EKS-MOD-00298
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00298
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/Alpha314.92.9E-9417561974219
StatusUnreviewed
Ensembl ProteinENSMODP00000002478
UniProt AccessionF6QWI3;
Protein Name
Protein Synonyms/Alias
Gene NameTRPM6
Gene Synonyms/Alias TRPM6;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000002031ENSMODP00000002478ENSMODT00000002530
OrganismMonodelphis domestica
Functional Description
Protein Length2024
Protein Sequence
(FASTA)
MRRSQKSWIE GVFDKRECIQ FIPSSKDPHR CTAECQVCQN LIRCYCGRLI GDHHELPYHW 60
AASSTTQGQE EEWSVEKHTK KSPTDTFGTI NFQDGEHTYH AKYIRTSYDT NLEQLLHLML 120
KEWKMELPKL VISVHGGIQN FELPCKLKQV FSQGLIKAAV TTGAWIITEG INTGISKHVG 180
DALKAYSSQS LRKIWTVGIP PWGIIENQRD LIGKDVVCLY QTLGNPLSKL TTLNSLHSHF 240
ILSDDGTVGK HGNEMKLRRN LEKYLSLQKI HFRMGQRVPV VGLVVEGGPN VILMVWEFVR 300
DSSPVPVVVC EGTGRAADLL AFTYKHTVDE GELRPLVKEQ IIHMIQNTFN FSLKQSNHLF 360
KILMQCMEHK DAITIFDAES EEQHDLDLAI LTALLKGTNL SASEQLNLAM AWNRMDIAKK 420
QILIYGQHWK AGSLEQAMMD ALVMDRVDFV KLLIEYGVNL HRFLTISRLE ELYNTKQGSV 480
NVLLNHLVRD VKQNNLPSDY RISLIDIGLV IEYLIGGAYR SSYTRKNFRA LYNNLCRKHK 540
RVSLSHPSHH QISHSRSLGG SAENTLHSQF IRTAQPYKFK DKTVVGLHKS RKKSKEEQNL 600
PEDPDSTGFI YPYNDLLVWA VLMKRQKMAM FFWQHGEEAM VKAVIACKLY RAMAHETEES 660
NMLDGTSEEF KNYSKEFGQL ALDVLEKAFK NNERMAMKLL TYELKNWSNS TCLKLAVSVG 720
LRSFVSHTCT QMLLTDMWMG RLKMGKNAWL KVIISILLPP TILTLEFKSK AEMSHVPQSQ 780
DSQFTWHNGD QSSSSIKEIL SVKNYDFEKG SDEKPDDSHN FASYHGPQSL PGTRKIYEFY 840
NAPIVKFWLY TMAYLTFLML FTYTVLVEMQ PQPTVQEWIV IIYIFTTAIE KVREIFISEP 900
GKFIQKVKVW INEYWNLIDT IAISLFTIGF ALRWADPPTQ TAGRLIYCID TIFWYSRLLD 960
FLAVNQHAGP YLTMIGKMTA NMFYIVIMMA IVILSFGVAR KAILSPHESP SWTLARDIVF 1020
QPYWMMFGEV YASEIDVCSS NPDCPPGSFL TPFLQAVYLF VQYIIMVNLL IAFFNNVFHQ 1080
MKAISNKLWK YNRYRYIMTY HEKPWLPPPF ILLSHIFLLF RCFCHYQAPN ELDQEEGDVG 1140
LKLYLSDEEL KKLHGFEEQC VKEYFHEKME NLNSSCGERI RVTSERVSDM FFQLKEVNER 1200
VSYIKESLLS LDSHVGHLQD LSALTLDTLK VLSAVDTLQL EEAFLASSEH SVGRKLPHSW 1260
SNVICTEMLS SLEKSGGVKC QYYSMPPSLL QSRVRSQNLS GRQKSSLLEI MNSQEENQEK 1320
