EKS-MOD-00380

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00380

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	336.4	1.5E-100	1276	1539	264

Status

Unreviewed

Ensembl Protein

ENSMODP00000000938

UniProt Accession

F6SSD8;

Protein Name

Protein Synonyms/Alias

Gene Name

YSK4

Gene Synonyms/Alias

YSK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000000785	ENSMODP00000000938	ENSMODT00000000957

Organism

Monodelphis domestica

Functional Description

Protein Length

1543

Protein Sequence
(FASTA)

MNKNKLIHDF LEGVSRGDVE LISNHISKVH SILGNLDFQH PTTGNTALII AAERNLIEVV 60

EFLLEKGADI TLCNYCNQTA VHVANNAVQK QLLLAIHGTR APHLQLLQIS WQGDLQQLQD 120

LLASEQFLDI NFPNQHGLTP LMLAVRDVDL FESLDMLTEY RPIELLSELL KHNADPKLCD 180

VNGKSAMHYV SQIKSSKKQQ LLDILMNSLP KLERHPESLL DICHETDPSE CGTLMTAKSQ 240

NIILQSISSS EESDQDEDFS YSTWTSEDEI PSEEIQDYGH KTKGDEIIIT FQREDDSPQE 300

MSQVDNDFEA HNQTIPMHRK WASECSISLP NETEMVEFKM RQQTMLPFLL KKEENLEQLH 360

GADFGFLVPR HCSEPNVSKS VMGKNSFQIM KAQLQHTKSD GFTTPAVKLS SRSTEFSLIP 420

LSFLPTESTQ LVLLENNKLL KKTERHISRT IYPVANLIEP TSRSDGFHLP TKLQQTQTRV 480

FVDCSLRTSD GYNSIWSRNM CSFRKDHWSS SGEGSKEHLE REDLKCDQAE DGAQLEDSVF 540

EKGQSWASIE NEDICKENHT TEAKETDSQE GGIRDTKEEN TQWMTLRNHP SLRHGKHEQD 600

QGKAHGTQTT LQEVHPLVMT QGQSEGSGNE LPSLNGASGR PNEASDQNCI PDPVFTTVPI 660

VITPGPTANI FKSHTGRETS TKIAASETTG TEMSEMVPLV CITFPGNDCP REPSTAKQGI 720

SKRKSPLHSN STTFHKLAHQ ENDKCRMKTH RKKSDSKTKM NSRTSQNLTI SIEGSIKPTL 780

QKASMKRQVF PTLGQAESRP RQSAKLQRRG PQIEEKPLDL HALRPQRQGF PCICKNSRPK 840

KAAVPVSVPL AKSNFNFSDL KYSDMFKEIN STDKGPGIYE MFGTPVYCHV REAGRQESKF 900

YRETSSAPAR RCLSNKCPAA QNERNGNGKV RISQKKGHPK PPKSSLGIKQ KHKNLISKEK 960

NHKSTEVVIE NMENDGMISE PDWHVKSSGD TSLSCKDEAQ HLNSVHSPED LAESLNQNEP 1020

GPNSDLSSGG KVLVEQSSKD EDHSQSQILA TSLRDLHELE ERHQTKSVTS VDIWLQPSQE 1080

NAMKSLLQER LSMEPKVNQT FSETPRSERV SNKLPSLTAF SFPERAQSAS SQVPQSPNWT 1140

HSMEHSSLAH KSVTDQSTGK TESVSSSISM DTLDSENNEK LTDELLGCLA AELLALDEKD 1200

TNSWQMVTND TNAETQNPII SGRGNTCQDL DKETTRLKIQ KYSNNFWLSD KEKPFFNLNE 1260

KPFSENSLKH EEPILWTKGE ILGKGAYGTV YCGLTSQGQL IAVKQVALDT SDQVANEREY 1320

QKLQEEVDLL KVLKHVNIVA YLGTCLEKNL VSIFMEFVPG GSISSIINRF GPLPEMVLSK 1380

YTKQILQGVA YLHENCVVHR DIKGNNVMLM PTGIIKLIDF GCARRLAYAS LTGTHSEMLK 1440

SMHGTPYWMA PEVINESGYG RKSDIWSIGC TVFEMATGKP PLASMDRMAA MFYIGTHRGL 1500

MPSLPDHFSE NAADFVRVCL TRDQHDRPSA LQLLKHSFLQ RNP 1543

Nucleotide Sequence
(FASTA)

