EKS-MOD-00265
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00265
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK452.87.5E-136242570329
StatusUnreviewed
Ensembl ProteinENSMODP00000000795
UniProt AccessionF6SBD5;
Protein Name
Protein Synonyms/Alias
Gene NameHIPK1
Gene Synonyms/Alias HIPK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000000665ENSMODP00000000795ENSMODT00000000813
OrganismMonodelphis domestica
Functional Description
Protein Length1266
Protein Sequence
(FASTA)
MEMESQREDQ REEEVLPKGK NARSHRKALW LPWKEDTLTR KKVLDIHFLQ WGMASQLQVF 60
SPPSVSSSAF CSAKKLKTEP SGWDVSGPSS NEKYYTHSKT LSATQGQASS SHQVTSFNLP 120
SYDQSLLLPA PTVEHIVVTA ADSTGGAATT SFQNSQTLTH RGNVSLLEPY QKCGLKRKSE 180
EVDSNGSVQI IEEHPPLMLQ NRTVVGAAAT TTTVTTKNSS SSGEGDYQLV QHEILCSMTN 240
SYEVLEFLGR GTFGQVAKCW KRSTKEIVAI KILKNHPSYA RQGQIEVSIL SRLSSENADE 300
YNFVRSYECF QHKNHTCLVF EMLEQNLYDF LKQNKFSPLP LKYIRPILQQ VATALMKLKS 360
LGLIHADLKP ENIMLVDPVR QPYRVKVIDF GSASHVSKAV CSTYLQSRYY RAPEIILGLP 420
FCEAIDMWSL GCVIAELFLG WPLYPGASEY DQIRYISQTQ GLPAEYLLSA GTKTSRFFNR 480
DPNLGYPLWR LKTPEEHELE TGIKSKEARK YIFNCLDDMA QVNMSTDLEG TDMLAEKADR 540
REYIDLLKKM LTIDADKRIT PLKTLNHSFV TMTHLLDFPH SNHVKSCFQN MEICKRRGHM 600
YDTVKQIKSP FTTHVAPNTS TNLTMTFSNH LNTGHIRASV LASSSTAAAA TLSLANSDVS 660
LLNYQSALYP SSAAPVAGVA QQSVSLQPGT TQICTQTDPF QQTFIVCPPT FQTGLQAPTK 720
HSGFPVRMDN AVPIVPQAPA AQPLQIQSGV LTQGSCTPLM VATLHPQVAT ITPQYAVPFT 780
LSCAAGRPAL VEQTAAVLQA WPGGTQQILL PSTWQQLPGV ALHNSVQPTA VIPETMGSNQ 840
QLGDWRQSMN AHSHGSQYST LMQQPSLLTN HVTLATAQPL NVGVAHVVRQ QQSGSLPSKK 900
NKQPAQASAK TVSTLDVLPT QVYSLIGSSP LRTNSSYNPL VPSQDQHQPI IIPDTPSPPV 960
SVITIRSDTD EEEDSKYKPS SSSLKPRSNV ISYVTVNDSP DSDSSLSSPY STDTLAAIRG 1020
NTGPLLEGPG RVVTDGPGAR TIIVPPLKAQ LGDCTVATQA SGLLTNKTKP VASVSGQSSG 1080
CCITPTGYRA QRGGTNIAQP LNLSQNQQSS APSLQERSSN PAPRRQQAFV APLSQAPYTF 1140
QHGSPLHSTG HPHLAPAPAH LPSQPHLYTY AAPTSAAALG STSSIAHLFS PQGSSRHTAA 1200
YTTHPSTLVH QVPVSVGPSL LTSASVAPAQ YQQQFATQSY IGSSRGSTIY TGYPLSPTKI 1260
SQYSYL 1266
Nucleotide Sequence
(FASTA)
ATGGAGATGG AAAGCCAAAG AGAGGATCAG AGAGAAGAGG AAGTTCTTCC TAAGGGAAAG 60
AATGCCAGAA GCCACAGAAA GGCCCTCTGG TTACCATGGA AGGAAGACAC GCTAACACGC 120
AAAAAGGTGT TGGACATACA TTTCTTGCAG TGGGGTATGG CATCACAGCT GCAGGTGTTC 180
TCCCCCCCGT CAGTCTCGTC GAGTGCCTTC TGCAGTGCAA AGAAACTGAA GACAGAGCCT 240
TCTGGCTGGG ATGTTTCAGG ACCAAGCAGC AACGAAAAGT ATTATACCCA CAGCAAGACC 300
CTTTCAGCCA CACAAGGGCA AGCCAGCTCC TCTCACCAAG TGACAAGTTT CAACCTCCCT 360