KGTSSGPVTV FFNSKLPPKL SQLLLISSSP TEISPLAKDD MSLSPTKPAA GPKLGWLATE 1380
QQQTRQENCS LCLNCQTSAA ADKESVEDSA LPKPARENNG DLLVPTTNSS PLSVKMTSLP 1440
FHTDSLRAGG GYVNLAFSEG DDETGVFSSK KKWHSQLPSS CNLACSDSDP CQVQLGRSKS 1500
FNSNSTRSLQ CSNISKLGSW LQPSTNIWIN PLRKDWTFLH NGSFRSYKEE RLMKTCKNKD 1560
CSRSSEKCQS VWTKAKFGSK ERKLLKEKKK LQQFQVPVIT VNSCFPNTQM NSEPAEKTFS 1620
GEEKEDNKNW LTVSEFSQIK PHISQKMKSQ ETGRHSICIS DNLKQPHEDL NKNSHWTSMK 1680
TSQNQNSVSR SLEGIDKASA YLKTTHDLHH HYSAVERNNL MRLSQTIPFT PIHQFAGEEV 1740
TIYKLEESSP LSLDKSMSSW SQRGTAAIIQ VLSREEMDGG LRKAMKVVST WSEDDVIKPG 1800
QVFIVKSFLP EVVQTWHKIF REHTVLHLCL REIQQQRAAQ KLIYTFNQLK PHTIPYAPRF 1860
LDVFLIYCHS ANQWLTIEKY MTGEFRKYNN NNGDEISPSN TLEELMLAFS HWTYEYTRGE 1920
LLVLDLQGVG ENLTDPSVIK PEDKQSRGMV FGPANLGEDA IRNFIAKHRC NSCCRKLKLP 1980
DLKRNDYSPG RINSTFQLQR KIEPAKGSVT EESVGDPRED LTRL 2024
Nucleotide Sequence
(FASTA)
ATGAGGAGGT CTCAGAAGTC CTGGATTGAA GGAGTCTTCG ACAAAAGGGA ATGTATCCAA 60
TTTATACCCA GCTCAAAAGA TCCTCACAGA TGCACTGCAG AATGCCAAGT GTGCCAAAAT 120
TTAATAAGGT GTTATTGTGG ACGATTGATT GGAGACCATC ATGAGTTGCC ATATCATTGG 180
GCTGCATCTT CAACCACCCA AGGCCAAGAA GAAGAATGGT CTGTGGAAAA ACACACAAAG 240
AAAAGTCCTA CTGATACCTT TGGCACTATT AACTTCCAGG ATGGAGAACA TACCTACCAT 300
GCCAAGTATA TACGAACATC TTACGATACA AATTTGGAGC AACTGTTACA TCTGATGTTG 360
AAAGAATGGA AAATGGAACT GCCAAAGCTT GTCATTTCTG TTCACGGGGG CATTCAGAAC 420
TTTGAGCTGC CTTGCAAACT GAAGCAGGTG TTCAGTCAAG GGCTGATCAA AGCTGCAGTG 480
ACAACAGGAG CATGGATAAT CACTGAAGGC ATCAACACAG GAATTTCCAA GCATGTTGGG 540
GATGCTCTCA AAGCATATTC CTCTCAAAGC CTCAGAAAAA TCTGGACAGT TGGAATTCCT 600
CCTTGGGGAA TCATCGAAAA TCAGAGAGAT CTTATTGGAA AAGATGTGGT TTGCCTGTAT 660
CAAACTCTGG GCAATCCTCT CAGCAAGCTG ACCACCCTCA ACAGCCTACA CTCTCATTTC 720
ATTCTATCAG ATGATGGTAC TGTGGGAAAA CATGGAAATG AAATGAAGCT GAGGAGGAAC 780
CTAGAAAAAT ACCTTTCCTT GCAAAAAATA CATTTCCGAA TGGGCCAACG TGTACCAGTG 840
GTGGGTCTGG TGGTAGAAGG AGGTCCTAAT GTAATCCTCA TGGTGTGGGA GTTTGTCAGA 900
GACAGTTCCC CAGTTCCTGT GGTGGTCTGT GAGGGCACAG GCAGAGCTGC TGATCTCCTG 960
GCCTTCACTT ACAAACACAC AGTTGATGAA GGGGAACTCC GTCCTTTGGT GAAGGAACAG 1020
