EKS-MOD-00249

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00249

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	322.8	1.4E-96	13	265	253

Status

Unreviewed

Ensembl Protein

ENSMODP00000037411

UniProt Accession

F7FWS7;

Protein Name

Protein Synonyms/Alias

Gene Name

MELK

Gene Synonyms/Alias

MELK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000002695	ENSMODP00000037411	ENSMODT00000039008

Organism

Monodelphis domestica

Functional Description

Protein Length

657

Protein Sequence
(FASTA)

MAVGDYDELL KYYELYETIG TGGFAKVKLA RHILTGEKVA IKIMDKNTLG NDLPRVKTEI 60

DAMKNLSHQH ICRLYHVLET DNKIFMVMEY CPGGELFDYI IAKDRLSEEE TRVFFRQIVS 120

AVAYVHSQGY AHRDLKPENL LIDEYHKLKL IDFGLCAKPK GNKDYHLQTC CGSPAYAAPE 180

LIQGKSYIGS EADVWSMGIL LYALLCGFLP FDDDNVMALY KKITRGKYDI PKWLSPGSIL 240

LLQQMLQVDP KKRISVKHLL SHPWIIQDNL CPVDWQTKYP CGRLDEDCVT ELAVYHKQNR 300

QLMEDLISLW QYDQLTATYF LLLAKKSHGK PVRLRLPSVG GEQTIIPSFK ELQSLIHNHC 360

YETVVLFEKI TLPGRRNQNR TVCHISLGDF LLKILNKLAK HWKESNDVES EPLTPVLCRA 420

ATRKLENKEN VCMPKSAMKD EEHFVLPIPK TPGSKSLHER GILTVTNHPT PYRERNQCKE 480

EILIKTINPE KTKELPTSII SPERRCRSVE LDLNQVHRDS PQRRKGMFGS LERGLDKMIT 540

MLTPNKKKGS TRDGPRRLRA HYNVTTTRLV NPDQLLAEII SILPKKHVDF HHSRVVLKPY 600

TLKCQTQSDF GKVTMQFELE VCQLSKPEVV GIRRQRLKGD AWVYKRLVED ILSSCKV 657

Nucleotide Sequence
(FASTA)

