EKS-MOD-00197

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00197

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/MAST	528.1	5.1E-159	407	680	274

Status

Unreviewed

Ensembl Protein

ENSMODP00000003869

UniProt Accession

F6VY61;

Protein Name

Protein Synonyms/Alias

Gene Name

MAST3

Gene Synonyms/Alias

MAST3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000003178	ENSMODP00000003869	ENSMODT00000003955

Organism

Monodelphis domestica

Functional Description

Protein Length

1532

Protein Sequence
(FASTA)

MDEPSILRRR GLQKELSLPR RGRSLSPCSQ SPTLLSPCSP ASPCSPLQTL HPWSCRSGNR 60

KSLVVGTPSP TLSRPLSPLS VPTAGSSPLD SPRNFSASTT VNFPFARSHG PRTDRADGRR 120

WSLASLPSSG YGTNTPSSTV SSSSSSRERL HQLPYQPTPD ELHFLSKHFR SSESIVDEDG 180

GRRSPCMRPR SRSLSPGRTT GAFDSDIVMM NHVYKERFPK ATAQMEERLQ DIITTFSPSN 240

TLALADGVLS FIHHQIVELA RDCLAKARED LVTSRYFLEL QEKLEKMLQD AHERSESQEV 300

SFIGQLVRKL LIVISRPARL LECLEFDPEE FYHLLEAAEG HARVGQGIKT DIPRYIIGQL 360

GLTKDPLEEM VQLGPPNAGS TAPEDGDPPE NRSLTVPSRR KPCESDFETI KLISNGAYGA 420

VYLVRHRETR QRFAIKKINK QNLVLRNQIQ QVFVERDILT FAENPFVVSM FCSFETRRHL 480

CMVMEYVEGG DCATLLKNMG PLPVDMARMY FAETVLALEY LHNYGIVHRD LKPDNLLITS 540

LGHIKLTDFG LSKIGLMSMT TNLYEGHIEK DAREFVDKQV CGTPEYIAPE VIFRQGYGKP 600

VDWWAMGVIL YEFLVGCVPF FGDTPEELFG QVISDDIIWP EGDEALPADA QDLITKLLRQ 660

SPLDRLGTGG AYEVKQHPFF FNLDWTGLLR QKAEFIPQLE AEDDTSYFDT RSERYRHLGS 720

EDDETNDEES STEIPQFSSC SHRFSKVYSS SEFLAVQSHF SERSYSEDKE ERSERWDRGS 780

GEEEKTRPLS TEVRLRSWTS SGSLRHSSSS SSQPERSQSP SALSTTYSLD PMPKFAFSSE 840

DEGPCQGPAK PERPVFVLGD PEELARETAK VSALTADVSS LNHVRLRSNS TGAKNSTPRV 900

LEGGGPGRRG QKETPEKQKT SPGGSRVPKS ASVSALSLVI TSDDCSSGAL MSPISPHSLS 960

SNPSSRDSSP SRDSSIGITS LRPPIIIHSS GKKFGFSLRA IRVYMGDSDV YTVHHMVWSV 1020

EEGSPAQEAG LRAGDLITHI NGESVLGLVH MDVVELLLKS NNKISLRTTA LENTSIKVGP 1080

ARKHNNKGRM ARRGKKSRKR ESQDRRKSLF KKISKQSTML HTSRSFSSGL HHSLSSSESL 1140

PGSPTHSLSP GPATPCRSPA PDAPPDTVSP QSTSPSSSTP TSPAGHIRPS SLHGLASKLG 1200

APRYKVGRRK STSSIPPSPL ACTPSPGPQP PSPQRSPSPL PGYPKNLYAF QGKTLSPPMI 1260

SRQTSRPRSA ETPRSPLLKR GLSADKITPC SMEKKPLGGR KLTLEMPAGD GDGLEEMSVQ 1320

AFSGAGYTGT ASRGRDWAGD RHDRDQEVVV MRRLNLSERR DSFKKQEAVQ EVSFDEPEAP 1380

GDEGPRGQEG RGPRPGAREQ KPPPVPQIAV QGSEGDVHEP GSAEWECQGS YPPLQLLAKV 1440

YTEQTDGTKA VEYKSLSAQR RGSRDLRDLS SGGQQQPPRA GRPLRAPLQA AKSLPILQLS 1500

GGQERAGPEP RTPRASQRDA TGPSRKMDGD RR 1532

Nucleotide Sequence
(FASTA)

