EKS-MOD-00385
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00385
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl533.21.2E-160522787266
StatusUnreviewed
Ensembl ProteinENSMODP00000000113
UniProt AccessionF6YC68;
Protein Name
Protein Synonyms/Alias
Gene NameTYRO3
Gene Synonyms/Alias TYRO3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000000092ENSMODP00000000113ENSMODT00000000117
OrganismMonodelphis domestica
Functional Description
Protein Length883
Protein Sequence
(FASTA)
HGAAAPRMAL RRSMEWPRLR LRLPLRFSQL LLAGLAALLL PELSAAGLKL IGAPLKLTVS 60
QGQPVKLNCS VEGLEEPEIQ WVKDGAVVQS VDQVYIPISE QHWIGFLSLK SVDRSDAGRY 120
WCQVEEGGET ETSQPVWLTV EGVPYFTVEP EDLTVPNAPF QLSCEAVGPP EPVTIFWWRG 180
GTQVGEPALS PSILNVTGVT QSTVFSCEAH NLKGLASSRP ATVYLQALPA APSNVTVTRL 240
SSNNASVAWI PGSDGQALLH SCTVQVTEAP GGWEVLAVVV PVPPFSCLLR GLEPATNYSL 300
RVRCTNALGP SPYADWVPFQ TQGLAPSSAP QNLHAIRTDY GLILEWEEVI PESSSESPLG 360
PYRISWVQEN GTQGEMTVLG TRANLTGWDP LKDLTARVCV SNEVGCGPWS QPLLVSYRDG 420
AGQQGPPHSR TSWVPVVLGV LTALVTAAAL ALILLRKRRK ETRFGQAFDS VMARGEPAVH 480
FRAARSFNRE GPERIEATLD SLGISDELKD KLEDVLIPEQ QFTLGRMLGK GQFGSVREAQ 540
LKQADGSFEK VAVKMLKADI INSSDIEEFL REAACMKEFN HPHVAKLIGV SLRSRAKGRL 600
PIPMVILPFM KHGDLHAFLL ASRIGENPFN LPLQTLIRFM VDIASGMEYL SSQNFIHRDL 660
AARNCMLAED MTVCVADFGL SRKIYSGDYY RQGCASKLPV KWLALESLAD NLYTVHSDVW 720
AFGVTMWEIM TRGQTPYAGI ENAEIYNYLI SGNRLKQPPE CLEEVYELMY QCWCSDPKQR 780
PTFPTLRMEL EEILGRMSVL SASRDPLYIN IEKAEEQAEE GSQLGGDQAV SGDGDRNSNG 840
TGPVGGIPSD YRYILTPGRL AEQSGEEQQS EGACGEAQRR MLL 883
Nucleotide Sequence
(FASTA)
CATGGTGCGG CGGCGCCGCG GATGGCGCTG AGGCGGAGCA TGGAGTGGCC GCGGCTCCGG 60
CTCCGGCTCC CGCTCCGATT CTCGCAGCTG TTGCTGGCGG GACTGGCCGC GCTGCTGCTC 120
CCGGAGCTCT CAGCCGCAGG CCTGAAGCTC ATTGGGGCCC CTCTGAAGCT GACAGTATCT 180
CAAGGGCAAC CAGTGAAGTT GAACTGCAGT GTGGAGGGAT TAGAGGAACC TGAGATCCAG 240
TGGGTCAAGG ATGGGGCCGT GGTGCAGAGT GTGGACCAAG TCTACATTCC TATCAGTGAA 300
CAGCATTGGA TCGGGTTCCT CAGCCTGAAG TCAGTAGATC GATCGGATGC TGGGCGGTAC 360
TGGTGCCAAG TAGAAGAAGG GGGAGAAACA GAGACATCCC AGCCAGTGTG GCTTACAGTA 420
GAAGGTGTGC CGTACTTCAC CGTGGAGCCA GAGGACCTCA CAGTGCCCAA TGCCCCTTTC 480
CAACTGTCTT GTGAAGCTGT GGGGCCCCCA GAACCCGTAA CCATCTTCTG GTGGAGGGGG 540
GGCACACAGG TGGGAGAACC AGCTCTCTCT CCCTCCATTT TGAATGTTAC AGGGGTGACC 600
CAGAGCACTG TGTTCTCCTG TGAAGCTCAT AACCTGAAAG GTTTGGCCTC CTCCCGTCCA 660
GCCACAGTCT ATCTTCAAGC TCTGCCAGCA GCACCCTCTA ATGTAACAGT GACCCGGCTA 720
TCGAGCAACA ATGCCAGTGT GGCCTGGATT CCTGGCTCTG ATGGCCAGGC TCTACTCCAT 780
TCCTGCACAG TCCAGGTAAC AGAGGCCCCA GGAGGCTGGG AGGTCCTGGC GGTGGTGGTC 840
