EKS-MOD-00372

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00372

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	293.5	1.5E-87	463	719	257

Status

Unreviewed

Ensembl Protein

ENSMODP00000000408

UniProt Accession

F6RUY6;

Protein Name

Protein Synonyms/Alias

Gene Name

TNNI3K

Gene Synonyms/Alias

TNNI3K;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000000344	ENSMODP00000000408	ENSMODT00000000417

Organism

Monodelphis domestica

Functional Description

Protein Length

825

Protein Sequence
(FASTA)

MGNYKSRPAQ TCTDEWKRKV SESYLMVTER LEEDLQIQEP ETQEMRLVFS SDEALSKVNL 60

NYRTENGLSL LHLCCICGGT KAHIRSLMLK GLRPSRLTRN GFTALHLAVY MDRTDLVTGL 120

LHSGADVQQA GYGALTALHV ATLAGHLQAA NVLLQHGAYV NVQDAVFFTP LHIAAYYGHE 180

QVTRLLLKFG ADVNVGGEVG DRPLHLASAK GFLNIAKLLM EEGSKADVNA QDNEDHVPLH 240

FCSRFGHHEM VKFLLQSDFE VQPHTANIYG DTPLHLACYN GKFEVAKEII QVSGTESLAK 300

ENIFSETAFH SACTYGRSIE LVKFLLDQNV VSVNHQGRDG HTGLHSACYH GHIRLVQFLL 360

DSGADMNLVA CDPSRSSGDK DEQTCLMWAY EKGHDAIVTL LKHYKRPQDE LPCNEYSQPG 420

GDGSYVSVPS PLGKIKSMTK EKADVLLLRA GLPSHFHLQL SEIEFHEIIG SGSFGKVYKG 480

RCRNKMVAIK RYRAHTYCSK SDVDMFCREV SILCRLNHPC VIQFVGACLN DPSQFAIVTQ 540

YISGGSLFAL LHEQKRILDL QSKLIIAVDV AKGMEYLHNL TQPIIHRDLN SHNILLYEDG 600

HAVVSDFGES RFLQSPDEDN LTKQPGNLRW MAPEVFTQCT RYTIKADVFS YALCLWELLT 660

GEIPFAHLKP AAAAADMAYH HIRPPIGYSI PKPISSLLMR GWNACPEGRP EFSEVVTKLE 720

ECLCNIELMS PASSNSSGSL SPSSSSDCLE SRGGPSRSHV AALRSRFELE YALNARSCMY 780

WSQSPGQLLS QGPSLEEMRR NFRFPHIDKN DCFKMCVFNL ARSQR 825

Nucleotide Sequence
(FASTA)