ATCATTCACA TGATTCAAAA CACTTTCAAT TTTAGCCTTA AACAGTCCAA TCACCTTTTT 1080
AAAATTCTGA TGCAGTGTAT GGAGCATAAG GATGCTATCA CCATATTTGA TGCTGAGTCA 1140
GAGGAGCAGC ATGACCTCGA TTTAGCAATC CTGACTGCTC TGCTAAAAGG TACAAATTTG 1200
TCAGCCTCAG AACAATTAAA CCTAGCAATG GCCTGGAACA GAATGGATAT TGCTAAGAAG 1260
CAGATTCTAA TTTATGGACA ACACTGGAAG GCTGGGTCTT TGGAACAAGC CATGATGGAT 1320
GCTTTAGTGA TGGATCGGGT AGATTTTGTG AAACTCTTAA TAGAATATGG AGTGAACCTG 1380
CACCGGTTTC TCACTATTTC CCGGCTAGAA GAGCTCTACA ATACAAAACA AGGATCTGTC 1440
AATGTGCTCT TGAATCATCT TGTTCGAGAT GTAAAACAGA ACAATCTTCC TTCAGACTAC 1500
AGAATATCAT TGATTGATAT TGGATTGGTG ATAGAGTACC TTATTGGTGG AGCATATCGG 1560
AGCAGCTACA CAAGGAAGAA TTTCAGAGCC TTGTATAATA ACCTCTGCAG AAAACATAAG 1620
AGAGTAAGTT TATCTCATCC TTCCCATCAC CAGATCAGCC ATTCAAGAAG CCTGGGTGGA 1680
TCTGCTGAAA ACACTTTGCA TTCCCAGTTC ATTAGAACAG CACAACCATA CAAATTCAAG 1740
GACAAGACAG TAGTAGGCCT TCATAAATCA AGAAAGAAGT CAAAGGAAGA ACAAAATTTA 1800
CCAGAGGATC CAGACTCTAC TGGCTTTATT TACCCATATA ATGACTTGCT GGTTTGGGCA 1860
GTGTTGATGA AAAGACAGAA GATGGCCATG TTCTTTTGGC AGCATGGAGA AGAAGCTATG 1920
GTTAAGGCAG TAATTGCTTG CAAACTGTAT CGTGCAATGG CACACGAAAC TGAGGAGAGC 1980
AACATGCTTG ATGGTACCTC AGAAGAGTTT AAAAATTACT CAAAAGAGTT TGGTCAGCTT 2040
GCTCTGGATG TACTAGAAAA AGCATTTAAA AATAATGAGA GAATGGCCAT GAAACTGCTG 2100
ACCTATGAAC TGAAGAATTG GAGTAACTCC ACCTGCTTGA AACTGGCTGT GTCTGTTGGG 2160
TTACGATCTT TCGTTTCTCA TACTTGTACT CAAATGTTAC TGACTGATAT GTGGATGGGA 2220
CGTCTGAAAA TGGGAAAGAA TGCCTGGTTA AAGGTCATCA TAAGTATTCT TTTACCCCCC 2280
ACCATACTAA CATTAGAGTT CAAAAGCAAG GCAGAAATGT CACATGTTCC CCAGTCACAA 2340
GACTCTCAAT TTACATGGCA TAATGGTGAC CAGAGTTCCA GCAGTATTAA AGAAATCCTC 2400
TCAGTGAAGA ATTATGATTT TGAAAAGGGA TCTGATGAGA AACCTGATGA TAGCCACAAC 2460
TTTGCTTCAT ATCATGGACC CCAAAGCCTT CCTGGAACCA GAAAAATTTA TGAATTCTAC 2520
AATGCTCCGA TTGTCAAGTT CTGGTTGTAC ACGATGGCAT ACTTGACATT TCTCATGCTC 2580
TTCACATATA CTGTCTTGGT AGAGATGCAG CCTCAACCTA CAGTGCAAGA GTGGATTGTT 2640
ATTATCTACA TTTTCACCAC TGCCATTGAG AAAGTCAGGG AGATATTTAT TTCAGAACCA 2700
GGAAAGTTCA TCCAAAAAGT GAAGGTGTGG ATTAATGAAT ACTGGAACTT AATAGACACT 2760