TCTTACGACC AGAGCCTTCT CCTGCCAGCT CCCACGGTGG AGCACATTGT GGTGACGGCC 420
GCTGACAGCA CAGGCGGCGC TGCCACAACA TCCTTCCAGA ACAGCCAGAC CCTCACTCAT 480
AGAGGCAACG TTTCTTTGCT GGAGCCCTAT CAAAAATGTG GATTGAAAAG AAAAAGTGAG 540
GAGGTGGACA GCAACGGTAG CGTGCAGATC ATAGAAGAAC ATCCCCCTCT CATGCTGCAG 600
AACAGGACTG TGGTGGGTGC TGCTGCCACG ACCACCACTG TGACCACCAA GAATAGCAGT 660
TCCAGTGGAG AAGGGGATTA CCAGCTGGTC CAGCATGAAA TCCTTTGCTC CATGACCAAC 720
AGCTACGAGG TCCTAGAGTT CTTGGGCCGA GGGACATTTG GGCAAGTGGC CAAGTGCTGG 780
AAGCGGAGTA CCAAGGAAAT AGTGGCGATT AAGATCTTGA AAAATCACCC TTCTTATGCC 840
CGACAGGGTC AGATCGAAGT GAGCATCCTC TCCCGTCTGA GTAGTGAGAA TGCTGATGAG 900
TACAATTTTG TCCGCTCTTA CGAGTGCTTC CAGCACAAGA ATCATACCTG CCTCGTATTT 960
GAGATGCTGG AGCAGAACTT ATATGATTTC CTAAAGCAGA ACAAGTTCAG CCCATTGCCG 1020
CTGAAGTACA TCCGGCCTAT CCTGCAGCAG GTGGCCACTG CCCTGATGAA GCTCAAGAGT 1080
CTCGGCTTGA TTCATGCCGA CCTCAAGCCA GAAAACATCA TGTTGGTGGA CCCTGTGCGC 1140
CAGCCATACC GTGTGAAGGT TATCGACTTT GGTTCCGCCA GTCATGTATC CAAAGCTGTG 1200
TGCTCCACCT ACTTACAGTC GCGCTACTAC AGAGCTCCTG AAATCATTCT TGGACTGCCA 1260
TTTTGTGAGG CTATTGATAT GTGGTCCTTG GGCTGTGTAA TAGCTGAGCT GTTCCTGGGG 1320
TGGCCTCTGT ATCCTGGTGC TTCAGAATAT GATCAGATTC GTTACATTTC ACAAACACAA 1380
GGCCTGCCGG CAGAATATCT TCTGAGTGCA GGAACCAAAA CAAGCAGATT TTTCAACAGA 1440
GATCCTAATT TGGGTTATCC GTTGTGGAGA CTAAAGACAC CAGAGGAGCA TGAATTAGAA 1500
ACAGGAATAA AATCAAAAGA AGCCCGGAAG TATATATTTA ACTGTTTAGA TGACATGGCT 1560
CAGGTGAATA TGTCTACGGA CTTAGAGGGA ACAGATATGT TGGCAGAAAA GGCGGATCGA 1620
AGAGAGTACA TTGATTTGTT AAAAAAGATG TTGACGATTG ATGCAGATAA GAGAATTACT 1680
CCACTAAAAA CCCTCAACCA CTCATTTGTG ACAATGACTC ATCTTTTGGA TTTCCCACAC 1740
AGCAATCATG TTAAGTCATG CTTTCAGAAT ATGGAGATCT GCAAAAGGAG GGGTCACATG 1800
TATGATACGG TGAAACAGAT CAAGAGCCCA TTCACCACCC ATGTTGCCCC TAACACAAGC 1860
ACAAATCTAA CCATGACCTT CAGCAACCAT CTTAATACTG GGCACATCAG GGCCAGTGTT 1920
TTAGCGTCCA GTTCTACTGC AGCAGCTGCT ACGCTCTCTT TGGCTAATTC GGATGTCTCC 1980
CTGCTAAACT ACCAGTCTGC TCTGTACCCG TCATCTGCAG CACCTGTTGC AGGAGTTGCC 2040
CAGCAGAGTG TTTCCTTGCA GCCTGGAACT ACTCAGATTT GCACTCAGAC CGATCCATTC 2100
CAGCAGACAT TCATCGTGTG TCCACCTACT TTTCAAACTG GACTTCAGGC ACCTACAAAA 2160
CATTCTGGAT TCCCTGTGAG GATGGATAAT GCTGTGCCAA TTGTACCCCA GGCTCCTGCT 2220
GCTCAACCAC TACAGATCCA GTCAGGAGTC CTCACCCAGG GAAGCTGTAC ACCACTAATG 2280
GTAGCAACTC TCCATCCTCA AGTAGCCACC ATCACACCGC AGTATGCGGT GCCCTTTACT 2340
CTGAGCTGCG CAGCCGGCCG GCCGGCGCTG GTTGAACAGA CTGCCGCTGT ACTGCAGGCC 2400
