EKS-MOD-00162
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00162
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb442.93.7E-133424684261
StatusUnreviewed
Ensembl ProteinENSMODP00000003191
UniProt AccessionF7FUC1;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA5
Gene Synonyms/Alias RPS6KA5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000002626ENSMODP00000003191ENSMODT00000003259
OrganismMonodelphis domestica
Functional Description
Protein Length795
Protein Sequence
(FASTA)
MEEGGGGGVS AEGTRADGGD QLLTVKHELR TANLTGHAEK VGIENFELLK VLGTGAYGKV 60
FLVRKISGHD AGKLYAMKVL KKATIVQKAK TAEHTKTERQ VLEHIRLSPF LVTLHYAFQT 120
ETKLHLILDY INGGELFTHL SQRERFTENE VQIFIGEIVL ALEHLHKLGI IYRDIKLENI 180
LLDNNGHVVL TDFGLSKEFL ADETERAYSF CGTIEYMAPD IVRGGDAGHD KAVDWWSLGV 240
LMYELLTGAS PFTVDGEKNS QAEISRRILK SEPPYPPEMS ALAKDIIQHL LVKDPKKRLG 300
CGPRDADEIK EHPFFQKINW DDLAAKKVPA PFKPVIRDEL DVSNFAEEFT EMDPTYSPAA 360
LPQSSERLFQ GYSFVAPSIL FKRNAAVIDP LQFHMGIERP GVTNVARSAM MKDSPFYQHY 420
DLDLKDKPLG EGSFSICRKC LHRKSNQEYA VKIISKRMEA NTQKEITALK LCEGHPNIVK 480
LYEVYHDQLH TFLVMELLNG GELFERIKKK KHFSETEASY IMRKLVSAVS HMHDVGVVHR 540
DLKPENLLFT DENDNLEIKV IDFGFARLKP PDNQPLKTPC FTLHYAAPEL LNHNGYDESC 600
DLWSLGVILY TMLSGQVPFQ SHDKSLTCTS AVEIMKKIKK GDFSFEGEAW KNVSQEAKDL 660
IQGLLTVDPN KRLKMSGLRY NEWLQDGSQL SSNPLMTPDI LGSSGAAVHT CVKATFHAFN 720
KYKREGFCLQ NVDKAPLAKR RKMKKTSTST ETRSSSSESS HSSSSHSHGK TTPTKTLQPS 780
NPDSNNPETI FQFSD 795
Nucleotide Sequence
(FASTA)
ATGGAGGAGG GTGGTGGCGG CGGTGTCAGC GCCGAGGGGA CGAGAGCGGA CGGAGGGGAC 60
CAGCTCTTAA CTGTCAAACA CGAGCTGCGT ACCGCTAATT TAACAGGACA TGCGGAGAAA 120
GTGGGAATTG AAAATTTTGA ACTTCTGAAG GTTCTAGGAA CAGGAGCCTA TGGAAAAGTA 180
TTCTTAGTCC GTAAAATAAG TGGTCATGAT GCTGGAAAGT TGTATGCTAT GAAGGTTCTG 240
AAGAAAGCCA CAATTGTTCA GAAAGCCAAG ACAGCAGAGC ACACCAAGAC AGAGCGACAA 300
GTACTAGAGC ACATTAGGCT GTCACCCTTT CTGGTTACAC TGCATTATGC TTTCCAGACA 360
GAGACGAAAC TGCATCTCAT TCTCGATTAC ATAAATGGTG GTGAGCTTTT TACTCACCTT 420
TCTCAAAGAG AACGTTTCAC AGAAAATGAA GTACAGATAT TCATTGGAGA AATCGTGCTT 480
GCCCTTGAAC ACCTTCATAA GCTGGGTATT ATATATCGTG ACATTAAACT AGAGAATATT 540
CTTCTTGATA ATAATGGCCA TGTGGTGCTA ACAGATTTTG GTCTGAGTAA GGAGTTCCTT 600
GCTGATGAAA CTGAAAGAGC ATATTCCTTT TGTGGAACTA TAGAATACAT GGCACCTGAT 660
ATTGTCAGAG GAGGAGATGC AGGGCACGAT AAGGCAGTTG ATTGGTGGAG TCTAGGTGTT 720
CTTATGTATG AATTATTAAC TGGAGCATCT CCGTTTACTG TTGATGGAGA GAAAAATTCC 780
CAAGCTGAAA TCTCTAGGAG AATCTTAAAA AGTGAACCTC CATATCCCCC AGAAATGAGT 840
GCTTTAGCTA AAGATATAAT TCAGCATCTC TTGGTGAAAG ATCCTAAGAA AAGATTGGGT 900
TGTGGACCAC GAGATGCAGA TGAAATCAAA GAGCATCCCT TCTTTCAGAA AATAAATTGG 960
GATGATTTAG CTGCCAAAAA AGTGCCCGCA CCATTTAAAC CAGTAATCCG GGATGAGTTA 1020
GATGTCAGTA ATTTTGCAGA GGAGTTTACA GAAATGGATC CCACATATTC TCCTGCAGCT 1080
CTGCCTCAGA GTTCTGAGAG ACTATTTCAG GGATATTCTT TTGTAGCTCC TTCTATCTTA 1140
TTTAAGCGCA ATGCAGCTGT CATAGATCCT CTTCAGTTTC ACATGGGAAT TGAACGTCCA 1200
GGAGTGACAA ATGTTGCCAG GAGTGCAATG ATGAAGGACT CTCCATTTTA CCAGCACTAT 1260
GACCTAGATC TTAAAGACAA GCCCCTGGGA GAAGGAAGTT TTTCAATTTG TCGAAAATGC 1320
TTACACAGAA AAAGCAACCA AGAATATGCA GTCAAAATAA TAAGCAAAAG AATGGAAGCC 1380
AACACTCAGA AAGAAATAAC AGCTTTGAAA CTCTGTGAAG GACACCCCAA TATAGTGAAG 1440
TTGTATGAAG TTTATCATGA TCAGCTTCAC ACATTTCTGG TGATGGAACT TCTGAACGGG 1500
GGAGAGCTGT TTGAACGAAT TAAGAAAAAG AAACATTTCA GTGAGACTGA AGCCAGTTAT 1560
