EPS-MOD-00008

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MOD-00008

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	150.7	2.7E-44	133	278	146

Status

Unreviewed

Ensembl Protein

ENSMODP00000003055

UniProt Accession

F7B956;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP27

Gene Synonyms/Alias

DUSP27;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000002519	ENSMODP00000003055	ENSMODT00000003120

Organism

Monodelphis domestica

Functional Description

Protein Length

1158

Protein Sequence
(FASTA)

MATSNDPEEE QIVPDTEDGA DVKAVQARYL RSPSPSQYSM VSDAETESIF MDPIHLSSAV 60

AAKQIINEEL KPREIKTDTV CPGMLESAEQ LLVEDLYNRV KEKIDDTSLY NTPCVMDLQR 120

ALVQDRQESP WNEVDEVWPN VFIAEKSVAV NKGRLKRLGV THILNAAHGT GVYTGPEFYN 180

GLEIQYLGVE VDDFPEVDIS QHFRKAAEFL DEALLTYRGK ILVSSEMGIS RSAVLVVAYL 240

MIFHHMTILE ALMTVRKKRA IYPNDGFLKQ LRELNEKLME ERDQDYGREG GDYEDEIDSH 300

SAPMGEGDTG SVLGARVHSI IVEEEEDTTS TLSGSSVRTT GRVSKPVTLI DEEEEEKLYE 360

DWREKQGLPQ IRNRQSPSLL DEEGGKESEE DLERVIQEWQ SRNEKYQTER SHKWSKEEAE 420

EEGGEGDGDS LLGRGRRRTF SECSTSESTI SRDIRILKQQ LELSSQRQTQ RRRSDSVSSE 480

STWDMWNQRL LEIEKEASQK YHCRSKQEET ESNSESGRRE REDDEESVAS DASSFYNFCK 540

RNKDKLTALE RWKIKRIQFG FHKRDSEAGD GSSEQGEETT EGEKKNLSDV NLTAYQAWKL 600

KHQKKIGNEN KDEVVELSKG EDSVLAKKKQ RRLELLERTR QTLEESQSMD SWDAESTATS 660

KSIPLSAFWP SMASTRADGD SGSVLSMQSS RSHLSQTPSS VSGPMPTIPL PNLQVGPGDT 720

ISVASIQNWI ANVVTETLAQ KQNEMLLLSR PPSTASMKPT PSSNGMGDDQ MSCLSGQSAQ 780

SLGTSLLTRP HDRPSADTQS MLSCSTVSSR TEGARGKGTS KPFYSLFADD INLKELKQKE 840

KEMQSGLREK MSEYKMEKLA SDHKRSHLFK KKKAKEEEEE DAGEEDTDSA IGSFRNSSQS 900

ESHKPETAIS SSSSLAVSNR HGSTNVANLE VDRSINRWLS GLKTEEEVPP QRNWSRSSGE 960

RYTRSSTLRE VESETSSYRI SKSRSEERDS SSHHQSDGSS VRSTSRFSSS STRENKEMYK 1020

FSRSKFRETS RSREESPEPY FFQRSPEPSQ GEESPEPLRR SWARTPDWED VEESSKSDFS 1080

EFGAKRKFTQ SFMRSDEEGE RERMENTEEG RFASGRRFQY RRSTDKEDEK EMDDEAIIAA 1140

WRRRQEETKT KLQKRREE 1158

Nucleotide Sequence
(FASTA)

