EKS-MOD-00012

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00012

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	378.2	1.6E-113	648	899	252

Status

Unreviewed

Ensembl Protein

ENSMODP00000001174

UniProt Accession

F7ES42;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHB6

Gene Synonyms/Alias

EPHB6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000000983	ENSMODP00000001174	ENSMODT00000001198

Organism

Monodelphis domestica

Functional Description

Protein Length

1006

Protein Sequence
(FASTA)

MLIKGATQPG DKVEDMVWIW ALLFIIPALA LEEVLLDTTG ETSEIGWLTY PPGGWDEVSV 60

LDNQQRLTRT FEACHVAEGL GLGQDNWLQT HFVDRQGAHR AHIRLHFSVR ACTSLGVGGG 120

MCRETFTLYY RQAEEPDDPS HASAWHLGPW IKVDTIAADE SFPASASSSS WSGGAGLQLN 180

VKERSFGPLT QRGFYVAFQD TGACLALVVV KIFAYSCPAV LQAFASFPET QASGAGGASL 240

VEAVGTCVAQ AEPEDDGVGS NLPRLHCNGE GEWMVAVGSC HCRPGYQPAH GDRACQACPR 300

GSFKALAGGA SCIPCPSRSH SAMPGASMCP CLSGFYRSSS DAPEAPCTGP PSAPRDLWFE 360

VQGSSLMLYW RLPQDLGGRG DVRFNIVCKQ CGEEHSPESG ACHHCGDEVY FDPRQQGLTE 420

SRVLVGGLRA HVPYILEVQS LNGVSEFSFE PPKTAAINVS IIHEVPPAVP LLHQVSRASD 480

SITVSWSQPD QRHGRVLDYQ LRYYDQADEA HFSILTSETN TATVSQLSPG HIYGFQVRAR 540

SAAGHGPYGG KVYFQTLPQG ELSRLIPERL PLVVGSALGA LAFLVLAVIT IFAFIFQRKR 600

QRTGYTEPLQ QYASPSGLGV KYYIDPSTYE DPSQAIREFT REVDPAYVKI EEVIGPGSFG 660

EVCRGWLQPR GRREQAVAIR TLWASGVESQ RDAFLGRAAV LGQFHHPNVL RLEGVVTKSQ 720

PLMVLTELME NGPLDSFLRQ QEGQFSNLQL VAMQRGVAAA MQYLSSCGFV HRALTAHSVL 780

VNGHLVCKVA HLSHGHSYLS HNSQGLQPPL RWSAPEVLTH GKFTTASDIW SFGILMWEVM 840

SYGERPYWDM SDQEVVHAIE QEFRLPPPPG CPNGLHLLML DTWQQDSAQR PHFDQLVAAL 900

DKMIRKPEML QAGGVHRGRQ SQSLLSPVTL DFSSLETPQA WLTAIGMECY QDSFSKVGLC 960

SFNEVAQLSL EDMPALGITL AGHQKKLLHN IHLLQQHLSQ PGPVEV 1006

Nucleotide Sequence
(FASTA)

