EKS-MAM-00251

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00251

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	316.5	2.0E-94	20	268	249

Status

Unreviewed

Ensembl Protein

ENSMMUP00000036709

UniProt Accession

F6ZPR3;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK2

Gene Synonyms/Alias

SIK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000030914	ENSMMUP00000036709	ENSMMUT00000043718

Organism

Macaca mulatta

Functional Description

Protein Length

923

Protein Sequence
(FASTA)

MVMADGPRHL QRGPVRVGFY DIEGTLGKGN FAVVKLGRHR ITKTEVAIKI IDKSQLDAVN 60

LEKIYREVQI MKMLDHPHII KLYQVMETKS MLYLVTEYAK NGEIFDYLAN HGRLNESEAR 120

RKFWQILSAV DYCHGRKIVH RDLKAENLLL DNNMNIKIAG NWDTTGSNMI RPCPSVPPYA 180

APEVFEGQQY EGPQLDIWSM GVVLYVLVCG ALPFDGPTLP ILRQRVLEGR FRIPYFMSED 240

CEHLIRRMLV LDPSKRLTIA QIREHKWMLI EVPVQRPVLY PQEQENEPSI GEFNEQVLRL 300

MHSLGIDQQK TIESLQNKSY NHFAAIYFLL VERLKSHRSS FPVEQRLDGR QRRPSTIAEQ 360

TVAKAQTVGL PVTMHSPNMR LLRSALLPQA SNMEAFSFPA SGCQAEAAFM EEECVDTPKV 420

NGCLLDPVPP VLVRKGCQSL PSNMMETSID EGLETEGEAE EDPAHAFEAF QSTRSGQRRH 480

TLSEVTNQLV VMPGAGKIFS MNDSPSLDSV DSEYDMGSVQ RDLNFLEDNP SLKDIMLANQ 540

PSPRMTSPFI SLRPTNPAMQ ALSSQKREVH NRSPVSFREG RRASDTSLTQ GIVAFRQHLQ 600

NLARTKGILE LNKVQLLYEQ IGPEADPNLA PAAPQLQDLT SSCPQEEVSP PQESVSTLPA 660

SVHPQLSPRQ SLETQYLQHR LQKPSLLSKA QNTCQLYCKE PPRSLEQQLQ EHRLQQKRLF 720

LQKQSQLQAY FNQMQIAESS YPQPSQQLPL PRQETAPPSQ QAPPFSLTQP LSPVLEPSSE 780

QMQYSPFLSQ YQEMQLQPLP STSGPRAAPP LPTQLQQQQP PPPPPPPPPR QPGAAAAPLQ 840

FSYQTCELPR AASPASDYPA PCQHPVDGAQ QSDLTGPDCP RNPGLQEAPS SYDPLALSEL 900

PGLFDCEMLD AVDPQHNGYV LVN 923

Nucleotide Sequence
(FASTA)