ATGGCGACCA GCAACGACCC AGAAGAGGAG CAAATTGTTC CGGATACAGA AGATGGAGCC 60

GATGTCAAGG CGGTACAGGC TCGGTATCTC CGAAGTCCTT CTCCCAGCCA GTACTCCATG 120

GTCTCAGATG CTGAAACAGA GAGTATTTTC ATGGATCCCA TTCATCTATC ATCAGCAGTC 180

GCTGCCAAGC AGATCATCAA TGAAGAACTC AAGCCAAGGG AAATCAAAAC AGATACTGTA 240

TGCCCTGGGA TGCTGGAGTC TGCAGAGCAG CTACTGGTCG AGGACCTATA CAACAGGGTC 300

AAAGAGAAGA TTGATGACAC CAGTCTGTAT AACACGCCTT GCGTCATGGA CCTTCAACGG 360

GCTTTGGTTC AGGACCGCCA GGAGTCCCCC TGGAATGAGG TGGATGAGGT CTGGCCTAAC 420

GTCTTTATTG CAGAAAAGAG TGTGGCCGTG AATAAGGGGC GGCTGAAGAG GTTAGGTGTG 480

ACTCACATCC TTAATGCAGC TCATGGCACA GGTGTTTACA CTGGACCAGA GTTCTACAAT 540

GGCCTGGAGA TCCAATACCT AGGTGTAGAG GTGGATGATT TTCCTGAGGT AGATATCTCC 600

CAGCATTTTC GGAAGGCTGC AGAGTTCCTT GATGAAGCTC TGCTAACTTA CAGAGGGAAA 660

ATCCTGGTCA GTAGTGAAAT GGGTATCAGC CGCTCAGCTG TGTTAGTGGT TGCTTACCTG 720

ATGATTTTCC ACCATATGAC CATCCTAGAA GCCCTGATGA CTGTGAGGAA GAAACGGGCC 780

ATCTACCCCA ATGATGGCTT CCTGAAACAA CTGAGGGAGC TGAATGAGAA GTTGATGGAG 840

GAACGCGACC AGGATTATGG AAGGGAAGGA GGAGATTATG AGGATGAAAT AGACAGTCAT 900

TCTGCACCAA TGGGGGAAGG AGACACAGGG AGTGTGCTTG GGGCCAGAGT ACACTCAATC 960

ATTGTGGAGG AGGAGGAAGA TACCACCAGC ACCCTGAGTG GTTCTTCGGT GAGGACCACT 1020

GGCAGGGTCT CCAAGCCTGT CACCCTCATT GATGAAGAAG AGGAGGAGAA GTTGTATGAG 1080

GATTGGAGGG AGAAGCAAGG TCTCCCCCAG ATTAGGAATA GACAATCACC ATCACTCTTG 1140

GATGAGGAAG GAGGGAAAGA GTCGGAGGAG GATTTAGAGA GGGTCATTCA GGAGTGGCAA 1200

AGTCGAAATG AGAAGTACCA AACAGAAAGG TCCCACAAGT GGTCTAAGGA GGAGGCAGAG 1260

GAAGAAGGGG GGGAGGGGGA TGGAGACTCC CTCTTGGGGA GAGGCAGGAG ACGTACATTC 1320

AGTGAATGTA GTACCTCAGA GAGTACGATA AGCCGCGATA TCCGAATCCT GAAACAGCAG 1380

TTGGAGCTCA GCAGCCAGAG GCAGACACAA AGGAGGCGTT CTGACTCTGT GTCCTCAGAG 1440

AGCACCTGGG ACATGTGGAA CCAAAGACTG CTGGAGATTG AGAAAGAAGC ATCTCAAAAA 1500

TATCACTGTA GGAGCAAACA GGAGGAAACT GAGTCAAATT CAGAGTCAGG GAGGAGAGAG 1560

AGAGAAGATG ATGAGGAAAG TGTGGCCTCA GATGCCAGTT CCTTCTATAA CTTCTGCAAA 1620

AGGAACAAGG ATAAGTTGAC TGCCCTAGAG CGGTGGAAGA TCAAGAGAAT CCAGTTTGGA 1680

TTTCACAAGA GGGATTCAGA AGCAGGAGAT GGCAGTAGTG AACAAGGTGA AGAGACCACA 1740

GAAGGGGAGA AGAAGAACCT CTCAGATGTC AACCTGACAG CCTACCAGGC TTGGAAATTA 1800

AAACACCAGA AAAAGATAGG CAATGAAAAC AAGGATGAGG TGGTGGAGCT CAGTAAAGGT 1860

GAGGACTCGG TTTTGGCCAA GAAGAAACAA AGAAGACTGG AGCTGCTAGA GAGGACCAGG 1920

CAGACCCTGG AGGAGAGTCA GTCCATGGAT AGCTGGGATG CTGAGAGCAC AGCTACCAGC 1980

AAAAGTATTC CCCTCTCTGC TTTCTGGCCT TCTATGGCCT CCACCAGGGC CGATGGGGAC 2040

TCAGGCTCTG TGCTGAGCAT GCAAAGCAGT AGATCCCACC TTTCTCAGAC TCCAAGCTCT 2100

GTCTCAGGCC CCATGCCTAC CATACCTTTG CCCAACCTGC AGGTGGGACC TGGAGACACC 2160

ATCTCTGTGG CCAGCATCCA GAACTGGATT GCCAACGTGG TCACTGAGAC CCTTGCTCAA 2220

AAACAAAATG AGATGTTATT GCTGTCTCGA CCTCCCTCTA CTGCAAGCAT GAAGCCCACT 2280