ATGTTGATTA AAGGGGCCAC TCAGCCTGGG GACAAAGTGG AGGATATGGT GTGGATCTGG 60

GCCCTCTTGT TTATAATTCC AGCTTTAGCC CTTGAAGAGG TATTGCTGGA CACTACAGGA 120

GAGACATCTG AAATAGGCTG GCTCACCTAC CCACCAGGAG GGTGGGATGA GGTCAGTGTC 180

CTGGATAATC AGCAGCGTCT GACTAGAACA TTTGAGGCAT GCCATGTAGC AGAGGGCTTA 240

GGTCTTGGAC AGGACAACTG GCTACAAACC CATTTTGTGG ATCGGCAAGG AGCTCATCGG 300

GCACATATCC GACTCCACTT CTCTGTGAGG GCATGTACCA GCCTGGGAGT GGGTGGGGGG 360

ATGTGCCGAG AGACCTTTAC CCTCTACTAC CGCCAGGCTG AGGAACCAGA TGACCCCAGC 420

CATGCATCAG CCTGGCATCT TGGGCCCTGG ATCAAGGTGG ACACGATTGC TGCAGATGAA 480

AGCTTCCCTG CTTCTGCCTC TTCCTCTTCT TGGTCAGGAG GAGCTGGGCT TCAGCTCAAT 540

GTTAAGGAGA GGAGCTTTGG GCCATTAACC CAGCGAGGCT TCTATGTGGC CTTCCAGGAT 600

ACAGGAGCAT GTCTTGCCCT TGTAGTTGTG AAGATATTTG CCTATTCCTG CCCTGCTGTA 660

CTTCAGGCCT TTGCTTCTTT TCCTGAGACG CAAGCCAGTG GGGCAGGGGG AGCTTCCCTG 720

GTGGAGGCAG TGGGTACTTG TGTGGCACAG GCAGAGCCAG AGGATGATGG AGTAGGTAGC 780

AACCTTCCAA GGCTTCACTG TAATGGTGAA GGCGAGTGGA TGGTAGCTGT GGGAAGCTGT 840

CACTGTCGCC CTGGGTACCA ACCTGCACAT GGCGACAGAG CCTGCCAAGC CTGCCCCAGG 900

GGATCCTTTA AGGCTTTGGC TGGGGGTGCC TCCTGTATAC CCTGCCCTTC CCGAAGCCAC 960

TCTGCCATGC CTGGTGCATC TATGTGCCCC TGTCTCAGTG GCTTCTACCG GTCCAGCTCT 1020

GATGCCCCTG AAGCTCCCTG CACTGGGCCT CCATCAGCAC CCCGAGACCT ATGGTTTGAG 1080

GTACAGGGCT CATCCTTGAT GCTGTATTGG CGACTGCCCC AAGACTTGGG TGGTCGAGGG 1140

GATGTGCGAT TTAACATCGT GTGCAAGCAG TGTGGAGAGG AACATAGTCC TGAGAGTGGA 1200

GCTTGTCACC ACTGTGGAGA TGAGGTGTAC TTTGATCCTC GACAGCAAGG CCTTACTGAA 1260

AGCCGAGTGC TGGTTGGAGG GCTACGAGCC CATGTGCCCT ACATCCTGGA GGTGCAGTCT 1320

CTCAATGGAG TATCTGAGTT CAGCTTTGAA CCGCCAAAGA CCGCAGCCAT CAATGTCAGC 1380

ATCATCCATG AAGTCCCCCC GGCAGTTCCT CTGCTGCACC AGGTGAGCCG GGCATCTGAC 1440

AGCATCACTG TGTCCTGGTC ACAGCCTGAT CAACGGCATG GACGTGTCCT GGATTATCAG 1500

CTCCGGTACT ATGACCAGGC AGATGAGGCC CACTTCTCCA TACTGACCAG TGAGACCAAC 1560

ACAGCTACTG TATCCCAACT GAGCCCTGGC CATATCTACG GCTTCCAGGT TCGGGCACGG 1620

AGTGCAGCAG GTCATGGCCC CTATGGGGGC AAGGTCTATT TCCAAACTCT CCCACAAGGT 1680

GAGTTGTCCC GGCTGATACC AGAGAGGCTC CCATTGGTGG TTGGTTCTGC CCTGGGCGCT 1740

CTGGCCTTCC TCGTGTTAGC AGTCATTACC ATCTTTGCCT TCATCTTCCA GAGGAAGCGT 1800

CAACGGACAG GCTACACGGA ACCACTGCAG CAGTACGCCA GCCCTAGTGG CCTTGGAGTG 1860

AAGTACTACA TTGATCCATC TACATATGAA GATCCTAGCC AAGCCATCAG GGAGTTCACC 1920

AGGGAGGTGG ATCCAGCATA TGTCAAGATC GAAGAGGTTA TTGGACCAGG CTCCTTTGGT 1980

GAGGTATGCA GAGGCTGGCT GCAGCCTCGA GGACGTCGAG AACAAGCTGT AGCCATTCGA 2040

ACTCTATGGG CCAGTGGAGT AGAAAGCCAA CGTGATGCCT TCCTAGGCCG GGCTGCAGTA 2100

CTGGGTCAGT TTCATCATCC TAATGTTCTT CGGCTTGAGG GTGTGGTTAC CAAGAGTCAA 2160

CCCCTCATGG TGCTAACTGA GCTCATGGAG AATGGCCCAC TGGACAGCTT TCTCAGGCAA 2220

CAAGAGGGCC AGTTCAGTAA CCTGCAACTT GTGGCTATGC AGCGGGGTGT GGCAGCAGCC 2280

ATGCAGTACC TATCCAGTTG TGGCTTTGTA CACAGGGCTC TGACAGCCCA TAGTGTACTG 2340