ATGGTCATGG CGGATGGCCC GAGGCACTTG CAGCGCGGGC CGGTCCGGGT GGGGTTCTAC 60

GACATCGAGG GCACGCTGGG CAAGGGCAAC TTCGCCGTGG TGAAGCTGGG GCGGCACCGG 120

ATCACCAAGA CGGAGGTGGC AATAAAAATA ATCGATAAGT CTCAGCTGGA TGCAGTGAAC 180

CTTGAGAAAA TCTACCGAGA AGTACAAATA ATGAAAATGT TAGACCACCC TCACATAATC 240

AAACTTTATC AGGTAATGGA GACCAAAAGT ATGTTGTACC TTGTGACAGA ATATGCCAAA 300

AATGGAGAAA TTTTTGACTA TCTTGCTAAT CATGGCCGGT TAAATGAATC TGAAGCCAGG 360

CGAAAATTCT GGCAAATCCT ATCTGCTGTT GATTATTGTC ATGGTCGGAA GATTGTGCAC 420

CGTGACCTCA AAGCTGAAAA TCTCCTGCTG GATAACAACA TGAATATCAA AATAGCAGGT 480

AACTGGGACA CAACTGGCTC TAACATGATC CGACCCTGTC CTTCAGTCCC CCCTTATGCA 540

GCCCCAGAAG TCTTTGAAGG GCAGCAGTAT GAAGGACCAC AGCTGGACAT CTGGAGTATG 600

GGAGTTGTTC TTTACGTCCT TGTCTGTGGA GCTCTGCCCT TTGATGGACC GACTCTTCCA 660

ATTTTGAGAC AGAGGGTTCT GGAAGGAAGA TTCCGGATTC CGTATTTCAT GTCAGAAGAT 720

TGCGAGCACC TTATTCGAAG GATGTTGGTC CTAGACCCAT CCAAACGGCT AACCATAGCT 780

CAAATCAGGG AGCATAAATG GATGCTCATA GAAGTTCCTG TTCAGAGACC TGTTCTGTAT 840

CCACAAGAGC AAGAAAATGA GCCATCCATC GGGGAGTTTA ATGAGCAGGT TCTGCGACTG 900

ATGCACAGCC TTGGAATAGA TCAGCAGAAA ACCATTGAGT CTTTGCAGAA CAAGAGCTAT 960

AACCACTTTG CTGCCATTTA TTTCTTGTTG GTGGAGCGCC TGAAATCACA TAGGAGCAGT 1020

TTCCCAGTGG AGCAGAGACT TGACGGCCGC CAGCGTCGGC CTAGCACCAT TGCTGAGCAA 1080

ACAGTTGCCA AGGCACAGAC TGTAGGGCTC CCAGTGACCA TGCATTCACC GAACATGAGG 1140

CTGCTGCGAT CTGCCCTCCT GCCCCAGGCA TCCAACATGG AGGCCTTTTC ATTTCCGGCA 1200

TCTGGCTGTC AGGCAGAAGC TGCATTCATG GAAGAAGAGT GTGTGGACAC TCCAAAGGTC 1260

AATGGCTGTC TGCTTGACCC TGTGCCTCCT GTCCTGGTGC GGAAGGGATG CCAGTCACTG 1320

CCCAGCAACA TGATGGAGAC CTCCATTGAC GAAGGGCTGG AGACAGAAGG AGAGGCTGAG 1380

GAAGACCCCG CTCATGCCTT TGAGGCATTT CAGTCCACAC GCAGCGGGCA GAGACGGCAC 1440

ACTCTGTCAG AAGTGACCAA TCAACTGGTC GTGATGCCTG GAGCAGGGAA AATTTTCTCC 1500

ATGAATGATA GCCCCTCCCT TGACAGTGTG GACTCGGAGT ATGATATGGG GTCTGTTCAG 1560

AGGGACCTGA ACTTTCTGGA GGACAACCCA TCCCTTAAGG ACATCATGTT AGCCAATCAG 1620

CCCTCACCCC GCATGACATC TCCCTTCATA AGCCTGAGAC CTACCAACCC AGCCATGCAG 1680

GCTCTGAGCT CCCAGAAACG AGAGGTCCAC AACAGGTCTC CAGTGAGCTT CAGAGAGGGC 1740

CGCAGAGCAT CGGATACCTC CCTCACCCAG GGAATTGTAG CATTTAGACA ACATCTTCAG 1800

AATCTGGCTA GAACCAAAGG AATTCTAGAG TTGAACAAAG TGCAGTTGCT GTATGAACAA 1860

ATAGGACCAG AGGCGGACCC TAACCTGGCG CCGGCGGCTC CTCAGCTCCA GGACCTTACT 1920

AGCAGCTGCC CTCAGGAGGA AGTTTCTCCA CCGCAGGAAA GCGTCTCCAC TCTCCCTGCC 1980

AGCGTGCATC CCCAGCTGTC CCCACGGCAG AGCCTGGAGA CCCAGTACCT GCAGCACAGG 2040

CTCCAGAAGC CCAGCCTTCT GTCAAAGGCA CAGAACACCT GTCAGCTTTA TTGCAAAGAA 2100

