EPS-MOD-00027

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MOD-00027

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	179.5	1.1E-52	777	1023	247

Status

Unreviewed

Ensembl Protein

ENSMODP00000002804

UniProt Accession

F6YE58;

Protein Name

Protein Synonyms/Alias

Gene Name

PHLPP2

Gene Synonyms/Alias

PHLPP2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000002299	ENSMODP00000002804	ENSMODT00000002860

Organism

Monodelphis domestica

Functional Description

Protein Length

1313

Protein Sequence
(FASTA)

MKRSGSRHCL HRRSRFSSRE RDWLKEDVKR GCVYLYGAET AAATAAATSS SLELHLVLCT 60

VDTAASEICA GEGKESLYLQ LHGDLVRRLD PTERPLQMVY EYLSSLGFED PVRIQEEATN 120

PDLSCMIRFY GEKPCHMDHL DRILLSGIYN VRKGKTQLHK WAERLVVLCG TCLIVSSVKD 180

CQTGKMHILP LVGGKVEELK RRQHSLAFSS AGAQAPTYHV SFESLAECQR WHRQASKVVS 240

QRISTVDLSC YSLEEVPEHL FYSQDITYLN LRHNFMQLER PGGLDCLYRF SQLKGLNLSH 300

NKLGLFPILL CEISTLTELN LSCNGLLELP GQIGNLLNLQ TLCLDGNFLT TLPEELGNLP 360

HLSTLGLSFN NFSQIPEACM KLSMLDKLAM AGNQLEVLNL GVLNVMKHIK HVDLRLNSLK 420

RTVVDNMEGN KHVIHMDLRD NQLTDLDLSS LGSLQQLHCE RNQLRDLTLS GFTLRALCAN 480

SNRLTTVNVY PVPSLLTSLE LSRNQLEYIP DWVCESKKIE VLDMSYNLLT EIPIRILSSL 540

SLRKLMVGHN QLQSLPVLLE HIPLEVLDLQ HNLLSRLPDT LFSKALNLRY LNASANSLES 600

LPSACTGEES LSMLQLLYLT NNQLTDQCIP VLVGHPHLRI LHLANNQLQT FPASKLNKLE 660

HLEELNLSSN KLKTIPTTIA NCKQLHTLVA HSNNISIFPE ILHLPQIQFV DLSCNDLTEI 720

LIPEALPPTL QDLDLTGNIN LVLEHKTLDI FSHITTLKID QKPLPTADSA NASTFWSHGL 780

AEMAGQRNKL CVSSLAVDNF TDGVEAVYGM FDGDRNEELP RLLQCTMADV LLEEVQQSPV 840

DTIFMTNTFL VSHRKLGMAG QKLGSSALLC YVRHDAAEST SGFTLTVANV GTCQAVLCRN 900

GQPLPLSRVF SLEQCPEELQ RVKEQKAIIT EDNKVNGVTC CTRMLGCTYL YPWILPKPHI 960

YSLPLTVQDE LLILGNKALW ERLSFPEAVA AVRHVHDPLG AAKKLCTLAQ SYGCQDNVGA 1020

MVIYLNVGED SCTCEANGLT LPGPGGFASA TTVRDAPKPT TPSSSSGIAS EFSSEMSTSE 1080

VSSEVGSTAS DEHNSTGLDA SLLPRPERRC SLHPMPTSGI FQRQPSCATF SSNQSDNGLD 1140

SDDDQPVEGV ITNGSKVEVE VDIHCCKGKG LEASPPAPEE ASLPLGPEED SGGLFFRFRR 1200

QNSVNCGTLF PLSRELQKSP STSCLYGKKL SNGSIVPLED SLNLIEVATE APKKKTGYFC 1260

APTQLEPEDQ LIVPHDLEEE VKEQLKSPQD TRGVAEPCEE AQGDRPEEFD TAL 1313

Nucleotide Sequence
(FASTA)