GTCAATGGCC ACCTGGTGTG CAAAGTGGCC CACCTTAGCC ATGGCCACAG CTACCTGAGT 2400

CACAACAGCC AGGGTTTACA GCCTCCACTC CGATGGTCAG CTCCTGAGGT CCTAACTCAT 2460

GGAAAATTCA CAACAGCCAG TGATATCTGG AGCTTTGGGA TTCTAATGTG GGAAGTAATG 2520

AGTTATGGGG AACGCCCATA CTGGGACATG AGTGACCAAG AGGTGGTACA TGCTATAGAA 2580

CAGGAGTTCC GTCTTCCTCC ACCTCCAGGA TGCCCCAATG GGCTGCACCT ACTGATGCTA 2640

GACACTTGGC AACAGGATTC TGCCCAGCGG CCTCACTTTG ACCAGCTGGT AGCTGCCTTG 2700

GACAAGATGA TCCGCAAACC CGAGATGCTA CAAGCTGGAG GAGTCCATAG GGGAAGACAA 2760

TCCCAGAGCC TATTGAGTCC TGTGACCTTG GACTTCTCCT CACTGGAAAC ACCTCAGGCC 2820

TGGTTGACTG CCATCGGGAT GGAGTGCTAT CAGGACAGCT TCTCCAAAGT TGGGCTCTGT 2880

AGCTTCAATG AGGTGGCTCA GCTCAGCCTT GAGGATATGC CTGCCTTGGG CATCACTCTG 2940

GCTGGACACC AGAAGAAACT TCTCCACAAC ATCCATCTGC TCCAACAACA CCTAAGCCAG 3000

CCAGGCCCAG TGGAGGTCTG A 3021

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         vkie+viG G+fGevc+G l+ +g+re+avai+tl+a+  e+qr  fl +a++lGqf+hp

Q: 648   VKIEEVIGPGSFGEVCRGWLQPRGRREQAVAIRTLWASGVESQRDAFLGRAAVLGQFHHP  707

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         n++rleGvvtks+p+m++te meng ldsflr+++gqf+ +qlv+m+rG+a++m+yls+

Q: 708   NVLRLEGVVTKSQPLMVLTELMENGPLDSFLRQQEGQFSNLQLVAMQRGVAAAMQYLSSC  767

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180

         g+vhr l+a+++lvn +lvckv+++ +++        +++++g + p+rw+ape+++++k

Q: 768   GFVHRALTAHSVLVNGHLVCKVAHLSHGHS-----YLSHNSQGLQPPLRWSAPEVLTHGK  822

         ************************988876.....3567899******************

S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240

         ft+asd+ws+Gi++wev+syGerpywdms+q+v++aie+++rlppp +cp++l+ lmld+

Q: 823   FTTASDIWSFGILMWEVMSYGERPYWDMSDQEVVHAIEQEFRLPPPPGCPNGLHLLMLDT  882

         ************************************************************

S: 241   wqkdraerpkfeqivsi  257

         wq+d a+rp+f+q+v++

Q: 883   WQQDSAQRPHFDQLVAA  899

         **************987

Domain Sequence
(FASTA)

VKIEEVIGPG SFGEVCRGWL QPRGRREQAV AIRTLWASGV ESQRDAFLGR AAVLGQFHHP 60

NVLRLEGVVT KSQPLMVLTE LMENGPLDSF LRQQEGQFSN LQLVAMQRGV AAAMQYLSSC 120

GFVHRALTAH SVLVNGHLVC KVAHLSHGHS YLSHNSQGLQ PPLRWSAPEV LTHGKFTTAS 180

DIWSFGILMW EVMSYGERPY WDMSDQEVVH AIEQEFRLPP PPGCPNGLHL LMLDTWQQDS 240

AQRPHFDQLV AA 252

Keyword

ATP-binding; Complete proteome; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity
GO:0055074	; P:calcium ion homeostasis
GO:0035898	; P:parathyroid hormone secretion

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR011510	; SAM_2.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641	; Tyr-kin_ephrin_A/B_rcpt-like.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07699	; GCC2_GCC3; 1.
PF07714	; Pkinase_Tyr; 1.
PF07647	; SAM_2; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013