EPS-MOD-00136

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MOD-00136

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP2B	429.6	1.7E-129	48	248	201

Status

Unreviewed

Ensembl Protein

ENSMODP00000000263

UniProt Accession

F6SZ60;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP3CB

Gene Synonyms/Alias

PPP3CB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000000220	ENSMODP00000000263	ENSMODT00000000267

Organism

Monodelphis domestica

Functional Description

Protein Length

479

Protein Sequence
(FASTA)

MDGIPRVDVL KNHLVKEGRV DEEIALRIIN EGAAILRREK TMIEVEAPIT VCGDIHGQFF 60

DLMKLFEVGG SPANTRYLFL GDYVDRGYFS IECVLYLWVL KILYPSTLFL LRGNHECRHL 120

TEYFTFKQEC KIKYSERVYE ACMEAFDSLP LAALLNQQFL CVHGGLSPEI HTLDDIRRLD 180

RFKEPPAFGP MCDLLWSDPS EDFGNEKSQE HFSHNTVRGC SYFYNYPAVC EFLQNNNLLS 240

IIRAHEAQDA GYRMYRKSQT TGFPSLITIF SAPNYLDVYN NKAAVLKYEN NVMNIRQFNC 300

SPHPYWLPNF MDVFTWSLPF VGEKVTEMLV NVLSICSDDE LMTEGEDQFD GSAAARKEII 360

RNKIRAIGKM ARVFSVLREE SESVLTLKGL TPTGMLPSGV LAGGRQTLQS ATVEAIEAEK 420

AIRGFSPPHR ICSFEEAKGL DRINERMPPR KDAGQQDGFN SLNTAHATEN HGTGNHGAQ 479

Nucleotide Sequence
(FASTA)

