCHRHMVVHR DLKPENVLLD AHMNAKIADF GLSNMMSDGE FLRTSCGSPN 180

YAAPEVISGR LYAGPEVDIW SSGVILYALL CGTLPFDDDH VPTLFKKICD GIFYTPQYLN 240

PSVISLLKHM LQVDPMKRAT IKDIREHEWF KQDLPKYLFP EDPSYSSTMI DDEALKEVCE 300

KFECSEEEVL SCLYNRNHQD PLAVAYHLII DNRRIMNEAK DFYLATSPPD SFLDDHHLSR 360

PHPERVPFLV AETPRARHTL DELNPQKSKH QGVRKAKWHL GIRSQSRPND IMAEVCRAIK 420

QLDYEWKVVN PYYLRVRRKN PVTSTYSKMS LQLYQVDSRT YLLDFRSIDD EITEAKSGTA 480

TPQRSGSVSN YRSCQRSDSD AEAQGKSSEV SLTSSVTSLD SSPVDLTPRP GSHTIEFFEM 540

CANLIKILAQ 550

Nucleotide Sequence
(FASTA)

ATGGCGACAG CCGAGAAGCA GAAACACGAC GGGCGGGTGA AGATCGGCCA CTACATCCTG 60

GGTGACACGC TGGGGGTCGG CACCTTCGGC AAAGTGAAGG TTGGCAAACA TGAATTGACT 120

GGGCATAAAG TTGCTGTGAA GATACTCAAT CGACAGAAGA TTCGGAGCCT TGATGTGGTA 180

GGAAAAATCC GCAGAGAAAT TCAGAACCTC AAGCTTTTCA GGCATCCTCA TATAATTAAA 240

CTGTACCAGG TCATCAGTAC ACCATCTGAT ATTTTCATGG TGATGGAATA TGTCTCAGGA 300

GGAGAGCTAT TTGATTATAT CTGTAAGAAT GGAAGGCTGG ATGAAAAAGA AAGTCGACGT 360

CTATTCCAAC AGATCCTTTC TGGTGTGGAT TATTGTCACA GGCATATGGT AGTCCATAGA 420

GATTTGAAAC CTGAAAATGT CCTGCTTGAT GCACACATGA ATGCAAAGAT AGCCGATTTT 480

GGTCTTTCAA ACATGATGTC AGATGGTGAA TTTTTAAGAA CAAGTTGTGG CTCACCCAAC 540

TATGCTGCAC CAGAAGTAAT TTCAGGAAGA TTGTATGCAG GCCCAGAGGT AGATATATGG 600

AGCAGTGGGG TTATTCTCTA TGCTTTATTA TGTGGAACCC TTCCATTTGA TGATGACCAT 660

GTGCCAACTC TTTTTAAGAA GATATGTGAT GGGATCTTCT ATACCCCTCA ATATTTAAAT 720

CCTTCTGTGA TTAGCCTTTT GAAACATATG CTGCAGGTGG ATCCCATGAA GAGGGCCACA 780

ATCAAAGATA TCAGGGAACA TGAATGGTTT AAACAGGACC TTCCAAAGTA TCTCTTTCCT 840

GAGGATCCAT CATATAGTTC AACCATGATT GACGATGAAG CCTTAAAAGA AGTATGTGAA 900

AAGTTTGAGT GCTCAGAAGA GGAAGTTCTC AGCTGTCTTT ATAACAGAAA TCACCAGGAT 960

CCTTTGGCAG TTGCATACCA TCTCATAATA GATAACAGGA GAATAATGAA TGAAGCCAAA 1020

GATTTCTATT TGGCGACAAG CCCACCTGAT TCTTTTCTTG ATGATCATCA CCTGTCTCGG 1080

CCCCATCCTG AAAGAGTACC ATTCTTGGTT GCTGAAACAC CAAGGGCACG CCATACCCTT 1140

GATGAATTAA ATCCGCAGAA ATCCAAACAC CAAGGTGTAA GGAAAGCAAA ATGGCATTTA 1200

GGAATTAGAA GTCAAAGTCG TCCAAATGAT ATTATGGCAG AAGTATGTAG AGCAATTAAA 1260

CAATTGGATT ATGAATGGAA GGTTGTAAAC CCATATTATT TGCGTGTACG AAGGAAGAAT 1320

CCTGTGACAA GCACTTACTC GAAAATGAGT CTACAGTTAT ACCAGGTGGA TAGTAGAACT 1380

TATCTACTGG ATTTCCGTAG TATTGATGAT GAAATTACAG AAGCCAAATC AGGGACTGCT 1440

ACTCCACAGA GATCGGGATC AGTTAGCAAC TATCGATCTT GCCAAAGGAG TGATTCAGAT 1500

GCTGAGGCTC AAGGAAAATC CTCAGAAGTT TCTCTTACCT CATCTGTGAC CTCACTTGAC 1560

TCTTCTCCTG TTGACCTAAC TCCAAGACCT GGAAGTCACA CAATAGAATT TTTTGAGATG 1620

TGTGCAAATC TAATTAAAAT TCTTGCACAA TAA 1653

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl.seeslekikrEieilkklkhpn  59

         y l++tlG g+fgkVk+ kh++t++kvavKi++++k+ s + + ki+rEi+ lk ++hp+

Q: 18    YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIrSLDVVGKIRREIQNLKLFRHPH  77

         8899********************************96667788****************

S: 60    iikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

         iikl++vi+t +++++v+ey+sggeLfdyi ++grl+eke+r+lf+q++s+v+Y+h++ +

Q: 78    IIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMV  137

         ************************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlKpeN+lld+++n kiaDFGl+n++++g+ l+t+cGsp+YaaPe+++g+ Y gp+v

Q: 138   VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEV  197

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         D+Ws Gv+Lyal++g+lPfd++++ +l++ki +g + +p++l+++++sLl+++L+vdp k

Q: 198   DIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMK  257

         ************************************************************

S: 240   Ratieeilkhewl  252

         Rati++i++hew+

Q: 258   RATIKDIREHEWF  270

         ************7

Domain Sequence
(FASTA)

YILGDTLGVG TFGKVKVGKH ELTGHKVAVK ILNRQKIRSL DVVGKIRREI QNLKLFRHPH 60

IIKLYQVIST PSDIFMVMEY VSGGELFDYI CKNGRLDEKE SRRLFQQILS GVDYCHRHMV 120

VHRDLKPENV LLDAHMNAKI ADFGLSNMMS DGEFLRTSCG SPNYAAPEVI SGRLYAGPEV 180

DIWSSGVILY ALLCGTLPFD DDHVPTLFKK ICDGIFYTPQ YLNPSVISLL KHMLQVDPMK 240

RATIKDIREH EWF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0004679	; F:AMP-activated protein kinase activity
GO:0005524	; F:ATP binding
GO:0003682	; F:chromatin binding
GO:0035174	; F:histone serine kinase activity
GO:0042149	; P:cellular response to glucose starvation
GO:0019395	; P:fatty acid oxidation
GO:0042593	; P:glucose homeostasis
GO:0006006	; P:glucose metabolic process
GO:0008610	; P:lipid biosynthetic process
GO:0043066	; P:negative regulation of apoptotic process
GO:0050995	; P:negative regulation of lipid catabolic process
GO:0032007	; P:negative regulation of TOR signaling cascade
GO:0010508	; P:positive regulation of autophagy
GO:0042752	; P:regulation of circadian rhythm

KEGG

mcc:695558

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013