EKS-MOD-00068

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00068

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	346.6	1.1E-103	175	454	280

Status

Unreviewed

Ensembl Protein

ENSMODP00000002193

UniProt Accession

F6WIC1;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK18

Gene Synonyms/Alias

CDK18;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000001795	ENSMODP00000002193	ENSMODT00000002238

Organism

Monodelphis domestica

Functional Description

Protein Length

503

Protein Sequence
(FASTA)

LTMNKMKNFK RRFSLSVPRT ETIEESLAEF TEQFNQLNSR RSERHLQLGP LVGDFQPEPS 60

AISPSEEDGD SHSQSSPGIR YRKHNQRRFS MEVRDGSLEL STWINTTRGS LIRNPLFIVP 120

LQDVSKRLSL PMDIRLPPEF LQKLQLESPE LPKPLSRMSR RASLSDIGFG KLETYVKLDK 180

LGEGTYATVF KGRSKLTENL VALKEIRLEH EEGAPCTAIR EVSLLKNLKH ANIVTLHDLI 240

HTERSLTLVF EYLDSDLKHY LDHCGNLMSM HNVKVFMFQL LRGLSYCHRR KILHRDLKPQ 300

NLLINEKGEL KLADFGLARA KSVPTKTYSN EVVTLWYRPP DVLLGSTEYS TPIDMWGVGC 360

IHYEMATGRP MFPGSTVKEE LHLIFRLLGE YPVSCHQRAP QHNKTSVGSL FPTSPSGCHR 420

YRLDTDGIDL LTSLPLYEAK SRISAEEALR HPYFGPLGER VHQLPDTASI FSLKEIQLQK 480

DPGYRGLSFQ QTGRGKNRRQ SIF 503

Nucleotide Sequence
(FASTA)

CTGACCATGA ATAAGATGAA GAATTTCAAG CGTCGATTCT CCCTCTCAGT GCCCCGAACA 60

GAGACCATAG AGGAATCTCT GGCTGAATTC ACTGAGCAGT TCAACCAACT TAACAGCCGA 120

CGGAGCGAAA GGCACCTTCA GCTTGGCCCT CTAGTAGGAG ACTTCCAGCC TGAGCCCAGT 180

GCCATCTCAC CATCAGAGGA GGATGGGGAC AGCCACAGCC AGTCCTCACC TGGTATTCGT 240

TACCGAAAAC ACAACCAGCG TCGCTTCTCC ATGGAGGTAA GAGATGGCTC CCTGGAACTC 300

AGTACCTGGA TAAACACAAC ACGTGGAAGT CTCATCCGAA ACCCTCTTTT CATTGTTCCC 360

CTCCAGGATG TCAGCAAACG GCTCTCCCTG CCCATGGACA TCCGCCTGCC GCCCGAGTTT 420

CTGCAGAAGC TGCAGCTGGA GAGCCCGGAA CTCCCGAAGC CTCTGAGCAG AATGTCCCGC 480

CGGGCATCCC TATCTGATAT CGGCTTTGGG AAACTGGAAA CTTATGTGAA ACTGGACAAG 540

TTAGGTGAGG GCACCTATGC CACCGTCTTC AAAGGGCGAA GCAAACTCAC TGAGAACCTG 600

GTGGCACTGA AGGAAATCCG TCTGGAGCAT GAGGAGGGTG CCCCTTGCAC TGCCATCCGG 660

GAAGTGTCGC TGCTGAAAAA CTTAAAACAT GCCAACATTG TGACCCTGCA TGACCTGATC 720

CACACGGAAC GGTCCCTTAC CCTCGTCTTT GAGTACCTGG ACAGTGACTT GAAGCACTAC 780

TTGGACCACT GCGGAAACCT CATGAGCATG CACAATGTCA AGGTCTTTAT GTTCCAGCTG 840

CTCCGAGGTC TCTCTTACTG CCACCGACGG AAGATCCTTC ACAGGGACCT GAAGCCCCAG 900

AACTTGCTCA TCAACGAGAA GGGGGAGCTA AAACTGGCAG ACTTCGGCCT GGCTCGGGCC 960

AAGTCAGTGC CCACCAAGAC TTACTCCAAT GAAGTAGTGA CCCTTTGGTA CCGGCCCCCT 1020

GACGTGCTGC TGGGCTCTAC GGAATACTCT ACTCCCATCG ATATGTGGGG TGTGGGCTGC 1080

ATCCACTATG AGATGGCCAC TGGAAGGCCC ATGTTCCCTG GCTCCACTGT CAAAGAAGAA 1140

TTGCACCTTA TCTTCCGCCT GCTTGGTGAG TACCCTGTCT CTTGCCACCA GAGGGCTCCT 1200

CAGCATAACA AGACTTCTGT TGGCTCACTC TTCCCCACCT CACCTTCTGG ATGTCATCGT 1260

TACAGGTTGG ACACAGACGG CATTGACCTA CTTACCAGCC TCCCTCTGTA TGAAGCCAAG 1320

AGCCGGATCT CTGCAGAGGA AGCCCTGAGA CACCCTTACT TTGGGCCCCT GGGGGAGCGT 1380

GTGCACCAAC TCCCTGACAC TGCCTCCATC TTCTCTCTAA AGGAAATTCA GCTCCAGAAG 1440

GACCCAGGTT ACCGGGGCTT ATCCTTCCAG CAGACAGGCC GAGGGAAGAA CCGGAGACAA 1500

AGCATCTTCT GA 1512

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y kl+k+geGty++v+k+++k t+++vAlK+irle+e eg p+ta+rE+sllk+lkh+ni

Q: 175   YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANI  233

         7899********************************9.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L+++++ ++++l+Lvfe+l++dLk++l+++ +  +s+++vk +++qll+gl+y+H++k

Q: 234   VTLHDLIH-TERSLTLVFEYLDSDLKHYLDHCGN-LMSMHNVKVFMFQLLRGLSYCHRRK  291

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLi+++g+lklaDfGlara s+p+kty++evvTlwYr+P++Llg++eYst

Q: 292   ILHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYST  351

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksfp  239

          +D+W+vgci  e++t +p+f+g++ +++l+ if+llg+   + +++  + ++ +  s+

Q: 352   PIDMWGVGCIHYEMATGRPMFPGSTVKEELHLIFRLLGEYPVSCHQRAPQHNKTSvGSLF  411

         ***************************************999999998888888865666

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +++++ ++++  +l+++++dll++l  ++ k+Risa+eal+h+yf

Q: 412   PTSPSGCHRY--RLDTDGIDLLTSLPLYEAKSRISAEEALRHPYF  454

         6566555544..48999***************************9

Domain Sequence
(FASTA)

YVKLDKLGEG TYATVFKGRS KLTENLVALK EIRLEHEEGA PCTAIREVSL LKNLKHANIV 60

TLHDLIHTER SLTLVFEYLD SDLKHYLDHC GNLMSMHNVK VFMFQLLRGL SYCHRRKILH 120

RDLKPQNLLI NEKGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID 180

MWGVGCIHYE MATGRPMFPG STVKEELHLI FRLLGEYPVS CHQRAPQHNK TSVGSLFPTS 240

PSGCHRYRLD TDGIDLLTSL PLYEAKSRIS AEEALRHPYF 280

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013