EKS-MAM-00345
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00345
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PEK370.78.6E-111167583417
StatusUnreviewed
Ensembl ProteinENSMMUP00000035507
UniProt AccessionF7F136;
Protein Name
Protein Synonyms/Alias
Gene NameEIF2AK1
Gene Synonyms/Alias EIF2AK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000030419ENSMMUP00000035507ENSMMUT00000042501
OrganismMacaca mulatta
Functional Description
Protein Length630
Protein Sequence
(FASTA)
MQGGNSGVRK REEEGDGEGA VAAPPAIDFP AESSDLKYDE SDVPAELQVL KEPLQQPTFP 60
FAVANQLLLV SLLEHLSHVH EPNPLRSRQV FKLLCQTFIK MGLLSSFTCS DEFSSLRLHH 120
NRAITHLMRS AKERVRQDPC EDVSHIQKIR SREVAFEAQT SRYLNEFEEV AILGKGGYGR 180
VYKVRNKLDG QYYAIKKILI KGATKTDCMK VLREVKVLAG LQHPNIVGYH TAWIEHVHVI 240
QPRADRAAIE LPTLEVLSDQ EEDREQYDVK NDESSSSSIV FAEPTPEKGK RFGESDTENQ 300
NDKSVKYTTS LVIRDSGELE STLELQENDL AGLSTSSIME QQLPLRRNSH LDDSFTSTEE 360
SSEENVNFLG QTEAQYHLML HIQMQLCELS LWDWIAERNK RSRECVDESA CPYVMANVAT 420
KIFQELVEGV FYIHNMGIVH RDLKPRNIFL HGPDQQVKIG DFGLACTDIL QKNADWTNRN 480
GKRTPTHTSR VGTCLYASPE QLEGSEYDAK SDMYSLGVIL LELFQPFGTE MERAEVLTGL 540
RTGQLPESLS KRCPVQAKYI QHLTRRNSSQ RPSAVQLLQS ELFQTSGNVN FTLQMKIIEQ 600
EKEIAELKKQ LNLLSQDKGV RDDGKDGGVP 630
Nucleotide Sequence
(FASTA)
ATGCAGGGGG GCAACTCTGG GGTCCGCAAG CGCGAAGAGG AGGGCGACGG GGAGGGGGCT 60
GTGGCAGCGC CGCCGGCCAT CGACTTTCCC GCCGAGAGCT CGGACCTCAA ATATGACGAA 120
TCTGATGTTC CTGCAGAACT CCAGGTGTTA AAAGAACCCC TACAACAGCC AACCTTCCCT 180
TTTGCAGTTG CAAACCAACT CTTGCTTGTT TCTTTGTTGG AGCACTTGAG CCATGTGCAT 240
GAACCAAACC CACTTCGTTC AAGACAGGTG TTTAAGTTAC TTTGCCAGAC CTTTATCAAA 300
ATGGGACTGC TGTCTTCTTT CACTTGTAGT GACGAGTTTA GCTCATTGAG ACTACATCAC 360
AACAGAGCTA TTACTCACCT AATGAGGTCC GCTAAAGAGA GAGTTCGTCA GGATCCCTGT 420
GAGGATGTTT CTCATATTCA GAAAATCAGA TCAAGGGAAG TCGCCTTCGA AGCACAGACT 480
TCACGTTACT TAAATGAATT TGAAGAAGTT GCCATCTTAG GAAAAGGTGG ATACGGAAGA 540
GTATACAAGG TCAGGAATAA ATTAGATGGT CAGTATTATG CAATAAAAAA GATCCTGATT 600
AAGGGTGCAA CTAAAACAGA TTGCATGAAG GTCCTACGGG AAGTGAAGGT GCTCGCAGGT 660
CTTCAGCACC CCAATATCGT TGGCTATCAC ACTGCGTGGA TAGAACATGT TCACGTGATT 720
CAGCCACGAG CAGACAGAGC TGCCATTGAG TTGCCAACTC TGGAAGTACT CTCCGACCAG 780
GAAGAGGACA GAGAACAATA TGATGTTAAA AATGATGAAA GTAGCAGCTC ATCCATTGTC 840
TTTGCTGAGC CCACCCCAGA AAAAGGAAAA CGCTTTGGAG AATCTGACAC TGAAAATCAG 900
AATGACAAGT CAGTGAAGTA TACCACCAGT TTAGTCATAA GAGACTCCGG TGAACTTGAG 960
TCAACCCTGG AGCTCCAGGA AAATGACTTG GCTGGTTTGT CTACCAGTTC AATTATGGAA 1020
CAGCAGCTGC CACTCAGGCG TAATTCCCAC CTAGATGATA GTTTCACATC CACCGAAGAA 1080
TCTTCCGAAG AAAATGTCAA CTTTTTGGGT CAGACAGAGG CCCAGTACCA CCTGATGCTG 1140
CACATCCAGA TGCAGCTGTG TGAGCTCTCG CTGTGGGACT GGATAGCCGA GAGAAACAAG 1200
CGCAGCCGGG AGTGTGTGGA CGAGTCTGCC TGTCCTTATG TTATGGCCAA TGTTGCAACA 1260
AAAATTTTTC AAGAATTGGT AGAAGGTGTG TTTTACATAC ATAACATGGG AATTGTGCAT 1320
CGAGATCTGA AGCCAAGAAA TATTTTTCTT CATGGCCCTG ATCAGCAAGT AAAAATAGGA 1380
GACTTTGGTC TGGCCTGCAC AGACATCCTA CAGAAGAACG CAGACTGGAC CAATAGAAAC 1440
GGGAAGAGAA CACCAACACA TACGTCCAGA GTGGGTACTT GTCTGTACGC TTCACCTGAA 1500
CAGTTGGAAG GATCTGAGTA TGATGCCAAG TCAGATATGT ACAGCTTGGG TGTGATCCTG 1560
CTAGAGCTCT TTCAGCCATT TGGAACAGAA ATGGAGCGAG CAGAAGTTCT AACAGGTTTA 1620
AGAACTGGTC AGTTGCCGGA ATCCCTCAGT AAAAGATGTC CAGTGCAAGC CAAGTATATC 1680
CAGCACTTAA CGAGAAGGAA CTCATCGCAG AGACCATCTG CTGTTCAGCT GCTGCAGAGC 1740
GAACTTTTCC AAACTTCTGG AAATGTTAAC TTCACTCTAC AGATGAAGAT AATAGAGCAA 1800
GAAAAAGAAA TTGCAGAACT AAAGAAGCAG CTAAACCTCC TTTCTCAAGA CAAAGGGGTG 1860
AGGGATGACG GAAAGGATGG GGGCGTACCT 1890
Domain Profile
S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakke.lekverevkaLaklehpni  59
         fee+++lGkGg+g+V+k++nkld+++yaik+i ++ a+k+ ++kv+revk+La l+hpni
