EKS-MOD-00294
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00294
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR451.21.1E-135619875257
StatusUnreviewed
Ensembl ProteinENSMODP00000002415
UniProt AccessionH9H5Z1;
Protein Name
Protein Synonyms/Alias
Gene NameERBB3
Gene Synonyms/Alias ERBB3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000001980ENSMODP00000002415ENSMODT00000002465
OrganismMonodelphis domestica
Functional Description
Protein Length1253
Protein Sequence
(FASTA)
MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM LNYNTNSSHA LRQLRLNQLT EILAGGVYIE 60
RNDKLCHMDT IDWRDIVRDP QAEIVVKDNG KNCPPCHESC GGKCWGPGPE DCQTLTKTIC 120
APQCNGHCFG PNPNQCCHDE CAGGCGGPRE TDCFACRHFN NSGACVSLCP QPLVYNKLTF 180
QLEPNPHTKY QYGGVCVASC PHNFVIDHTS CVRACPGDKM EVEKNGLKMC EPCGGLCPKA 240
CEGTGSGSRF QTVDSSNIDG FVNCTKILGN LDFLITGLNG DPWHNIPALD PEKLNVFQTV 300
REITGYLNIQ SWPPHMHNFS VFSNLTTIGG RSLYNRGFSL LIMKNVNVTS LGLRSLKEVS 360
AGRVYISANR QLCYHHSLNW TRLLRGPKEG RLDIKHNRSK KDCVAEGRVC DPLCSSGGCW 420
GPGPGQCLSC RNYSRGGVCV TQCNFLNGEP REFAHEDECF SCHPECQPVE GNVTCYGSGS 480
DACAQCVHFR DGPHCVNTCP HGLLGAKGPI YKYSDAHGEC LPCHENCTQG CKGPELHDCF 540
GQPEGFSSKT HVAVGLAVVA GLVVITLVLL LALLYWRGRK IQNKRAMRRY LERGESLEPL 600
DPGEKANKVL ARIFKETELR KLKVLGSGVF GTVHKGIWIP EGESIKIPVC IKVIEDRSGR 660
QSFQAVTDHM LAIGSLDHTH IVRLLGLCPG SSLQLVTQFL PLGSLLDHVR QHRGALGPQL 720
LLNWGVQIAK GMYYLEEHGM VHRNLAARNV LLKSPSQVQV ADFGVADLLP PDDKQLLHSE 780
AKTPIKWMAL ESIHFGKYTH QSDVWSYGVT IWELMTFGDI PYKGLRLTEV PDLLEKGERL 840
PQPQICTIDV YMVMVKCWMI DENIRPTFKE LANEFTRMAR DPPRYLVIKR DSGSGLPPGA 900
EPPALTDKEL EEVETLEPEL ELELELEEEE ELATTLGSAL SLPLGTLSRP RGSQNFLSPS 960
SGYMPMNQSN LGATRQGSMM RGSGERCPCP ASLHQNSRGR LASESSEGRG TSSEAEFQEA 1020
ESVCGSRSRS RSPRPRGDSA YHSQRHSLLT PLTPLTPPGL EEEDVNGYVM PDTHTKGIPS 1080
SRDGTLSSSV GLSSILGTEE EEEEDEEYEY MNQRRKQSLP RPPRPGSLEE LGYEYMDVGS 1140
DLSASLGSTH SCPLHPVPIL PATGTTPDED YEYMNRRHGG GTPGGDYAAM GGCPEAEQGY 1200
EEMGSFQGTG HHAPCIHDAH LKPLRSLEAT RSAFDNPDYW HSRLFSKASA QGT 1253
Nucleotide Sequence
(FASTA)
ATGAATGAGT TCTCTACTCT ACCACTCCCC AACCTTCGTG TGGTACGGGG GACCCAAGTC 60
TACGATGGGA AGTTTGCCAT CTTTGTCATG CTCAACTACA ACACAAACTC CAGCCATGCC 120
CTACGCCAGC TCCGCCTCAA TCAGCTCACA GAGATCCTGG CTGGGGGTGT TTACATTGAA 180
AGGAATGATA AACTTTGTCA CATGGACACA ATTGACTGGA GGGACATCGT GAGGGACCCA 240
