EPS-MOD-00011

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MOD-00011

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	112.6	1.5E-32	6	143	138

Status

Unreviewed

Ensembl Protein

ENSMODP00000001147

UniProt Accession

F7F7G1;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP12

Gene Synonyms/Alias

DUSP12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000000962	ENSMODP00000001147	ENSMODT00000001171

Organism

Monodelphis domestica

Functional Description

Protein Length

313

Protein Sequence
(FASTA)

MAAAEILEVR PGLYLGGVAA REQCRLREAG ITAVLTVDTE EPSGDTEGLQ TLFISARDEP 60

ETDLLSQLDN CFNFISRARA DGAAVLVHCH AGVSRSVAVV TAYIMKSEKL TFEDAYGNLQ 120

TIRPEAKMNE GFEWQLKLYQ AMGCEVDTSS AIYKQYRLQK VTEKYPELQN LPREVFAVDP 180

TLISQELKNE ILYKCRKCRR SLFRSSSILD HSEGSGPAAF AHKKMAPLIM NTGDETKCTS 240

YFIEPVQWME SALLGVMDGQ LLCPKCSAKL GSFNWYGEQC SCGRWMTPAF QIHKNRVDEM 300

KMLPLLGSQT RKT 313

Nucleotide Sequence
(FASTA)

ATGGCGGCGG CCGAAATACT GGAGGTGCGG CCGGGCCTCT ATCTGGGCGG GGTCGCAGCC 60

AGAGAGCAGT GTCGGCTGAG GGAGGCAGGA ATCACGGCCG TGCTGACAGT GGACACCGAG 120

GAACCTAGCG GCGACACCGA AGGCCTGCAG ACGCTCTTTA TTTCCGCACG GGATGAGCCC 180

GAGACGGACC TGCTCAGTCA GTTGGACAAC TGCTTCAACT TCATCAGCCG GGCACGCGCG 240

GACGGCGCCG CCGTGCTTGT TCACTGTCAT GCTGGTGTTA GTCGAAGTGT TGCTGTTGTG 300

ACTGCTTACA TAATGAAGTC AGAGAAGCTC ACCTTTGAAG ATGCCTATGG AAACCTCCAG 360

ACCATCAGGC CAGAGGCTAA AATGAATGAA GGCTTTGAGT GGCAGCTGAA GCTTTACCAG 420

GCGATGGGTT GCGAAGTGGA CACCTCTAGT GCAATATATA AACAGTATCG TTTACAAAAG 480

GTTACTGAGA AATATCCTGA ATTACAGAAT TTGCCACGGG AGGTCTTTGC TGTTGATCCC 540

ACTCTTATTT CCCAGGAATT GAAAAATGAG ATCCTTTACA AATGTAGGAA GTGCCGGCGT 600

TCCTTATTTC GAAGTTCCAG CATTTTGGAT CATAGTGAAG GGAGTGGACC AGCAGCCTTT 660

GCTCATAAGA AAATGGCACC TTTAATAATG AACACCGGGG ATGAAACTAA ATGTACTTCT 720

TATTTCATTG AACCTGTTCA GTGGATGGAA TCTGCATTGT TGGGTGTGAT GGATGGACAG 780

CTCCTTTGCC CGAAGTGCAG TGCCAAGTTG GGTTCCTTCA ACTGGTATGG TGAACAGTGT 840

TCGTGTGGTC GGTGGATGAC GCCTGCTTTT CAGATACATA AGAACAGAGT AGATGAAATG 900

AAAATGCTGC CCCTTCTTGG ATCACAAACA AGAAAAACAT AA 942

Domain Profile

S: 2     vteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvd  61

         + e+ pglylg+ a a ++  L+++git v+++ ++            ++g + + i +

Q: 6     ILEVRPGLYLGGVA-AREQCRLREAGITAVLTVDTEEPS-------GDTEGLQTLFISAR  57

         67899******986.78999*************999988.......45789999******

S: 62    DsdvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAie  121

         D+++tdll+ +d++ +fi +a+ +g +vlvHC+aGvsRS+++v+aY+mk e+l+++dA+

Q: 58    DEPETDLLSQLDNCFNFISRARADGAAVLVHCHAGVSRSVAVVTAYIMKSEKLTFEDAYG  117

         ************************************************************

S: 122   avkrkrpsiepnegfleQLlelekkl  147

         ++++ rp++++negf +QL +++ ++

Q: 118   NLQTIRPEAKMNEGFEWQLKLYQAMG  143

         **********************9886

Domain Sequence
(FASTA)

ILEVRPGLYL GGVAAREQCR LREAGITAVL TVDTEEPSGD TEGLQTLFIS ARDEPETDLL 60

SQLDNCFNFI SRARADGAAV LVHCHAGVSR SVAVVTAYIM KSEKLTFEDA YGNLQTIRPE 120

AKMNEGFEWQ LKLYQAMG 138

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0008270	; F:zinc ion binding
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR016278	; DUSP12.
IPR000387	; Tyr/Dual-specificity_Pase.
IPR007087	; Znf_C2H2.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.
PS50157	; ZINC_FINGER_C2H2_2; 1.

Prints

Created Date

20-Feb-2013