Q: 167   FEEVAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTdCMKVLREVKVLAGLQHPNI  226
         899*********************************************************
S: 60    vrYfaawleekeesl.................................tdsseveaeael  86
         v Y++aw+e+ + ++                                 ++ss v+ae ++
Q: 227   VGYHTAWIEHVHVIQpradraaielptlevlsdqeedreqydvkndesSSSSIVFAEPTP  286
         ************999******************************995449999999999
S: 87    eesesseesdtk................................................  98
         e+ +++ esdt+                                                
Q: 287   EKGKRFGESDTEnqndksvkyttslvirdsgelestlelqendlaglstssimeqqlplr  346
         999999999999************************************************
S: 99    ................................llyiqmelceketLkdwiderk......  120
                                         +l+iqm+lce  +L+dwi er+      
Q: 347   rnshlddsftsteesseenvnflgqteaqyhlMLHIQMQLCE-LSLWDWIAERNkrsrec  405
         ******************************************.********999899998
S: 121   llesrselvm.....rlfkqllegleylHskgliHrdLkpsniFld.sddqvKigDFgLa  174
         ++es++ +vm     ++f++l+eg+ y+H++g++HrdLkp+niFl+  d+qvKigDFgLa
Q: 406   VDESACPYVManvatKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHgPDQQVKIGDFGLA  465
         9999999999************************************99************
S: 175   talaealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGlilfeLly  234
         ++++ ++++d+++++ +++++ht++vgt+ly+sPeqle+s+Y++k+D++sLG+il+eL++
Q: 466   CTDILQKNADWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVILLELFQ  525
         ************************************************************
S: 235   pfstemervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasellksell  292
         pf temer+e+lt lr+g++pe++++++p+++k++q+l++r++++Rpsa +ll+sel+
Q: 526   PFGTEMERAEVLTGLRTGQLPESLSKRCPVQAKYIQHLTRRNSSQRPSAVQLLQSELF  583
         *******************************************************986
Domain Sequence
(FASTA)
FEEVAILGKG GYGRVYKVRN KLDGQYYAIK KILIKGATKT DCMKVLREVK VLAGLQHPNI 60
VGYHTAWIEH VHVIQPRADR AAIELPTLEV LSDQEEDREQ YDVKNDESSS SSIVFAEPTP 120
EKGKRFGESD TENQNDKSVK YTTSLVIRDS GELESTLELQ ENDLAGLSTS SIMEQQLPLR 180
RNSHLDDSFT STEESSEENV NFLGQTEAQY HLMLHIQMQL CELSLWDWIA ERNKRSRECV 240
DESACPYVMA NVATKIFQEL VEGVFYIHNM GIVHRDLKPR NIFLHGPDQQ VKIGDFGLAC 300
TDILQKNADW TNRNGKRTPT HTSRVGTCLY ASPEQLEGSE YDAKSDMYSL GVILLELFQP 360
FGTEMERAEV LTGLRTGQLP ESLSKRCPVQ AKYIQHLTRR NSSQRPSAVQ LLQSELF 417
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00318
EKS-ANC-00332
EKS-BOT-00340
EKS-CAJ-00349
EKS-CAF-00348
EKS-CAP-00374
EKS-CII-00191
EKS-CIS-00092
EKS-DAR-00704
EKS-EQC-00332
EKS-FEC-00331
EKS-GAG-00286
EKS-GAA-00423
EKS-GOG-00338
EKS-HOS-00347
EKS-ICT-00324
EKS-LAC-00356
EKS-LOA-00351
EKS-MEG-00281
EKS-MOD-00336
EKS-MUM-00375
EKS-MUP-00334
EKS-MYL-00339
EKS-ORN-00444
EKS-ORA-00299
EKS-ORC-00319
EKS-ORL-00411
EKS-OTG-00345
EKS-PAT-00323
EKS-PES-00300
EKS-PEM-00181
EKS-POA-00332
EKS-PTV-00080
EKS-RAN-00355
EKS-SAH-00319
EKS-SUS-00303
EKS-TAG-00416
EKS-TAR-00447
EKS-TEN-00443
EKS-XET-00433
EKS-XIM-00431
EKS-SCP-00085
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0020037; F:heme binding
GO:0008285; P:negative regulation of cell proliferation
GO:0046986; P:negative regulation of hemoglobin biosynthetic process
GO:0046777; P:protein autophosphorylation
GO:0046501; P:protoporphyrinogen IX metabolic process
GO:0010999; P:regulation of eIF2 alpha phosphorylation by heme
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
InterPros
IPR015516; Haem-reg_EIF2A_Kinase.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013