EKS-MOD-00011
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00011
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph420.52.0E-126628883256
StatusUnreviewed
Ensembl ProteinENSMODP00000001779
UniProt AccessionF7APP4;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA1
Gene Synonyms/Alias EPHA1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000001465ENSMODP00000001779ENSMODT00000001817
OrganismMonodelphis domestica
Functional Description
Protein Length980
Protein Sequence
(FASTA)
MQRRCPLGLG LLLLLCAQLP PGAPAKEVTL LDTSTAQGEL GWLLDPPETG WSEVQQMLNG 60
TPMYMYQDCP MLAGGDTEHW LRSNWIYRGE AASRVHVELQ FTVRDCKSFP GGSGPQGCKE 120
TFNLFYMESD HDVGIQLRRP LFQKVTTVAA DQSFTIRDLA TGAVRLNVER CLLGHLTRRG 180
LYLAFHNPGA CVALVAVRVF YQRCAEIVHK LAHFPDTLPK SMGLVEVAGT CLPHAQYAPG 240
PSVAPRMHCS TDGEWLVPVG RCYCNPGYQE VKEENGVEQC AACPVNFYRS EMDTPSCLKC 300
PPHSTAKSVG ATICTCVSGH YRTPGEGPQV ACTRPPSAPQ NISFSLSGTQ LSLQWKPPKD 360
SGGRRDVIYN VECAQCQGIA PDEGLCQPCG AAVHFSPGTK GLTLPALQIN GLEPYANYTF 420
RVEAKNGVSD LDPSGSPSAM LSLSIGHAEP LSGLSLSLVK RGPRRLELSW AGSQPRSPGV 480
NLSYELHVLN QKEERYQMVP EPRALLTELQ PDTTYVVRVR TLTPLGPGPY SPDHEFRTSP 540
PLFKGLSGGE IVAVVFGLML ALALILGFFI FRKRRRTQKQ KRQRECPSDG GDREDKLWLK 600
PYVDLQAYED PAQGALDFAR ELDPTWLTVD TVIGEGEFGE VYRGILRIPS HDCFTVAIKT 660
LKASSPDGHW WNFLREATIM SQFNHQHILH LEGVITKRKP IMIITEFMEN GALDAFLRAQ 720
EEQLAPGQLV SMLQGIASGM SHLSDHRYVH RDLAARNILV SQDLCCKVSD FGLTRLLDND 780
RDGTYETQGG KIPIRWTAPE AIAHRVFTSA SDVWSFGVVM WEVLSFGDKP YGDMSNQEVM 840
KSIEDGYRLP PPVDCPAPLY DLMKCCWAYD RTCRPRFRQL QTQLEQLLDS PHTLRTIANF 900
DPRVTLRLPS VSGSDGIPYR SVSEWLESIR MKRYILHFRS AGLDTMECVL ELTTEDLKQM 960
GITQAGHQKR ILCSIQGFKD 980
Nucleotide Sequence
(FASTA)
ATGCAGCGGC GCTGCCCCCT GGGGCTCGGG CTCCTGCTGC TGCTCTGCGC CCAGCTGCCC 60
CCGGGGGCGC CCGCCAAAGA AGTAACTCTG CTAGACACCA GCACTGCACA AGGAGAACTG 120
GGCTGGCTAT TGGACCCACC AGAGACTGGG TGGAGTGAAG TGCAACAGAT GTTGAATGGA 180
ACGCCAATGT ACATGTACCA GGACTGTCCA ATGCTGGCTG GGGGTGACAC AGAACACTGG 240
CTTCGCTCCA ATTGGATCTA CCGGGGGGAG GCAGCTTCTC GAGTTCATGT GGAGCTTCAG 300
TTTACTGTTC GAGACTGCAA GAGTTTCCCG GGAGGGTCAG GACCACAGGG CTGCAAGGAG 360
ACATTCAACC TCTTCTACAT GGAAAGTGAT CATGATGTGG GCATCCAGCT TCGCCGACCC 420
CTCTTCCAAA AGGTGACGAC AGTGGCTGCA GACCAGAGTT TTACCATACG GGACCTGGCA 480
ACTGGTGCCG TGCGGCTAAA TGTGGAGCGA TGCCTGCTGG GCCACCTGAC TCGTCGTGGC 540
CTTTACCTTG CTTTTCACAA CCCAGGAGCT TGTGTGGCCC TGGTGGCTGT TCGTGTATTC 600
TACCAGCGTT GTGCTGAGAT TGTGCATAAG CTAGCACACT TCCCTGACAC CCTTCCAAAG 660
TCGATGGGTT TGGTGGAGGT GGCAGGGACC TGCCTGCCTC ATGCCCAGTA TGCCCCTGGC 720
CCCTCGGTTG CCCCTCGAAT GCACTGTAGC ACTGATGGAG AATGGCTGGT ACCCGTGGGT 780
AGATGTTACT GCAACCCAGG CTATCAGGAG GTCAAGGAGG AGAATGGTGT CGAACAATGT 840