TGGCCTGGAG GGACCCAGCA GATACTCTTG CCTTCAACTT GGCAGCAGTT GCCTGGGGTA 2460
GCTCTACACA ATTCTGTTCA GCCTACAGCA GTTATTCCAG AGACCATGGG GAGTAACCAA 2520
CAGCTGGGAG ATTGGAGGCA AAGTATGAAT GCCCACTCAC ATGGCAGCCA GTACAGTACT 2580
CTCATGCAGC AGCCCTCCCT GCTGACGAAC CATGTGACTC TGGCTACAGC TCAGCCTCTC 2640
AACGTTGGTG TTGCTCATGT TGTCAGGCAG CAGCAGTCTG GCTCCCTCCC CTCCAAGAAG 2700
AACAAGCAGC CGGCCCAAGC TTCGGCCAAA ACTGTCTCCA CATTGGATGT CTTACCTACC 2760
CAAGTCTATT CACTGATTGG GAGCAGCCCA CTCCGTACCA ACTCTTCCTA TAATCCCCTG 2820
GTCCCTTCAC AAGATCAGCA CCAGCCTATC ATTATCCCAG ACACCCCGAG CCCTCCTGTG 2880
AGCGTCATCA CTATCCGCAG TGACACCGAT GAGGAGGAGG ATAGCAAGTA TAAGCCCAGC 2940
AGCTCCAGCC TGAAGCCAAG GTCCAATGTC ATCAGCTATG TCACTGTCAA TGACTCTCCT 3000
GACTCCGACT CATCTCTGAG CAGTCCATAT TCTACAGATA CTCTGGCTGC AATTCGGGGC 3060
AATACAGGGC CCCTCCTAGA AGGACCAGGC CGGGTTGTGA CCGATGGCCC TGGGGCACGA 3120
ACCATCATTG TGCCACCTTT GAAAGCTCAA CTTGGTGATT GCACAGTGGC AACCCAGGCC 3180
TCAGGCCTCC TAACAAATAA GACCAAGCCA GTTGCCTCAG TGAGTGGTCA GTCGTCTGGC 3240
TGCTGTATCA CTCCCACAGG GTACCGGGCA CAGCGTGGGG GAACAAACAT AGCACAGCCG 3300
CTCAACCTTA GCCAGAACCA GCAGTCATCA GCTCCATCCT TGCAAGAGAG AAGCAGCAAC 3360
CCTGCCCCCC GCAGGCAGCA AGCGTTCGTG GCCCCGCTCT CCCAAGCCCC CTACACCTTT 3420
CAGCATGGCA GTCCGCTGCA CTCAACGGGA CACCCACACC TGGCCCCAGC CCCTGCCCAC 3480
CTGCCAAGCC AGCCCCACCT GTACACCTAT GCTGCTCCCA CTTCTGCAGC TGCCCTGGGC 3540
TCTACCAGCT CCATTGCACA TCTCTTCTCC CCCCAGGGAT CCTCAAGGCA CACTGCAGCC 3600
TATACCACCC ATCCTAGCAC CCTGGTCCAT CAGGTCCCTG TCAGTGTTGG GCCGAGCCTT 3660
CTCACCTCAG CCAGTGTGGC TCCTGCCCAG TACCAGCAAC AGTTTGCCAC CCAGTCCTAC 3720
ATTGGGTCCT CTCGAGGCTC AACAATTTAT ACTGGATATC CACTCAGCCC CACGAAGATC 3780
AGCCAGTATT CCTACTTGTA G 3801
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevle++g+G+fgqV+k+++++tkeivaiki+kn++++arq+q+Ev+iL++l++ +++++
Q: 242   YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSS-ENADE  300
         9****************************************************9.999**
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         yn+vr +e+f+++nh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aL++Lk+
Q: 301   YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS  360
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
         l++iHaDlKPeNi+lv++ r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+
Q: 361   LGLIHADLKPENIMLVDPVRQPyrVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP  420