ATGGACGAAC CGAGCATCCT GAGGCGCCGG GGACTGCAGA AGGAACTCAG CTTGCCACGA 60

CGGGGAAGGT CTTTGTCGCC ATGTAGCCAG AGCCCGACCC TGCTGAGCCC CTGCAGCCCT 120

GCTAGCCCCT GCAGCCCATT ACAGACCCTG CACCCCTGGA GCTGCCGCAG TGGCAACAGG 180

AAAAGTCTGG TGGTGGGGAC ACCGTCGCCC ACCCTCTCCC GACCCCTGTC CCCACTCTCT 240

GTGCCTACAG CTGGCAGCAG CCCCTTAGAT AGTCCTCGGA ACTTCTCGGC CAGCACGACT 300

GTAAACTTCC CCTTCGCACG AAGTCATGGG CCCCGGACTG ACAGGGCTGA TGGCCGGAGA 360

TGGTCGCTTG CTTCCCTCCC CTCCTCAGGC TACGGGACCA ATACCCCCAG CTCCACTGTC 420

TCGTCATCCT CATCTTCCCG AGAGCGGCTG CACCAGCTGC CATACCAGCC AACGCCAGAT 480

GAGCTCCACT TTCTTTCCAA GCACTTTCGC AGCTCAGAGA GCATCGTGGA TGAAGATGGG 540

GGCCGCCGCT CTCCCTGCAT GCGGCCTCGC TCCCGCAGCC TCAGCCCCGG GCGAACCACA 600

GGAGCTTTTG ACAGTGACAT TGTCATGATG AATCATGTCT ACAAGGAGCG ATTTCCTAAG 660

GCCACTGCAC AGATGGAGGA GCGGCTGCAG GACATCATTA CTACCTTCTC CCCCTCTAAC 720

ACCCTGGCCC TGGCCGATGG TGTCCTGAGC TTCATTCACC ACCAGATAGT GGAGCTGGCT 780

CGAGACTGTC TGGCCAAGGC CCGGGAGGAC CTGGTCACCT CCCGCTACTT CTTGGAGCTT 840

CAGGAAAAGC TAGAGAAGAT GCTGCAAGAT GCCCACGAGC GCTCAGAGAG CCAAGAGGTC 900

TCCTTCATCG GCCAGCTGGT TCGGAAGCTC CTGATCGTCA TCTCCCGGCC GGCGCGGCTC 960

CTGGAGTGCC TGGAATTTGA TCCAGAAGAG TTCTACCACC TCCTGGAAGC AGCAGAAGGA 1020

CATGCCCGGG TGGGTCAGGG CATCAAGACA GACATTCCTC GATACATCAT TGGTCAGTTG 1080

GGCCTCACCA AGGACCCTCT AGAGGAGATG GTGCAACTGG GTCCTCCGAA TGCTGGCTCG 1140

ACTGCACCTG AGGATGGAGA CCCACCCGAG AACCGATCTC TCACTGTGCC TTCCCGGAGG 1200

AAACCCTGTG AGAGCGACTT TGAGACCATC AAACTGATCA GCAACGGGGC ATATGGGGCT 1260

GTGTACCTGG TCAGGCATCG AGAGACCCGC CAGCGCTTTG CTATCAAGAA GATCAATAAG 1320

CAGAACCTAG TGCTCCGGAA CCAGATCCAG CAGGTGTTTG TGGAGCGGGA CATCCTGACC 1380

TTTGCCGAGA ACCCCTTTGT CGTCAGTATG TTCTGCTCCT TTGAGACTCG GAGGCACCTC 1440

TGTATGGTCA TGGAATATGT GGAAGGCGGA GACTGCGCCA CACTGCTAAA GAACATGGGC 1500

CCCCTCCCTG TGGACATGGC CCGGATGTAC TTCGCAGAGA CTGTCCTGGC TTTGGAGTAT 1560

CTTCACAATT ACGGCATCGT GCACCGGGAC CTCAAGCCTG ACAACCTGTT AATCACATCC 1620

CTGGGCCATA TCAAACTAAC GGACTTTGGG CTGTCCAAGA TCGGGCTGAT GAGTATGACC 1680

ACCAATCTGT ATGAGGGGCA CATCGAGAAG GACGCCCGGG AGTTTGTGGA CAAGCAGGTC 1740

TGTGGGACCC CTGAATACAT TGCACCTGAA GTGATCTTCC GACAAGGCTA TGGGAAGCCG 1800

GTGGACTGGT GGGCCATGGG CGTCATCCTC TATGAATTTC TCGTGGGCTG TGTCCCTTTT 1860

TTTGGTGACA CCCCCGAGGA ACTTTTTGGC CAAGTCATCA GTGATGACAT CATCTGGCCA 1920

GAAGGAGATG AAGCACTCCC TGCTGATGCT CAGGACCTGA TCACTAAGCT GCTGAGACAG 1980

AGTCCCCTGG ACCGATTAGG CACAGGTGGT GCCTACGAAG TCAAGCAGCA CCCCTTCTTC 2040

TTCAACCTTG ACTGGACGGG TCTCCTACGG CAGAAGGCAG AATTCATCCC ACAACTGGAG 2100

GCGGAAGATG ACACTAGCTA CTTTGACACT CGATCGGAAC GTTACCGCCA CCTGGGGTCA 2160