GCTGCCTGCC CTGTCAATTT CTACCGCTCT GAGATGGACA CCCCCAGCTG CCTCAAGTGC 900
CCTCCCCACA GCACAGCTAA GTCTGTGGGG GCTACAATCT GCACCTGTGT GAGTGGCCAC 960
TACAGAACTC CTGGGGAAGG GCCCCAGGTA GCATGCACAC GTCCTCCCTC AGCCCCTCAA 1020
AACATCAGCT TCTCTCTTTC GGGGACTCAA CTCTCTCTGC AATGGAAGCC ACCCAAGGAT 1080
TCAGGAGGAC GTCGAGATGT GATCTACAAT GTGGAGTGTG CACAGTGTCA GGGAATAGCC 1140
CCAGATGAGG GACTATGTCA GCCTTGTGGG GCAGCTGTGC ACTTCTCCCC TGGCACCAAG 1200
GGACTCACAC TGCCTGCCCT TCAAATCAAT GGCCTTGAAC CCTATGCCAA CTACACCTTT 1260
CGTGTTGAAG CCAAAAATGG AGTATCTGAC CTGGACCCAT CTGGTTCTCC CAGCGCTATG 1320
CTCAGCCTTA GCATTGGACA TGCAGAACCA CTGTCCGGCT TATCCTTGAG CCTGGTGAAG 1380
AGAGGGCCCC GACGCCTTGA GCTCTCCTGG GCAGGCTCAC AACCTCGCAG CCCTGGAGTC 1440
AACCTGAGCT ATGAGTTGCA TGTTCTGAAC CAGAAGGAAG AGAGATACCA GATGGTGCCA 1500
GAGCCCAGAG CGTTGCTGAC AGAGCTACAG CCTGACACTA CCTACGTGGT GCGAGTCCGA 1560
ACACTAACTC CTCTGGGTCC TGGACCCTAC TCTCCTGATC ATGAGTTTCG GACCAGCCCT 1620
CCTCTATTTA AGGGCCTGTC TGGGGGAGAG ATCGTGGCTG TTGTTTTTGG CCTGATGCTG 1680
GCGTTGGCTC TGATCCTTGG ATTCTTCATC TTCCGTAAAA GGAGGAGAAC TCAAAAGCAA 1740
AAAAGGCAGC GAGAGTGTCC TTCTGATGGT GGGGATCGTG AGGACAAGCT CTGGCTGAAG 1800
CCCTATGTAG ACCTACAGGC ATATGAGGAT CCTGCACAAG GTGCCTTGGA CTTCGCTCGA 1860
GAGCTCGACC CAACCTGGCT AACTGTTGAC ACAGTCATAG GGGAAGGAGA GTTTGGGGAA 1920
GTGTATCGAG GGATCTTGAG AATCCCCAGC CATGACTGTT TCACAGTGGC CATCAAGACT 1980
CTGAAAGCCT CATCTCCAGA TGGTCATTGG TGGAATTTCC TTCGAGAAGC CACTATCATG 2040
AGCCAGTTTA ATCACCAACA CATCTTGCAC CTGGAGGGCG TGATCACCAA GAGGAAGCCC 2100
ATTATGATCA TCACAGAGTT TATGGAGAAT GGGGCCCTGG ATGCCTTCTT AAGGGCACAG 2160
GAAGAACAAC TTGCCCCTGG ACAACTGGTC TCCATGCTGC AAGGTATTGC CTCTGGTATG 2220
AGCCACCTGA GTGACCATAG GTATGTTCAT CGAGACCTGG CTGCCAGAAA CATCCTTGTG 2280
AGCCAGGACC TGTGCTGCAA GGTATCTGAC TTTGGCCTGA CCCGATTGCT GGATAATGAC 2340
CGTGATGGCA CTTATGAAAC CCAGGGAGGG AAGATCCCAA TCCGTTGGAC AGCCCCAGAA 2400
GCCATTGCCC ATCGAGTCTT TACCTCAGCC AGTGATGTGT GGAGCTTTGG GGTTGTGATG 2460
TGGGAGGTGC TAAGCTTTGG GGATAAGCCA TATGGGGACA TGAGCAACCA GGAGGTGATG 2520
AAGAGCATTG AAGATGGCTA TCGTCTACCT CCTCCTGTTG ATTGCCCTGC CCCTTTGTAT 2580
GATCTCATGA AATGCTGCTG GGCTTATGAT CGAACCTGCA GGCCTCGATT CCGACAGCTT 2640
CAAACACAGC TAGAACAGCT GCTCGACAGC CCCCATACAC TGAGAACCAT TGCCAACTTT 2700
GACCCTCGTG TTACCCTTCG GCTACCAAGT GTAAGTGGCT CAGATGGGAT CCCATACAGA 2760
AGCGTCTCTG AGTGGCTTGA ATCCATCCGC ATGAAACGCT ACATACTGCA CTTCAGATCT 2820
GCAGGGCTAG ACACTATGGA GTGCGTGCTG GAGCTGACTA CTGAGGACCT GAAGCAGATG 2880
GGAATAACAC AGGCTGGACA TCAGAAGCGA ATTCTCTGCA GTATCCAGGG ATTCAAGGAC 2940
TGA 2943
Domain Profile
S: 2     kiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpn  61
         ++++viG+GefGev++G l++p++   +vaiktlka+s + ++++fl+ea+i+ qf+h++