ATGAATAAAA ACAAACTGAT TCATGATTTC CTGGAGGGTG TTTCAAGAGG TGATGTGGAA 60

CTCATCAGCA ACCATATTTC TAAAGTTCAT TCCATTCTTG GAAACTTAGA TTTTCAGCAC 120

CCCACAACTG GAAATACAGC CCTCATTATT GCTGCAGAAA GAAATTTAAT AGAGGTTGTT 180

GAATTTCTTT TGGAAAAGGG AGCAGACATA ACACTCTGTA ACTACTGTAA TCAGACAGCC 240

GTTCATGTAG CTAACAATGC TGTCCAAAAG CAGCTTCTCT TGGCCATCCA TGGAACCCGA 300

GCGCCTCATT TGCAATTGCT TCAAATTTCC TGGCAAGGGG ACCTGCAGCA ACTTCAGGAC 360

TTGCTGGCTT CGGAACAATT CTTGGATATA AATTTCCCAA ATCAACATGG ATTGACTCCT 420

CTGATGCTGG CAGTGAGAGA TGTTGACCTC TTTGAAAGCC TTGATATGTT AACAGAGTAT 480

AGGCCCATTG AACTTCTTTC AGAACTTCTC AAGCATAATG CAGATCCCAA GCTCTGTGAT 540

GTTAATGGAA AATCAGCCAT GCATTATGTA TCACAAATAA AAAGTTCAAA GAAACAACAA 600

TTACTGGATA TACTAATGAA TTCTTTGCCC AAACTAGAAA GACATCCTGA ATCATTGCTT 660

GACATTTGTC ACGAAACGGA TCCTTCTGAA TGTGGAACAC TGATGACTGC CAAAAGCCAA 720

AACATCATTT TGCAAAGCAT TAGCAGCAGC GAGGAATCTG ACCAGGATGA AGATTTTAGT 780

TATTCTACAT GGACCAGTGA AGATGAAATC CCAAGTGAGG AAATACAGGA CTATGGGCAT 840

AAGACAAAAG GTGATGAAAT TATTATTACT TTTCAAAGAG AAGATGATAG TCCCCAAGAA 900

ATGAGCCAAG TTGACAACGA TTTTGAAGCA CACAATCAGA CAATACCAAT GCACAGAAAG 960

TGGGCAAGTG AGTGCTCTAT TTCTCTTCCA AATGAAACTG AAATGGTGGA ATTCAAAATG 1020

AGGCAACAGA CTATGTTACC TTTCCTTCTC AAGAAAGAAG AAAACTTAGA GCAGCTGCAC 1080

GGGGCTGACT TTGGCTTTCT GGTGCCAAGA CATTGCTCAG AACCTAATGT TTCCAAGTCT 1140

GTAATGGGTA AGAATAGCTT CCAGATTATG AAGGCACAGC TTCAACACAC TAAATCTGAT 1200

GGTTTTACCA CACCTGCTGT CAAACTTAGT AGTCGAAGTA CTGAGTTTTC CTTAATACCA 1260

TTATCATTCT TGCCTACTGA GTCAACTCAA CTTGTTCTTC TAGAAAATAA CAAGCTTCTT 1320

AAAAAGACAG AAAGACATAT TTCCAGAACC ATATATCCAG TGGCTAATCT TATAGAGCCC 1380

ACTAGTCGAT CTGATGGCTT TCATTTACCA ACTAAATTGC AACAAACCCA GACTAGAGTC 1440

TTTGTGGACT GTAGTCTCAG AACATCTGAC GGTTATAATT CCATTTGGTC TAGGAACATG 1500

TGCTCCTTTC GGAAGGATCA TTGGTCCTCA TCAGGAGAGG GCTCGAAAGA ACATCTGGAA 1560

AGAGAAGATC TAAAATGCGA CCAAGCTGAA GATGGTGCAC AACTGGAAGA CTCTGTCTTT 1620

GAAAAAGGCC AGTCATGGGC ATCCATTGAG AATGAGGACA TTTGTAAAGA AAATCACACC 1680

ACTGAAGCAA AAGAGACGGA TTCCCAGGAG GGTGGAATTA GAGATACCAA GGAGGAAAAT 1740

ACTCAGTGGA TGACATTAAG AAATCATCCT AGCTTGAGGC ATGGGAAGCA TGAACAAGAT 1800

CAAGGAAAGG CACATGGCAC TCAAACCACG CTCCAAGAAG TTCACCCTTT AGTAATGACT 1860

CAAGGCCAGA GTGAAGGTTC TGGAAATGAG CTTCCCAGTC TGAACGGTGC ATCAGGACGT 1920

CCAAATGAAG CCAGTGATCA AAATTGCATT CCAGATCCTG TCTTTACAAC CGTGCCTATT 1980

GTTATCACTC CTGGCCCAAC AGCAAACATA TTCAAAAGCC ACACAGGCAG AGAGACGTCC 2040