CCACCGCGGA GCCTTGAGCA GCAGCTGCAG GAACACAGGC TCCAGCAGAA GCGACTCTTT 2160

CTCCAGAAGC AATCTCAACT GCAGGCATAT TTTAATCAGA TGCAGATAGC AGAGAGCTCC 2220

TACCCACAGC CAAGTCAGCA GCTGCCCCTT CCCCGCCAGG AGACTGCACC GCCTTCTCAG 2280

CAGGCCCCAC CGTTCAGCCT GACCCAGCCC CTGAGCCCGG TCCTGGAGCC TTCCTCTGAG 2340

CAGATGCAAT ACAGCCCTTT CCTCAGCCAG TACCAGGAGA TGCAGCTTCA GCCCCTGCCC 2400

TCCACTTCCG GCCCCCGAGC TGCTCCTCCT CTGCCCACGC AGCTACAGCA GCAGCAGCCG 2460

CCACCGCCAC CACCACCTCC ACCACCACGA CAGCCAGGAG CTGCCGCAGC CCCCTTACAG 2520

TTCTCCTACC AGACTTGTGA GCTGCCGCGC GCTGCTTCCC CGGCGTCAGA CTATCCCGCT 2580

CCCTGTCAGC ATCCTGTGGA TGGAGCCCAG CAGAGTGACC TGACGGGGCC AGACTGTCCC 2640

AGAAACCCAG GACTGCAAGA GGCCCCCTCC AGCTATGACC CACTAGCCCT CTCCGAGCTG 2700

CCTGGACTCT TTGATTGTGA AATGCTAGAC GCTGTGGATC CACAACACAA CGGGTATGTC 2760

CTGGTGAATT AG 2772

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++  tlG+g+f+ Vkl +h+ tk++va+Kii+k++l++ +leki+rE++i+k+l+hp+i

Q: 20    YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHI  79

         89999*******************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ikl++v+etk++lylv+eya++ge+fdy+ ++grl+e+ear+ f q++sav+Y+h ++iv

Q: 80    IKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIV  139

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGs.ppYaaPellkgkkYegpkv  179

         HrDlK+eNllld+++nikia    +n+ ++g+ + + c s ppYaaPe+++g++Yegp++

Q: 140   HRDLKAENLLLDNNMNIKIA----GNWDTTGSNMIRPCPSvPPYAAPEVFEGQQYEGPQL  195

         *******************8....5777777666666665379*****************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         D+Ws+GvvLy+lv+g+lPfd+++l  l++++l+g+++ip+ +s+++e+L+r++Lv dp+k

Q: 196   DIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSK  255

         ************************************************************

S: 240   Ratieeilkhewl  252

         R+ti +i++h+w+

Q: 256   RLTIAQIREHKWM  268

         ************8

Domain Sequence
(FASTA)

YDIEGTLGKG NFAVVKLGRH RITKTEVAIK IIDKSQLDAV NLEKIYREVQ IMKMLDHPHI 60

IKLYQVMETK SMLYLVTEYA KNGEIFDYLA NHGRLNESEA RRKFWQILSA VDYCHGRKIV 120

HRDLKAENLL LDNNMNIKIA GNWDTTGSNM IRPCPSVPPY AAPEVFEGQQ YEGPQLDIWS 180

MGVVLYVLVC GALPFDGPTL PILRQRVLEG RFRIPYFMSE DCEHLIRRML VLDPSKRLTI 240

AQIREHKWM 249

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008286	; P:insulin receptor signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR017090	; Ser/Thr_kinase_SIK1/2.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013