EKS-MOD-00311

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00311

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	345.7	1.8E-103	25	289	265

Status

Unreviewed

Ensembl Protein

ENSMODP00000002743

UniProt Accession

F7DF59;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP4K4

Gene Synonyms/Alias

MAP4K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000002250	ENSMODP00000002743	ENSMODT00000002798

Organism

Monodelphis domestica

Functional Description

Protein Length

1321

Protein Sequence
(FASTA)

MANDSPAKSL VDIDLSSLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL AAIKVMDVTE 60

DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ LWLVMEFCGA GSITDLVKNT 120

KGNTLKEDWI AYISREILRG LAHLHAHHVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 180

TVGRRNTFLE RLYWMAPEVI ACDENSDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR 240

ALFLIPRNPP PRLKSKKWSK KFFSFIEGCL VKNYMQRPST EQLLKHPFIR DQPNERQVRI 300

QLKDHIDRTR KKRGEKDETE YEYSGSEEEE EEVPEQEGEP SSIVNVPGES TLRRDFLRLQ 360

QENKERSEAL RRQQLLQEQQ LREQEEYKRQ LLAERQKRIE QQKEQRRRLE EQQRREREAR 420

RQQEREQRRR EQEEKRRLED LERRRKEEEE RRRAEEEKRR VEREQEYIRR QLEEEQRHLE 480

ILQQQLLQEQ AMLLEYRWRE MEEHRQAERL QRQLQQEQAY LLSLQHDHRR HHQQQQQQQQ 540

QQQQERNKQS YHPPETKPHY EAAERAREVE DRFRKTNQGS PEAQSKQTGK ILEPPVPSRS 600

ESFSNGNSES VHPALQRPVE PQVQWSHLAS LKNNVSPVSR SHSFSDPSPP KFAHHHLRSQ 660

DPCPPSRSEV LSQCSDSKSE VSDPTQKAWS RSDSDEVPPR VPVRTTSRSP VLSRRDSPLQ 720

GSGQQNNQAG QRNSTSNIEP RLLWERVEKL VPRPGSGSSS GSSNSGSQPG SHPGSQSGSG 780

ERFRVRSSSK SEGSPSQRHE NATKKPEEKK EVFRPHKPAV RKDLTALAKE LRAVEDVRPP 840

HKVTDYSSSS EESGTTDEED DDMEQEGADE STSGPEDTRA VSSLNLSNGE TESVKTMIVH 900

DDIESEPAMT PSKEGTLIVR QTQSASNTLQ KHKSSSSFTP FIDPRLLQIS PSSGTTVTSV 960

VGFSTEAMRC EAIRQDPTRK GSVVNVNPTN TRPQSDTPEI RKYKKRFNSE ILCAALWGVN 1020

LLVGTESGLM LLDRSGQGKV YPLINRRRFQ QMDVLEGLNV LVTISGKKNK LRVYYLSWLR 1080

NKILHNDPEV EKKQGWTTVG DLEGCVHYKV VKYERIKFLV IALKNSVEVY AWAPKPYHKF 1140

MAFKSFGELI HKPLLVDLTV EEGQRLKVIY GSCAGFHAVD VDSGSVYDIY LPTHIQSSIQ 1200

PHAIIILPNT DGMELLVCYE DEGVYVNTYG RITKDVVLQW GEMPTSVAYI RSNQIMGWGE 1260

KAIEIRSVET GHLDGVFMHK RAQRLKFLCE RNDKVFFASV RSGGSSQVYF MTLGRTSLLS 1320

W 1321

Nucleotide Sequence
(FASTA)