ACAAAAATAG CAGCATCAGA AACAACAGGA ACAGAAATGA GTGAAATGGT GCCTCTGGTC 2100

TGCATTACTT TTCCTGGAAA CGATTGCCCC AGGGAGCCAA GCACAGCCAA ACAGGGCATC 2160

TCAAAGAGGA AGAGTCCTCT TCATAGCAAC AGCACCACCT TCCATAAACT TGCTCACCAA 2220

GAAAATGACA AATGTAGAAT GAAGACCCAC AGGAAGAAAT CAGATTCAAA GACAAAAATG 2280

AACAGCAGGA CGTCTCAGAA CCTCACAATT TCTATTGAGG GTTCCATCAA ACCTACTCTT 2340

CAAAAAGCAA GCATGAAAAG GCAAGTGTTC CCCACTTTAG GGCAGGCTGA GTCCAGGCCC 2400

AGGCAATCAG CCAAGCTTCA GAGAAGAGGG CCACAAATAG AAGAGAAGCC TTTAGACCTC 2460

CACGCTTTGA GACCCCAAAG GCAAGGATTT CCCTGCATCT GCAAAAATTC TCGACCAAAA 2520

AAGGCTGCTG TTCCTGTTTC TGTCCCTCTG GCAAAGTCAA ACTTTAATTT TTCAGACCTG 2580

AAATATAGTG ATATGTTCAA GGAAATCAAT TCAACTGACA AAGGACCAGG AATTTATGAA 2640

ATGTTTGGGA CTCCTGTATA TTGTCACGTC CGAGAAGCTG GGCGTCAGGA AAGCAAATTC 2700

TATAGGGAAA CAAGTTCTGC TCCAGCTAGA AGGTGCCTTT CGAACAAATG CCCTGCCGCA 2760

CAGAATGAAA GAAATGGTAA TGGCAAAGTA AGGATTTCCC AGAAAAAGGG ACATCCAAAA 2820

CCTCCCAAAA GTTCTCTTGG CATTAAACAA AAGCACAAAA ATTTAATTTC AAAAGAAAAA 2880

AATCACAAGT CAACAGAGGT TGTCATAGAA AATATGGAAA ATGATGGTAT GATTTCAGAA 2940

CCTGATTGGC ATGTGAAATC TTCAGGAGAC ACCTCTCTCT CTTGTAAAGA TGAAGCTCAG 3000

CACCTTAATT CGGTTCACTC TCCAGAGGAT CTTGCTGAAT CTCTAAATCA GAATGAACCC 3060

GGTCCTAACT CAGATTTGTC CAGTGGGGGG AAAGTTTTAG TGGAACAGTC CTCTAAGGAT 3120

GAAGACCATT CTCAGAGTCA AATACTTGCC ACAAGCCTCA GAGACCTGCA TGAGCTTGAA 3180

GAGAGACATC AGACTAAATC TGTGACTTCA GTGGATATAT GGTTACAGCC AAGTCAAGAG 3240

AATGCCATGA AGTCTTTATT ACAAGAAAGA CTCTCTATGG AGCCGAAAGT CAACCAGACT 3300

TTTTCTGAGA CTCCAAGATC TGAGAGGGTT TCCAATAAAC TTCCATCGCT GACTGCTTTC 3360

TCTTTCCCAG AGAGGGCCCA AAGTGCATCT TCTCAGGTAC CACAAAGCCC AAACTGGACA 3420

CATTCAATGG AACACAGCAG TTTAGCACAC AAGTCAGTTA CAGATCAGAG CACTGGAAAA 3480

ACTGAAAGCG TTTCAAGCTC AATTTCTATG GACACTTTGG ACTCCGAAAA CAATGAAAAA 3540

TTAACAGATG AATTACTAGG TTGTCTAGCA GCAGAACTAT TGGCTCTCGA TGAGAAAGAC 3600

ACAAATTCCT GGCAAATGGT GACAAATGAC ACAAATGCTG AAACACAAAA CCCAATCATC 3660

AGTGGAAGAG GAAATACCTG CCAAGACCTT GACAAAGAGA CAACAAGACT CAAAATACAG 3720

AAGTACAGTA ACAATTTCTG GCTATCTGAC AAGGAAAAGC CTTTTTTCAA CTTGAATGAA 3780

AAGCCATTTT CTGAAAACAG TTTAAAGCAT GAAGAGCCTA TTCTATGGAC CAAAGGGGAA 3840

ATCCTTGGGA AGGGTGCATA TGGCACGGTG TACTGTGGTC TCACAAGCCA GGGCCAACTC 3900

ATAGCTGTCA AACAAGTAGC TCTGGATACC TCTGATCAGG TGGCTAATGA GAGAGAGTAC 3960

CAGAAACTGC AAGAAGAAGT GGACCTGCTC AAGGTCCTGA AGCACGTCAA TATTGTGGCT 4020

TACTTGGGAA CATGCTTGGA AAAGAACCTT GTAAGTATTT TCATGGAATT TGTTCCCGGT 4080

