EPS-MOD-00019

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MOD-00019

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	292.2	4.7E-87	23	293	271

Status

Unreviewed

Ensembl Protein

ENSMODP00000000810

UniProt Accession

F6WMG0;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1B

Gene Synonyms/Alias

PPM1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000000678	ENSMODP00000000810	ENSMODT00000000828

Organism

Monodelphis domestica

Functional Description

Protein Length

480

Protein Sequence
(FASTA)

MGAFLDKPKT EKHNAHGAGN GLRYGLSSMQ GWRVEMEDAH TAVVGIPHGL ENWSFFAVYD 60

GHAGSRVANY CSTHLLEHIT NNEDFRAAEK PGSALVPSVE NVKSGIRTGF LKIDEYMRNF 120

SDLRNGMDRS GSTAVGVMIS PEHVYFINCG DSRAILCRNG QVCFSTQDHK PCNPREKERI 180

QNAGGSVMIQ RVNGSLAVSR ALGDYDYKCV DGKGPTEQLV SPEPEVYEIL RAEEDEFIIL 240

ACDGIWDVMS NEELCEFVKS RLEVSDDLEK VCNWVVDTCL HKGSRDNMSI VLVCFPSAPK 300

VSDEAVKKDS DLDKHLESRV EEIMEKSGEE GMPDLAHVMR ILSAENIPNL PPGGGLAGKR 360

NIIEAVYNRL NPHRENDGAS DDAEENGSQG KLVEALRQMR INHRGNYRQL LEEMLTSYRI 420

AKIQGEDSPP PESAAAATSS NNDPEDLVEM VEANTETKSD LAELENSNED SGTEMSDSNI 480

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TTTTGGACAA ACCCAAAACT GAGAAACACA ATGCTCATGG TGCTGGGAAT 60

GGTTTGCGTT ATGGCCTAAG CAGCATGCAA GGATGGAGAG TGGAAATGGA AGATGCTCAC 120

ACAGCGGTTG TAGGTATTCC TCATGGCTTG GAAAACTGGT CGTTTTTTGC TGTTTATGAT 180

GGTCATGCTG GATCTCGAGT GGCAAATTAT TGCTCAACAC ACTTATTAGA ACATATAACT 240

AATAATGAAG ATTTTAGGGC AGCAGAAAAA CCTGGGTCTG CTCTTGTACC TTCAGTGGAA 300

AACGTTAAGA GTGGAATCAG AACTGGCTTC CTGAAAATTG ATGAATACAT GCGTAACTTT 360

TCAGATCTCA GAAATGGGAT GGACAGGAGT GGCTCAACTG CTGTGGGTGT TATGATTTCA 420

CCTGAACATG TCTACTTTAT AAACTGTGGA GATTCACGTG CCATCCTGTG TAGGAATGGA 480

CAAGTCTGCT TTTCAACCCA GGATCACAAA CCTTGCAATC CAAGAGAGAA GGAACGAATC 540

CAAAATGCAG GAGGCAGTGT AATGATACAG CGTGTTAATG GTTCATTAGC AGTTTCTCGA 600

GCTCTGGGGG ACTATGATTA CAAGTGTGTT GATGGCAAGG GTCCTACGGA ACAACTTGTT 660

TCTCCAGAAC CTGAGGTTTA CGAAATTTTA AGAGCAGAAG AGGATGAATT TATCATCTTG 720

GCTTGTGATG GGATCTGGGA TGTTATGAGC AATGAGGAGC TCTGTGAATT TGTTAAATCT 780

AGGCTTGAGG TATCTGATGA CCTGGAAAAA GTGTGCAATT GGGTTGTGGA CACTTGTTTA 840

CATAAGGGAA GTCGAGATAA CATGAGTATT GTGCTAGTTT GTTTTCCAAG TGCTCCTAAG 900

GTCTCAGATG AGGCAGTGAA AAAAGATTCA GATTTGGATA AGCACTTGGA ATCACGGGTT 960

GAAGAAATTA TGGAGAAGTC TGGTGAGGAA GGAATGCCTG ATCTTGCCCA TGTCATGCGT 1020

ATCTTGTCTG CAGAAAATAT TCCTAATTTA CCTCCAGGGG GAGGTCTTGC TGGCAAGCGC 1080

AATATTATTG AGGCTGTTTA TAATAGACTA AATCCACATA GAGAGAATGA TGGGGCCTCC 1140

GATGATGCTG AGGAAAATGG ATCACAGGGA AAATTGGTGG AAGCTCTCAG GCAAATGAGA 1200

ATTAATCATA GGGGAAACTA CCGACAACTT CTGGAAGAGA TGCTGACTAG TTACAGGATA 1260

GCTAAAATAC AGGGAGAAGA CAGCCCTCCT CCTGAATCAG CTGCTGCAGC TACTTCTTCG 1320

AACAATGATC CTGAAGACCT AGTGGAAATG GTGGAAGCCA ATACTGAAAC AAAAAGTGAT 1380

CTTGCTGAAT TAGAAAATTC TAATGAAGAT TCAGGGACAG AGATGAGCGA TTCAAACATA 1440

TGA 1443

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++    e   +++ff+vyDGh+gs+va++cs++l e++

Q: 23    RYGLSSMQGWRVEMEDAHTAVVGIPHGLE---NWSFFAVYDGHAGSRVANYCSTHLLEHI  79

         69****************98655554444...4***************************

S: 62    aeele.........sseseerkvkkalakaFlstdeelkvleeksldidksGstavvali  112

         +++ +         +  ++ ++vk+ ++++Fl++de ++++++ ++ +d+sGstav ++i

Q: 80    TNNEDfraaekpgsALVPSVENVKSGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMI  139

         ***99********9999*******************************************

S: 113   kdsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvL  172

         +++++y++n+GdSra+Lcrng+++  ++dHkp +++E+eRi++aggsv+ +   Rv+G+L

Q: 140   SPEHVYFINCGDSRAILCRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQ---RVNGSL  196

         ***************************************************...******

S: 173   avsRalGdlylk.........pyvtpePevtshrltsedefliLasDGlwdvvsneeavs  223

         avsRalGd+++k         ++v+pePev+++ + +edef+iLa+DG+wdv+snee+++

Q: 197   AVSRALGDYDYKcvdgkgpteQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCE  256

         ************************************************************

S: 224   lvrdvlekkeaeqeaakkLvklalargskdnvsaivv  260

         +v+++le +++++++++ +v+++l++gs+dn+s+++v

Q: 257   FVKSRLEVSDDLEKVCNWVVDTCLHKGSRDNMSIVLV  293

         ********************************98875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VVGIPHGLEN WSFFAVYDGH AGSRVANYCS THLLEHITNN 60

EDFRAAEKPG SALVPSVENV KSGIRTGFLK IDEYMRNFSD LRNGMDRSGS TAVGVMISPE 120

HVYFINCGDS RAILCRNGQV CFSTQDHKPC NPREKERIQN AGGSVMIQRV NGSLAVSRAL 180

GDYDYKCVDG KGPTEQLVSP EPEVYEILRA EEDEFIILAC DGIWDVMSNE ELCEFVKSRL 240

EVSDDLEKVC NWVVDTCLHK GSRDNMSIVL V 271

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation

KEGG

mdo:100033369

;

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013