ATGGCGAACG ACTCCCCTGC AAAAAGTCTG GTGGACATAG ACCTCTCCTC CTTGCGGGAT 60

CCTGCTGGGA TTTTTGAGCT GGTGGAAGTA GTTGGCAATG GCACTTATGG ACAAGTCTAT 120

AAGGGCCGAC ATGTCAAGAC GGGTCAGCTG GCGGCTATCA AAGTCATGGA TGTTACTGAG 180

GATGAAGAGG AAGAAATCAA ACTGGAGATA AATATGCTGA AGAAATATTC TCATCATAGA 240

AATATTGCAA CATACTATGG TGCTTTCATT AAGAAGAGTC CTCCAGGACA TGATGACCAA 300

TTATGGCTGG TGATGGAATT CTGTGGTGCA GGATCCATTA CAGACCTTGT GAAGAACACC 360

AAAGGCAACA CATTGAAAGA AGATTGGATA GCTTACATCT CCAGAGAGAT TCTGAGGGGA 420

TTGGCACATC TTCATGCCCA CCACGTGATT CACCGGGATA TCAAGGGTCA GAATGTATTG 480

CTGACAGAAA ATGCAGAAGT GAAACTTGTG GATTTTGGTG TCAGTGCTCA GTTGGATAGG 540

ACAGTTGGAC GAAGAAACAC TTTTTTGGAA CGCCTCTACT GGATGGCTCC TGAGGTCATT 600

GCCTGTGATG AGAATTCTGA TGCGACTTAT GATTACAGAA GTGACCTTTG GTCCTGTGGC 660

ATTACGGCCA TTGAGATGGC AGAAGGTGCT CCCCCTCTCT GTGACATGCA TCCAATGAGA 720

GCACTTTTCC TGATTCCCCG GAATCCTCCT CCCCGTCTAA AGTCAAAGAA ATGGTCAAAA 780

AAGTTTTTTA GCTTTATAGA GGGGTGCCTA GTGAAGAACT ACATGCAACG TCCCTCCACA 840

GAGCAGCTTT TGAAACATCC TTTTATAAGG GATCAGCCAA ATGAAAGGCA AGTTAGGATC 900

CAGCTTAAGG ACCATATAGA TCGGACGAGA AAGAAGAGAG GGGAGAAAGA TGAAACAGAG 960

TATGAGTATA GTGGAAGTGA GGAAGAAGAG GAGGAAGTAC CTGAGCAAGA AGGAGAACCC 1020

AGTTCCATTG TTAATGTGCC CGGTGAATCT ACCCTTCGAC GGGATTTCCT GAGACTTCAA 1080

CAGGAAAACA AGGAACGTTC CGAGGCCCTT CGAAGGCAAC AGCTGCTGCA AGAACAGCAA 1140

CTCAGAGAGC AAGAAGAATA TAAGCGGCAG CTGCTGGCAG AGAGACAGAA ACGCATTGAA 1200

CAGCAGAAAG AGCAGAGGAG ACGACTGGAA GAGCAACAGA GAAGAGAGCG TGAGGCTCGA 1260

CGGCAACAGG AGAGGGAGCA GAGGAGGAGG GAACAGGAAG AGAAGAGGCG CCTGGAGGAC 1320

CTGGAGAGAA GGCGGAAGGA AGAGGAGGAG CGGAGAAGGG CTGAGGAAGA GAAGAGAAGA 1380

GTGGAGAGGG AGCAGGAGTA TATCAGGCGA CAGCTAGAAG AGGAGCAGCG GCACTTGGAA 1440

ATCCTTCAGC AGCAGCTGCT CCAGGAGCAG GCCATGTTAC TGGAATACAG ATGGCGGGAG 1500

ATGGAAGAAC ACCGGCAGGC GGAGAGGCTT CAGAGGCAGT TACAGCAAGA GCAAGCGTAT 1560

CTCCTGTCCT TACAGCATGA CCACAGGAGG CATCATCAAC AGCAGCAACA ACAGCAGCAG 1620

CAGCAGCAGC AAGAGAGAAA TAAACAGAGC TATCATCCCC CAGAAACGAA ACCTCACTAT 1680

GAAGCCGCTG AAAGAGCTCG AGAGGTGGAA GATAGATTTA GAAAAACTAA CCAAGGCTCC 1740

CCTGAAGCAC AGTCTAAGCA GACAGGCAAA ATTCTGGAGC CACCAGTGCC TTCAAGATCA 1800

GAGTCTTTTT CCAATGGCAA CTCCGAGTCC GTACACCCTG CACTCCAGAG ACCAGTGGAA 1860

CCACAGGTAC AGTGGTCCCA TCTGGCATCT CTCAAGAACA ATGTTTCCCC TGTCTCGCGA 1920

TCCCATTCCT TCAGTGACCC TTCTCCTCCC AAATTTGCAC ATCACCATCT TCGTTCTCAG 1980

GACCCATGTC CACCTTCACG CAGTGAGGTG CTAAGTCAGT GTTCTGACTC TAAGTCGGAG 2040

GTATCCGATC CCACCCAAAA GGCTTGGTCT AGATCAGACA GTGACGAGGT GCCTCCAAGG 2100

GTACCTGTGA GAACAACTTC CCGTTCTCCT GTTTTATCTC GCCGTGATTC TCCACTGCAG 2160

GGCAGTGGGC AGCAAAATAA CCAAGCAGGT CAAAGAAACT CTACGAGCAA TATTGAACCC 2220

AGACTGCTGT GGGAAAGGGT AGAGAAGCTG GTTCCAAGAC CTGGCAGTGG TAGCTCCTCA 2280

GGTTCAAGTA ATTCAGGATC ACAGCCAGGG TCTCATCCTG GCTCTCAGAG TGGATCTGGT 2340

GAACGCTTCA GAGTGAGATC ATCATCAAAA TCAGAAGGTT CACCATCCCA ACGCCATGAA 2400

AATGCAACAA AAAAGCCGGA AGAAAAAAAA GAAGTCTTCA GACCTCACAA ACCTGCTGTA 2460

AGAAAGGACT TGACCGCCTT AGCCAAGGAA CTACGAGCTG TAGAAGATGT TCGACCTCCT 2520

CACAAAGTAA CAGACTATTC TTCATCTAGT GAAGAATCTG GGACAACGGA CGAAGAGGAT 2580

GATGATATGG AACAAGAAGG GGCAGACGAA TCCACTTCTG GTCCTGAGGA CACCAGAGCA 2640

GTATCATCTT TGAATCTAAG CAATGGTGAA ACTGAATCAG TGAAAACTAT GATTGTTCAT 2700

GATGACATAG AAAGTGAACC CGCCATGACT CCGTCGAAGG AAGGCACCTT AATCGTCCGC 2760

