EKS-MOD-00355
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00355
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src447.51.4E-134284533250
StatusUnreviewed
Ensembl ProteinENSMODP00000000300
UniProt AccessionF6WR53;
Protein Name
Protein Synonyms/Alias
Gene NameSRC
Gene Synonyms/Alias SRC;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000000247ENSMODP00000000300ENSMODT00000000304
OrganismMonodelphis domestica
Functional Description
Protein Length550
Protein Sequence
(FASTA)
MGSSKSKPKD PSQRRRSLEP TESVLHSGFS ISQTPNKASA PDTHRTPNPP FGTTAPEPKL 60
FGGFNTSDTV TSPQRSGPLA GGVTTFVALY DYESRTETDL SFKKGERLQI VNNTRKVDVS 120
QTWFTFRWLQ REGDWWLAHS LTTGQTGYIP SNYVAPSDSI QAEEWYFGKI TRRESERLLL 180
NSENPRGTFL VRESETTKGA YCLSVSDFDN AKGLNVKHYK IRKLDSGGFY ITSRTQFNSL 240
QQLVAYYSKH ADGLCHRLTN VCPTSKPQTQ GLAKDAWEIP RESLRLEVKL GQGCFGEVWM 300
GTWNGTTRVA IKTLKPGTMS PEAFLQEAQV MKKLRHEKLV QLYAVVSEEP IYIVTEYMNK 360
GSLLDFLKGD MGKYLRLPQL VDMAAQIASG MAYVERMNYV HRDLRAANIL VGENLVCKVA 420
DFGLARLIED NEYTARQGAK FPIKWTAPEA ALYGRFTIKS DVWSFGILLT ELTTKGRVPY 480
PGMVNREVLD QVERGYRMPC PPECPESLHD LMCQCWRKDP EERPTFEYLQ AFLEDYFTST 540
EPQYQPGENL 550
Nucleotide Sequence
(FASTA)
ATGGGGAGTA GCAAAAGCAA ACCCAAAGAC CCCAGTCAGA GACGTCGAAG CCTGGAACCC 60
ACTGAGAGTG TGCTCCACAG TGGTTTCTCT ATTTCTCAGA CTCCCAACAA GGCATCTGCA 120
CCTGATACCC ACCGTACTCC CAACCCACCC TTTGGGACCA CAGCACCTGA GCCAAAGCTC 180
TTTGGAGGCT TCAACACATC AGACACAGTC ACCTCTCCAC AGCGCTCAGG GCCTCTGGCA 240
GGTGGGGTGA CGACTTTCGT GGCCCTATAT GACTATGAGT CCCGCACTGA GACAGATCTG 300
TCCTTCAAGA AGGGAGAACG CCTGCAGATA GTCAACAACA CGAGAAAAGT GGATGTCAGC 360
CAGACCTGGT TCACATTCAG ATGGCTCCAA AGAGAGGGAG ACTGGTGGCT GGCCCACTCA 420
CTCACCACCG GACAGACTGG CTACATCCCC AGCAACTACG TAGCCCCATC GGATTCCATC 480
CAGGCTGAGG AGTGGTACTT TGGCAAGATC ACCCGTCGAG AGTCTGAGCG GCTGCTGCTT 540
AATTCGGAGA ATCCCCGAGG CACGTTTCTG GTTCGGGAAA GTGAGACCAC CAAAGGTGCC 600
TACTGCCTTT CTGTCTCTGA CTTCGACAAT GCCAAGGGCC TCAACGTGAA ACATTATAAG 660
ATCCGAAAGC TGGACAGTGG AGGCTTTTAT ATCACCTCCC GCACACAGTT TAACAGCCTG 720
CAGCAGCTGG TGGCCTATTA CTCCAAACAT GCTGATGGCT TGTGCCACAG ACTCACCAAT 780
GTCTGCCCCA CGTCCAAGCC ACAGACCCAG GGCCTGGCTA AGGATGCCTG GGAGATCCCC 840
CGGGAGTCCC TGCGGCTGGA AGTGAAACTG GGTCAGGGCT GCTTTGGAGA AGTGTGGATG 900
GGAACCTGGA ATGGCACTAC CAGGGTGGCA ATAAAGACCC TGAAGCCTGG CACTATGTCC 960
CCGGAAGCCT TCTTGCAAGA AGCACAGGTC ATGAAGAAAC TTCGGCATGA GAAACTAGTA 1020
CAGTTGTATG CTGTGGTGTC TGAGGAGCCC ATCTATATTG TTACAGAATA CATGAACAAG 1080
GGAAGCTTGC TGGACTTCCT TAAAGGTGAC ATGGGCAAGT ATCTTCGGCT ACCCCAGCTG 1140
GTGGACATGG CGGCTCAGAT TGCATCTGGC ATGGCCTATG TGGAAAGAAT GAACTATGTC 1200
CATCGCGACC TCCGGGCTGC CAACATCCTG GTGGGAGAGA ATCTGGTGTG CAAGGTGGCA 1260
GACTTTGGGC TGGCCCGGCT TATTGAGGAC AACGAATACA CTGCCAGACA AGGTGCCAAA 1320
TTTCCCATCA AGTGGACAGC TCCAGAAGCT GCCCTATATG GCCGGTTCAC CATCAAGTCT 1380
