EKS-MOD-00241

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00241

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	386.8	4.3E-116	87	338	252

Status

Unreviewed

Ensembl Protein

ENSMODP00000005696

UniProt Accession

F6XLB8;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK1

Gene Synonyms/Alias

MARK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000004622	ENSMODP00000005696	ENSMODT00000005816

Organism

Monodelphis domestica

Functional Description

Protein Length

821

Protein Sequence
(FASTA)

MSARTPLPTV NERDTENSLK WCGNKNTKFL TSNDCLVGET AYYMHTSVDG YPEPHIQPTK 60

SSSRQNIPRC RNSITSSTDE QPHIGNYRLL KTIGKGNFAK VKLARHVLTG REVAVKIIDK 120

TQLNPTSLQK LFREVRIMKI LNHPNIVKLF EVIETEKTLY LVMEYASGGE VFDYLVAHGR 180

MKEKEARAKF RQIVSAVQYC HQKCIVHRDL KAENLLLDAD MNIKIADFGF SNEFTIGNKL 240

DTFCGSPPYA APELFQGKKY DGPEVDVWSL GVILYTLVSG SLPFDGQNLK ELRERVLRGK 300

YRIPFYMSTD CENLLKKLLV LNPIKRGSLE QIMKDRWMNV GHEEEELKPY TEPEPDFNDT 360

KRIDIMVTMG FSRDEINVSL INQKYDEVMA TYLLLGRKPP EFEGSESLSS GNLCQRSRPS 420

SDLNNSSMQS PAHLKVQRSI SANQKQRRFS DHVGPTIPAA VSYTKRAQAN SAESEQKEEW 480

DKDVSHKLGS TIVGSKAEMT ASPLVGPERK KSSTMPSNNA FSGTGMTRRN TYVCERTTDR 540

YSAIQNGKDS SLTEMSATST SSAGSAITSA APSTRPRHQK SMSASGHPIK VTLPTIKDGT 600

DYRPGTTQRV PAASPSAHSI SATTPDRTRF PRGSSSRSTF HGEQLRERRN ATYNGPPASP 660

SHETGTFSHA RRGTSTGIIS KITSKFVRRD PSEGEASGRT DTSRSTSGEP KEREKEDSKD 720

SKPRSLRFTW SMKTTSSMDP NDMMREIRKV LDANNCDYEQ KEKFLLFCVH GDARQDSLVQ 780

WEMEVCKLPR LSLNGVRFKR ISGTSIAFKN IASKIANELK L 821

Nucleotide Sequence
(FASTA)

