EKS-MOD-00275

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00275

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	447.1	2.8E-134	258	545	288

Status

Unreviewed

Ensembl Protein

ENSMODP00000005457

UniProt Accession

F6SCC5;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1

Gene Synonyms/Alias

ACVR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000004431	ENSMODP00000005457	ENSMODT00000005575

Organism

Monodelphis domestica

Functional Description

Protein Length

559

Protein Sequence
(FASTA)

MTLNLSLLLL GPLFHLREKQ KVLLYAGHCI KPFTDLSLDL YNNPENCTML DGVMILPVLM 60

MITFPSPSVE DEEPKLNSNL YMCVCEGTSC GNRDHCEGQQ CFASLSINDG VQVYQKGCFQ 120

VYEQGKMTCK TPPSPDQAVE CCQGNWCNGN ITAQLPTSKG KSFPGAYSRF SLDYVAIFIG 180

LSIAACLFII LLVVGIRKFK KRNQERLNPR EVEYGTIDGL ITTNVGDSTL ADLMDHSCTS 240

GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGHWQGE NVAVKIFSSR DEKSWFRETE 300

LYNTVLLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL DTVSCLRIVL 360

SIASGLAHLH IEIFGTQGKP AISHRDLKSK NILVKKNGQC CIADLGLAVI HSQTNNHLDV 420

GNNPRVGTKR YMAPEVLDET IQVNCFDSYK RVDIWAFGLV LWEVARRMVS NGIVEDYKPP 480

FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ NSSARLTALR 540

IKKTLTKIDN SLDKLKADC 559

Nucleotide Sequence
(FASTA)

