EKS-MOD-00146

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00146

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	560.5	5.2E-169	314	590	277

Status

Unreviewed

Ensembl Protein

ENSMODP00000005261

UniProt Accession

F6TEU5;

Protein Name

Protein Synonyms/Alias

Gene Name

FGFR3

Gene Synonyms/Alias

FGFR3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000004268	ENSMODP00000005261	ENSMODT00000005374

Organism

Monodelphis domestica

Functional Description

Protein Length

654

Protein Sequence
(FASTA)

MDKKLLAVPA ANTVRFRCPA AGNPTPSIYW LKNGREFKGE HRIGGIKLRH QQWSLVMESV 60

VPSDRGNYTC VVENKYGSIQ QTYTLDVLER SPHRPILQAG LPANQTVVVG SNVEFHCKVY 120

SDAQPHIQWL KHVEVNGSKY GPDGTPYVTV LKTAGVNTTD KELEILYLRN VTFEDAGEYT 180

CLAGNSIGFS HHSAWLMVLP AEAMVEEDDS GSVFAGLLSY GLGFCLFIVV VAVAVAICRL 240

KMPSKKAINT PTVQKVSKFP LKRQVSLESN SSMNSNTPLV RIARLSSSEG PMLANVSELE 300

LPADPKWELC RSRLTLGKPL GEGCFGQVVM AEAIGIDKDK PNKPVTVAVK MLKDDATDKD 360

LSDLVSEMEM MKMIGKHKNI INLLGACTQD GPLYVLVEYA SKGNLREYLR ARRPPGMDYS 420

FDTCKLPEEQ LTFKDLVSCA YQVARGMEYL ASQKCIHRDL AARNVLVTED SVMKIADFGL 480

ARDVHNIDYY KKTTNGRLPV KWMAPEALFD RVYTHQSDVW SFGVLLWEIF TLGGSPYPGI 540

PVEELFKLLK EGHRMDKPAN CTHDLYMIMR ECWHAVPSQR PTFKQLVEDL DRVLTVTSTD 600

EYLDLSVPFE QYSPTCQDSH STCSSGDDSV FAHDLLPEEP CLPKAPKCNG ALRT 654

Nucleotide Sequence
(FASTA)

