EKS-MOD-00261
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00261
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PLK365.81.3E-10960307248
StatusUnreviewed
Ensembl ProteinENSMODP00000003120
UniProt AccessionF7A1E8;
Protein Name
Protein Synonyms/Alias
Gene NamePLK3
Gene Synonyms/Alias PLK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000002562ENSMODP00000037713ENSMODT00000039317
ENSMODG00000002562ENSMODP00000003120ENSMODT00000003186
OrganismMonodelphis domestica
Functional Description
Protein Length574
Protein Sequence
(FASTA)
MEPVAFFSQP LASPEPRSRA LGTGSDSRAG PREPERSRSG AEPLLDPTRL IRDPQSGRTY 60
YRGRLLGKGG FARCYEATDT GSGHIYAVKV IPQSRVAKPH QREKEPILQE IALHRSLHHR 120
HIVHFSHHFE DEGNIYIFLE HCSRKARHTL LEPRVRYYLR QVIAALCYLH QRGVLHRDLK 180
LGNFFITENM ELKLGDFGLA ARLEPQDQRK KTICGTPNYL APEVLLRQGH GPESDVWSLG 240
CVMYTLLCGN PPFETADLKE TYRCIKQVRY TLPPYLSSAA RHLLATILRP VPQDRPSLEE 300
ILQHEFFTKG YTPAQLPPCS CTTVPDLTPP SPAESFFTKV TKSLFGRKKN KSKIAPQEQD 360
NLSRLVSDLV LTSICPLSST KEPRQAQADV APSLAETAPE EGSPRSLAAL GSSSEGSEEY 420
LTAATVMEST LCALRNCLAF MPPARQNPAP LATPEHLLWV SNPALGEGRG PSSLGGDLPS 480
VDETEGPSPL LLQWVKTDQA LLLLFSDGTV QVNFYVDHTK LILSGWEPLL ITFVARDRRT 540
CTYQAPHLQR LGCSQELRLR LRYVLHLLRQ RSGT 574
Nucleotide Sequence
(FASTA)
ATGGAACCGG TAGCCTTCTT CTCGCAGCCC TTGGCCAGTC CCGAGCCCCG CTCCCGGGCC 60
CTCGGCACGG GCAGTGACTC CAGAGCCGGG CCCCGGGAGC CCGAGCGGAG TCGCTCGGGA 120
GCCGAGCCGC TGCTGGACCC CACCCGCCTC ATCAGAGACC CGCAGAGTGG ACGCACCTAC 180
TACCGGGGCC GTCTCCTGGG CAAGGGGGGC TTTGCCCGAT GCTATGAGGC CACGGACACC 240
GGCAGTGGGC ACATCTATGC AGTCAAGGTC ATTCCCCAGA GCCGAGTGGC CAAACCACAC 300
CAGCGAGAGA AAGAGCCTAT CCTGCAGGAG ATTGCCTTGC ATCGAAGCCT CCACCACCGG 360
CACATCGTGC ACTTCTCTCA CCACTTTGAG GATGAAGGCA ACATCTACAT ATTTCTGGAG 420
CACTGTAGCC GCAAGGCCAG GCACACGCTG CTGGAGCCGA GGGTTCGATA CTACCTCCGA 480
CAGGTCATTG CTGCCTTGTG CTACCTGCAC CAACGAGGGG TCCTTCATCG AGACCTCAAG 540
CTGGGAAACT TTTTCATCAC GGAGAACATG GAACTGAAGC TCGGGGACTT TGGACTGGCA 600
GCTAGGCTGG AGCCCCAGGA TCAAAGGAAG AAGACCATAT GTGGGACCCC CAATTATCTG 660
GCTCCGGAGG TGCTGCTGCG CCAGGGTCAT GGCCCCGAGT CTGACGTGTG GTCCCTGGGC 720
TGTGTCATGT ATACACTGCT GTGTGGGAAC CCCCCCTTTG AGACGGCTGA CCTGAAGGAG 780
ACGTACCGTT GCATCAAGCA GGTTCGGTAC ACGCTACCCC CCTATCTTTC CTCGGCTGCC 840
CGACACCTCC TTGCCACCAT CCTTCGTCCT GTGCCTCAAG ACCGGCCCTC CCTGGAGGAG 900
ATCCTTCAAC ATGAATTCTT CACCAAGGGA TATACCCCAG CTCAACTGCC CCCCTGCAGC 960
TGCACCACAG TCCCTGACCT GACACCCCCC AGCCCTGCCG AAAGCTTCTT CACTAAAGTG 1020
ACCAAGAGCC TCTTTGGCCG CAAAAAGAAC AAGAGTAAGA TCGCTCCCCA GGAGCAGGAC 1080
AACCTCTCTC GCCTGGTCAG CGACCTCGTG CTGACATCCA TCTGTCCTCT GAGCAGCACC 1140
AAGGAGCCGA GGCAGGCCCA GGCCGATGTC GCCCCCAGCC TGGCAGAAAC AGCCCCAGAG 1200
GAGGGCTCCC CCAGGTCCTT GGCAGCCCTG GGCAGCAGCA GTGAGGGCTC TGAGGAGTAT 1260
CTGACGGCAG CCACAGTCAT GGAGTCGACC CTCTGTGCCC TCCGCAACTG CCTGGCCTTC 1320
ATGCCCCCAG CTCGGCAGAA CCCAGCACCC CTGGCCACAC CAGAGCACCT GCTGTGGGTC 1380
AGTAACCCTG CTCTGGGTGA GGGGCGGGGG CCAAGCTCTC TTGGTGGGGA CCTGCCCAGC 1440
GTGGACGAGA CGGAGGGCCC TTCCCCCCTG CTCCTGCAGT GGGTCAAGAC GGACCAGGCC 1500
CTGCTTCTCC TGTTCAGCGA TGGCACAGTG CAGGTGAACT TCTACGTGGA CCACACCAAG 1560