GAGGATGATG AAACAAATGA TGAGGAGTCG TCTACAGAAA TCCCCCAGTT TTCTTCCTGC 2220

TCACACCGGT TTAGTAAGGT TTATAGCAGC TCTGAATTCC TTGCTGTTCA GTCACACTTT 2280

TCTGAGAGAA GCTATAGTGA GGACAAGGAG GAGAGGTCGG AGAGGTGGGA CCGGGGTTCG 2340

GGTGAGGAGG AGAAGACCCG CCCTTTGAGC ACAGAGGTCA GGCTGAGGTC CTGGACGTCA 2400

TCCGGCTCGC TGCGGCACTC CTCGTCTTCG TCCTCCCAGC CAGAGCGGAG CCAGAGCCCC 2460

TCAGCCCTGA GCACCACCTA CAGCCTGGAC CCCATGCCCA AGTTCGCCTT CTCTTCCGAG 2520

GACGAAGGCC CTTGCCAGGG ACCGGCCAAA CCTGAGAGGC CCGTTTTTGT GCTGGGAGAC 2580

CCCGAGGAGC TGGCGAGAGA AACGGCTAAG GTGTCTGCCC TCACAGCGGA CGTTTCCAGC 2640

CTCAACCACG TCCGATTACG GAGTAATAGT ACCGGGGCAA AGAACTCCAC GCCTCGGGTC 2700

CTGGAAGGTG GCGGGCCGGG CCGGCGTGGC CAGAAAGAAA CGCCTGAGAA ACAGAAGACG 2760

TCCCCCGGGG GCAGCCGGGT CCCCAAATCG GCCTCTGTCT CCGCCCTCTC CCTAGTCATC 2820

ACTTCAGACG ACTGCAGCAG CGGGGCCCTC ATGAGTCCCA TCTCCCCCCA TTCCCTCTCC 2880

TCCAACCCCT CCTCCCGGGA CTCCTCCCCG AGCCGGGACT CCTCCATCGG CATCACCAGC 2940

CTGCGGCCTC CCATCATCAT CCACAGCTCC GGAAAGAAGT TCGGCTTCAG CCTGAGGGCC 3000

ATCCGCGTCT ACATGGGCGA CAGCGACGTC TACACTGTGC ACCACATGGT CTGGAGCGTG 3060

GAGGAGGGCA GCCCGGCCCA AGAAGCTGGC CTGCGGGCGG GAGACCTCAT CACCCACATC 3120

AACGGGGAGT CCGTGCTGGG CCTGGTTCAC ATGGACGTGG TGGAGCTCCT GCTGAAGAGC 3180

AACAACAAGA TCTCCCTCAG AACCACGGCC CTGGAGAACA CCTCCATCAA GGTGGGGCCG 3240

GCCCGAAAGC ACAACAACAA AGGCAGGATG GCCCGGCGAG GCAAGAAAAG CAGGAAGCGT 3300

GAGAGTCAGG ACAGGCGAAA GTCTCTCTTC AAGAAGATCT CCAAGCAGTC CACGATGCTG 3360

CACACGAGTC GGAGTTTCTC ATCTGGGCTC CACCACTCCC TATCTTCCAG CGAGAGCCTT 3420

CCTGGCTCTC CTACCCACAG CCTGTCCCCT GGCCCTGCCA CCCCCTGCCG CAGCCCCGCT 3480

CCCGATGCCC CCCCAGATAC GGTGTCTCCA CAGAGCACTT CACCCTCGTC CAGCACGCCC 3540

ACCTCCCCGG CGGGCCACAT CCGGCCCAGC TCCCTGCATG GCCTGGCCTC CAAGCTGGGG 3600

GCCCCGCGCT ACAAAGTCGG CCGCCGGAAG TCGACGAGCA GCATCCCTCC ATCCCCGCTG 3660

GCCTGTACGC CCTCACCGGG ACCCCAGCCC CCGTCGCCCC AGAGATCTCC GTCTCCTTTA 3720

CCGGGTTACC CCAAAAACCT CTATGCCTTC CAGGGGAAGA CCTTGTCGCC CCCGATGATC 3780

AGCCGGCAGA CGTCCAGGCC GCGGAGCGCC GAGACCCCCC GGTCCCCCCT CCTGAAGCGA 3840

GGGCTGTCTG CCGACAAAAT CACGCCCTGC TCCATGGAAA AGAAGCCCCT GGGGGGCCGA 3900

AAGCTCACCC TCGAGATGCC GGCGGGGGAC GGGGACGGCC TCGAGGAGAT GTCGGTCCAG 3960

GCCTTCTCGG GGGCCGGTTA CACAGGCACG GCGAGCCGGG GGAGAGACTG GGCCGGAGAC 4020

CGGCACGACA GGGACCAGGA GGTGGTGGTC ATGAGACGCC TAAACCTGTC CGAGCGTCGA 4080

GACTCGTTCA AAAAGCAAGA GGCCGTCCAG GAGGTGAGCT TCGACGAGCC CGAGGCCCCG 4140

GGGGACGAGG GCCCCCGCGG GCAGGAGGGC CGGGGGCCAC GGCCGGGGGC GCGAGAACAA 4200

AAGCCGCCCC CCGTGCCCCA GATCGCCGTG CAGGGCTCCG AGGGCGACGT GCACGAGCCG 4260