CCTGTGCCAC CCTTCAGTTG TCTGCTTCGG GGCTTAGAAC CTGCCACCAA CTACAGTTTA 900
AGAGTTCGAT GTACCAATGC CTTAGGGCCT TCCCCATATG CAGACTGGGT GCCCTTCCAG 960
ACCCAGGGTC TGGCCCCATC CAGTGCCCCT CAGAACCTCC ATGCCATCCG AACAGACTAT 1020
GGTCTCATCC TGGAGTGGGA AGAAGTCATT CCTGAGAGCT CTAGTGAGAG CCCCTTAGGG 1080
CCCTACAGAA TATCCTGGGT TCAAGAAAAT GGGACCCAGG GTGAGATGAC TGTTCTGGGG 1140
ACCAGAGCCA ACCTGACTGG CTGGGATCCC CTGAAGGACC TGACAGCCAG AGTGTGTGTT 1200
TCCAATGAAG TCGGCTGTGG CCCTTGGAGC CAGCCTCTGC TTGTCTCCTA TCGTGATGGG 1260
GCTGGTCAGC AGGGCCCCCC TCACAGTCGC ACATCTTGGG TGCCTGTCGT CTTGGGTGTT 1320
CTGACAGCAC TCGTGACAGC TGCTGCCCTG GCCTTAATCC TGCTACGTAA AAGAAGGAAG 1380
GAAACACGAT TTGGGCAAGC CTTTGACAGC GTCATGGCCC GTGGGGAGCC TGCTGTTCAT 1440
TTTCGTGCTG CCAGATCCTT TAATAGAGAA GGTCCAGAAC GAATTGAAGC CACACTGGAC 1500
AGCCTGGGTA TCAGTGATGA GCTAAAAGAC AAACTGGAGG ATGTGCTGAT ACCGGAGCAA 1560
CAATTCACCT TGGGCCGGAT GTTGGGCAAA GGTCAGTTTG GGTCAGTGAG GGAAGCCCAG 1620
CTGAAGCAGG CAGATGGCTC CTTTGAGAAA GTAGCCGTGA AAATGCTAAA AGCGGACATC 1680
ATCAACTCCA GTGACATTGA AGAGTTTCTT CGAGAAGCTG CTTGCATGAA AGAATTTAAC 1740
CACCCACACG TGGCCAAGCT TATTGGGGTG AGCCTTCGGA GCCGGGCCAA GGGCCGCTTG 1800
CCTATCCCCA TGGTGATCCT GCCCTTCATG AAGCATGGAG ACCTACATGC TTTCCTGCTT 1860
GCCTCCCGAA TTGGAGAAAA TCCTTTTAAC CTGCCCTTGC AGACACTGAT CCGATTCATG 1920
GTGGACATTG CCAGTGGCAT GGAGTACCTG AGTTCCCAGA ACTTCATCCA CAGGGACCTG 1980
GCTGCTCGGA ATTGCATGTT AGCCGAGGAC ATGACTGTGT GTGTGGCTGA CTTTGGCCTA 2040
TCTCGGAAGA TCTACAGTGG TGATTATTAC CGGCAGGGCT GTGCCTCCAA ATTACCTGTC 2100
AAATGGTTAG CCCTGGAAAG CTTGGCTGAT AACCTGTACA CAGTGCATAG TGATGTGTGG 2160
GCGTTCGGTG TGACCATGTG GGAGATAATG ACACGGGGAC AAACACCTTA TGCCGGTATC 2220
GAAAACGCGG AGATTTACAA CTACCTCATC AGTGGGAATC GTCTGAAGCA GCCACCTGAA 2280
TGTCTGGAGG AAGTCTATGA GCTCATGTAC CAGTGCTGGT GCTCAGACCC CAAGCAGCGC 2340
CCTACTTTCC CGACCCTTCG GATGGAGCTG GAAGAGATCC TGGGCCGAAT GTCTGTTCTC 2400
TCTGCCAGTC GAGACCCTCT CTACATCAAT ATCGAGAAGG CTGAGGAACA AGCAGAAGAG 2460
GGAAGCCAGC TGGGTGGGGA CCAGGCTGTC AGTGGGGATG GGGATAGGAA CAGTAATGGT 2520
ACAGGGCCAG TAGGAGGTAT TCCCAGTGAC TATCGGTATA TCCTTACCCC TGGTAGGCTG 2580
GCGGAACAGT CTGGGGAGGA ACAGCAGTCA GAGGGGGCCT GTGGGGAGGC CCAGAGGAGG 2640
ATGCTACTCT AG 2652
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         ++lg++lg+g+fgsv+e+qlkq dgs+ kvavk+lk+dii +s+ieefl+eaacmkef+h
Q: 522   FTLGRMLGKGQFGSVREAQLKQADGSFEKVAVKMLKADIINSSDIEEFLREAACMKEFNH  581
         68**********************************************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         p+v++l+gvsl+s++kgrlp+p+vilpfmk+gdlhafll+sr+genp++lplqtl++fmv