GACGTGTGGT CCTTTGGAAT CCTGCTAACT GAGCTAACGA CCAAGGGCCG AGTGCCATAC 1440
CCAGGGATGG TGAACCGGGA GGTGCTGGAC CAGGTTGAGC GAGGATACCG GATGCCCTGC 1500
CCACCAGAAT GCCCTGAATC CCTGCATGAC CTCATGTGCC AGTGCTGGAG AAAGGACCCT 1560
GAAGAACGGC CCACTTTCGA ATACCTGCAA GCATTCCTGG AGGACTACTT CACATCCACA 1620
GAGCCCCAGT ATCAGCCTGG GGAGAATCTA TAG 1653
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly
Q: 284   LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  343
         68999*******************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m+kGslldflk + gk+l+lp+lvd+aaq+a+Gmay+e++n++hr
Q: 344   AVVSE-EPIYIVTEYMNKGSLLDFLKGDMGKYLRLPQLVDMAAQIASGMAYVERMNYVHR  402
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lvge+lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv
Q: 403   DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  462
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte++tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+kdpee
Q: 463   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEE  522
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq++l
Q: 523   RPTFEYLQAFL  533
         *******9876
Domain Sequence
(FASTA)
LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60
AVVSEEPIYI VTEYMNKGSL LDFLKGDMGK YLRLPQLVDM AAQIASGMAY VERMNYVHRD 120
LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180
SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKDPEER 240
PTFEYLQAFL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00340
EKS-ANC-00356
EKS-BOT-00366
EKS-CAJ-00371
EKS-CAF-00367
EKS-CAP-00399
EKS-DAR-00747
EKS-DIO-00054
EKS-EQC-00357
EKS-FEC-00354
EKS-GAM-00220
EKS-GAG-00310
EKS-GAA-00450
EKS-GOG-00366
EKS-HOS-00372
EKS-ICT-00347
EKS-LAC-00383
EKS-LOA-00375
EKS-MAM-00366
EKS-MEG-00302
EKS-MIM-00048
EKS-MUM-00398
EKS-MUP-00360
EKS-MYL-00367
EKS-NOL-00334
EKS-ORN-00475
EKS-ORC-00344
EKS-ORL-00436
EKS-OTG-00369
EKS-PAT-00346
EKS-PES-00326
EKS-POA-00356
EKS-RAN-00380
EKS-SAH-00337
EKS-SUS-00323
EKS-TAG-00439
EKS-TAR-00470
EKS-TEN-00465
EKS-XET-00482
EKS-XIM-00463
Gene Ontology
GO:0005901; C:caveola
GO:0005770; C:late endosome
GO:0005764; C:lysosome
GO:0005743; C:mitochondrial inner membrane
GO:0005524; F:ATP binding
GO:0020037; F:heme binding
GO:0004713; F:protein tyrosine kinase activity
GO:0060444; P:branching involved in mammary gland duct morphogenesis
GO:0016477; P:cell migration
GO:0030900; P:forebrain development
GO:0007243; P:intracellular protein kinase cascade
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway
GO:0048477; P:oogenesis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0033146; P:regulation of intracellular estrogen receptor signaling pathway
GO:0070555; P:response to interleukin-1
GO:0060065; P:uterus development
KEGG
mdo:100029391;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013