ATTGCCATCA GCTTGTTCAC AATTGGTTTT GCCCTTCGAT GGGCTGATCC CCCTACACAA 2820
ACAGCTGGAA GGTTAATTTA CTGCATAGAT ACTATATTCT GGTATTCTCG ACTCTTGGAC 2880
TTTCTTGCTG TGAATCAACA TGCTGGTCCA TATTTAACCA TGATTGGGAA GATGACAGCA 2940
AATATGTTCT ACATTGTGAT CATGATGGCT ATCGTGATCT TGAGCTTTGG AGTGGCTCGA 3000
AAAGCAATTC TTTCTCCACA TGAGTCTCCA TCTTGGACAC TGGCTCGTGA TATTGTGTTT 3060
CAGCCATACT GGATGATGTT TGGAGAGGTG TATGCTTCAG AGATAGATGT TTGTTCAAGT 3120
AACCCGGACT GCCCTCCTGG TTCCTTCCTC ACTCCATTCC TTCAAGCTGT CTACCTTTTT 3180
GTCCAGTATA TCATCATGGT GAATTTACTG ATTGCTTTCT TCAACAATGT TTTCCATCAA 3240
ATGAAGGCCA TTTCCAATAA ACTCTGGAAA TATAATCGCT ACCGTTACAT CATGACTTAT 3300
CATGAGAAGC CATGGCTGCC TCCACCGTTC ATCTTACTGA GTCATATATT CCTCCTATTC 3360
CGTTGCTTCT GTCATTACCA GGCACCAAAT GAACTGGACC AAGAAGAGGG TGATGTTGGA 3420
TTGAAACTCT ACCTGAGTGA TGAGGAACTT AAGAAGCTCC ATGGTTTTGA GGAACAGTGT 3480
GTAAAAGAAT ACTTCCATGA GAAGATGGAG AACCTGAATT CCAGTTGTGG GGAGAGGATA 3540
CGAGTGACCT CTGAAAGGGT TTCAGATATG TTCTTCCAAC TAAAAGAAGT GAATGAGAGA 3600
GTGTCCTACA TAAAGGAGTC CTTGCTTTCT CTGGACAGCC ATGTGGGACA CCTGCAAGAT 3660
CTCTCTGCCC TAACATTGGA TACATTGAAA GTACTTTCAG CTGTTGACAC CCTGCAACTA 3720
GAAGAAGCCT TTTTGGCCAG CTCAGAGCAC TCTGTTGGTA GAAAACTCCC CCACAGCTGG 3780
AGCAATGTCA TCTGCACAGA GATGCTGAGC AGCTTGGAAA AATCTGGGGG AGTCAAGTGC 3840
CAGTACTATA GCATGCCCCC ATCCTTGCTT CAGAGCCGGG TGAGAAGCCA GAATCTTTCT 3900
GGAAGGCAGA AGAGCTCCCT TTTAGAGATT ATGAACAGCC AAGAAGAGAA CCAGGAAAAG 3960
AAAGGAACAT CAAGTGGTCC AGTTACAGTG TTTTTTAACA GCAAATTGCC TCCAAAGCTT 4020
AGTCAGTTAC TCCTTATTTC TTCTAGTCCA ACAGAGATTT CTCCTTTGGC AAAAGATGAC 4080
ATGTCTCTAT CTCCTACAAA ACCTGCAGCT GGGCCCAAGT TAGGCTGGTT GGCAACAGAG 4140
CAACAACAGA CCAGACAGGA AAATTGTTCT CTTTGTCTGA ATTGTCAGAC ATCAGCTGCT 4200
GCTGACAAAG AGTCAGTTGA AGACTCTGCC TTGCCTAAAC CTGCAAGAGA GAACAATGGA 4260
GATCTCCTTG TGCCCACTAC CAATTCTTCC CCTTTGTCAG TAAAAATGAC TTCACTTCCT 4320
TTCCACACAG ACAGTCTGAG AGCAGGAGGT GGCTATGTGA ACTTGGCATT TTCAGAAGGG 4380
GATGATGAAA CTGGAGTGTT CAGCTCAAAG AAAAAATGGC ATTCACAGTT ACCTTCCAGT 4440
TGTAACTTGG CTTGTTCAGA CTCTGATCCC TGCCAAGTCC AGTTGGGGAG AAGCAAATCC 4500