ATCATGCGGA AGCTTGTTTC AGCTGTAAGC CACATGCATG ATGTGGGAGT GGTACATAGA 1620
GATCTGAAGC CTGAGAATTT ATTATTCACT GATGAAAATG ATAATTTAGA AATTAAGGTA 1680
ATTGATTTTG GATTTGCACG TTTAAAGCCA CCTGATAATC AGCCTCTTAA GACACCGTGC 1740
TTTACCCTTC ATTATGCTGC TCCAGAGCTC TTAAATCATA ATGGCTATGA TGAATCTTGT 1800
GATCTGTGGA GCTTAGGAGT CATTTTGTAT ACAATGCTGT CAGGACAAGT TCCATTCCAG 1860
TCTCATGACA AAAGCTTAAC ATGTACCAGT GCTGTAGAAA TCATGAAAAA AATTAAAAAG 1920
GGAGATTTCT CTTTTGAAGG AGAAGCCTGG AAGAATGTAT CCCAAGAGGC CAAAGATTTG 1980
ATTCAAGGAC TTCTTACAGT GGATCCCAAT AAAAGACTTA AAATGTCTGG CTTGAGGTAC 2040
AATGAATGGC TACAAGATGG CAGTCAGCTG TCTTCAAATC CTTTGATGAC TCCAGACATA 2100
CTAGGATCTT CAGGAGCTGC TGTGCATACC TGTGTAAAAG CAACCTTTCA TGCCTTCAAC 2160
AAGTATAAAA GGGAGGGATT CTGCCTCCAG AATGTTGATA AGGCTCCTCT TGCAAAGAGA 2220
AGAAAGATGA AGAAAACCAG CACAAGTACA GAGACCCGCA GCAGCTCCAG TGAAAGTTCT 2280
CATTCTTCTT CCTCTCATTC TCATGGTAAA ACTACACCAA CAAAGACACT GCAACCTAGT 2340
AATCCTGATA GCAATAATCC AGAAACCATC TTCCAGTTCT CTGACTGA 2388
Domain Profile
S: 2     evkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkd  60
         +++++lG+Gs+s+c++c+h+++nqe+avkii+k+ +++t++ei++l+++e+hpniv+l +
Q: 424   LKDKPLGEGSFSICRKCLHRKSNQEYAVKIISKRmEANTQKEITALKLCEGHPNIVKLYE  483
         5789******************************9*************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vy+d+++++lv+ell+GGel++rikkkk+fse+eas+i+r+lv+av+++h++Gvvhrdlk
Q: 484   VYHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK  543
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         pen+l++de+dn+e ik+idfGfa+lk+++n++lktpc+tl+++ape+l+++Gyde+cdl
Q: 544   PENLLFTDENDNLE-IKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNHNGYDESCDL  602
         **************.*********************************************
S: 181   wslGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvs  236
         wslGv+lytml+G+vpf    +++++++a+ei++kik+G+fs++Geaw++vs+eakdl++
Q: 603   WSLGVILYTMLSGQVPFqshdKSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ  662
         *****************98888899***********************************
S: 237   klltvdpakrlkleqllkhswl  258
         +lltvdp+krlk+++l++++wl
Q: 663   GLLTVDPNKRLKMSGLRYNEWL  684
         *********************7
Domain Sequence
(FASTA)
LKDKPLGEGS FSICRKCLHR KSNQEYAVKI ISKRMEANTQ KEITALKLCE GHPNIVKLYE 60
VYHDQLHTFL VMELLNGGEL FERIKKKKHF SETEASYIMR KLVSAVSHMH DVGVVHRDLK 120
PENLLFTDEN DNLEIKVIDF GFARLKPPDN QPLKTPCFTL HYAAPELLNH NGYDESCDLW 180
SLGVILYTML SGQVPFQSHD KSLTCTSAVE IMKKIKKGDF SFEGEAWKNV SQEAKDLIQG 240
LLTVDPNKRL KMSGLRYNEW L 261
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-BOT-00163
EKS-CAE-00125
EKS-CAJ-00167
EKS-CAF-00170
EKS-CAP-00162
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00452
EKS-DIO-00087
EKS-DRM-00077
EKS-EQC-00162
EKS-FEC-00153
EKS-GAG-00140
EKS-GAA-00192
EKS-GOG-00163
EKS-HOS-00169
EKS-ICT-00158
EKS-LAC-00173
EKS-LOA-00162
EKS-MAM-00160
EKS-MAE-00060
EKS-MEG-00130
EKS-MUM-00169
EKS-MUP-00167
EKS-MYL-00173
EKS-NOL-00156
EKS-ORN-00202
EKS-ORA-00141
EKS-ORC-00151
EKS-ORL-00189
EKS-OTG-00170
EKS-PAT-00153
EKS-PES-00145
EKS-PEM-00087
EKS-POA-00160
EKS-RAN-00161
EKS-SAH-00157
EKS-SUS-00141
EKS-TAG-00191
EKS-TAR-00209
EKS-TEN-00202
EKS-XET-00152
EKS-XIM-00197
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043990; P:histone H2A-S1 phosphorylation
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013