ATGAAGCGGA GTGGAAGCAG GCACTGTTTG CACAGGAGAA GTAGGTTCAG CTCCCGGGAG 60

AGAGACTGGC TAAAAGAGGA TGTGAAGAGG GGCTGTGTCT ACCTCTATGG AGCCGAAACA 120

GCTGCTGCCA CTGCTGCTGC CACCTCATCC TCTTTGGAAT TACACCTTGT CCTTTGCACA 180

GTAGACACAG CAGCATCTGA GATATGTGCT GGAGAGGGAA AAGAAAGCCT TTATCTACAG 240

CTCCATGGAG ATCTAGTCAG GAGGCTGGAT CCTACTGAAA GACCTCTTCA GATGGTGTAT 300

GAATACTTAA GTAGCTTGGG CTTTGAGGAT CCTGTTCGTA TACAAGAGGA GGCAACAAAC 360

CCTGACCTCA GCTGTATGAT TCGCTTTTAT GGTGAAAAAC CATGCCATAT GGATCATCTA 420

GACCGAATCC TGCTGTCTGG CATCTATAAT GTCCGCAAGG GAAAGACCCA GCTTCATAAG 480

TGGGCTGAGC GCTTAGTTGT TCTCTGTGGG ACTTGCCTTA TTGTGTCTTC AGTGAAAGAC 540

TGCCAGACTG GAAAGATGCA CATTTTGCCC CTCGTTGGGG GAAAGGTAGA AGAACTGAAA 600

CGACGGCAAC ACAGTCTTGC CTTTAGCTCT GCAGGAGCCC AAGCTCCAAC TTACCACGTC 660

AGCTTCGAGT CATTGGCAGA GTGCCAGAGG TGGCACCGCC AGGCCTCCAA GGTGGTGTCA 720

CAGCGGATAA GTACAGTTGA TCTCTCGTGT TATAGCCTTG AGGAGGTTCC TGAGCATCTC 780

TTCTATAGTC AAGATATCAC CTACCTCAAC TTGCGGCATA ACTTTATGCA ATTAGAAAGA 840

CCAGGAGGCC TTGATTGTCT CTATAGGTTT TCTCAGCTGA AGGGACTGAA CTTGTCTCAC 900

AATAAGCTCG GGTTATTCCC CATTTTACTT TGTGAGATTT CTACTCTAAC AGAACTGAAC 960

CTTTCTTGTA ATGGACTTCT TGAGCTGCCT GGTCAGATTG GCAATCTCCT TAATCTTCAG 1020

ACTCTCTGTC TTGATGGCAA CTTCCTCACT ACTTTACCAG AAGAATTGGG AAATTTGCCA 1080

CACCTTTCCA CTCTTGGACT CTCCTTCAAC AATTTCAGCC AAATTCCTGA GGCTTGTATG 1140

AAGCTCTCAA TGTTAGATAA ACTGGCTATG GCGGGAAACC AGCTAGAAGT CCTGAATTTG 1200

GGGGTTTTGA ATGTGATGAA GCATATCAAG CATGTTGATT TAAGGTTGAA CAGTTTGAAG 1260

AGAACAGTTG TTGACAACAT GGAGGGGAAC AAGCATGTTA TTCACATGGA TTTGCGTGAT 1320

AATCAGTTGA CTGACCTGGA TTTGAGTTCC CTGGGAAGCC TGCAGCAGCT TCACTGTGAA 1380

CGGAATCAAC TGAGGGATCT AACACTCAGT GGCTTCACCC TTCGGGCCCT CTGTGCCAAC 1440

TCCAACAGGC TGACCACAGT GAATGTTTAT CCAGTGCCCA GTCTGCTTAC TTCCTTAGAA 1500

CTCTCTAGGA ATCAATTAGA ATATATTCCT GACTGGGTCT GTGAATCAAA GAAGATTGAA 1560

GTGTTGGACA TGAGCTATAA TCTCCTAACA GAGATTCCTA TTAGGATTCT GAGTAGTCTG 1620

AGTCTTAGGA AGCTGATGGT GGGACACAAC CAGTTGCAAA GTCTTCCAGT CCTTCTAGAA 1680

CACATTCCCC TTGAGGTCTT GGATCTACAG CATAATTTAC TCTCCAGGTT GCCAGATACC 1740

CTCTTCTCCA AGGCATTAAA TCTCAGGTAC CTGAATGCCT CTGCAAACAG TCTAGAGTCT 1800

CTGCCATCTG CTTGTACTGG GGAAGAGAGT CTTAGTATGC TGCAACTCCT CTACCTGACC 1860

AATAACCAGC TGACAGACCA GTGTATCCCT GTCCTCGTGG GACACCCGCA TCTCCGCATC 1920

