EKS-MOD-00463

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00463

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	344.9	3.5E-103	20	316	297

Status

Unreviewed

Ensembl Protein

ENSMODP00000002390

UniProt Accession

F6V2H6;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC100619004

Gene Synonyms/Alias

LOC100619004;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000001962	ENSMODP00000002390	ENSMODT00000002440

Organism

Monodelphis domestica

Functional Description

Protein Length

722

Protein Sequence
(FASTA)

MAEKFESLMN IHGFDLGSRY MDLKPLGCGG NGLVFSAVDN DCDKRVAVKK IVLTDPQSVK 60

HALREIKIIR RLDHDNIVKV FEILGPSGSQ LTDDVGSLTE LNSVYIVQEY METDLANLLE 120

QGPLLEEHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFI NTEDLVLKIG DFGLARIMDP 180

HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ 240

MQLILESIPV VHEEDRQELL SVIPVYIKND MTEPHKPLTQ LLPGISREAL DFLEQILTFS 300

PMDRLTAEEA LSHPYMSIYS FPMDEPISSH PFHIEDEVDD ILLMDETHSH IYNWERYHDC 360

QFSDHDWPIH NNFDIEEVQR DPRALSDVTD EEEVQVDPRK YLDGDREKYL KDPAFDTHFS 420

TEPCWQYPDH HENKYCDLEC SHTCNYKMRS SSYLDNLVWR ESEVNHYYEP KLIIDLSNWK 480

EQSKEKSDKK GKSKCERNGL VKAQIALEEA SQQLVEKERE KNQGFDFDSF IAGTIQLSSQ 540

HESTDVVDKL NDLNSSVSQL ELKSLISKSV SREKQEKGMA NLAQLEALYQ SSWDSQFVSG 600

GEECFLIDQF CCEVRKDEQI EKENTYTSYL DKFFSRKEDT EMLETEPIED GKFGERESEE 660

GFLNNSGEFL FNKQLESIGI PQFHSPVGSP LKSIQATLTP SAMKSSPQIP HKTYSSILKH 720

LN 722

Nucleotide Sequence
(FASTA)