ATGGATGGGA TACCAAGAGT TGATGTTTTA AAGAATCATT TGGTAAAAGA AGGTCGAGTT 60

GATGAAGAAA TTGCACTTAG AATTATTAAT GAGGGTGCTG CCATCCTTCG GAGAGAGAAA 120

ACCATGATAG AAGTAGAAGC TCCAATTACA GTGTGCGGTG ACATCCACGG CCAGTTTTTT 180

GATCTCATGA AGCTGTTTGA AGTGGGAGGA TCCCCTGCTA ACACAAGATA CCTCTTCCTT 240

GGCGATTATG TGGACAGAGG TTATTTTAGC ATAGAGTGTG TCTTATATTT ATGGGTCCTG 300

AAGATTCTCT ACCCAAGCAC ATTATTTCTT TTGAGAGGCA ACCATGAATG CAGACACCTT 360

ACTGAATATT TCACCTTTAA GCAGGAATGT AAAATTAAGT ATTCAGAAAG AGTCTATGAA 420

GCTTGTATGG AAGCTTTTGA TAGCCTGCCT CTTGCTGCAC TTTTAAACCA ACAGTTTCTT 480

TGTGTTCATG GTGGACTTTC ACCAGAAATA CACACACTGG ATGATATTAG GAGATTAGAT 540

AGATTTAAAG AACCTCCTGC CTTTGGACCA ATGTGTGATT TGCTATGGTC TGATCCTTCA 600

GAAGACTTTG GAAATGAAAA ATCACAGGAA CACTTTAGTC ACAATACAGT TCGAGGATGC 660

TCTTATTTTT ATAACTATCC AGCAGTGTGT GAATTTTTGC AAAACAATAA TTTGTTATCG 720

ATTATTAGAG CTCATGAAGC TCAAGATGCA GGCTATAGAA TGTACAGAAA AAGTCAAACT 780

ACAGGGTTCC CTTCATTAAT AACAATTTTT TCGGCACCTA ATTACTTAGA TGTCTACAAT 840

AATAAAGCTG CTGTATTAAA ATATGAAAAT AATGTGATGA ATATTCGACA GTTTAACTGC 900

TCTCCACATC CTTACTGGTT ACCCAATTTT ATGGATGTCT TCACATGGTC ACTACCATTT 960

GTTGGAGAAA AAGTGACAGA GATGTTGGTA AATGTTCTGA GTATTTGCTC CGATGATGAA 1020

CTAATGACTG AAGGCGAAGA TCAATTTGAC GGATCAGCGG CGGCACGGAA AGAAATAATC 1080

CGGAACAAAA TCCGAGCAAT TGGCAAGATG GCAAGAGTCT TCTCTGTCCT CAGGGAGGAG 1140

AGTGAAAGTG TGCTGACACT CAAGGGCCTG ACTCCCACAG GGATGTTGCC TAGTGGAGTG 1200

TTGGCTGGAG GACGACAGAC CCTGCAAAGT GCCACAGTTG AGGCAATTGA GGCTGAAAAA 1260

GCAATACGAG GATTCTCTCC ACCACATAGA ATCTGCAGTT TTGAAGAAGC AAAAGGTTTG 1320

GATAGGATCA ATGAGAGAAT GCCACCCCGG AAAGACGCTG GGCAGCAAGA TGGTTTCAAT 1380

TCTCTGAACA CCGCACATGC CACTGAGAAC CACGGGACTG GCAACCACGG TGCCCAGTGA 1440

Domain Profile

S: 1     pvtvcgdihgqffdllklfevggspantrylflgdyvdrgyfsiecvlylyalkilypkt  60

         p+tvcgdihgqffdl+klfevggspantrylflgdyvdrgyfsiecvlyl++lkilyp+t

Q: 48    PITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPST  107

         9***********************************************************

S: 61    lfllrgnhecrhlteyftfkqelkikyservydacleafdalplaallnqqflcvhggls  120

         lfllrgnhecrhlteyftfkqe+kikyservy+ac+eafd+lplaallnqqflcvhggls

Q: 108   LFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLS  167

         ************************************************************

S: 121   pelktlddirkldrfkeppayglmcdllwsdpledfgnekseeefvhnsvrgcsyfysyk  180

         pe++tlddir+ldrfkeppa+g+mcdllwsdp edfgneks+e+f+hn+vrgcsyfy+y+

Q: 168   PEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYP  227

         ************************************************************

S: 181   avceflqennllsiiraheaq  201

         avceflq+nnllsiiraheaq

Q: 228   AVCEFLQNNNLLSIIRAHEAQ  248

         ********************8

Domain Sequence
(FASTA)

PITVCGDIHG QFFDLMKLFE VGGSPANTRY LFLGDYVDRG YFSIECVLYL WVLKILYPST 60

LFLLRGNHEC RHLTEYFTFK QECKIKYSER VYEACMEAFD SLPLAALLNQ QFLCVHGGLS 120

PEIHTLDDIR RLDRFKEPPA FGPMCDLLWS DPSEDFGNEK SQEHFSHNTV RGCSYFYNYP 180

AVCEFLQNNN LLSIIRAHEA Q 201

Keyword

Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005955	; C:calcineurin complex
GO:0005886	; C:plasma membrane
GO:0005509	; F:calcium ion binding
GO:0005516	; F:calmodulin binding
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0008144	; F:drug binding
GO:0030346	; F:protein phosphatase 2B binding
GO:0017156	; P:calcium ion-dependent exocytosis
GO:0035690	; P:cellular response to drug
GO:0007507	; P:heart development
GO:0001915	; P:negative regulation of T cell mediated cytotoxicity
GO:0035774	; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0006470	; P:protein dephosphorylation
GO:0006468	; P:protein phosphorylation
GO:0010468	; P:regulation of gene expression
GO:0034097	; P:response to cytokine stimulus
GO:0035176	; P:social behavior
GO:0030217	; P:T cell differentiation
GO:0043029	; P:T cell homeostasis

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013