CAGACTCAGT CCGCTAGTAA CACACTCCAG AAACACAAAT CTTCCTCCTC CTTTACACCT 2820

TTTATAGACC CCAGATTACT ACAGATTTCT CCATCTAGTG GGACAACAGT GACTTCTGTG 2880

GTGGGATTTT CTACTGAAGC AATGAGATGT GAAGCAATAA GACAAGACCC CACCCGGAAG 2940

GGATCAGTTG TCAATGTGAA TCCTACAAAT ACTCGGCCAC AGAGTGATAC CCCGGAAATT 3000

CGTAAATACA AGAAGAGGTT TAATTCTGAA ATTTTATGTG CTGCCTTATG GGGAGTGAAT 3060

TTGTTAGTGG GTACAGAGAG TGGCCTGATG TTGTTGGACA GAAGCGGCCA GGGAAAGGTA 3120

TACCCACTTA TCAATCGAAG GCGGTTCCAG CAGATGGATG TCCTTGAAGG CTTGAATGTC 3180

TTGGTGACAA TATCTGGTAA GAAAAATAAA TTACGGGTCT ACTACTTGTC TTGGCTACGG 3240

AATAAAATAC TTCATAATGA CCCAGAAGTA GAGAAGAAAC AGGGATGGAC AACTGTAGGT 3300

GATTTGGAAG GATGTGTGCA CTATAAAGTT GTAAAATATG AAAGAATCAA GTTTCTGGTT 3360

ATTGCTTTGA AGAATTCTGT GGAAGTCTAT GCATGGGCCC CAAAGCCATA CCACAAATTT 3420

ATGGCCTTCA AGTCTTTTGG AGAATTGATA CATAAGCCAT TGCTGGTTGA TCTCACCGTA 3480

GAGGAAGGCC AACGGTTAAA AGTAATTTAT GGATCCTGTG CTGGATTCCA TGCTGTCGAT 3540

GTGGATTCCG GATCAGTCTA TGATATTTAT CTCCCGACGC ACATTCAGAG TAGCATACAA 3600

CCCCATGCTA TCATCATACT CCCCAACACA GACGGGATGG AGTTGCTAGT GTGCTATGAG 3660

GATGAAGGGG TTTATGTGAA TACATATGGG AGGATCACAA AGGATGTGGT TCTTCAATGG 3720

GGAGAGATGC CTACATCTGT CGCATATATT CGATCCAATC AGATCATGGG CTGGGGTGAG 3780

AAGGCCATTG AGATACGATC GGTGGAGACT GGTCATTTGG ATGGCGTGTT TATGCACAAG 3840

CGGGCACAGA GGCTCAAGTT CTTATGTGAA CGCAATGACA AGGTATTCTT TGCCTCCGTT 3900

CGTTCTGGTG GAAGCAGTCA AGTTTATTTC ATGACTTTAG GCAGGACTTC TCTTCTAAGT 3960

TGGTAG 3966

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         +el+e++g+G++g+vy++r++ktg+l+aik++++++ +++ee++ ei++lkk++h +ni

Q: 25    FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKLEINMLKKYSHhRNIA  83

         899********************************8.999*************998****

S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113

         +y+++f+k      +++lwlvme++ +Gs++dlvk+++ ++lkE++iayi re+l++L++

Q: 84    TYYGAFIKksppghDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAH  143

         *************9**********************************************

S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173

         lH+++viHrdik++n+Llte++eVkL+dfgv+aql++t+ +r+t+++  ywmAPEvia++

Q: 144   LHAHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFLERLYWMAPEVIACD  203

         ***********************************************************9

S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230

            + +Yd+++D+ws+GItaie+aeg+pP++d++p++al++i++n+pp+lksk k+sk+f

Q: 204   ensDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSK-KWSKKF  262

         888899********************************************888.******

S: 231   kefvekclqknpekRpsasellkhkFl  257

          +f+e cl kn+ +Rps+++llkh+F+

Q: 263   FSFIEGCLVKNYMQRPSTEQLLKHPFI  289

         **************************7

Domain Sequence
(FASTA)

FELVEVVGNG TYGQVYKGRH VKTGQLAAIK VMDVTEDEEE EIKLEINMLK KYSHHRNIAT 60

YYGAFIKKSP PGHDDQLWLV MEFCGAGSIT DLVKNTKGNT LKEDWIAYIS REILRGLAHL 120

HAHHVIHRDI KGQNVLLTEN AEVKLVDFGV SAQLDRTVGR RNTFLERLYW MAPEVIACDE 180

NSDATYDYRS DLWSCGITAI EMAEGAPPLC DMHPMRALFL IPRNPPPRLK SKKWSKKFFS 240

FIEGCLVKNY MQRPSTEQLL KHPFI 265

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0046328	; P:regulation of JNK cascade
GO:0006950	; P:response to stress

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013