EKS-MOD-00273

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00273

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	454.3	1.7E-136	197	484	288

Status

Unreviewed

Ensembl Protein

ENSMODP00000005434

UniProt Accession

F6SV50;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1C

Gene Synonyms/Alias

ACVR1C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000004411	ENSMODP00000005434	ENSMODT00000005551

Organism

Monodelphis domestica

Functional Description

Protein Length

495

Protein Sequence
(FASTA)

MTRALHFALH QALVLFAIAA SLSAGLKCVC LLCEYSNFTC QTEGACWTSV MLTNGREEVI 60

KSCVSLPELN AQVFCHSSNN ITKTECCFTD FCNNITLHLP AAAASPKLQK LGPVELTIII 120

TVPVCLLSIA AMLTICTCQG RQCTYKKKKR QNVEEPLNEC NLVNAGKTLK DLICDMTTSG 180

SGSGLPLLVQ RTIARTIVLQ EIVGKGRFGE VWHGRWCGED VAVKIFSSRD ERSWFREAEI 240

YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSEYHEQGSL YDYLNRNTVT VDGMVRLALS 300

VASGLAHLHM EIVGTQGKPA IAHRDLKSKN ILVKKCEACA IADLGLAVKH DSALNTIDIP 360

QNPRVGTKRY MAPEVLDDTM NMNIFESFKR SDIYSLGLVY WEIARRCSVG GITEEYQLPF 420

YDMVPSDPSI EDMRKVVCDQ KYRPNIPNQW QSCEALRVMG RIMRECWYAN GAARLTALRI 480

KKTISQLCVK EDSKV 495

Nucleotide Sequence
(FASTA)

ATGACCCGGG CGCTCCACTT CGCGCTCCAC CAGGCTCTGG TGCTCTTCGC CATCGCCGCC 60

TCTCTCTCTG CAGGACTGAA GTGTGTGTGT CTGTTATGTG AATATTCAAA CTTTACCTGC 120

CAAACTGAAG GGGCATGTTG GACCTCAGTC ATGCTAACAA ATGGTAGAGA AGAGGTGATC 180

AAATCCTGTG TCTCCCTTCC AGAGCTCAAT GCTCAAGTCT TCTGTCACAG CTCTAACAAC 240

ATTACAAAGA CTGAATGCTG CTTCACAGAT TTTTGCAACA ATATTACCCT ACACCTCCCA 300

GCAGCTGCAG CATCTCCCAA ACTGCAAAAA CTAGGACCAG TGGAGCTGAC CATAATTATT 360

ACCGTGCCAG TATGCCTTTT GTCCATTGCT GCAATGTTGA CTATATGTAC CTGTCAAGGA 420

CGTCAATGTA CTTATAAAAA GAAAAAGAGG CAAAATGTGG AAGAACCATT AAATGAATGC 480

AACTTAGTAA ATGCTGGCAA AACTCTTAAA GATCTTATTT GTGATATGAC TACATCTGGG 540

TCTGGATCTG GTTTACCTTT ATTGGTCCAG AGGACAATTG CAAGGACAAT CGTACTTCAG 600

GAAATAGTAG GAAAAGGTAG ATTTGGTGAA GTCTGGCATG GCAGGTGGTG TGGGGAAGAT 660

GTGGCTGTGA AAATATTCTC ATCAAGAGAT GAAAGGTCTT GGTTTCGGGA GGCAGAAATC 720

TACCAAACAG TTATGCTGAG ACATGAAAAC ATCCTTGGTT TCATTGCTGC TGATAATAAA 780

GATAATGGAA CTTGGACTCA GTTGTGGCTT GTATCTGAAT ACCATGAGCA GGGCTCTTTA 840

TATGACTATT TAAATAGAAA CACAGTTACA GTGGATGGTA TGGTCCGTTT GGCACTGTCA 900

GTAGCCAGTG GTCTGGCCCA TCTACATATG GAGATAGTTG GTACCCAAGG CAAACCTGCA 960

ATTGCTCATC GAGATCTAAA ATCAAAGAAT ATTTTAGTGA AAAAATGTGA AGCCTGTGCC 1020

ATTGCAGACT TAGGACTAGC TGTGAAGCAT GATTCAGCCC TGAACACAAT TGACATCCCT 1080

CAAAATCCCA GAGTTGGAAC AAAGAGGTAT ATGGCTCCTG AAGTACTTGA TGACACAATG 1140

AATATGAATA TCTTTGAGTC CTTTAAACGT TCTGATATAT ATTCTCTTGG TCTTGTGTAT 1200

TGGGAGATAG CACGGAGATG TTCAGTTGGA GGAATCACTG AGGAGTACCA ATTGCCTTTC 1260

TATGACATGG TGCCTTCAGA TCCCTCAATA GAAGACATGC GGAAAGTTGT TTGTGACCAG 1320

AAATATAGAC CAAATATTCC AAACCAGTGG CAAAGCTGTG AGGCACTCCG GGTAATGGGT 1380

AGAATAATGA GGGAGTGTTG GTATGCAAAT GGGGCAGCTC GCCTGACAGC TCTGCGTATT 1440

AAGAAGACCA TTTCTCAACT CTGTGTAAAA GAAGACTCCA AAGTATAA 1488

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e++gkGr+geVw++++ ge+vAvKifs++de+sw+rE+eiyqtv+lrhenil+fia

Q: 197   IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA  256

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv+eyhe+gsL+dyL+r+t++v+ ++rlals+asGlahLH+eivgt+

Q: 257   ADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNTVTVDGMVRLALSVASGLAHLHMEIVGTQ  316

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk ++c+iaDlGLa+k++++ +++d+ +n +vGtkRYmaPE

Q: 317   G--KPAIAHRDLKSKNILVKKCEACAIADLGLAVKHDSALNTIDIPQNPRVGTKRYMAPE  374

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n++ fe+fkr D+YslgLv+WE+a+Rc+  ++++eey+lpf+++v+sdPs+e+m

Q: 375   VLDDTMNMNIFESFKRSDIYSLGLVYWEIARRCSV-GGITEEYQLPFYDMVPSDPSIEDM  433

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++k rP+ip++w+++eal+++ ++++ecW+a+++aRltalr+kk++

Q: 434   RKVVCDQKYRPNIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTI  484

         ************************************************986

Domain Sequence
(FASTA)

IVLQEIVGKG RFGEVWHGRW CGEDVAVKIF SSRDERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSEYHE QGSLYDYLNR NTVTVDGMVR LALSVASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKC EACAIADLGL AVKHDSALNT IDIPQNPRVG TKRYMAPEVL 180

DDTMNMNIFE SFKRSDIYSL GLVYWEIARR CSVGGITEEY QLPFYDMVPS DPSIEDMRKV 240

VCDQKYRPNI PNQWQSCEAL RVMGRIMREC WYANGAARLT ALRIKKTI 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013