ATGGCTGTGG GAGACTATGA TGAACTTCTC AAATATTATG AATTATATGA AACTATTGGG 60

ACAGGTGGCT TTGCAAAGGT TAAGCTTGCT CGCCATATTC TCACCGGAGA AAAGGTAGCA 120

ATAAAAATCA TGGACAAGAA TACACTAGGG AATGATTTGC CTCGTGTAAA GACAGAGATT 180

GATGCTATGA AGAACCTCAG TCATCAACAT ATTTGTCGTC TTTACCATGT GCTTGAGACT 240

GACAACAAAA TATTTATGGT TATGGAGTAC TGCCCCGGAG GAGAGCTGTT TGATTATATA 300

ATTGCCAAGG ATCGTCTGTC AGAGGAGGAA ACACGTGTCT TCTTCCGTCA GATTGTGTCA 360

GCTGTGGCTT ATGTACATAG TCAGGGTTAT GCTCATAGGG ACCTTAAACC AGAAAACTTG 420

CTGATTGATG AATACCATAA ATTGAAGTTG ATTGACTTCG GTCTTTGTGC AAAGCCCAAA 480

GGTAACAAGG ATTATCATTT ACAGACATGT TGTGGAAGTC CGGCTTATGC AGCCCCTGAA 540

CTAATTCAAG GCAAATCCTA TATTGGATCA GAGGCAGATG TTTGGAGTAT GGGAATTCTC 600

TTATATGCAC TACTGTGTGG ATTTCTACCA TTTGATGATG ATAATGTCAT GGCTTTATAT 660

AAGAAGATCA CGCGAGGAAA ATATGACATT CCTAAATGGC TGTCTCCTGG CAGTATTCTA 720

CTTCTTCAAC AAATGCTGCA GGTGGACCCA AAGAAACGGA TTTCTGTGAA ACATCTGCTG 780

AGCCACCCCT GGATCATACA AGATAACTTG TGTCCTGTTG ACTGGCAGAC TAAATATCCA 840

TGTGGACGTC TTGATGAAGA CTGTGTTACA GAACTTGCAG TATATCATAA ACAGAACAGA 900

CAGTTAATGG AAGATTTAAT TTCATTGTGG CAATATGATC AACTTACAGC TACCTATTTC 960

CTCCTCCTTG CTAAGAAATC TCATGGAAAA CCCGTTCGCT TAAGGCTTCC TTCTGTTGGT 1020

GGAGAACAAA CAATTATTCC TTCATTCAAA GAGCTACAGT CCTTAATTCA TAATCACTGT 1080

TATGAGACAG TTGTATTGTT TGAGAAGATA ACCTTGCCGG GAAGAAGAAA CCAGAATAGA 1140

ACTGTTTGCC ACATCTCTTT AGGGGATTTT TTACTAAAAA TCCTTAACAA GCTTGCAAAG 1200

CATTGGAAAG AATCAAATGA TGTAGAATCT GAGCCATTAA CTCCAGTATT ATGCAGAGCA 1260

GCCACAAGGA AATTGGAGAA CAAAGAAAAT GTGTGCATGC CTAAGTCTGC TATGAAGGAT 1320

GAAGAACACT TTGTACTGCC CATTCCGAAG ACTCCTGGTA GCAAGAGTTT GCATGAAAGA 1380

GGAATATTAA CTGTAACAAA TCACCCTACA CCTTACAGAG AGAGAAATCA GTGCAAGGAA 1440

GAAATCCTGA TTAAAACTAT AAACCCAGAG AAGACAAAAG AATTACCAAC TTCCATTATT 1500

AGTCCTGAGA GACGATGCCG TTCAGTGGAA TTGGATCTTA ATCAAGTACA CAGAGACAGT 1560

CCTCAAAGGA GGAAAGGAAT GTTTGGAAGT CTTGAAAGGG GTTTGGATAA AATGATTACA 1620

ATGCTGACCC CCAACAAAAA GAAAGGATCC ACTAGAGACG GACCAAGAAG ACTAAGGGCT 1680

CATTATAATG TGACCACAAC CAGACTAGTG AATCCAGATC AACTCTTGGC TGAAATAATT 1740

TCTATCCTTC CAAAAAAGCA TGTCGACTTT CATCATAGCC GTGTGGTCTT GAAGCCCTAT 1800

ACCCTGAAGT GCCAAACACA GTCCGATTTT GGCAAAGTGA CAATGCAGTT TGAGCTAGAG 1860

GTGTGCCAGC TTAGCAAGCC GGAGGTGGTG GGCATCCGCA GGCAGAGGCT GAAGGGCGAT 1920

GCTTGGGTTT ACAAGAGATT AGTGGAAGAC ATTCTTTCTA GCTGCAAGGT GTGA 1974

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+l +t+G+g f+kVkla+h +t+ekva+Ki++k++l ++ l ++k+Ei+++k+l+h++i

Q: 13    YELYETIGTGGFAKVKLARHILTGEKVAIKIMDKNTLGND-LPRVKTEIDAMKNLSHQHI  71

         999*******************************999755.89*****************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ++l++v+et++k+++v+ey+ ggeLfdyi +k rl+e+e+r +f+q+vsav Y+hs+g +

Q: 72    CRLYHVLETDNKIFMVMEYCPGGELFDYIIAKDRLSEEETRVFFRQIVSAVAYVHSQGYA  131

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg..klletfcGsppYaaPellkgkkYegpk  178

         HrDlKpeNll+d+ +++k++DFGl+++ k +   +l+t+cGsp+YaaPel++gk+Y g++

Q: 132   HRDLKPENLLIDEYHKLKLIDFGLCAKPKGNkdYHLQTCCGSPAYAAPELIQGKSYIGSE  191

         *************************9665443389*************************

S: 179   vDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpe  238

         +DvWs+G++Lyal++g lPfd++n+ +l++ki++gk++ipk+ls+  + Ll+++L+vdp+

Q: 192   ADVWSMGILLYALLCGFLPFDDDNVMALYKKITRGKYDIPKWLSPGSILLLQQMLQVDPK  251

         ************************************************************

S: 239   kRatieeilkhewl  252

         kR++++++l+h+w+

Q: 252   KRISVKHLLSHPWI  265

         *************7

Domain Sequence
(FASTA)

YELYETIGTG GFAKVKLARH ILTGEKVAIK IMDKNTLGND LPRVKTEIDA MKNLSHQHIC 60

RLYHVLETDN KIFMVMEYCP GGELFDYIIA KDRLSEEETR VFFRQIVSAV AYVHSQGYAH 120

RDLKPENLLI DEYHKLKLID FGLCAKPKGN KDYHLQTCCG SPAYAAPELI QGKSYIGSEA 180

DVWSMGILLY ALLCGFLPFD DDNVMALYKK ITRGKYDIPK WLSPGSILLL QQMLQVDPKK 240

RISVKHLLSH PWI 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005938	; C:cell cortex
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005509	; F:calcium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006915	; P:apoptotic process
GO:0061351	; P:neural precursor cell proliferation
GO:0043065	; P:positive regulation of apoptotic process
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013