CTGCATCTTG CAAACAACCA GCTACAAACT TTCCCAGCCA GCAAATTGAA CAAGTTGGAA 1980

CATTTGGAGG AGCTGAACCT GAGTAGCAAC AAACTAAAGA CAATTCCTAC AACCATTGCA 2040

AACTGTAAAC AGCTGCATAC TCTTGTTGCA CATTCCAACA ATATCAGCAT ATTTCCAGAG 2100

ATCCTGCATT TGCCACAGAT CCAGTTTGTA GATTTAAGCT GCAATGACTT GACAGAAATT 2160

CTGATTCCTG AGGCTTTGCC TCCCACCCTA CAGGACCTTG ACCTCACTGG AAATATAAAT 2220

CTGGTTCTGG AACATAAGAC ATTGGACATC TTCAGTCACA TCACCACCCT GAAAATTGAT 2280

CAGAAACCCC TGCCAACGGC TGATTCTGCA AATGCATCGA CGTTCTGGAG CCACGGACTC 2340

GCTGAGATGG CCGGTCAGAG GAATAAACTC TGCGTTTCCT CTTTGGCTGT GGATAACTTC 2400

ACCGACGGTG TGGAAGCCGT GTACGGCATG TTTGATGGCG ACCGCAATGA GGAGCTCCCG 2460

CGCCTCCTCC AGTGCACCAT GGCAGACGTG CTTTTGGAAG AGGTGCAGCA GTCGCCCGTG 2520

GACACCATTT TCATGACTAA CACGTTTCTG GTGTCGCACA GAAAATTGGG AATGGCTGGC 2580

CAGAAGCTGG GTTCCTCTGC TCTCCTCTGT TATGTCCGAC ATGATGCTGC AGAATCTACA 2640

AGTGGCTTCA CCCTGACAGT GGCCAATGTG GGCACATGCC AAGCAGTCCT GTGCCGAAAT 2700

GGACAGCCCT TGCCCCTCTC CAGAGTCTTC AGCTTGGAAC AATGCCCAGA GGAGTTACAG 2760

CGGGTGAAAG AACAGAAAGC CATCATAACA GAGGACAACA AAGTGAATGG AGTAACCTGC 2820

TGTACGCGGA TGTTGGGGTG TACATACCTC TACCCTTGGA TCCTTCCAAA GCCCCATATA 2880

TATTCCCTTC CACTTACAGT ACAAGATGAG CTGCTGATCT TGGGAAACAA AGCGCTGTGG 2940

GAACGCCTGT CTTTCCCGGA AGCTGTCGCT GCTGTACGGC ATGTCCATGA TCCATTAGGA 3000

GCCGCCAAGA AGCTGTGCAC TTTAGCACAA AGCTATGGCT GTCAGGACAA CGTTGGGGCA 3060

ATGGTGATCT ATCTGAATGT TGGGGAAGAT AGTTGTACTT GTGAGGCGAA TGGGCTCACC 3120

CTTCCAGGCC CTGGGGGATT TGCCTCAGCC ACTACCGTTA GAGATGCTCC AAAGCCAACC 3180

ACCCCTTCCT CCAGTAGCGG CATTGCTTCA GAGTTCAGCA GTGAAATGTC TACCTCGGAA 3240

GTGAGCAGCG AAGTGGGGTC CACAGCTTCT GATGAGCACA ATTCCACAGG CCTGGATGCC 3300

AGCCTGCTGC CAAGGCCAGA AAGACGCTGC AGCCTCCATC CCATGCCCAC CTCGGGGATA 3360

TTTCAGCGCC AGCCTTCTTG TGCCACTTTC TCGAGTAACC AGTCTGACAA TGGCCTGGAC 3420

AGTGATGATG ACCAGCCAGT TGAGGGGGTC ATAACAAATG GCAGCAAGGT GGAGGTGGAA 3480

GTAGATATCC ATTGCTGTAA AGGAAAGGGT CTTGAGGCGT CTCCTCCTGC TCCTGAAGAG 3540

GCTTCTCTGC CTCTCGGTCC TGAGGAGGAC TCCGGAGGAT TGTTCTTTAG ATTCCGGAGA 3600

CAGAACAGTG TGAACTGTGG GACACTCTTT CCATTAAGCA GGGAGTTACA GAAATCTCCA 3660

TCCACTTCTT GCCTCTATGG GAAAAAACTC TCTAATGGCT CTATTGTGCC CCTGGAAGAT 3720

AGCTTAAACC TCATTGAGGT GGCCACGGAA GCACCCAAGA AGAAAACGGG ATACTTCTGT 3780

GCCCCGACTC AGCTGGAGCC AGAGGATCAG CTCATTGTAC CTCATGACCT AGAAGAAGAA 3840

