EKS-MOD-00008
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00008
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph502.12.4E-151485744260
StatusUnreviewed
Ensembl ProteinENSMODP00000005844
UniProt AccessionF6XJC5;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB4
Gene Synonyms/Alias EPHB4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000004739ENSMODP00000005844ENSMODT00000005967
OrganismMonodelphis domestica
Functional Description
Protein Length857
Protein Sequence
(FASTA)
MENPYIKVDT VAAEHLSRKR QGSETTGKVN VKTLRLGPLT KAGFYLAFQD QGACMALLSL 60
HLFYKKCSKL TVNLTHFPET VPHELVVPVA GSCVADAVPA SGPGPSLYCR EDGQWADQPV 120
TGCTCAAGHE AVEDNTKCRA CMQGTFKPLA GEGSCQLCPA NSQSNSFGST ICQCRIGYFR 180
APTDPLGAPC TTPPSAPRSV VAHLNGSSLR LEWSAPLESG GRGDLTYALR CRECHPRGSC 240
VSCGKDMTFD PGPENLAEPW VGVQGLRPDL TYAFEVMAIN GVSSVALGPV PVEAVNVTTD 300
REVPPPVSDI QVTGASPSSL SLTWPIPYSS NGAVLDYEVK YHEKGVEGPS GVRFLKTSEN 360
QAELQGLKRG TSYLVQVRAR SEAGYGPFGR EHDSQTKLDE NETWREQLAL ISGTAAVGVI 420
LILVVIVIAV LCLRKQSSGR DAEYSDKHGQ YLIGHGTKVY IDPFTYEDPN EAVREFAKEI 480
DVSYVKIEEV IGAGEFGEVC RGRLKTPGKK ESYVAIKTLK GGYTERQRRE FLSEASIMGQ 540
FEHPNIIRLE GVVTNSVPVM ILTEFMENGA LDSFLRLNDG QFTAIQLVGM LRGIASGMRY 600
LAEMSYVHRD LAARNILVNS NLVCKVSDFG LSRFLEENSS DPTYTSSLGG KIPIRWTAPE 660
AIAFRKFTSA SDAWSYGIVM WEVMSFGERP YWDMSNQDVI NAIEQDYRLP PPSDCPTSLH 720
QLMLDCWQKD RNARPRFPQV VSALDKLIRN PASLKIVARE NGGASHPLLD QRLPHFSAFG 780
SVGEWLRAIK MGRYEESFAA AGFGSFELVS QISAEDLLRI GVTLAGHQKK ILSSIQHMRS 840
QAKPATPGGA GGPAPQY 857
Nucleotide Sequence
(FASTA)
ATGGAGAATC CCTATATTAA GGTGGACACA GTTGCAGCGG AGCATCTGAG TCGGAAGCGA 60
CAAGGGAGTG AGACAACTGG GAAGGTGAAT GTGAAGACCC TGAGATTAGG CCCCCTCACC 120
AAGGCTGGTT TCTACCTGGC CTTTCAAGAC CAAGGTGCCT GCATGGCCCT GTTATCTCTC 180
CACCTCTTCT ATAAGAAGTG TTCTAAGCTG ACTGTCAATC TGACTCATTT CCCTGAGACT 240
GTGCCTCATG AACTAGTGGT ACCTGTAGCT GGGAGCTGTG TAGCAGATGC TGTCCCAGCC 300
TCTGGCCCTG GTCCTAGCCT CTACTGCAGA GAGGATGGCC AGTGGGCAGA TCAACCAGTC 360
ACTGGCTGTA CCTGTGCTGC AGGCCATGAA GCAGTGGAAG ACAACACCAA ATGCCGAGCC 420
TGTATGCAGG GAACCTTCAA GCCTCTTGCA GGAGAGGGGT CATGCCAGTT ATGCCCAGCT 480
AATAGCCAGT CCAACTCCTT TGGTTCGACC ATTTGCCAGT GCCGAATTGG CTACTTTCGT 540
GCCCCCACAG ACCCCCTGGG AGCTCCTTGT ACCACCCCAC CCTCAGCCCC CCGAAGTGTA 600
GTGGCTCATC TCAATGGCTC ATCTCTTCGT CTGGAGTGGA GTGCACCCCT TGAATCGGGA 660
GGCCGAGGAG ATCTGACTTA TGCCCTTCGT TGCCGGGAAT GCCATCCACG AGGCTCCTGT 720
GTATCATGTG GAAAAGATAT GACCTTTGAC CCAGGTCCTG AAAACCTGGC TGAGCCCTGG 780
GTAGGGGTTC AAGGACTTCG TCCTGACCTT ACCTATGCCT TTGAGGTCAT GGCCATCAAT 840
GGGGTATCCT CTGTGGCCCT TGGACCAGTT CCAGTGGAAG CAGTCAATGT CACCACAGAT 900
CGAGAGGTAC CACCTCCAGT GTCAGACATC CAGGTGACAG GAGCATCTCC CAGCAGCTTA 960
AGCCTGACTT GGCCCATCCC CTATTCCTCC AATGGGGCAG TGCTGGATTA TGAGGTCAAG 1020
TATCATGAGA AGGGTGTGGA AGGACCAAGT GGAGTACGCT TCCTGAAAAC ATCAGAAAAT 1080
CAAGCGGAGC TACAAGGACT GAAAAGGGGG ACAAGTTACC TTGTCCAAGT TCGGGCACGC 1140
TCTGAGGCTG GCTATGGGCC CTTTGGCCGT GAACATGACA GTCAGACCAA ACTGGATGAA 1200
AATGAGACCT GGAGGGAACA GCTGGCACTG ATCTCGGGCA CAGCAGCCGT GGGGGTTATT 1260
CTTATTCTAG TGGTCATTGT CATCGCAGTC CTCTGCCTCA GGAAACAGAG CAGCGGGAGG 1320
GATGCTGAAT ATTCTGACAA GCATGGACAG TATCTCATCG GGCATGGCAC AAAAGTCTAC 1380
ATTGACCCCT TTACTTATGA AGACCCCAAT GAGGCTGTGA GAGAATTTGC AAAGGAAATT 1440