ATGTCTGCCC GGACGCCATT GCCGACCGTG AACGAGCGGG ACACGGAGAA TTCTCTTAAG 60

TGGTGTGGAA ACAAAAATAC AAAATTCCTG ACTTCAAATG ATTGTTTGGT TGGAGAGACA 120

GCATATTACA TGCATACATC TGTTGATGGA TACCCTGAAC CACATATCCA GCCTACCAAA 180

TCAAGTAGTC GACAAAATAT ACCACGGTGT AGAAATTCCA TTACATCCTC TACAGATGAA 240

CAGCCTCACA TTGGAAATTA TCGTTTGCTA AAAACAATAG GGAAGGGAAA TTTTGCCAAA 300

GTGAAATTGG CAAGACATGT TCTTACTGGT AGAGAGGTTG CAGTAAAAAT AATAGATAAA 360

ACTCAGCTGA ATCCCACCAG TCTACAAAAG TTATTTCGAG AAGTACGAAT AATGAAGATA 420

TTGAATCATC CCAATATAGT AAAATTATTT GAAGTTATTG AAACAGAGAA GACACTGTAT 480

TTAGTAATGG AATATGCCAG TGGGGGTGAA GTGTTTGATT ACTTAGTTGC CCATGGAAGA 540

ATGAAGGAGA AAGAGGCCCG TGCAAAATTT AGACAGATTG TGTCCGCAGT ACAGTATTGT 600

CATCAAAAGT GTATTGTACA TCGTGATCTC AAGGCAGAGA ATCTTCTTCT TGATGCTGAC 660

ATGAACATTA AAATTGCTGA CTTTGGTTTT AGTAATGAAT TTACAATTGG AAACAAATTA 720

GATACATTTT GTGGCAGTCC TCCCTATGCA GCTCCTGAAC TTTTCCAAGG AAAAAAATAT 780

GATGGCCCTG AAGTAGATGT ATGGAGTCTT GGTGTCATTT TGTATACGTT AGTCAGCGGA 840

TCATTACCAT TTGATGGTCA GAACCTAAAG GAACTACGGG AGCGAGTCTT ACGAGGAAAG 900

TATCGTATTC CTTTCTATAT GTCTACAGAC TGTGAAAATC TTCTGAAAAA ATTATTAGTA 960

CTGAATCCAA TAAAAAGAGG CAGCTTGGAA CAAATAATGA AAGATCGGTG GATGAATGTT 1020

GGTCATGAAG AAGAAGAACT AAAGCCATAT ACTGAGCCTG AACCAGATTT CAATGACACA 1080

AAGAGAATAG ACATTATGGT AACAATGGGT TTTTCAAGGG ATGAAATAAA TGTATCCTTA 1140

ATAAACCAGA AATATGATGA AGTCATGGCC ACTTATCTAC TTCTGGGCAG AAAACCACCT 1200

GAATTTGAAG GAAGTGAATC TTTGTCCAGT GGTAACTTGT GTCAGCGGTC TCGACCTAGC 1260

AGTGACTTAA ACAACAGTTC TATGCAATCT CCTGCTCATC TGAAGGTCCA GAGGAGTATA 1320

TCAGCAAATC AGAAACAGAG GCGTTTCAGT GATCATGTTG GTCCGACAAT TCCTGCTGCT 1380

GTGTCATACA CCAAAAGGGC TCAGGCAAAC AGTGCGGAAA GTGAGCAAAA AGAGGAGTGG 1440

GACAAAGATG TATCTCATAA GCTTGGCAGC ACTATAGTTG GATCCAAAGC AGAGATGACA 1500

GCAAGTCCTC TTGTAGGACC CGAAAGAAAA AAATCTTCTA CTATGCCAAG TAACAATGCT 1560

TTTTCTGGAA CTGGTATGAC AAGAAGGAAT ACATATGTTT GTGAAAGGAC TACAGATCGA 1620

TATTCTGCAA TTCAGAATGG GAAAGACAGC AGTCTGACAG AAATGTCTGC GACTAGCACA 1680

TCTTCTGCGG GCTCTGCCAT CACTTCTGCT GCACCATCTA CTCGGCCTCG ACACCAGAAA 1740

TCTATGTCTG CCTCTGGCCA CCCTATAAAA GTCACATTGC CAACCATCAA AGATGGCACT 1800

GACTATCGAC CAGGTACAAC TCAGAGAGTT CCTGCTGCTT CCCCATCTGC TCATAGTATT 1860

AGTGCTACTA CACCAGACCG AACCCGTTTT CCTCGTGGGA GTTCAAGTCG AAGTACTTTT 1920

CATGGTGAAC AGCTCCGGGA ACGACGTAAT GCTACTTATA ATGGACCACC TGCTTCACCA 1980

TCACATGAAA CTGGTACATT TTCACATGCC AGAAGGGGGA CATCAACTGG TATAATAAGC 2040

AAAATAACTT CCAAGTTTGT TCGAAGGGAT CCAAGTGAAG GCGAAGCCAG TGGCAGAACT 2100

GACACCTCAA GAAGTACTTC TGGAGAACCA AAAGAAAGAG AAAAAGAGGA TAGTAAAGAT 2160

TCCAAGCCAC GTTCTTTACG GTTCACTTGG AGTATGAAGA CCACTAGTTC TATGGACCCC 2220

AATGATATGA TGAGAGAGAT CCGAAAAGTG TTGGATGCAA ATAACTGTGA TTATGAACAA 2280

AAAGAGAAGT TTTTGCTCTT CTGTGTACAC GGAGATGCCA GACAAGATAG CCTTGTTCAG 2340

TGGGAGATGG AAGTTTGCAA GTTGCCACGC TTGTCTCTAA ATGGGGTACG CTTCAAAAGA 2400

ATATCTGGGA CTTCAATTGC ATTTAAGAAC ATTGCATCCA AAATTGCAAA TGAGCTTAAA 2460

CTGTAA 2466

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++vavKii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 87    YRLLKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  146

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 147   VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIV  206

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 207   HRDLKAENLLLDADMNIKIADFGFSNEFTIGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  266

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+klLv +p kR

Q: 267   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKR  326

         ************************************************************

S: 241   atieeilkhewl  252

          ++e+i+k++w+

Q: 327   GSLEQIMKDRWM  338

         ***********8

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH VLTGREVAVK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKCIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTI GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KLLVLNPIKR 240

GSLEQIMKDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013