GTGAAGGAGC AGCTGAAGTC CCCCCAGGAC ACCCGGGGTG TTGCAGAGCC CTGTGAGGAG 3900

GCACAGGGGG ACCGTCCTGA AGAGTTTGAC ACTGCTCTGT AG 3942

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++++ g+rn+++ ++ +++nf +  e+     ++g++DG++++e  + +++++ ++l

Q: 777   SHGLAEMAGQRNKLCVSSLAVDNFTDGVEA-----VYGMFDGDRNEELPRLLQCTMADVL  831

         6899********************998775.....9************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

          ee++    ++   + +++++Fl  +++l       ++ +k Gs+a++++++++

Q: 832   LEEVQ----QSPVDTIFMTNTFLVSHRKL------GMAGQKLGSSALLCYVRHDaaests  881

         ***99....33333447************......89****************99*****

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsr.edEleRieeaggsvilkdgaRvlGvL  172

           +l+vanvG ++avLcrng++++ls+ ++ ++ ++El+R++e+++ +++++  +v+Gv+

Q: 882   gfTLTVANVGTCQAVLCRNGQPLPLSRVFSLEQcPEELQRVKEQKAIITEDN--KVNGVT  939

         ******************************87527**********9999998..******

S: 173   avsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekk  232

         +++R+lG++yl+p++ p+P+++s +lt +de liL+ + lw+ +s  eav++vr+v++

Q: 940   CCTRMLGCTYLYPWILPKPHIYSLPLTVQDELLILGNKALWERLSFPEAVAAVRHVHD--  997

         **********************************************************..

S: 233   eaeqeaakkLvklalargskdnvsaivv  260

           +  aakkL++la+++g++dnv a+v+

Q: 998   --PLGAAKKLCTLAQSYGCQDNVGAMVI  1023

         ..************************97

Domain Sequence
(FASTA)

SHGLAEMAGQ RNKLCVSSLA VDNFTDGVEA VYGMFDGDRN EELPRLLQCT MADVLLEEVQ 60

QSPVDTIFMT NTFLVSHRKL GMAGQKLGSS ALLCYVRHDA AESTSGFTLT VANVGTCQAV 120

LCRNGQPLPL SRVFSLEQCP EELQRVKEQK AIITEDNKVN GVTCCTRMLG CTYLYPWILP 180

KPHIYSLPLT VQDELLILGN KALWERLSFP EAVAAVRHVH DPLGAAKKLC TLAQSYGCQD 240

NVGAMVI 247

Keyword

Complete proteome; Leucine-rich repeat; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0003824	; F:catalytic activity
GO:0005543	; F:phospholipid binding
GO:0008152	; P:metabolic process

KEGG

InterPros

IPR001611	; Leu-rich_rpt.
IPR025875	; Leu-rich_rpt_4.
IPR003591	; Leu-rich_rpt_typical-subtyp.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR001932	; PP2C-like.

Pfam

PF00560	; LRR_1; 1.
PF12799	; LRR_4; 1.
PF00481	; PP2C; 1.

SMARTs

SM00369	; LRR_TYP; 1.
SM00233	; PH; 1.
SM00332	; PP2Cc; 1.

Prosites

PS51450

; LRR; 17.

Prints

Created Date

20-Feb-2013