ATGGGGAATT ACAAGTCCAG ACCGGCCCAA ACCTGCACTG ATGAGTGGAA GAGAAAAGTC 60

AGCGAATCCT ACCTCATGGT AACGGAGAGG CTGGAGGAGG ACCTGCAGAT CCAGGAGCCC 120

GAGACCCAGG AAATGCGGCT CGTCTTCAGC TCCGATGAAG CCCTCAGCAA AGTCAATTTA 180

AATTACCGCA CGGAAAACGG GCTGTCCCTA CTTCATCTGT GCTGCATTTG TGGGGGCACC 240

AAGGCCCACA TCCGGAGCCT CATGTTAAAA GGGCTGCGCC CATCCCGGCT GACAAGAAAT 300

GGATTTACTG CTCTGCACTT GGCAGTTTAC ATGGACAGAA CAGACCTGGT CACGGGCCTC 360

CTGCACAGCG GGGCGGACGT CCAGCAGGCT GGCTACGGGG CTCTGACGGC CCTGCACGTC 420

GCCACCCTGG CCGGGCACCT GCAGGCTGCC AACGTCCTGC TGCAGCATGG AGCTTACGTC 480

AACGTCCAAG ATGCAGTCTT TTTCACCCCT CTCCACATTG CAGCATACTA TGGACATGAA 540

CAAGTCACGC GGCTCCTGCT GAAGTTTGGC GCTGACGTGA ATGTCGGGGG GGAAGTTGGA 600

GATCGGCCCC TGCACTTGGC ATCTGCCAAA GGATTCCTCA ACATCGCCAA ACTCTTGATG 660

GAAGAAGGCA GCAAAGCCGA TGTGAATGCC CAGGATAATG AAGACCACGT GCCTCTGCAC 720

TTCTGCTCTC GCTTTGGACA CCATGAGATG GTCAAGTTTC TGCTCCAGAG CGATTTCGAG 780

GTTCAGCCCC ACACAGCTAA CATCTATGGA GACACCCCTT TGCACTTGGC TTGCTACAAT 840

GGAAAATTTG AAGTTGCCAA GGAAATAATT CAAGTGTCAG GAACAGAAAG TCTGGCAAAG 900

GAAAACATCT TCAGTGAAAC AGCTTTTCAC AGCGCTTGTA CCTACGGCAG GAGCATCGAG 960

CTCGTTAAAT TTCTTCTGGA CCAAAACGTC GTGAGCGTCA ATCATCAAGG AAGGGACGGA 1020

CACACGGGGC TGCACTCGGC CTGCTACCAC GGACACATCC GCCTCGTTCA GTTCTTACTG 1080

GATAGCGGCG CCGACATGAA CCTGGTGGCC TGCGATCCCA GCAGGTCCAG CGGCGACAAG 1140

GATGAGCAGA CCTGTTTGAT GTGGGCCTAC GAGAAAGGGC ATGATGCCAT TGTCACGCTT 1200

CTGAAGCATT ATAAGAGACC TCAGGATGAA TTGCCCTGCA ACGAGTATTC TCAGCCAGGA 1260

GGAGATGGCT CCTATGTTTC TGTTCCATCT CCCTTGGGAA AGATTAAAAG CATGACTAAA 1320

GAAAAGGCAG ATGTCCTCCT CCTGCGGGCA GGGCTGCCTT CCCATTTCCA TCTCCAGCTC 1380

TCAGAAATTG AATTCCATGA AATTATCGGC TCAGGATCTT TCGGGAAAGT GTACAAAGGG 1440

AGATGCAGGA ACAAGATGGT GGCTATCAAA CGCTATCGGG CTCACACCTA CTGCTCCAAG 1500

TCGGACGTGG ATATGTTCTG CAGAGAGGTG TCCATTCTGT GCCGCCTCAA CCACCCCTGC 1560

GTGATCCAGT TTGTTGGTGC CTGCTTGAAT GATCCCAGTC AATTCGCCAT CGTCACTCAG 1620

TATATCTCCG GCGGGTCTCT CTTCGCTCTC CTCCACGAAC AGAAGAGGAT TCTGGACTTA 1680

CAGTCGAAAT TAATCATCGC GGTAGACGTC GCCAAAGGCA TGGAATATCT TCACAACCTG 1740

ACGCAGCCCA TCATCCACCG GGACTTGAAC AGCCACAACA TTCTCCTCTA CGAAGACGGC 1800

CACGCGGTCG TCTCGGACTT CGGAGAGTCC AGATTCCTGC AGTCTCCGGA CGAGGACAAC 1860

CTGACGAAGC AGCCCGGGAA CCTGCGCTGG ATGGCCCCCG AAGTCTTCAC GCAGTGCACT 1920

CGGTACACCA TCAAAGCCGA CGTGTTCAGC TACGCCTTGT GTCTGTGGGA GCTCCTCACC 1980

GGGGAGATCC CGTTCGCTCA TCTCAAGCCA GCCGCAGCAG CTGCCGACAT GGCTTACCAT 2040

CACATCCGAC CTCCCATAGG CTATTCCATC CCCAAACCCA TCTCGTCCTT GTTAATGAGA 2100

GGCTGGAACG CGTGCCCGGA GGGAAGACCA GAATTTTCTG AAGTTGTGAC TAAACTGGAA 2160

GAATGCCTTT GCAACATTGA GTTGATGTCT CCTGCATCAA GCAACAGCAG TGGATCTCTG 2220

TCTCCTTCCT CATCCTCTGA CTGCCTGGAG AGCCGGGGAG GCCCCAGTCG CAGTCATGTC 2280

GCCGCCCTCC GAAGCCGTTT CGAACTCGAG TACGCCCTGA ATGCCAGATC CTGCATGTAC 2340

TGGTCCCAGA GTCCTGGACA GCTCCTCTCT CAAGGTCCAT CTCTGGAAGA AATGAGGAGA 2400

AATTTTCGGT TCCCACACAT TGACAAAAAT GATTGTTTTA AAATGTGTGT ATTCAACTTA 2460

GCAAGATCCC AACGCTAA 2478

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaee.kekleklereakllsklshpnii  59

         ie++e+igsg+fgkvyk+++r+k va+K++r+++++ k+++++++re+++l++l+hp++i

Q: 463   IEFHEIIGSGSFGKVYKGRCRNKMVAIKRYRAHTYCsKSDVDMFCREVSILCRLNHPCVI  522

         5899*****************************9998999********************

S: 60    ellGvcleepn.lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhsea  118

         +++G+cl++p+ +++v++y++ggsL+ +lhe +kr +dl+  + +a+++A+Gm+YLh+ +

Q: 523   QFVGACLNDPSqFAIVTQYISGGSLFALLHE-QKRILDLQSKLIIAVDVAKGMEYLHNLT  581

         ***********99******************.99*************************6

S: 119   pkkiihrdLksknvLlseekktlkicdFGtarelsk..stkmsaa.gtlawmaPEvl.ke  174

         + +iihrdL+s+n+Ll  e+ ++ ++dFG++r+l++  +++ +++ g+l+wmaPEv+ ++

Q: 582   Q-PIIHRDLNSHNILL-YEDGHAVVSDFGESRFLQSpdEDNLTKQpGNLRWMAPEVFtQC  639

         6.9*************.9*****************99877777778**************

S: 175   ekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmk  234

         ++++ k+Dv+Sy+++LWellt+e+P+++l+++a+a+++a++++r+pi+ s+p+++++L+

Q: 640   TRYTIKADVFSYALCLWELLTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLM  699

         ************************************************************

S: 235   ecwnedpekRpsfseivksl  254

         + wn++pe Rp+fse+v++l

Q: 700   RGWNACPEGRPEFSEVVTKL  719

         ****************9875

Domain Sequence
(FASTA)

IEFHEIIGSG SFGKVYKGRC RNKMVAIKRY RAHTYCSKSD VDMFCREVSI LCRLNHPCVI 60

QFVGACLNDP SQFAIVTQYI SGGSLFALLH EQKRILDLQS KLIIAVDVAK GMEYLHNLTQ 120

PIIHRDLNSH NILLYEDGHA VVSDFGESRF LQSPDEDNLT KQPGNLRWMA PEVFTQCTRY 180

TIKADVFSYA LCLWELLTGE IPFAHLKPAA AAADMAYHHI RPPIGYSIPK PISSLLMRGW 240

NACPEGRPEF SEVVTKL 257

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0004190	; F:aspartic-type endopeptidase activity
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0006508	; P:proteolysis

KEGG

mdo:100533989

;

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011009	; Kinase-like_dom.
IPR001969	; Peptidase_aspartic_AS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF00023	; Ank; 3.
PF12796	; Ank_2; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 10.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 6.
PS00141	; ASP_PROTEASE; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013