GGCTCCATTT CTAGTATTAT AAACCGTTTT GGGCCCCTGC CTGAGATGGT GCTCTCCAAA 4140

TACACCAAGC AAATTCTCCA AGGTGTAGCC TATTTGCACG AGAACTGTGT GGTACACAGA 4200

GATATCAAAG GGAATAATGT CATGCTCATG CCGACCGGAA TAATAAAGCT GATTGACTTT 4260

GGATGCGCCA GGCGTTTGGC CTATGCAAGC TTAACTGGCA CTCACAGTGA AATGCTTAAA 4320

TCTATGCATG GGACGCCATA TTGGATGGCA CCTGAAGTCA TCAATGAATC CGGCTATGGA 4380

AGGAAGTCAG ACATCTGGAG CATTGGCTGC ACTGTATTCG AGATGGCCAC AGGAAAACCA 4440

CCTTTAGCTT CTATGGATAG GATGGCAGCA ATGTTTTACA TTGGCACTCA TAGAGGGCTA 4500

ATGCCTTCTT TACCAGACCA CTTTTCAGAA AATGCAGCAG ACTTTGTACG CGTCTGTTTA 4560

ACCAGAGATC AGCATGATCG GCCATCTGCT CTGCAACTCC TGAAGCACTC TTTCCTTCAG 4620

AGAAATCCCT AA 4632

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekk.sekkevkalkeEikllkelk  59

         w+k+e++gkG++g+vy++l+ ++g+l+avK+v++++ ++ ++++e+++l+eE++llk lk

Q: 1276  WTKGEILGKGAYGTVYCGLT-SQGQLIAVKQVALDTSDQvANEREYQKLQEEVDLLKVLK  1334

         89*****************8.89***********8766514556****************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H niv y+G++ e++ ++if+E+v+gGs+ss+++++g+l e+v++kytkqil+g+ayLHe

Q: 1335  HVNIVAYLGTCLEKNLVSIFMEFVPGGSISSIINRFGPLPEMVLSKYTKQILQGVAYLHE  1394

         ************************************************************

S: 120   kkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaae...lesltGtlaymaPEvi  176

         +++vHRDiKg+N++l+ +g++kl DFG+++rla ++ + ++   l+s++Gt+++maPEvi

Q: 1395  NCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAYASLTGTHsemLKSMHGTPYWMAPEVI  1454

         *********************************9998877767789**************

S: 177   kkkekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakk.tkPeipeklsee  235

         +++  gygrk+DiWs+gc+v+em+tgk+P a++ +++a+mf +g+++  +P++p+++se+

Q: 1455  NES--GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGTHRgLMPSLPDHFSEN  1511

         988..****************************.9**********9989***********

S: 236   gkdflekcleldpkkrpsaeeLLkhefl  263

         + df++ cl++d+++rpsa +LLkh+fl

Q: 1512  AADFVRVCLTRDQHDRPSALQLLKHSFL  1539

         **************************96

Domain Sequence
(FASTA)

WTKGEILGKG AYGTVYCGLT SQGQLIAVKQ VALDTSDQVA NEREYQKLQE EVDLLKVLKH 60

VNIVAYLGTC LEKNLVSIFM EFVPGGSISS IINRFGPLPE MVLSKYTKQI LQGVAYLHEN 120

CVVHRDIKGN NVMLMPTGII KLIDFGCARR LAYASLTGTH SEMLKSMHGT PYWMAPEVIN 180

ESGYGRKSDI WSIGCTVFEM ATGKPPLASM DRMAAMFYIG THRGLMPSLP DHFSENAADF 240

VRVCLTRDQH DRPSALQLLK HSFL 264

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013