ATGACCTTAA ACTTGTCACT TCTTCTCTTA GGGCCTCTGT TCCATCTGAG GGAGAAGCAG 60

AAAGTCCTAC TATATGCTGG ACACTGTATT AAGCCCTTTA CAGATCTCTC ACTTGATCTT 120

TACAACAATC CTGAGAATTG TACAATGTTA GATGGAGTTA TGATTCTGCC TGTTCTCATG 180

ATGATAACTT TCCCTTCTCC TAGTGTGGAA GATGAGGAAC CAAAGTTGAA TTCAAACCTG 240

TATATGTGTG TGTGTGAAGG CACATCCTGT GGGAATCGGG ATCACTGTGA GGGACAACAG 300

TGTTTTGCCT CATTGAGCAT AAACGATGGT GTTCAAGTCT ACCAGAAAGG ATGCTTCCAA 360

GTATATGAGC AGGGGAAGAT GACCTGTAAG ACTCCCCCAT CCCCTGATCA AGCTGTGGAG 420

TGCTGTCAGG GAAACTGGTG TAATGGAAAC ATTACAGCCC AGCTGCCAAC TTCAAAAGGG 480

AAATCCTTCC CAGGAGCATA TTCACGCTTC AGCCTGGATT ATGTGGCCAT CTTTATAGGT 540

CTCTCTATAG CAGCATGCCT TTTTATTATT CTACTGGTTG TGGGCATCCG GAAATTCAAA 600

AAACGCAATC AGGAACGGCT TAACCCTAGA GAAGTGGAAT ATGGCACCAT TGATGGACTC 660

ATCACTACAA ATGTTGGCGA TAGCACCTTA GCAGATTTAA TGGATCATTC TTGTACATCA 720

GGAAGTGGCT CTGGTCTTCC TTTTCTCGTA CAAAGAACTG TGGCTCGTCA GATTACACTA 780

TTGGAATGTG TAGGAAAAGG CCGATATGGA GAGGTGTGGC GGGGCCACTG GCAAGGAGAA 840

AATGTTGCAG TGAAGATATT CTCTTCCCGT GATGAGAAAT CTTGGTTCAG AGAAACAGAG 900

CTATATAACA CTGTATTACT AAGACATGAA AATATTCTAG GGTTCATTGC TTCAGATATG 960

ACATCAAGAC ACTCCAGTAC TCAGTTGTGG TTAATTACAC ATTACCATGA AATGGGATCA 1020

TTATATGACT ACCTGCAGCT CACTACTTTG GACACAGTTA GCTGTCTTCG AATTGTGCTG 1080

TCTATAGCTA GTGGTCTAGC ACATTTGCAC ATAGAGATAT TTGGGACTCA GGGGAAGCCA 1140

GCTATATCCC ACCGGGATTT AAAGAGCAAA AATATCCTTG TTAAGAAGAA TGGACAGTGC 1200

TGTATAGCAG ATTTGGGACT TGCAGTGATC CACTCCCAGA CCAACAATCA CCTAGATGTT 1260

GGAAACAACC CCCGTGTGGG TACCAAGCGC TACATGGCTC CTGAAGTTTT AGATGAAACC 1320

ATCCAAGTGA ACTGTTTTGA CTCTTATAAA AGAGTTGACA TTTGGGCCTT TGGATTAGTC 1380

CTATGGGAGG TAGCCAGGAG AATGGTGAGC AATGGTATCG TGGAAGATTA TAAGCCACCC 1440

TTCTATGATG TAGTTCCTAA TGATCCAAGT TTTGAAGATA TGAGAAAGGT GGTCTGTGTG 1500

GATCAGCAGA GGCCAAACAT TCCCAACAGA TGGTTCTCAG ACCCGACGTT AACCTCTTTG 1560

GCTAAGCTTA TGAAAGAGTG CTGGTATCAG AATTCATCCG CAAGGCTAAC AGCACTGCGT 1620

ATCAAAAAGA CTTTGACCAA AATTGATAAT TCCTTAGATA AATTGAAAGC TGACTGTTGA 1680

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++lle++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+e+y+tvllrhenil+fia

Q: 258   ITLLECVGKGRYGEVWRGHWQGENVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIA  317

         789*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe+gsL+dyL+ +tld+ ++lr++ls+asGlahLH ei+gt+

Q: 318   SDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQ  377

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kpai+HRDlkskNilvkk+++cciaDlGLa+ +++++++ld+ +n +vGtkRYmaPE

Q: 378   G--KPAISHRDLKSKNILVKKNGQCCIADLGLAVIHSQTNNHLDVGNNPRVGTKRYMAPE  435

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++++++f+++kr+D++++gLvlWEva+R+ + +++ve+yk+pf++vv++dPs+e+m

Q: 436   VLDETIQVNCFDSYKRVDIWAFGLVLWEVARRMVS-NGIVEDYKPPFYDVVPNDPSFEDM  494

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++++rP+ip++w ++++l++l+kl++ecW+++++aRltalr+kk+l

Q: 495   RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNSSARLTALRIKKTL  545

         *************************************************97

Domain Sequence
(FASTA)

ITLLECVGKG RYGEVWRGHW QGENVAVKIF SSRDEKSWFR ETELYNTVLL RHENILGFIA 60

SDMTSRHSST QLWLITHYHE MGSLYDYLQL TTLDTVSCLR IVLSIASGLA HLHIEIFGTQ 120

GKPAISHRDL KSKNILVKKN GQCCIADLGL AVIHSQTNNH LDVGNNPRVG TKRYMAPEVL 180

DETIQVNCFD SYKRVDIWAF GLVLWEVARR MVSNGIVEDY KPPFYDVVPN DPSFEDMRKV 240

VCVDQQRPNI PNRWFSDPTL TSLAKLMKEC WYQNSSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0045177	; C:apical part of cell
GO:0005887	; C:integral to plasma membrane
GO:0016361	; F:activin receptor activity, type I
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0002526	; P:acute inflammatory response
GO:0003289	; P:atrial septum primum morphogenesis
GO:0030509	; P:BMP signaling pathway
GO:0060923	; P:cardiac muscle cell fate commitment
GO:0007368	; P:determination of left/right symmetry
GO:0003143	; P:embryonic heart tube morphogenesis
GO:0003197	; P:endocardial cushion development
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0001702	; P:gastrulation with mouth forming second
GO:0007281	; P:germ cell development
GO:0001701	; P:in utero embryonic development
GO:0001707	; P:mesoderm formation
GO:0003183	; P:mitral valve morphogenesis
GO:0032926	; P:negative regulation of activin receptor signaling pathway
GO:0043066	; P:negative regulation of apoptotic process
GO:0001755	; P:neural crest cell migration
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0001569	; P:patterning of blood vessels
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0060037	; P:pharyngeal system development
GO:0030501	; P:positive regulation of bone mineralization
GO:2000017	; P:positive regulation of determination of dorsal identity
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0023014	; P:signal transduction by phosphorylation
GO:0051145	; P:smooth muscle cell differentiation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013