EKS-MOD-00277

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00277

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	418.6	1.3E-125	192	478	287

Status

Unreviewed

Ensembl Protein

ENSMODP00000004027

UniProt Accession

F7EG01;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2A

Gene Synonyms/Alias

ACVR2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000003295	ENSMODP00000004027	ENSMODT00000004113

Organism

Monodelphis domestica

Functional Description

Protein Length

513

Protein Sequence
(FASTA)

MGAAAKLAFA VFLISCSSGA ILGRSETQEC IFYNANWEKD RTNRTGVEPC YGDKDKRRHC 60

FATWKNISGS IEIVKQGCWL DDINCYDRND CVEKKDNPEV YFCCCEGNMC NERFFYFPEM 120

EITIPTSNPV TPKPPLFSTL LYSLVPIMLI AGIVLLSFWM YRHHKLAYPP VLVPTQDPGP 180

PPPSPLLGLK PLQLLEIKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 240

MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLTDFLK ANVVSWNELC HIAETMARGL 300

AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 360

GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 420

QHPSLEDMQE VVVHKKKRPI LRECWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERII 480

QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL 513

Nucleotide Sequence
(FASTA)

ATGGGAGCCG CTGCAAAGTT GGCGTTTGCT GTCTTTCTTA TCTCTTGTTC TTCAGGTGCT 60

ATACTTGGCA GATCAGAAAC ACAGGAGTGC ATCTTCTATA ATGCTAATTG GGAAAAAGAT 120

AGAACTAATC GTACTGGTGT TGAACCTTGT TATGGTGACA AAGATAAAAG ACGACACTGC 180

TTTGCAACCT GGAAAAATAT TTCTGGCTCA ATTGAAATAG TAAAGCAAGG TTGTTGGTTG 240

GATGATATTA ACTGTTATGA CAGGAATGAT TGTGTTGAAA AAAAGGACAA CCCTGAAGTG 300

TATTTCTGTT GCTGTGAAGG CAATATGTGC AATGAAAGGT TTTTCTATTT TCCGGAGATG 360

GAGATCACAA TACCAACTTC CAATCCAGTT ACACCCAAGC CACCCTTGTT CAGCACCTTG 420

CTTTACTCAT TGGTACCCAT CATGCTAATT GCAGGAATTG TGCTGCTTTC ATTTTGGATG 480

TACAGGCATC ACAAGTTAGC ATACCCTCCT GTACTTGTTC CAACTCAAGA TCCAGGACCA 540

CCCCCACCCT CTCCATTACT AGGCTTGAAG CCCTTACAGT TATTGGAAAT AAAAGCTAGG 600

GGGAGATTTG GTTGTGTCTG GAAAGCTCAG TTACTCAATG AGTATGTGGC TGTTAAAATC 660

TTTCCAATAC AGGACAAACA GTCATGGCAA AATGAATATG AAGTATATAG TCTTCCTGGA 720

ATGAAACATG AGAATATATT GCAATTTATT GGTGCAGAAA AAAGAGGCAC CAGTGTTGAT 780

GTTGACCTCT GGCTAATCAC AGCATTTCAC GAAAAGGGTT CATTAACTGA CTTTCTCAAA 840

GCCAATGTGG TTTCTTGGAA TGAATTGTGC CATATTGCTG AAACTATGGC CAGAGGGTTG 900

GCATATTTAC ATGAAGATAT ACCTGGTTTA AAAGATGGTC ACAAACCTGC CATATCACAC 960

AGGGACATCA AAAGCAAAAA TGTGTTGTTG AAAAACAATC TCACAGCTTG TATTGCTGAC 1020

TTTGGTTTGG CATTAAAATT TGAGGCAGGG AAGTCTGCAG GTGATACCCA TGGACAGGTT 1080

GGTACCCGAA GGTATATGGC TCCAGAAGTT TTAGAGGGTG CTATAAACTT TCAAAGGGAT 1140

GCATTTTTGA GAATAGACAT GTATGCCATG GGATTAGTAC TGTGGGAACT TGCCTCCCGC 1200

TGCACTGCTG CAGATGGTCC CGTGGATGAG TACATGTTGC CATTTGAAGA GGAAATTGGC 1260

CAGCATCCAT CCCTTGAAGA TATGCAGGAA GTTGTCGTGC ATAAAAAAAA GAGACCTATT 1320

TTAAGGGAGT GTTGGCAGAA ACATGCTGGA ATGGCAATGC TCTGTGAAAC AATAGAAGAA 1380

TGTTGGGATC ACGATGCAGA AGCCAGGTTA TCAGCTGGCT GTGTAGGAGA AAGGATTATT 1440

CAAATGCAAA GACTAACAAA TATTATCACA ACAGAGGACA TTGTGACTGT GGTCACTATG 1500

GTGACAAACG TTGACTTTCC TCCCAAAGAA TCCAGTCTAT GA 1542

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E e+y+++ ++henilqfi+

Q: 192   LQLLEIKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIG  251

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++ ++l+l+t++hekgsL+d+Lk+++++++el+++a+++a+Gla+LHe+i+g k

Q: 252   AEKRGTSVDVDLWLITAFHEKGSLTDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK  311

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kpai+HRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPE

Q: 312   DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE  369

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ +af r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee++g++Psle+m

Q: 370   VLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDM  428

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         +evvv+kk+rP ++e w+k++ +++l++++eecWd+d+eaRl+a +v +r

Q: 429   QEVVVHKKKRPILRECWQKHAGMAMLCETIEECWDHDAEARLSAGCVGER  478

         ***********************************************987

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL LNEYVAVKIF PIQDKQSWQN EYEVYSLPGM KHENILQFIG 60

AEKRGTSVDV DLWLITAFHE KGSLTDFLKA NVVSWNELCH IAETMARGLA YLHEDIPGLK 120

DGHKPAISHR DIKSKNVLLK NNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAMG LVLWELASRC TAADGPVDEY MLPFEEEIGQ HPSLEDMQEV 240

VVHKKKRPIL RECWQKHAGM AMLCETIEEC WDHDAEARLS AGCVGER 287

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005737	; C:cytoplasm
GO:0034673	; C:inhibin-betaglycan-ActRII complex
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0015026	; F:coreceptor activity
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0030509	; P:BMP signaling pathway
GO:0007368	; P:determination of left/right symmetry
GO:0048706	; P:embryonic skeletal system development
GO:0001702	; P:gastrulation with mouth forming second
GO:0007498	; P:mesoderm development
GO:0043084	; P:penile erection
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030510	; P:regulation of BMP signaling pathway
GO:0050999	; P:regulation of nitric-oxide synthase activity
GO:0060011	; P:Sertoli cell proliferation
GO:0023014	; P:signal transduction by phosphorylation
GO:0042713	; P:sperm ejaculation
GO:0007283	; P:spermatogenesis

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013