EKS-MOD-00315

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00315

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	326.9	9.7E-98	339	586	248

Status

Unreviewed

Ensembl Protein

ENSMODP00000028523

UniProt Accession

F6Y1B2;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK7

Gene Synonyms/Alias

PAK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000004734	ENSMODP00000028523	ENSMODT00000030106
ENSMODG00000004734	ENSMODP00000005832	ENSMODT00000005955

Organism

Monodelphis domestica

Functional Description

Protein Length

605

Protein Sequence
(FASTA)

GVSIMFGKKK KRLEISGPSN FEHRVHTGFD PREQKFTGLP QQWHSLLADT ANRPKPMVDP 60

SCITPIQLAP MKTIVRGNKP CKETSINGLL EEFDNISVTR SNSLRKESPP TPHQGTSNHV 120

QGHSEENDYR DPFQLTPSRT AGTSECSKES LVYSESEWRP SMEDYDKRPK SSYINQTSPQ 180

PAMRQRSRSG SGLQEPAMPY GASTFKSHPQ GHSYSSYTYP RLSETTTPTL SGSDTYPRGP 240

VKLPQSQNKV NYSSSGYQYP SGYHKAAHYH QPGLQTSSPY ISTASYPSSP SVSSSAYPPP 300

SWGSSSDQQP SRVSHEQFRA ALQLVVSPGD PREYLDNFIK IGEGSTGIVC IATEKHTGKQ 360

VAVKKMDLRK QQRRELLFNE VVIMRDYHHD NVVDMYNSYL VGDELWVVME FLEGGALTDI 420

VTHTRMNEEQ IATVCLSVLK ALSYLHNQGV IHRDIKSDSI LLTSDGRIKL SDFGFCAQVS 480

KEVPKRKSLV GTPYWMAPEV ISRLPYGTEV DIWSLGIMVI EMIDGEPPYF NEPPLQAMRR 540

IRDNLPPRVK DLHKVSSVLR GFLDLMLVRE PSQRGTAQEL LRHPFLKLAG PPSCIVPLMR 600

QYRHR 605

Nucleotide Sequence
(FASTA)