Q: 628   TVDTVIGEGEFGEVYRGILRIPSHDCFTVAIKTLKASSPDGHWWNFLREATIMSQFNHQH  687
         789********************9999*********************************
S: 62    iirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmg  121
         i++leGv+tk+kp+mi+te+mengald+flr +++q++  qlv+ml+Giasgm +lsd+ 
Q: 688   ILHLEGVITKRKPIMIITEFMENGALDAFLRAQEEQLAPGQLVSMLQGIASGMSHLSDHR  747
         ************************************************************
S: 122   yvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkf  181
         yvhrdlaarnilv+++l+ckvsdfGl+r l++d++ +y+t+ggkipirwtapeaia+r f
Q: 748   YVHRDLAARNILVSQDLCCKVSDFGLTRLLDNDRDGTYETQGGKIPIRWTAPEAIAHRVF  807
         ************************************************************
S: 182   tsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcw  241
         tsasdvws+G+v+wevls+G++py dmsnq+v+k+ie+gyrlppp+dcpa ly lm+ cw
Q: 808   TSASDVWSFGVVMWEVLSFGDKPYGDMSNQEVMKSIEDGYRLPPPVDCPAPLYDLMKCCW  867
         ************************************************************
S: 242   qkdraerpkfeqivsi  257
           dr+ rp+f+q+++ 
Q: 868   AYDRTCRPRFRQLQTQ  883
         ************9875
Domain Sequence
(FASTA)
TVDTVIGEGE FGEVYRGILR IPSHDCFTVA IKTLKASSPD GHWWNFLREA TIMSQFNHQH 60
ILHLEGVITK RKPIMIITEF MENGALDAFL RAQEEQLAPG QLVSMLQGIA SGMSHLSDHR 120
YVHRDLAARN ILVSQDLCCK VSDFGLTRLL DNDRDGTYET QGGKIPIRWT APEAIAHRVF 180
TSASDVWSFG VVMWEVLSFG DKPYGDMSNQ EVMKSIEDGY RLPPPVDCPA PLYDLMKCCW 240
AYDRTCRPRF RQLQTQ 256
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>
EKS-AIM-00011
EKS-ANC-00010
EKS-BOT-00011
EKS-CAJ-00011
EKS-CAF-00012
EKS-CAP-00009
EKS-EQC-00012
EKS-FEC-00009
EKS-GAG-00011
EKS-GOG-00012
EKS-HOS-00012
EKS-ICT-00011
EKS-LAC-00015
EKS-LOA-00012
EKS-MAM-00010
EKS-MEG-00010
EKS-MUM-00012
EKS-MUP-00012
EKS-MYL-00013
EKS-NOL-00011
EKS-OCP-00003
EKS-ORC-00011
EKS-OTG-00012
EKS-PAT-00010
EKS-PES-00009
EKS-POA-00009
EKS-RAN-00011
EKS-SAH-00009
EKS-SUS-00009
EKS-TAG-00011
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0032862; P:activation of Rho GTPase activity
GO:0030336; P:negative regulation of cell migration
GO:0006469; P:negative regulation of protein kinase activity
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045766; P:positive regulation of angiogenesis
GO:0030335; P:positive regulation of cell migration
GO:0008284; P:positive regulation of cell proliferation
GO:0001954; P:positive regulation of cell-matrix adhesion
GO:0051496; P:positive regulation of stress fiber assembly
GO:0046777; P:protein autophosphorylation
GO:0032314; P:regulation of Rac GTPase activity
GO:0034446; P:substrate adhesion-dependent cell spreading
KEGG
mdo:100011941;
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013