CAGGCTGAGA TTGTGGTCAA GGATAATGGC AAAAACTGTC CCCCTTGTCA CGAGTCCTGT 300
GGGGGGAAAT GCTGGGGTCC TGGACCAGAA GACTGCCAGA CATTGACAAA GACAATCTGT 360
GCCCCACAAT GCAATGGCCA CTGCTTTGGA CCCAACCCCA ACCAGTGCTG CCATGATGAG 420
TGTGCAGGTG GATGTGGAGG TCCCCGGGAG ACAGACTGCT TTGCATGCCG ACACTTCAAT 480
AACAGTGGAG CCTGTGTGTC TCTGTGCCCA CAGCCCCTCG TCTACAACAA GCTCACCTTC 540
CAACTGGAGC CCAATCCTCA CACTAAATAC CAGTATGGAG GGGTCTGTGT GGCCAGCTGC 600
CCCCATAACT TTGTGATAGA TCACACCTCC TGTGTCAGGG CCTGTCCTGG GGACAAGATG 660
GAGGTAGAAA AGAATGGATT GAAGATGTGT GAGCCCTGTG GAGGGCTGTG TCCAAAAGCC 720
TGTGAGGGGA CAGGCTCAGG GAGCCGATTT CAGACTGTAG ATTCCAGTAA CATTGATGGG 780
TTTGTGAACT GTACCAAGAT CTTGGGCAAC CTGGACTTCC TTATCACTGG ACTCAATGGA 840
GACCCCTGGC ACAACATACC AGCCCTGGAT CCTGAGAAGC TCAATGTTTT TCAGACAGTT 900
CGGGAGATCA CAGGTTACCT GAACATCCAG TCATGGCCTC CCCACATGCA CAATTTCAGT 960
GTCTTCTCCA ACCTAACCAC CATTGGAGGC CGGAGTCTCT ACAATCGGGG CTTCTCACTG 1020
CTGATCATGA AAAACGTGAA TGTGACATCC TTGGGCCTGA GGTCCCTGAA AGAAGTCAGT 1080
GCTGGGCGTG TCTATATCAG TGCCAACCGG CAGCTCTGCT ACCACCACTC TCTGAACTGG 1140
ACCAGGCTGC TTCGGGGACC AAAGGAAGGG AGGCTGGACA TCAAGCACAA CCGGTCCAAA 1200
AAGGACTGTG TGGCAGAGGG CCGAGTGTGT GACCCGCTAT GCTCCTCTGG GGGTTGCTGG 1260
GGCCCTGGGC CTGGCCAGTG CTTGTCCTGT CGCAACTACA GCCGAGGGGG AGTCTGTGTG 1320
ACCCAATGCA ACTTCCTGAA TGGAGAACCT CGAGAGTTTG CTCACGAGGA TGAGTGCTTC 1380
TCCTGCCATC CTGAGTGCCA GCCTGTGGAG GGCAATGTCA CCTGCTATGG CTCGGGCTCA 1440
GATGCTTGTG CTCAGTGTGT CCACTTCAGG GATGGGCCAC ACTGTGTGAA TACCTGCCCC 1500
CATGGCCTCC TGGGTGCCAA AGGACCCATC TACAAGTACT CTGATGCTCA TGGAGAGTGT 1560
CTACCTTGCC ATGAGAACTG CACTCAAGGG TGTAAGGGAC CAGAGCTCCA TGACTGTTTC 1620
GGTCAACCAG AGGGCTTCAG CAGCAAGACC CATGTGGCTG TGGGCCTGGC TGTGGTAGCA 1680
GGGCTGGTGG TGATTACCTT GGTCTTATTG CTTGCCTTAC TCTACTGGCG AGGGCGAAAG 1740
ATTCAGAATA AGCGGGCAAT GAGACGCTAC CTGGAACGGG GTGAGAGCTT GGAGCCTTTG 1800
GACCCTGGGG AGAAGGCCAA CAAGGTCTTG GCCCGAATAT TCAAGGAAAC AGAGCTGAGA 1860
AAACTCAAAG TGCTTGGCTC AGGTGTCTTC GGAACTGTGC ACAAGGGCAT TTGGATCCCA 1920
GAAGGCGAGT CTATCAAGAT CCCAGTCTGC ATTAAGGTCA TTGAAGACAG GAGTGGTCGG 1980
CAAAGTTTCC AGGCTGTGAC TGATCACATG TTAGCCATTG GCAGCTTAGA TCACACCCAC 2040
ATTGTTCGGC TGCTGGGGCT ATGCCCAGGG TCATCGTTGC AGCTGGTCAC CCAATTTCTG 2100
CCACTGGGAT CACTGCTGGA CCACGTACGA CAACATCGAG GGGCTCTGGG ACCTCAGCTA 2160