CTGATCCTGA GCGGCTGGGA GCCGCTGCTC ATCACCTTTG TGGCCCGAGA CCGCCGCACC 1620
TGCACTTACC AAGCACCGCA CCTGCAGCGG CTGGGCTGCA GCCAGGAGCT GCGGCTGCGG 1680
CTGCGCTACG TACTGCACCT GCTCCGACAG CGGAGCGGGA CCTAA 1725
Domain Profile
S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrek..vekeieihrslkh  58
         y rg+llGkGgfa+cye++d+ +++++avkv+p+s++ak++qrek  + +ei++hrsl+h
Q: 60    YYRGRLLGKGGFARCYEATDTGSGHIYAVKVIPQSRVAKPHQREKepILQEIALHRSLHH  119
         889***************************************9987799***********
S: 59    knivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhek  118
         ++iv+++++fed+ n+y++le csr       k+r++l ep vryylrq++++l ylh++
Q: 120   RHIVHFSHHFEDEGNIYIFLEHCSR-------KARHTLLEPRVRYYLRQVIAALCYLHQR  172
         ***********************98.......689*************************
S: 119   rilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsl  178
          +lhrdlklgn+f++e++e+k+gdfGla+rle++++rkkt+cGtPny+aPevl ++gh+ 
Q: 173   GVLHRDLKLGNFFITENMELKLGDFGLAARLEPQDQRKKTICGTPNYLAPEVLLRQGHGP  232
         ************************************************************
S: 179   evdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkeP  238
         e+d+WslGc++ytll+G+PPfet++lkety++ik+ +y+lP  ls++a++l+a++l++ P
Q: 233   ESDVWSLGCVMYTLLCGNPPFETADLKETYRCIKQVRYTLPPYLSSAARHLLATILRPVP  292
         ************************************************************
S: 239   eerpsleevlkdefl  253
         ++rpslee+l++ef+
Q: 293   QDRPSLEEILQHEFF  307
         **************8
Domain Sequence
(FASTA)
YYRGRLLGKG GFARCYEATD TGSGHIYAVK VIPQSRVAKP HQREKEPILQ EIALHRSLHH 60
RHIVHFSHHF EDEGNIYIFL EHCSRKARHT LLEPRVRYYL RQVIAALCYL HQRGVLHRDL 120
KLGNFFITEN MELKLGDFGL AARLEPQDQR KKTICGTPNY LAPEVLLRQG HGPESDVWSL 180
GCVMYTLLCG NPPFETADLK ETYRCIKQVR YTLPPYLSSA ARHLLATILR PVPQDRPSLE 240
EILQHEFF 248
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>
EKS-AIM-00245
EKS-BOT-00262
EKS-CAJ-00268
EKS-CAF-00269
EKS-CAP-00297
EKS-EQC-00253
EKS-FEC-00248
EKS-GOG-00260
EKS-HOS-00269
EKS-ICT-00247
EKS-MAM-00264
EKS-MAE-00013
EKS-MUM-00293
EKS-MUP-00259
EKS-MYL-00266
EKS-ORC-00248
EKS-OTG-00268
EKS-PAT-00249
EKS-PTV-00033
EKS-RAN-00277
EKS-SAH-00246
EKS-SUS-00227
EKS-TAR-00336
Gene Ontology
GO:0005813; C:centrosome
GO:0005795; C:Golgi stack
GO:0005730; C:nucleolus
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000082; P:G1/S transition of mitotic cell cycle
GO:0090166; P:Golgi disassembly
GO:0043066; P:negative regulation of apoptotic process
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:2000777; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
GO:0006974; P:response to DNA damage stimulus
GO:0006970; P:response to osmotic stress
GO:0009314; P:response to radiation
GO:0000302; P:response to reactive oxygen species
GO:0000084; P:S phase of mitotic cell cycle
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000959; POLO_box_duplicated_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR020658; Ser/Thr_kinase_Plk3.
Pfam
PF00069; Pkinase; 1.
PF00659; POLO_box; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50078; POLO_BOX; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013