GGGGTTTCCA TCATGTTTGG CAAGAAAAAG AAAAGGCTTG AAATCTCCGG ACCGTCTAAC 60

TTTGAGCACA GGGTTCACAC CGGGTTTGAT CCCCGAGAGC AGAAATTCAC AGGCCTTCCG 120

CAGCAGTGGC ACAGCTTGCT GGCAGACACG GCCAATCGCC CCAAGCCCAT GGTGGACCCT 180

TCGTGCATCA CGCCCATCCA GCTCGCGCCC ATGAAGACAA TTGTTAGAGG AAACAAACCC 240

TGCAAGGAAA CTTCCATCAA TGGTTTGCTA GAAGAATTTG ACAATATCTC TGTGACTCGT 300

TCCAATTCTC TAAGGAAAGA AAGCCCTCCC ACTCCTCACC AGGGTACTTC CAACCATGTC 360

CAGGGACATT CAGAAGAAAA TGATTACCGA GATCCCTTTC AATTAACTCC CTCTAGGACT 420

GCAGGGACAA GTGAGTGCTC CAAAGAAAGC CTGGTGTACA GTGAAAGTGA ATGGCGGCCC 480

AGCATGGAAG ACTATGATAA AAGACCAAAG TCTTCATATA TAAATCAGAC GAGCCCTCAG 540

CCAGCCATGA GGCAGAGGTC AAGATCAGGT TCTGGACTTC AGGAACCGGC CATGCCATAT 600

GGAGCAAGTA CATTTAAGTC ACACCCACAA GGACACTCAT ACAGCTCTTA CACCTACCCT 660

CGCCTCTCAG AAACCACCAC TCCAACTCTG TCTGGATCTG ACACTTACCC TCGGGGCCCA 720

GTCAAACTAC CTCAAAGTCA GAACAAAGTT AACTATTCCT CAAGTGGCTA CCAGTACCCT 780

TCTGGGTATC ACAAAGCTGC TCACTACCAC CAGCCCGGTC TCCAGACCAG CTCTCCATAC 840

ATCTCCACAG CTTCCTATCC AAGCTCCCCA AGCGTCTCTT CAAGTGCTTA CCCCCCACCT 900

AGCTGGGGGT CATCCTCAGA CCAGCAGCCT TCCAGGGTGT CCCATGAACA GTTCAGGGCT 960

GCTCTGCAGC TTGTGGTTAG CCCTGGTGAC CCTCGCGAAT ACTTGGATAA TTTTATTAAA 1020

ATAGGAGAAG GGTCGACTGG AATAGTTTGC ATTGCCACTG AGAAACACAC AGGGAAACAA 1080

GTCGCCGTGA AGAAAATGGA CCTCCGGAAA CAACAGCGGC GGGAGCTGCT TTTTAATGAG 1140

GTCGTGATAA TGAGGGATTA CCATCATGAC AATGTGGTCG ACATGTACAA TAGTTATCTT 1200

GTTGGTGATG AGCTTTGGGT TGTAATGGAG TTCCTAGAAG GTGGAGCTTT GACTGATATA 1260

GTGACTCACA CGAGAATGAA TGAAGAACAA ATAGCTACAG TCTGTTTATC AGTCCTGAAG 1320

GCCCTTTCTT ACCTTCACAA TCAAGGAGTT ATTCACCGAG ACATAAAGAG TGACTCCATT 1380

CTTCTGACGA GTGATGGCCG GATAAAGTTA TCTGATTTTG GTTTCTGTGC CCAAGTTTCC 1440

AAAGAGGTCC CAAAAAGAAA ATCACTGGTT GGTACTCCCT ACTGGATGGC ACCAGAAGTC 1500

ATATCTAGAC TACCTTATGG AACAGAGGTG GATATCTGGT CCCTTGGCAT TATGGTCATA 1560

GAAATGATAG ATGGAGAGCC TCCTTACTTC AATGAACCTC CACTCCAAGC AATGCGTAGG 1620

ATCCGTGATA ACTTACCTCC AAGAGTGAAG GACTTACACA AGGTTTCCTC AGTGCTCCGG 1680

GGGTTCCTAG ACTTGATGTT GGTGAGGGAA CCCTCCCAGA GGGGAACAGC ACAAGAACTC 1740

CTCAGACATC CGTTCTTGAA ACTTGCAGGC CCACCTTCTT GCATCGTGCC CCTCATGAGA 1800

CAATATAGGC ATCGCTGA 1818

Domain Profile

S: 5     eeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyles  64

          +ig+G++g v++a+ek+tg++va+kk++l+kq++ e+l++e+ ++++++h n+v++++s

Q: 339   IKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYNS  398

         68**********************************************************

S: 65    flkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdi  124

         +l+ +elw+vme+l+gG+l+d+v+   +++++Eeqia+++ +vlkaL+ylH+++viHrdi

Q: 399   YLVGDELWVVMEFLEGGALTDIVT---HTRMNEEQIATVCLSVLKALSYLHNQGVIHRDI  455

         ************************...9********************************

S: 125   kakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDiw  184

         k+++iLlt++g++kLsdfg++aq++k++ krk++vgtpywmAPEvi+  +  Y +++Diw

Q: 456   KSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS--RLPYGTEVDIW  513

         ***********************************************..9**********

S: 185   slGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpek  244

         slGI++ie+++gepP+++++pl+a+ +i +n pp++k+ +k+s+ ++ f++ +l ++p++

Q: 514   SLGIMVIEMIDGEPPYFNEPPLQAMRRIRDNLPPRVKDLHKVSSVLRGFLDLMLVREPSQ  573

         ************************************************************

S: 245   RpsasellkhkFl  257

         R +a+ell+h+Fl

Q: 574   RGTAQELLRHPFL  586

         ************7

Domain Sequence
(FASTA)

IKIGEGSTGI VCIATEKHTG KQVAVKKMDL RKQQRRELLF NEVVIMRDYH HDNVVDMYNS 60

YLVGDELWVV MEFLEGGALT DIVTHTRMNE EQIATVCLSV LKALSYLHNQ GVIHRDIKSD 120

SILLTSDGRI KLSDFGFCAQ VSKEVPKRKS LVGTPYWMAP EVISRLPYGT EVDIWSLGIM 180

VIEMIDGEPP YFNEPPLQAM RRIRDNLPPR VKDLHKVSSV LRGFLDLMLV REPSQRGTAQ 240

ELLRHPFL 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

mdo:100033279

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013