CTGCTCAACT GGGGCGTGCA GATCGCCAAG GGCATGTACT ACCTGGAGGA ACACGGCATG 2220
GTGCACAGAA ATCTGGCTGC CCGCAATGTG CTGCTCAAGT CTCCAAGTCA AGTGCAGGTG 2280
GCTGACTTTG GGGTGGCAGA TCTGTTACCC CCTGACGATA AACAACTGCT GCACAGTGAA 2340
GCTAAGACCC CAATCAAGTG GATGGCCCTG GAAAGCATCC ATTTTGGAAA ATATACACAC 2400
CAGAGTGACG TCTGGAGTTA CGGTGTGACA ATATGGGAAC TGATGACATT CGGGGACATA 2460
CCCTATAAAG GGCTTCGACT GACTGAGGTG CCTGACCTGC TGGAGAAGGG AGAGCGTCTC 2520
CCACAGCCAC AGATTTGCAC TATTGATGTC TACATGGTCA TGGTTAAGTG CTGGATGATT 2580
GATGAGAACA TACGACCAAC ATTCAAAGAA CTGGCTAATG AATTCACCCG AATGGCTCGG 2640
GATCCACCCC GCTATCTGGT CATCAAGAGA GATAGTGGTT CTGGGCTGCC TCCTGGGGCT 2700
GAGCCCCCTG CCCTTACTGA CAAAGAACTG GAGGAGGTGG AGACTCTGGA GCCAGAGCTG 2760
GAGCTGGAAC TGGAGCTGGA GGAGGAGGAG GAACTGGCCA CCACACTAGG CTCTGCCCTC 2820
AGCCTGCCAC TTGGCACACT GTCCCGACCC CGTGGGAGTC AGAACTTTCT GAGTCCTTCC 2880
TCTGGATATA TGCCAATGAA TCAGAGTAAC CTTGGAGCCA CTAGACAGGG TTCTATGATG 2940
CGTGGGAGTG GTGAACGATG CCCTTGCCCA GCCTCTCTGC ACCAGAACTC ACGAGGCCGA 3000
CTCGCATCAG AATCCTCAGA AGGCCGAGGG ACAAGCTCTG AGGCTGAGTT CCAAGAGGCA 3060
GAGTCTGTAT GTGGAAGCCG GAGCCGAAGC CGGAGCCCTC GGCCTCGAGG GGACAGTGCC 3120
TATCATTCCC AACGCCACAG CCTACTCACC CCACTCACCC CACTCACTCC ACCAGGGCTA 3180
GAGGAAGAGG ATGTCAATGG TTACGTTATG CCTGACACAC ATACCAAAGG TATTCCCTCT 3240
TCCCGGGATG GCACGCTGTC ATCATCTGTG GGCCTCAGTT CCATTCTGGG TACAGAAGAG 3300
GAAGAGGAAG AAGATGAGGA GTACGAATAT ATGAATCAGA GAAGAAAGCA GAGTCTGCCA 3360
AGACCCCCTA GGCCAGGATC TCTGGAAGAG CTGGGCTATG AGTACATGGA TGTGGGATCG 3420
GACCTCAGTG CCTCCTTAGG CAGTACCCAC AGCTGCCCAC TCCATCCTGT GCCTATCCTG 3480
CCTGCTACAG GAACTACTCC CGATGAAGAT TATGAGTATA TGAATCGTCG ACATGGTGGA 3540
GGAACTCCGG GAGGGGATTA TGCAGCCATG GGAGGTTGCC CAGAAGCAGA GCAAGGGTAT 3600
GAGGAAATGG GGTCATTTCA GGGCACTGGG CACCATGCCC CTTGCATCCA TGATGCCCAC 3660
CTCAAGCCCC TTCGAAGCCT AGAGGCCACT CGCTCTGCTT TTGACAACCC TGACTACTGG 3720
CATAGTAGAC TTTTCTCCAA GGCCAGTGCT CAGGGGACAT AA 3762
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+klkvlGsG+fGtv+kGiwipege++kipv+ikv+e+++g++++++++d++l+++sldh
Q: 619   LRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDRSGRQSFQAVTDHMLAIGSLDH  678
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         +++vrllglc  s+lqlvtq+lplG+lld+vr+h+++lG+q llnw+vqiakGm+ylee+
Q: 679   THIVRLLGLCPGSSLQLVTQFLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEH  738