TTTAATTCTA ACTCAACAAG GTCACTCCAA TGCAGTAACA TTTCAAAGTT AGGGTCATGG 4560
CTCCAGCCAA GCACAAACAT TTGGATCAAT CCCCTTCGTA AAGATTGGAC CTTTCTCCAC 4620
AATGGCAGCT TTAGATCTTA CAAGGAGGAA AGACTGATGA AGACCTGCAA AAATAAAGAT 4680
TGTTCAAGAT CCTCAGAGAA GTGCCAGTCA GTGTGGACCA AAGCAAAATT TGGTAGTAAA 4740
GAAAGGAAAT TGTTAAAAGA AAAAAAGAAA CTACAACAAT TTCAAGTTCC GGTGATTACA 4800
GTGAACAGCT GCTTTCCAAA CACACAGATG AATTCAGAAC CAGCAGAGAA AACTTTTTCT 4860
GGGGAAGAAA AGGAGGACAA TAAAAACTGG CTTACCGTCT CTGAATTTAG TCAGATAAAA 4920
CCACATATAT CCCAGAAAAT GAAATCTCAG GAAACTGGAA GACATTCCAT ATGCATCAGT 4980
GATAATCTGA AGCAACCCCA TGAGGATTTG AACAAAAATT CTCATTGGAC CTCTATGAAG 5040
ACCAGTCAGA ATCAGAACTC AGTGTCAAGA AGTTTAGAAG GAATTGACAA GGCCTCAGCC 5100
TATTTAAAAA CTACTCACGA TCTGCACCAT CATTATTCAG CTGTTGAAAG GAATAATTTA 5160
ATGAGGCTTT CTCAGACCAT ACCATTTACC CCAATACACC AATTCGCTGG AGAAGAAGTG 5220
ACCATCTATA AGCTAGAAGA GAGTTCTCCT TTGAGCCTTG ATAAAAGCAT GTCCTCCTGG 5280
TCCCAACGTG GAACAGCTGC AATAATCCAG GTCTTATCCC GGGAAGAAAT GGATGGAGGA 5340
CTCCGGAAAG CCATGAAAGT GGTCAGCACA TGGTCTGAAG ATGATGTGAT CAAGCCAGGG 5400
CAAGTTTTCA TTGTCAAGTC CTTTCTCCCT GAGGTGGTGC AGACCTGGCA CAAAATATTC 5460
CGAGAACACA CTGTACTACA TCTTTGTCTC AGAGAAATCC AACAACAAAG AGCTGCTCAA 5520
AAGCTGATCT ATACCTTCAA CCAATTGAAA CCACATACTA TTCCTTATGC ACCAAGGTTC 5580
CTGGACGTCT TTTTAATATA TTGCCATTCT GCCAATCAGT GGTTGACCAT AGAGAAATAC 5640
ATGACTGGTG AATTCCGCAA GTACAACAAC AACAATGGAG ATGAAATCTC TCCCAGCAAC 5700
ACCTTGGAGG AGCTGATGTT GGCTTTTTCT CACTGGACCT ATGAATATAC CCGAGGAGAG 5760
CTACTTGTTC TGGATTTGCA AGGTGTTGGA GAAAATCTGA CAGATCCATC TGTTATTAAA 5820
CCTGAAGACA AACAATCAAG AGGGATGGTG TTTGGACCAG CAAATTTAGG AGAAGATGCA 5880
ATTAGAAACT TCATTGCAAA GCATCGTTGC AATTCGTGTT GTAGGAAGCT CAAACTCCCG 5940
GATCTGAAAA GGAATGACTA CAGTCCTGGG AGGATCAATT CTACTTTTCA ACTTCAAAGA 6000
AAAATAGAAC CAGCCAAAGG ATCTGTGACA GAAGAGAGTG TTGGTGACCC CAGAGAAGAT 6060
CTCACACGCT TATAA 6075
Domain Profile
S: 1     ssesWsqqetivlikvlskeekkGalRkalrv..........kkgslflvkeelkevvry  50
         s++sWsq++t+++i+vls+ee++G+lRka++v          k+g++f+vk++l+evv++