CCCTCAAGTA ATGGCATGGG AGACGATCAA ATGTCCTGCC TCAGTGGACA GAGTGCCCAA 2340

TCCTTAGGCA CCTCCTTGCT AACTCGTCCC CATGACAGAC CCAGTGCTGA CACTCAGTCC 2400

ATGTTGTCTT GTAGTACAGT GAGCTCAAGG ACTGAAGGAG CTAGGGGAAA GGGAACAAGT 2460

AAGCCTTTCT ATAGCCTCTT TGCCGATGAC ATTAACCTGA AAGAGCTTAA ACAGAAGGAA 2520

AAGGAGATGC AAAGTGGTCT AAGAGAGAAG ATGTCTGAAT ACAAAATGGA GAAACTTGCT 2580

TCAGACCACA AACGCAGTCA CCTGTTCAAG AAAAAGAAGG CAAAGGAAGA AGAGGAGGAG 2640

GATGCAGGAG AAGAAGACAC TGATAGTGCT ATAGGGAGCT TCAGAAATTC TTCCCAGAGT 2700

GAGTCTCATA AGCCTGAGAC AGCCATCTCC TCTTCCTCCT CCTTGGCTGT CTCTAATCGT 2760

CATGGAAGTA CCAATGTGGC CAACTTAGAA GTAGACAGAA GTATTAATAG GTGGCTCAGT 2820

GGCCTCAAGA CAGAAGAAGA GGTTCCTCCC CAAAGGAACT GGTCTAGAAG CTCTGGGGAG 2880

AGGTACACCC GGTCAAGTAC TCTCCGGGAA GTGGAGTCAG AAACCTCTAG TTACAGGATT 2940

TCCAAGTCCA GGTCAGAAGA ACGGGACAGT TCATCACATC ATCAGTCAGA TGGCAGCTCA 3000

GTGAGGAGTA CCTCCCGATT CTCTTCTTCT TCCACTAGAG AGAACAAGGA AATGTACAAA 3060

TTTTCCAGGT CAAAATTCAG GGAGACCTCA AGGTCCAGAG AAGAAAGTCC TGAGCCATAC 3120

TTCTTCCAAA GGAGCCCAGA ACCTTCCCAG GGAGAGGAGT CCCCTGAGCC ACTCCGACGG 3180

AGCTGGGCCA GAACCCCTGA TTGGGAAGAT GTTGAAGAAT CATCCAAATC AGACTTTTCT 3240

GAATTTGGAG CCAAGAGGAA GTTTACCCAG AGTTTCATGA GGTCTGATGA GGAAGGAGAG 3300

AGGGAAAGAA TGGAAAATAC TGAAGAAGGA AGATTTGCAT CAGGGCGACG GTTCCAATAT 3360

CGGAGAAGCA CCGACAAAGA GGATGAGAAA GAGATGGATG ACGAAGCCAT CATCGCTGCC 3420

TGGAGACGCC GGCAAGAAGA AACCAAGACT AAACTTCAGA AAAGACGGGA AGAGTAA 3477

Domain Profile

S: 1     evteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipv  60

         ev+e++p+++++++ +a+++  L++lg+t+++na++++    ++Pe++   +i+y++++v

Q: 133   EVDEVWPNVFIAEKSVAVNKGRLKRLGVTHILNAAHGTGV-YTGPEFYNGLEIQYLGVEV  191

         69**********************************8765.79*****************

S: 61    dDsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdA  119

         dD ++ d++q+f++aaef+dea  + +gk+lv +++G+sRSa+lv+aYLm+++++++ +A

Q: 192   DDFPEVDISQHFRKAAEFLDEAlLTYRGKILVSSEMGISRSAVLVVAYLMIFHHMTILEA  251

         **********************8999**********************************

S: 120   ieavkrkrpsiepnegfleQLlelekkl  147

         +++v++kr +i+pn+gfl+QL+el++kl

Q: 252   LMTVRKKR-AIYPNDGFLKQLRELNEKL  278

         ********.***************9987

Domain Sequence
(FASTA)

EVDEVWPNVF IAEKSVAVNK GRLKRLGVTH ILNAAHGTGV YTGPEFYNGL EIQYLGVEVD 60

DFPEVDISQH FRKAAEFLDE ALLTYRGKIL VSSEMGISRS AVLVVAYLMI FHHMTILEAL 120

MTVRKKRAIY PNDGFLKQLR ELNEKL 146

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

mdo:100013554

;

InterPros

IPR020417	; Atypical_DUSP.
IPR020405	; Atypical_DUSP_famA.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

PR01908	; ADSPHPHTASE.
PR01909	; ADSPHPHTASEA.

Created Date

20-Feb-2013