Q: 582   PHVAKLIGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMV  641
         ************************************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         diasgmeylss+nfihrdlaarncmlaedmtvcvadfgls+kiysgdyyrqg+++klpvk
Q: 642   DIASGMEYLSSQNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVK  701
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         w+a+eslad++yt++sdvwafgvtmwei+trgqtpyag+enaeiy+yl+ gnrlkqp++c
Q: 702   WLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLISGNRLKQPPEC  761
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlr  266
         l+e+y+lmy+cw  dpk+rp+f +lr
Q: 762   LEEVYELMYQCWCSDPKQRPTFPTLR  787
         **********************9998
Domain Sequence
(FASTA)
FTLGRMLGKG QFGSVREAQL KQADGSFEKV AVKMLKADII NSSDIEEFLR EAACMKEFNH 60
PHVAKLIGVS LRSRAKGRLP IPMVILPFMK HGDLHAFLLA SRIGENPFNL PLQTLIRFMV 120
DIASGMEYLS SQNFIHRDLA ARNCMLAEDM TVCVADFGLS RKIYSGDYYR QGCASKLPVK 180
WLALESLADN LYTVHSDVWA FGVTMWEIMT RGQTPYAGIE NAEIYNYLIS GNRLKQPPEC 240
LEEVYELMYQ CWCSDPKQRP TFPTLR 266
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00372
EKS-ANC-00384
EKS-BOT-00399
EKS-CAJ-00404
EKS-CAF-00400
EKS-CAP-00424
EKS-CIS-00152
EKS-DAR-00777
EKS-EQC-00387
EKS-FEC-00382
EKS-GAG-00338
EKS-GAA-00488
EKS-GOG-00387
EKS-HOS-00403
EKS-ICT-00375
EKS-LOA-00403
EKS-MAM-00399
EKS-MEG-00329
EKS-MUM-00432
EKS-MUP-00390
EKS-MYL-00393
EKS-NOL-00364
EKS-ORN-00511
EKS-ORA-00344
EKS-ORC-00374
EKS-ORL-00465
EKS-OTG-00402
EKS-PAT-00374
EKS-PES-00355
EKS-POA-00391
EKS-PTV-00110
EKS-RAN-00411
EKS-SAH-00365
EKS-SUS-00346
EKS-TAG-00471
EKS-TAR-00502
EKS-TAS-00046
EKS-XET-00511
EKS-XIM-00503
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043277; P:apoptotic cell clearance
GO:0021885; P:forebrain cell migration
GO:0001779; P:natural killer cell differentiation
GO:0050728; P:negative regulation of inflammatory response
GO:0045824; P:negative regulation of innate immune response
GO:0051250; P:negative regulation of lymphocyte activation
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0034122; P:negative regulation of toll-like receptor signaling pathway
GO:0070050; P:neuron homeostasis
GO:0042698; P:ovulation cycle
GO:0070527; P:platelet aggregation
GO:0046777; P:protein autophosphorylation
GO:0043491; P:protein kinase B signaling cascade
GO:0032940; P:secretion by cell
GO:0007283; P:spermatogenesis
GO:0034446; P:substrate adhesion-dependent cell spreading
GO:0060068; P:vagina development
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 1.
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013