GGCTCGGCCG AGTGGGAGTG CCAAGGCTCT TACCCCCCCC TCCAGCTGCT GGCCAAGGTC 4320

TACACTGAGC AGACGGACGG GACCAAGGCG GTGGAGTACA AGAGCCTCTC GGCCCAGCGG 4380

CGGGGCAGCA GGGACCTCCG GGACTTGAGC TCGGGGGGGC AGCAGCAGCC CCCCAGGGCC 4440

GGCCGGCCTC TTCGGGCCCC CCTGCAGGCC GCCAAGTCCC TGCCCATTCT CCAGCTCTCG 4500

GGAGGCCAGG AGCGGGCAGG ACCTGAGCCT CGGACTCCCA GAGCGAGTCA GCGAGATGCC 4560

ACGGGGCCAT CGAGGAAGAT GGATGGGGAT CGGCGCTAG 4599

Domain Profile

S: 1     feiiklisrGayGavylvrhketrkrfavkkikkqdlilknqvqqvfaerdilalaenpf  60

         fe+iklis+GayGavylvrh+etr+rfa+kki+kq+l+l+nq+qqvf+erdil++aenpf

Q: 407   FETIKLISNGAYGAVYLVRHRETRQRFAIKKINKQNLVLRNQIQQVFVERDILTFAENPF  466

         99**********************************************************

S: 61    vvslyysletrrnlylvmeyveGGdvksllkniGaldvemarlyiaevvlaleylhryGi  120

         vvs+++s+etrr+l++vmeyveGGd+++llkn+G+l+v+mar+y+ae+vlaleylh+yGi

Q: 467   VVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARMYFAETVLALEYLHNYGI  526

         ************************************************************

S: 121   vhrdlkPdnllitseGhikltdfGlskvglmslttnlyegyidkdarefldkqvcgtPey  180

         vhrdlkPdnllits GhikltdfGlsk+glms+ttnlyeg+i+kdaref+dkqvcgtPey

Q: 527   VHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMTTNLYEGHIEKDAREFVDKQVCGTPEY  586

         ************************************************************

S: 181   iaPevilrqgygkpvdwwalgiilyeflvgivpffgdtpeelfaqvlsdeivwPekdeal  240

         iaPevi+rqgygkpvdwwa+g+ilyeflvg+vpffgdtpeelf+qv+sd+i+wPe+deal

Q: 587   IAPEVIFRQGYGKPVDWWAMGVILYEFLVGCVPFFGDTPEELFGQVISDDIIWPEGDEAL  646

         ************************************************************

S: 241   ssealelisellesnPrerlgtgsaaevkqhefl  274

         +++a++li++ll+++P +rlgtg+a+evkqh+f+

Q: 647   PADAQDLITKLLRQSPLDRLGTGGAYEVKQHPFF  680

         ********************************97

Domain Sequence
(FASTA)

FETIKLISNG AYGAVYLVRH RETRQRFAIK KINKQNLVLR NQIQQVFVER DILTFAENPF 60

VVSMFCSFET RRHLCMVMEY VEGGDCATLL KNMGPLPVDM ARMYFAETVL ALEYLHNYGI 120

VHRDLKPDNL LITSLGHIKL TDFGLSKIGL MSMTTNLYEG HIEKDAREFV DKQVCGTPEY 180

IAPEVIFRQG YGKPVDWWAM GVILYEFLVG CVPFFGDTPE ELFGQVISDD IIWPEGDEAL 240

PADAQDLITK LLRQSPLDRL GTGGAYEVKQ HPFF 274

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR015022	; MA_Ser/Thr_Kinase_dom.
IPR023142	; MAST_pre-PK_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF08926	; DUF1908; 1.
PF00595	; PDZ; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00228	; PDZ; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50106	; PDZ; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013