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
          +vhr+laarnvl+ksp++v+++dfG+a+ll  d+k+l ++++k+pikw+alesi++ ky
Q: 739   GMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKY  798
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvt+wel+tfG+ py+g++++e+pdllekGerl+qp+ictidvymv+vkcw
Q: 799   THQSDVWSYGVTIWELMTFGDIPYKGLRLTEVPDLLEKGERLPQPQICTIDVYMVMVKCW  858
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mid+++rp+fkela+ef
Q: 859   MIDENIRPTFKELANEF  875
         ****************9
Domain Sequence
(FASTA)
LRKLKVLGSG VFGTVHKGIW IPEGESIKIP VCIKVIEDRS GRQSFQAVTD HMLAIGSLDH 60
THIVRLLGLC PGSSLQLVTQ FLPLGSLLDH VRQHRGALGP QLLLNWGVQI AKGMYYLEEH 120
GMVHRNLAAR NVLLKSPSQV QVADFGVADL LPPDDKQLLH SEAKTPIKWM ALESIHFGKY 180
THQSDVWSYG VTIWELMTFG DIPYKGLRLT EVPDLLEKGE RLPQPQICTI DVYMVMVKCW 240
MIDENIRPTF KELANEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00281
EKS-ANC-00291
EKS-BOT-00299
EKS-CAJ-00306
EKS-CAF-00306
EKS-CAP-00335
EKS-DAR-00648
EKS-EQC-00291
EKS-FEC-00285
EKS-GAM-00190
EKS-GAA-00372
EKS-ICT-00282
EKS-LAC-00311
EKS-LOA-00310
EKS-MAM-00303
EKS-MUM-00331
EKS-MUP-00297
EKS-MYL-00301
EKS-NOL-00276
EKS-OCP-00048
EKS-ORN-00390
EKS-ORC-00282
EKS-ORL-00361
EKS-OTG-00305
EKS-POA-00291
EKS-PTV-00063
EKS-RAN-00316
EKS-SAH-00281
EKS-SUS-00263
EKS-TAR-00393
EKS-TEN-00390
EKS-TUT-00065
EKS-XET-00373
EKS-XIM-00382
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0016323; C:basolateral plasma membrane
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0016328; C:lateral plasma membrane
GO:0005524; F:ATP binding
GO:0030296; F:protein tyrosine kinase activator activity
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0021545; P:cranial nerve development
GO:0003197; P:endocardial cushion development
GO:0007162; P:negative regulation of cell adhesion
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0051048; P:negative regulation of secretion
GO:0009968; P:negative regulation of signal transduction
GO:0051402; P:neuron apoptotic process
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0042127; P:regulation of cell proliferation
GO:0014037; P:Schwann cell differentiation
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
mdo:100028103;
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013