ATGGATAAAA AACTCCTGGC AGTCCCTGCA GCCAATACTG TCCGCTTCCG GTGTCCAGCT 60

GCCGGCAATC CCACCCCATC CATCTACTGG CTGAAGAATG GCCGAGAATT CAAAGGAGAG 120

CATCGGATTG GGGGCATCAA GCTGAGACAC CAGCAGTGGA GTCTGGTCAT GGAGAGTGTG 180

GTGCCCTCAG ACCGAGGGAA CTATACCTGC GTGGTGGAGA ATAAATATGG CAGCATACAG 240

CAGACCTACA CGCTGGACGT CCTGGAGAGA TCCCCACACC GGCCCATTCT GCAGGCCGGC 300

CTCCCAGCCA ATCAGACCGT TGTTGTGGGG AGCAATGTGG AATTCCACTG TAAGGTGTAC 360

AGTGATGCTC AGCCCCATAT ACAGTGGCTG AAACACGTGG AAGTAAATGG CAGCAAGTAT 420

GGCCCGGATG GGACACCCTA TGTCACCGTC CTCAAGACAG CAGGAGTTAA CACAACGGAT 480

AAGGAACTAG AAATTCTCTA TTTGCGCAAT GTCACCTTTG AGGATGCCGG GGAGTATACT 540

TGTCTTGCTG GGAATTCTAT TGGGTTCTCA CACCATTCTG CTTGGCTGAT GGTTCTCCCA 600

GCCGAAGCGA TGGTGGAAGA GGACGACTCG GGCAGCGTCT TCGCTGGCCT CCTCAGCTAT 660

GGGCTTGGCT TTTGTCTCTT CATTGTGGTG GTGGCAGTGG CCGTCGCCAT ATGTCGGCTG 720

AAGATGCCCT CCAAGAAGGC CATCAACACC CCCACCGTTC AGAAGGTGTC CAAGTTCCCA 780

CTCAAGCGAC AGGTGTCCCT GGAGTCGAAC TCGTCCATGA ATTCCAACAC CCCGCTGGTG 840

AGAATCGCCC GCCTCTCCTC CAGCGAGGGG CCCATGCTGG CCAACGTGTC CGAGCTCGAG 900

CTCCCCGCCG ATCCCAAGTG GGAGCTGTGC CGATCTCGGC TTACCCTGGG AAAACCTCTT 960

GGTGAAGGCT GTTTTGGCCA AGTGGTAATG GCGGAAGCCA TCGGCATCGA CAAAGACAAG 1020

CCCAACAAAC CCGTGACCGT TGCCGTGAAG ATGCTGAAAG ATGATGCCAC AGACAAGGAC 1080

CTGTCCGACT TGGTCTCTGA AATGGAAATG ATGAAGATGA TTGGAAAACA CAAAAACATC 1140

ATTAACTTGT TGGGAGCCTG CACCCAGGAT GGTCCCCTCT ACGTCCTCGT GGAATATGCA 1200

TCCAAGGGGA ATCTTCGTGA GTATCTGCGG GCCCGGAGAC CTCCAGGGAT GGATTACTCC 1260

TTCGATACCT GCAAGCTCCC AGAAGAACAA CTGACCTTCA AGGACCTGGT GTCCTGTGCC 1320

TACCAGGTGG CCCGGGGCAT GGAGTACTTG GCATCCCAGA AGTGCATTCA CAGGGACCTG 1380

GCTGCTCGAA ATGTGCTAGT AACAGAAGAC AGCGTGATGA AGATTGCAGA CTTTGGCCTG 1440

GCCAGAGACG TGCACAACAT TGACTACTAC AAGAAAACAA CCAATGGGCG GCTGCCTGTG 1500

AAGTGGATGG CTCCAGAAGC CTTGTTTGAC CGGGTGTACA CTCACCAGAG TGATGTCTGG 1560

TCTTTTGGCG TCCTGCTTTG GGAGATCTTT ACCCTAGGAG GCTCCCCCTA CCCTGGGATT 1620

CCCGTAGAGG AGCTCTTCAA GTTGTTAAAA GAGGGCCATC GAATGGACAA ACCTGCCAAC 1680

TGCACCCATG ATCTATACAT GATCATGCGT GAGTGCTGGC ATGCAGTCCC GTCCCAGCGA 1740

CCCACCTTCA AGCAGCTCGT GGAAGACTTG GACCGGGTCC TCACCGTCAC ATCAACAGAT 1800

GAGTACCTGG ACCTGTCTGT CCCCTTTGAA CAATACTCCC CCACCTGCCA GGACAGCCAC 1860

AGCACCTGCT CCTCCGGAGA CGACTCAGTG TTTGCCCATG ACCTGCTGCC GGAGGAGCCC 1920

TGCCTCCCCA AGGCCCCAAA GTGTAACGGC GCCCTCAGGA CGTGA 1965

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aeaig+dkdk++k vtvavkmlk+datdkdl+dlvseme++k+

Q: 314   LTLGKPLGEGCFGQVVMAEAIGIDKDKPNKPVTVAVKMLKDDATDKDLSDLVSEMEMMKM  373

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyv+veya+kGnlre+lrarrp+g+++s d++k +eeqlt+

Q: 374   IGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKLPEEQLTF  433

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylas+kcihrdlaarnvlvted+v+kiadfGlardvh+idyykkt

Q: 434   KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDSVMKIADFGLARDVHNIDYYKKT  493

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvllwei+tlGgspypgi+veelfkllkeGh

Q: 494   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH  553

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kpa+ct++ly++mrecwha++s+rptfkqlvedl

Q: 554   RMDKPANCTHDLYMIMRECWHAVPSQRPTFKQLVEDL  590

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA IGIDKDKPNK PVTVAVKMLK DDATDKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVLVEYASKG NLREYLRARR PPGMDYSFDT CKLPEEQLTF 120

KDLVSCAYQV ARGMEYLASQ KCIHRDLAAR NVLVTEDSVM KIADFGLARD VHNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPANCTH DLYMIMRECW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 2.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013