ATGGCAGAAA AGTTTGAAAG TCTCATGAAC ATTCATGGTT TTGATCTGGG CTCTCGGTAT 60

ATGGACTTAA AACCGCTGGG TTGTGGTGGC AATGGCTTAG TTTTTTCTGC TGTCGATAAT 120

GACTGTGACA AAAGAGTGGC TGTCAAGAAA ATTGTTCTTA CAGATCCCCA GAGTGTTAAA 180

CATGCTTTAC GCGAAATCAA AATTATTAGA AGACTCGACC ATGATAACAT TGTGAAAGTA 240

TTTGAAATTC TTGGTCCCAG TGGAAGCCAG TTAACAGATG ATGTGGGCTC TCTGACAGAA 300

CTGAACAGTG TTTACATTGT TCAGGAGTAC ATGGAGACAG ACTTGGCTAA TCTGCTAGAG 360

CAGGGCCCTT TATTGGAGGA GCATGCCAGG CTTTTCATGT ATCAGCTGCT ACGTGGGCTC 420

AAGTATATTC ATTCTGCAAA TGTACTGCAC AGAGATCTCA AACCAGCTAA TCTTTTCATT 480

AATACCGAAG ACTTGGTGCT GAAGATAGGT GACTTTGGTC TTGCCCGGAT CATGGATCCC 540

CATTATTCCC ACAAGGGTCA TCTTTCTGAA GGATTGGTTA CTAAATGGTA CAGATCTCCA 600

CGACTTTTAC TTTCTCCTAA TAACTATACT AAAGCCATTG ATATGTGGGC TGCAGGATGC 660

ATCTTTGCTG AAATGCTGAC TGGGAAAACC CTCTTTGCAG GTGCACATGA ACTTGAACAG 720

ATGCAACTGA TTTTAGAATC TATTCCTGTT GTACATGAGG AAGATCGTCA GGAGCTTCTC 780

AGTGTAATCC CAGTTTACAT AAAAAATGAT ATGACTGAGC CACACAAACC CTTAACTCAG 840

CTGCTTCCAG GAATTAGTCG TGAAGCACTG GACTTCCTGG AACAAATTTT GACATTTAGT 900

CCCATGGATC GATTGACCGC AGAAGAAGCT CTGTCCCATC CTTATATGAG CATTTATTCC 960

TTTCCAATGG ATGAACCAAT TTCAAGCCAT CCTTTTCACA TTGAAGATGA AGTTGATGAT 1020

ATTTTGCTCA TGGATGAAAC TCATAGTCAT ATTTATAATT GGGAGAGGTA CCATGATTGT 1080

CAGTTTTCAG ACCATGACTG GCCTATACAT AATAATTTTG ATATTGAAGA AGTTCAGCGT 1140

GACCCAAGGG CTCTTTCTGA TGTCACTGAT GAAGAGGAAG TCCAAGTAGA TCCTCGAAAA 1200

TATTTGGATG GAGATCGTGA AAAGTATCTG AAGGATCCTG CCTTTGATAC CCATTTCTCT 1260

ACTGAGCCTT GTTGGCAATA TCCAGATCAT CATGAAAACA AGTATTGTGA TCTGGAATGC 1320

AGCCACACTT GTAACTACAA AATGAGGTCG TCATCATATC TAGATAACTT AGTTTGGAGA 1380

GAGAGTGAAG TTAACCATTA CTATGAACCC AAACTTATTA TAGATCTTTC TAATTGGAAA 1440

GAACAAAGCA AAGAAAAATC TGATAAGAAA GGCAAGTCAA AATGTGAAAG GAATGGATTG 1500

GTTAAAGCTC AAATAGCTCT TGAGGAAGCA TCACAGCAAC TGGTTGAAAA AGAAAGGGAG 1560

AAGAATCAAG GATTTGACTT TGATTCCTTT ATTGCAGGAA CTATTCAACT TAGTTCACAA 1620

CATGAGTCTA CTGATGTTGT TGATAAATTA AATGACTTGA ATAGCTCAGT GTCCCAACTA 1680

GAATTGAAAA GTTTGATATC AAAGTCAGTA AGCCGGGAAA AACAGGAAAA AGGAATGGCG 1740

AATTTGGCTC AGTTAGAAGC TTTGTACCAG TCTTCTTGGG ACAGCCAGTT TGTGAGTGGT 1800

GGGGAGGAAT GTTTTCTCAT AGATCAGTTT TGTTGTGAAG TAAGAAAGGA TGAACAGATT 1860

GAGAAGGAAA ACACTTACAC CAGTTACTTG GACAAGTTCT TTAGCAGGAA GGAAGATACT 1920

GAAATGCTAG AAACTGAGCC AATAGAGGAT GGCAAGTTTG GGGAAAGAGA AAGTGAGGAG 1980

GGTTTTCTTA ACAATAGTGG GGAGTTCCTC TTTAACAAGC AGCTTGAGTC TATAGGCATC 2040

CCACAGTTTC ATAGTCCAGT TGGTTCACCA CTTAAATCAA TACAGGCTAC ATTAACACCT 2100

TCTGCTATGA AATCTTCCCC CCAGATTCCC CATAAAACAT ACAGCAGCAT TCTGAAACAT 2160

CTGAACTAA 2169

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkplg G +g+v+savd+++++rva+kk++  +++ +s+k++lRE+k++++l+h+Ni

Q: 20    YMDLKPLGCGGNGLVFSAVDNDCDKRVAVKKIV--LTDPQSVKHALREIKIIRRLDHDNI  77

         7899****************************9..9************************

S: 61    iklldvftpee........eleelkdvYlvtelmetdLkkviksqklsdehiklllyqil  112

         +k+++++ p+         +l+el++vY+v+e+metdL++++++  l +eh++l++yq+l

Q: 78    VKVFEILGPSGsqltddvgSLTELNSVYIVQEYMETDLANLLEQGPLLEEHARLFMYQLL  137

         *********999999999999***************************************

S: 113   rglkylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwY  169

         rglky+Hsanv+HrDlKP+Nl++n++   lki dFGlar++d+++++k  l+e ++t+wY

Q: 138   RGLKYIHSANVLHRDLKPANLFINTEDLvLKIGDFGLARIMDPHYSHKghLSEGLVTKWY  197

         ************************876449**************999999**********

S: 170   raPeillslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflk  229

         r+P++lls ++ytka+D+W++GCI+aE+ltgk+lf+g++e++q+++ile ++ ++ee+ +

Q: 198   RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQ  257

         ************************************************************

S: 230   kieseearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         ++ s  +  yik+ +++++k++++l+p  s+eald+le++L+++p++R+++eeaL+hpY+

Q: 258   ELLSV-IPVYIKNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYM  316

         ****5.*****************************************************7

Domain Sequence
(FASTA)

YMDLKPLGCG GNGLVFSAVD NDCDKRVAVK KIVLTDPQSV KHALREIKII RRLDHDNIVK 60

VFEILGPSGS QLTDDVGSLT ELNSVYIVQE YMETDLANLL EQGPLLEEHA RLFMYQLLRG 120

LKYIHSANVL HRDLKPANLF INTEDLVLKI GDFGLARIMD PHYSHKGHLS EGLVTKWYRS 180

PRLLLSPNNY TKAIDMWAAG CIFAEMLTGK TLFAGAHELE QMQLILESIP VVHEEDRQEL 240

LSVIPVYIKN DMTEPHKPLT QLLPGISREA LDFLEQILTF SPMDRLTAEE ALSHPYM 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

mdo:100026361

;

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013