EKS-MOD-00062

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00062

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	371.8	2.2E-111	39	323	285

Status

Unreviewed

Ensembl Protein

ENSMODP00000004283

UniProt Accession

F7C8L6;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK10

Gene Synonyms/Alias

CDK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000003504	ENSMODP00000004283	ENSMODT00000004373

Organism

Monodelphis domestica

Functional Description

Protein Length

367

Protein Sequence
(FASTA)

MGDPEPESEQ IRLKCIRREG FFTVPPEDRL GQCRSVKEFE KLNRIGEGTY GIVYRARDTQ 60

TDEIVALKKV RMDKEKDGIP ISSLREITLL LRLRHPNIVE LKEVVVGNHL ESIFLVMGYC 120

EQDLASLLEN MQTPFSEAQV KCIILQVLKG LQYLHKNFII HRDLKVSNLL MTDKGCVKTA 180

DFGLARAYGV PVKPMTPKVV TLWYRAPELL LGTATQTTSI DMWAVGCILA ELLAHKPLLP 240

GSSEIHQIDL IVQLLGTPNE NIWPGFSKLP LVSQYSLRKQ PYNNLKHKFP WLSEAGLRLL 300

NFLFMYDPKK RATAGDCLES SYFKEKPLPC EPELMPTFPH HRNKRAATST TANPGAEGQS 360

QSKRSKP 367

Nucleotide Sequence
(FASTA)

ATGGGGGACC CTGAACCGGA ATCGGAGCAG ATTCGCCTGA AATGCATACG ACGCGAAGGT 60

TTCTTCACGG TGCCGCCAGA GGATAGGCTG GGGCAATGCC GGAGTGTGAA GGAATTTGAA 120

AAGCTGAATC GAATTGGGGA AGGCACCTAT GGTATTGTAT ATCGTGCCCG AGACACCCAG 180

ACGGATGAAA TTGTGGCCTT GAAGAAGGTT CGGATGGACA AGGAGAAGGA TGGGATCCCC 240

ATTAGTAGCC TCCGGGAAAT CACACTGCTC CTTCGGCTTC GTCACCCCAA CATTGTGGAG 300

CTGAAGGAGG TCGTTGTGGG AAACCATCTG GAGAGCATCT TCCTGGTGAT GGGTTACTGT 360

GAGCAGGACC TTGCCAGCCT CCTGGAGAAC ATGCAGACGC CCTTCTCAGA GGCTCAGGTA 420

AAGTGCATCA TTTTGCAAGT CCTCAAAGGC CTTCAGTACC TTCACAAAAA CTTCATCATT 480

CACAGGGATT TAAAGGTTTC CAATTTGCTC ATGACAGATA AGGGCTGTGT TAAGACAGCC 540

GACTTTGGCC TGGCTCGAGC TTATGGTGTC CCTGTGAAGC CAATGACCCC CAAAGTGGTC 600

ACCCTCTGGT ACCGGGCCCC TGAACTCCTG CTGGGGACAG CCACGCAGAC GACTAGCATT 660

GACATGTGGG CCGTGGGCTG TATCCTGGCT GAGTTGTTGG CTCATAAGCC CCTCCTCCCG 720

GGCAGTTCTG AGATCCACCA GATTGACCTG ATCGTGCAGC TGCTCGGGAC CCCCAATGAG 780

AACATCTGGC CGGGCTTCTC CAAGCTGCCT CTGGTCAGCC AGTATAGCCT GAGGAAGCAG 840

CCCTACAACA ACCTCAAACA CAAGTTCCCC TGGCTCTCTG AGGCCGGCCT GCGCCTGCTC 900

AACTTCCTCT TTATGTATGA CCCAAAGAAG AGGGCCACGG CTGGCGATTG CTTGGAAAGC 960

TCCTACTTCA AAGAGAAGCC CTTGCCTTGT GAGCCTGAGC TCATGCCCAC CTTCCCTCAT 1020

CACCGGAACA AGAGGGCTGC CACAAGCACC ACCGCCAACC CGGGGGCTGA GGGCCAGAGC 1080

CAGAGCAAGC GCAGCAAGCC CTGA 1104

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         +ekl++igeGtyg vy+a+d++t+e+vAlKk+r++kek+g+pi++lrEi+ll +l+h+ni

Q: 39    FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNI  98

         89**********************************************************

S: 61    vkLlevvakdk.kklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsn  119

         v+L+evv+ ++ ++++Lv+ ++eqdL++ll+++++  +s+++vk ++lq+l+gl+ylH+n

Q: 99    VELKEVVVGNHlESIFLVMGYCEQDLASLLENMQT-PFSEAQVKCIILQVLKGLQYLHKN  157

         ********5555**********************9.************************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

          i+HRDlK +NlL++++g++k aDfGlara+++p+k +t++vvTlwYraPelLlg+ + +

Q: 158   FIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTATQT  217

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksf  238

         t++D+W+vgcilaell++kpl++g+sei+q++ i++llgtp+e++wp++sklp ++ +s+

Q: 218   TSIDMWAVGCILAELLAHKPLLPGSSEIHQIDLIVQLLGTPNENIWPGFSKLPLVSqYSL  277

         ********************************************************88**

S: 239   pkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +k+++++lk+k++ l+e++l+ll+ l+++dpkkR +a ++l+++yf

Q: 278   RKQPYNNLKHKFPWLSEAGLRLLNFLFMYDPKKRATAGDCLESSYF  323

         *********************************************8

Domain Sequence
(FASTA)

FEKLNRIGEG TYGIVYRARD TQTDEIVALK KVRMDKEKDG IPISSLREIT LLLRLRHPNI 60

VELKEVVVGN HLESIFLVMG YCEQDLASLL ENMQTPFSEA QVKCIILQVL KGLQYLHKNF 120

IIHRDLKVSN LLMTDKGCVK TADFGLARAY GVPVKPMTPK VVTLWYRAPE LLLGTATQTT 180

SIDMWAVGCI LAELLAHKPL LPGSSEIHQI DLIVQLLGTP NENIWPGFSK LPLVSQYSLR 240

KQPYNNLKHK FPWLSEAGLR LLNFLFMYDP KKRATAGDCL ESSYF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

mdo:100027293

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013