         *********************999************************************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236
         ++eaiDmWSlGcv+aElf+G+pL+pG++e+dq+++i++++glp+e+ll++++k+++ff  
Q: 421   FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTSRFFnr  480
         **********************************************************66
S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286
           + ++p ++lkt          ks++++k+++n+ +++++++++++ e +++l+ek+d+
Q: 481   dPNLGYPLWRLKTPeeheletgiKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADR  540
         556778889998889********************************************9
S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315
         + ++dllk+ml++d++kRitp ++l+h+fv
Q: 541   ReYIDLLKKMLTIDADKRITPLKTLNHSFV  570
         99***************************7
Domain Sequence
(FASTA)
YEVLEFLGRG TFGQVAKCWK RSTKEIVAIK ILKNHPSYAR QGQIEVSILS RLSSENADEY 60
NFVRSYECFQ HKNHTCLVFE MLEQNLYDFL KQNKFSPLPL KYIRPILQQV ATALMKLKSL 120
GLIHADLKPE NIMLVDPVRQ PYRVKVIDFG SASHVSKAVC STYLQSRYYR APEIILGLPF 180
CEAIDMWSLG CVIAELFLGW PLYPGASEYD QIRYISQTQG LPAEYLLSAG TKTSRFFNRD 240
PNLGYPLWRL KTPEEHELET GIKSKEARKY IFNCLDDMAQ VNMSTDLEGT DMLAEKADRR 300
EYIDLLKKML TIDADKRITP LKTLNHSFV 329
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00250
EKS-ANC-00257
EKS-BOT-00268
EKS-CAE-00238
EKS-CAJ-00274
EKS-CAF-00275
EKS-CAP-00303
EKS-ECT-00028
EKS-EQC-00260
EKS-FEC-00254
EKS-GAM-00168
EKS-GAG-00225
EKS-GOG-00268
EKS-HOS-00274
EKS-LAC-00279
EKS-LOA-00278
EKS-MAM-00270
EKS-MEG-00213
EKS-MUP-00265
EKS-MYL-00270
EKS-NOL-00245
EKS-ORC-00253
EKS-OTG-00274
EKS-PAT-00253
EKS-PES-00238
EKS-POA-00259
EKS-PTV-00035
EKS-RAN-00283
EKS-SAH-00252
EKS-SUS-00239
EKS-TAG-00284
EKS-TUT-00033
EKS-VIP-00011
EKS-XET-00343
EKS-XIM-00339
Gene Ontology
GO:0005737; C:cytoplasm
GO:0016607; C:nuclear speck
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0009952; P:anterior/posterior pattern specification
GO:0048596; P:embryonic camera-type eye morphogenesis
GO:0060059; P:embryonic retina morphogenesis in camera-type eye
GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0061072; P:iris morphogenesis
GO:0060235; P:lens induction in camera-type eye
GO:0030182; P:neuron differentiation
GO:0008284; P:positive regulation of cell proliferation
GO:0010803; P:regulation of tumor necrosis factor-mediated signaling pathway
GO:0010842; P:retina layer formation
GO:0007224; P:smoothened signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013