Q: 1756  SMSSWSQRGTAAIIQVLSREEMDGGLRKAMKVvstwseddviKPGQVFIVKSFLPEVVQT  1815
         699*********************************************************
S: 51    vakiykeqkvlhlylrdverqraaqklvtefnqvkPkkivyiprlievfLkdrtsknqll  110
         ++ki++e++vlhl+lr++++qraaqkl+++fnq kP++i+y pr++ vfL++++s+nq+l
Q: 1816  WHKIFREHTVLHLCLREIQQQRAAQKLIYTFNQLKPHTIPYAPRFLDVFLIYCHSANQWL  1875
         ************************************************************
S: 111   tvEeyllGefvKynnnngdeikrenkleelmlafsHftyeytngellVvDlqGvgeklTD  170
         t+E+y++Gef+Kynnnngdei + n+leelmlafsH+tyeyt+gellV+DlqGvge+lTD
Q: 1876  TIEKYMTGEFRKYNNNNGDEISPSNTLEELMLAFSHWTYEYTRGELLVLDLQGVGENLTD  1935
         ************************************************************
S: 171   pqiat....ksrgtkfgkanlgeraiknFfakhhCNeiC  205
         p++++    +srg++fg+anlge+ai+nF+akh+CN++C
Q: 1936  PSVIKpedkQSRGMVFGPANLGEDAIRNFIAKHRCNSCC  1974
         ********9******************************
Domain Sequence
(FASTA)
SMSSWSQRGT AAIIQVLSRE EMDGGLRKAM KVVSTWSEDD VIKPGQVFIV KSFLPEVVQT 60
WHKIFREHTV LHLCLREIQQ QRAAQKLIYT FNQLKPHTIP YAPRFLDVFL IYCHSANQWL 120
TIEKYMTGEF RKYNNNNGDE ISPSNTLEEL MLAFSHWTYE YTRGELLVLD LQGVGENLTD 180
PSVIKPEDKQ SRGMVFGPAN LGEDAIRNFI AKHRCNSCC 219
KeywordComplete proteome; Ion transport; Ionic channel; Membrane; Reference proteome; Transmembrane; Transport.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00283
EKS-ANC-00295
EKS-BOT-00302
EKS-CAJ-00307
EKS-CAF-00308
EKS-EQC-00295
EKS-FEC-00290
EKS-GOG-00297
EKS-ICT-00286
EKS-LAC-00318
EKS-MUM-00333
EKS-MUP-00300
EKS-MYL-00302
EKS-NOL-00279
EKS-ORA-00266
EKS-OTG-00310
EKS-PAT-00285
EKS-PTV-00068
EKS-RAN-00319
EKS-SAH-00283
EKS-SUS-00267
EKS-TAG-00319
EKS-XET-00377
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005216; F:ion channel activity
GO:0004674; F:protein serine/threonine kinase activity
KEGG
InterPros
IPR005821; Ion_trans_dom.
IPR011009; Kinase-like_dom.
IPR004166; MHCK_EF2_kinase.
Pfam
PF02816; Alpha_kinase; 1.
PF00520; Ion_trans; 1.
SMARTs
SM00811; Alpha_kinase; 1.
Prosites
PS51158; ALPHA_KINASE; 1.
Prints
Created Date20-Feb-2013