GATGTATCCT ATGTCAAGAT TGAGGAAGTG ATTGGAGCAG GAGAGTTTGG AGAGGTGTGT 1500
CGGGGACGCC TGAAAACCCC AGGAAAGAAG GAGAGCTATG TGGCCATCAA GACCCTAAAA 1560
GGTGGCTATA CAGAAAGGCA GAGAAGGGAG TTCTTGAGTG AGGCCTCCAT TATGGGCCAG 1620
TTTGAACACC CCAATATCAT CCGACTAGAG GGCGTAGTCA CCAATAGTGT ACCTGTCATG 1680
ATCCTAACCG AATTCATGGA GAATGGGGCG CTGGATTCCT TCCTTCGGCT TAATGATGGA 1740
CAGTTCACAG CCATCCAGCT GGTGGGCATG CTTCGAGGCA TAGCCTCAGG CATGCGGTAC 1800
TTAGCAGAGA TGAGTTATGT GCATCGAGAC CTAGCTGCCC GAAACATTCT GGTCAACAGC 1860
AACTTGGTCT GCAAGGTTTC GGATTTCGGT CTCTCTAGAT TCCTAGAGGA GAATTCCTCT 1920
GACCCCACCT ACACCAGCTC TCTGGGTGGC AAGATCCCCA TTCGTTGGAC AGCCCCTGAA 1980
GCCATTGCCT TCCGGAAATT CACATCGGCT AGTGATGCTT GGAGTTATGG GATTGTGATG 2040
TGGGAAGTCA TGTCATTTGG GGAACGTCCA TATTGGGATA TGAGCAACCA GGATGTCATC 2100
AATGCCATTG AACAAGATTA CCGGCTACCC CCACCTTCAG ACTGTCCCAC CTCCTTGCAC 2160
CAGCTAATGC TGGACTGCTG GCAGAAGGAC CGAAATGCAA GACCCCGATT CCCCCAGGTG 2220
GTCAGTGCCC TTGACAAGCT GATCCGTAAT CCTGCTAGCC TCAAAATTGT GGCCCGGGAG 2280
AATGGAGGAG CCTCACATCC TCTCCTGGAT CAGCGGTTGC CTCATTTCTC AGCCTTTGGC 2340
TCAGTGGGAG AGTGGCTTCG GGCAATCAAG ATGGGCCGAT ATGAAGAGAG TTTCGCAGCT 2400
GCTGGGTTTG GCTCCTTTGA GCTGGTCAGT CAGATCTCAG CAGAGGATCT ACTCCGGATT 2460
GGCGTCACTC TGGCTGGACA CCAGAAGAAA ATACTGTCAA GCATCCAACA TATGAGATCA 2520
CAGGCCAAGC CTGCAACCCC AGGAGGGGCA GGAGGACCAG CTCCCCAGTA CTGA 2574
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevc+Grlk+pgk+e++vaiktlk+g+te+qrr+flseasi+Gqf+hp
Q: 485   VKIEEVIGAGEFGEVCRGRLKTPGKKESYVAIKTLKGGYTERQRREFLSEASIMGQFEHP  544
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvt+s pvmi+te+mengaldsflr +dgqft+iqlvgmlrGiasgm+yl++m
Q: 545   NIIRLEGVVTNSVPVMILTEFMENGALDSFLRLNDGQFTAIQLVGMLRGIASGMRYLAEM  604
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr+le++s +++yt+s ggkipirwtapeaia+
Q: 605   SYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSsDPTYTSSlGGKIPIRWTAPEAIAF  664
         *******************************99988*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasd+wsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlppp dcp++l+qlml
Q: 665   RKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPSDCPTSLHQLML  724
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rp+f q+vs+l
Q: 725   DCWQKDRNARPRFPQVVSAL  744
         *****************975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVCRGRL KTPGKKESYV AIKTLKGGYT ERQRREFLSE ASIMGQFEHP 60
NIIRLEGVVT NSVPVMILTE FMENGALDSF LRLNDGQFTA IQLVGMLRGI ASGMRYLAEM 120
SYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEENSSDPTY TSSLGGKIPI RWTAPEAIAF 180
RKFTSASDAW SYGIVMWEVM SFGERPYWDM SNQDVINAIE QDYRLPPPSD CPTSLHQLML 240
DCWQKDRNAR PRFPQVVSAL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00008
EKS-BOT-00007
EKS-CAJ-00008
EKS-CAF-00009
EKS-CAP-00006
EKS-DAR-00013
EKS-EQC-00009
EKS-FEC-00006
EKS-GAA-00011
EKS-GOG-00008
EKS-HOS-00009
EKS-ICT-00008
EKS-LAC-00014
EKS-LOA-00009
EKS-MAM-00007
EKS-MUM-00009
EKS-MUP-00009
EKS-MYL-00010
EKS-NOL-00008
EKS-ORN-00012
EKS-ORA-00007
EKS-ORC-00008
EKS-OTG-00009
EKS-PAT-00009
EKS-POA-00006
EKS-PRC-00003
EKS-RAN-00008
EKS-SAH-00007
EKS-SUS-00006
EKS-TUT-00005
EKS-XIM-00010
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013