EKS-MOD-00079
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00079
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Musk599.11.4E-180580860281
StatusUnreviewed
Ensembl ProteinENSMODP00000004898
UniProt AccessionF7F8Z2;
Protein Name
Protein Synonyms/Alias
Gene NameMUSK
Gene Synonyms/Alias MUSK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000003983ENSMODP00000004898ENSMODT00000005002
OrganismMonodelphis domestica
Functional Description
Protein Length874
Protein Sequence
(FASTA)
MKELAHIPVV HILALAAFSL AEKLPKAPII TTPLETVDAL VEEVATFMCA VESYPQPEIA 60
WTRNKILIKL SDTRYSIREN GQLLTILSVE DSDDGVYCCT ANNGVGVAAE SCGALQVKMK 120
PKITRPPINV KIIEGLKAVL PCTTMGNPKP SVSWIKGDTI LRENTRIAIL ESGSLRIHNV 180
QREDAGHYRC VAKNSLGTAY SKLVMLEVEV FARILRAPES HNVTFGSIVT LRCTATGIPV 240
PTITWLENGN AVSAGSILES VKDRVIDSQL QLLITKPGLF TCIATNKHGE KFSTVKAAAT 300
ISISGYIFGT KYKLPQEDPG YCSTYRGEVC GAVLAKDALV FYNSSYQDSG DAQELLVQTI 360
WSDLKALSPL CQPAMESLLC NHIFQGCNPA RFMPTPKPLC REHCLAVKDL FCAKEWLALE 420
EKAHKGLYKS GLHLFTLPEC TKLPSMHREP MACTKVPHLE KYNKKTNNEF TPLVTVKPSA 480
DIPDWSSSSS TFSPTYSMTV IIAIISSFAV IGFLTMTALL CCRQRRRQWK NKKRESATPT 540
LTTLPSELLL DRLHPNPMYQ RMPLLLNPKL LSLEYPRNNI EYVRDIGEGA FGRVFQARAP 600
GLRPYEPFTM VAVKMLKEEA SADMQADFQR EAALMAEFDH PNIVRLLGVC AVGKPMCLLF 660
EYMAYGDLNE YLRNMSPRTM CHLSHSNLAT RVRLSSPGPP PLCCAEQLCI ARQVAAGMAY 720
LSERKFVHRD LATRNCLVGN NMVVKIADFG LSRNIYSADY YKANENDAIP IRWMPPESIF 780
YNRYTTESDV WAYGVVLWEI FSYGLQPYYG MAHEEVIFYV RDGNILSCPE NCPLELYNLM 840
RLCWSKLPTD RPSFTSIHRI LQRMCERAEA AVGV 874
Nucleotide Sequence
(FASTA)
ATGAAAGAGC TAGCCCACAT TCCAGTCGTA CACATCCTTG CCCTGGCTGC CTTCAGCCTG 60
GCTGAGAAAC TTCCAAAAGC TCCTATCATC ACCACTCCTC TTGAAACAGT AGATGCATTA 120
GTTGAAGAAG TGGCCACCTT TATGTGTGCA GTAGAGTCCT ATCCCCAGCC TGAGATTGCC 180
TGGACTCGCA ATAAAATTCT CATCAAACTC TCTGATACTC GCTATAGCAT TCGAGAGAAT 240
GGACAGCTTC TCACCATCCT CAGTGTGGAA GACAGCGATG ATGGTGTGTA CTGCTGCACT 300
GCCAACAATG GGGTAGGAGT GGCTGCGGAG AGCTGTGGAG CTTTGCAAGT AAAAATGAAA 360
CCTAAAATAA CACGTCCTCC TATCAATGTA AAAATAATAG AGGGATTAAA GGCAGTCTTG 420
CCATGTACTA CAATGGGCAA TCCCAAGCCT TCAGTATCAT GGATCAAAGG AGACACAATA 480
CTCAGGGAAA ATACCCGAAT TGCAATTCTT GAATCTGGGA GTTTAAGAAT TCACAATGTT 540
CAACGGGAAG ATGCAGGACA TTACCGATGT GTGGCCAAAA ATAGTCTTGG GACAGCATAT 600
TCCAAACTAG TCATGCTGGA AGTAGAAGTG TTTGCCAGAA TTCTGCGGGC TCCTGAATCC 660
CACAATGTCA CCTTTGGCTC CATAGTGACC CTGCGCTGTA CTGCAACAGG CATTCCAGTT 720
CCTACTATCA CATGGCTTGA AAATGGAAAT GCTGTGTCTG CCGGGTCCAT TCTAGAAAGT 780
GTGAAAGACC GAGTGATTGA TTCCCAGCTA CAGCTGCTGA TCACCAAGCC TGGCCTGTTC 840
ACTTGCATCG CCACCAACAA GCACGGGGAG AAATTCAGCA CCGTGAAGGC TGCAGCCACC 900
ATCAGCATAT CAGGATATAT ATTTGGAACA AAATATAAAC TGCCCCAAGA AGATCCAGGC 960
TACTGCAGTA CCTACAGAGG GGAGGTTTGT GGTGCTGTCT TGGCAAAGGA TGCCCTTGTT 1020
TTCTACAACT CCTCCTATCA GGACTCAGGG GATGCTCAAG AGCTTCTTGT TCAAACCATC 1080
TGGAGTGACT TGAAGGCACT GAGTCCACTC TGCCAGCCAG CTATGGAGTC CCTGCTCTGT 1140
AACCACATCT TCCAGGGGTG CAACCCTGCT AGATTTATGC CAACTCCTAA ACCTTTATGC 1200
AGAGAGCACT GCCTGGCTGT AAAGGACCTT TTCTGCGCAA AAGAATGGTT GGCACTAGAA 1260
GAAAAAGCCC ACAAAGGCCT GTATAAATCT GGATTGCATC TGTTCACCTT GCCTGAGTGT 1320
ACCAAGCTTC CCAGCATGCA CAGGGAGCCC ATGGCTTGTA CAAAAGTGCC ACATTTAGAG 1380
AAATATAATA AAAAGACTAA TAATGAATTC ACCCCACTGG TAACAGTCAA GCCAAGTGCA 1440
GACATTCCAG ATTGGTCTTC TTCCTCATCT ACATTTTCAC CTACCTATTC AATGACTGTC 1500
ATCATCGCCA TCATCTCTAG CTTTGCAGTG ATTGGCTTTC TCACCATGAC TGCTCTCCTT 1560
TGTTGCCGCC AAAGGCGAAG ACAGTGGAAA AATAAGAAGA GGGAATCTGC AACGCCCACA 1620
CTTACAACTC TCCCTTCTGA ACTCTTGCTG GATAGACTTC ACCCCAACCC TATGTACCAG 1680
CGCATGCCAC TTCTTCTGAA CCCCAAACTT CTCAGCCTGG AGTATCCAAG AAATAATATT 1740
GAATATGTGA GAGATATTGG AGAAGGGGCA TTTGGAAGAG TCTTCCAAGC AAGAGCTCCT 1800
GGCCTACGAC CTTATGAGCC TTTCACCATG GTGGCAGTAA AGATGCTCAA AGAAGAAGCC 1860
TCAGCAGACA TGCAAGCAGA TTTCCAGAGG GAGGCAGCCC TGATGGCAGA GTTTGATCAT 1920
CCGAATATTG TTAGACTACT AGGAGTATGT GCTGTTGGTA AGCCGATGTG CTTGCTGTTC 1980
GAGTATATGG CCTATGGGGA CCTTAATGAG TATCTCCGGA ACATGTCACC TCGGACCATG 2040
TGCCACCTCA GCCACAGTAA CCTGGCTACC AGGGTCCGCC TTTCCAGTCC TGGGCCCCCA 2100
CCCCTGTGTT GTGCTGAGCA GCTCTGTATT GCAAGGCAGG TAGCCGCTGG CATGGCTTAC 2160
CTCTCAGAGC GCAAGTTTGT CCATCGGGAC TTAGCCACCA GAAATTGCCT AGTGGGTAAT 2220
AATATGGTGG TGAAAATTGC TGACTTTGGC CTCTCCAGGA ACATCTACTC AGCAGACTAT 2280
TACAAAGCCA ATGAGAATGA CGCTATCCCC ATCCGCTGGA TGCCTCCGGA GTCCATTTTC 2340
TACAACCGTT ACACAACAGA GTCTGATGTC TGGGCTTATG GGGTGGTCCT ATGGGAGATA 2400
TTCTCCTATG GCTTGCAGCC CTACTATGGG ATGGCACACG AGGAGGTGAT TTTCTACGTA 2460
AGGGATGGCA ACATCCTCTC CTGCCCTGAG AATTGCCCTC TAGAGCTCTA CAACCTGATG 2520
CGTCTCTGTT GGAGCAAGCT GCCCACAGAC AGACCCAGCT TCACTAGTAT TCATCGCATT 2580
CTACAACGCA TGTGCGAGAG AGCAGAGGCA GCGGTGGGTG TCTGA 2625
Domain Profile
S: 1     ieyvrdlgegafgrvfqarapgllpyeefllvavkmlkeeasadmqadfereaallaefd  60
         ieyvrd+gegafgrvfqarapgl pye+f++vavkmlkeeasadmqadf+reaal+aefd
Q: 580   IEYVRDIGEGAFGRVFQARAPGLRPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFD  639
         89**********************************************************
S: 61    npnivkllgvcavgkpmcllfeymaygdlneflrslspytvcslshsdlslraqvsspdr  120
         +pniv+llgvcavgkpmcllfeymaygdlne+lr +sp t+c lshs+l++r + ssp++
Q: 640   HPNIVRLLGVCAVGKPMCLLFEYMAYGDLNEYLRNMSPRTMCHLSHSNLATRVRLSSPGP  699
         ************************************************************
S: 121   lplseaellciarqvaagmaylserkfvhrdlatrnclvgetmvvkiadfglsrkiysad  180
         +pl +ae+lciarqvaagmaylserkfvhrdlatrnclvg++mvvkiadfglsr+iysad
Q: 700   PPLCCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGNNMVVKIADFGLSRNIYSAD  759
         ************************************************************
S: 181   yykadendaipirwmplesilynrytlesdvwaygvvlweifsyalqpyyglaheeviky  240
         yyka+endaipirwmp+esi+ynryt+esdvwaygvvlweifsy+lqpyyg+aheevi y
Q: 760   YYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIFY  819
         ************************************************************
S: 241   vrdgnilacpentplelyalmrlcwsklpadrpsfasihri  281
         vrdgnil+cpen+plely+lmrlcwsklp+drpsf+sihri
Q: 820   VRDGNILSCPENCPLELYNLMRLCWSKLPTDRPSFTSIHRI  860
         ***************************************98
Domain Sequence
(FASTA)
IEYVRDIGEG AFGRVFQARA PGLRPYEPFT MVAVKMLKEE ASADMQADFQ REAALMAEFD 60
HPNIVRLLGV CAVGKPMCLL FEYMAYGDLN EYLRNMSPRT MCHLSHSNLA TRVRLSSPGP 120
PPLCCAEQLC IARQVAAGMA YLSERKFVHR DLATRNCLVG NNMVVKIADF GLSRNIYSAD 180
YYKANENDAI PIRWMPPESI FYNRYTTESD VWAYGVVLWE IFSYGLQPYY GMAHEEVIFY 240
VRDGNILSCP ENCPLELYNL MRLCWSKLPT DRPSFTSIHR I 281
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00073
EKS-ANC-00070
EKS-BOT-00079
EKS-CAJ-00080
EKS-CAP-00079
EKS-DAR-00333
EKS-DRM-00037
EKS-EQC-00077
EKS-FEC-00076
EKS-GAG-00063
EKS-GAA-00097
EKS-GOG-00078
EKS-HOS-00081
EKS-ICT-00074
EKS-LAC-00084
EKS-LOA-00078
EKS-MAM-00078
EKS-MEG-00059
EKS-MUM-00082
EKS-MUP-00082
EKS-MYL-00087
EKS-NOL-00075
EKS-ORN-00106
EKS-ORA-00065
EKS-ORC-00074
EKS-ORL-00098
EKS-OTG-00083
EKS-PAT-00071
EKS-PES-00069
EKS-PEM-00043
EKS-POA-00076
EKS-RAN-00075
EKS-SAH-00075
EKS-TAG-00114
EKS-TAR-00112
EKS-TEN-00104
EKS-XET-00074
EKS-XIM-00101
Gene Ontology
GO:0016021; C:integral to membrane
GO:0031594; C:neuromuscular junction
GO:0005886; C:plasma membrane
GO:0045211; C:postsynaptic membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043525; P:positive regulation of neuron apoptotic process
GO:2000541; P:positive regulation of protein geranylgeranylation
GO:0001934; P:positive regulation of protein phosphorylation
GO:0008582; P:regulation of synaptic growth at neuromuscular junction
GO:0006355; P:regulation of transcription, DNA-dependent
GO:0071340; P:skeletal muscle acetylcholine-gated channel clustering
KEGG
InterPros
IPR020067; Frizzled_dom.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF01392; Fz; 1.
PF07679; I-set; 3.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50038; FZ; 1.
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013