EKS-MOD-00149
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00149
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR528.13.9E-159468744277
StatusUnreviewed
Ensembl ProteinENSMODP00000006035
UniProt AccessionF7C211;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR4
Gene Synonyms/Alias FGFR4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000004899ENSMODP00000006035ENSMODT00000006163
OrganismMonodelphis domestica
Functional Description
Protein Length805
Protein Sequence
(FASTA)
MQPLASVLGT LLAAAGFLVI HAFTSEEVEQ EPCQAPGPEE LEQHLTLALG QALRLCCGRA 60
NRGGHWYKEG TRLAPSGRVR AWRGRLEIAT LVYEDAGLYL CVSRGSGHVL HNLTISVIDS 120
LASGDDDEDS DSSPKDLPKG HIYPQQGPYW THPHRMEKKL HAVPAGNTVK FRCPAAGNPM 180
PTIRWLKNGE DFHGEHRIGG IRLRHQHWSL VMESVVPSDR GTYTCVIENA LGSLRYNYLL 240
DVLERSPHRP ILQAGLPANT TAVVGSDVEL LCKVYSDAQP HIQWLKHIEV NGSSFGADGF 300
PFVQVLKTAD INSSEVEVLY LRNVSSEDAG EYTCLAGNSI GLSYQSAWLT VLPEERLVWE 360
AAASEVKATD IIMYTSGSVA ILVILVIAGL CRGQALSSRP PHQPLAVQKL SRFPLIRQFS 420
LESGSSGKLS SSLVRGGRLS SSCTPMLPGL VELDLPLDAK WEFPRDRLVL GKPLGEGCFG 480
QVVWAEAYGM DPQQPDGAAT VAIKMLKDNA SDKDLADLIS EMEMMKLIGR HKNIINLLGV 540
CTQEGPLYVI VEFAAKGNLR EYLRARRPPS PDYTLEAPRT PEEQLSFQAL VSCAYQVARG 600
MEYLESRKCI HRDLAARNVL VTEDNVMKIA DFGLARGVHD IDYYKKTSNG RLPVKWMAPE 660
ALFDRVYTHQ SDVWSFGILL WEIFTLGGSP YPGIPVEELF SLLREGHRMD RPSHCPPELY 720
MLMRECWHAV PSQRPTFKQL VEALNKLLTA ISEEYLDLSM PFEQYSPAAE DTSSTCSSND 780
SVFTHEPLAP GGLSPSPFTY HNVRT 805
Nucleotide Sequence
(FASTA)
ATGCAGCCAC TGGCATCAGT GTTGGGGACT CTCTTGGCAG CAGCTGGATT CCTGGTCATT 60
CATGCCTTTA CCTCTGAAGA GGTGGAACAG GAGCCCTGCC AGGCCCCAGG CCCAGAAGAG 120
TTGGAACAGC ACCTGACCCT AGCATTGGGC CAAGCACTAC GACTCTGCTG TGGTCGTGCC 180
AACCGAGGTG GCCACTGGTA TAAAGAAGGC ACTCGTCTGG CACCATCAGG CCGTGTGCGA 240
GCCTGGCGAG GTCGCCTGGA AATCGCCACT CTAGTGTATG AGGATGCTGG CCTGTACCTG 300
TGTGTTTCTC GAGGCTCTGG CCATGTTCTG CACAATCTCA CTATCTCTGT CATAGATTCT 360
CTGGCCTCCG GGGATGATGA CGAGGACAGT GACAGCTCCC CTAAGGACCT TCCCAAGGGG 420
CACATTTATC CACAGCAAGG TCCCTACTGG ACACATCCCC ATCGCATGGA GAAGAAGCTG 480
CATGCAGTCC CTGCAGGCAA CACAGTCAAG TTCCGGTGCC CAGCTGCAGG CAACCCCATG 540
CCCACCATCC GCTGGCTGAA GAACGGAGAA GACTTCCATG GAGAGCACCG AATTGGGGGC 600
ATCCGGCTCA GACATCAGCA CTGGAGTCTC GTCATGGAAA GTGTAGTGCC CTCAGACCGT 660
GGCACTTACA CCTGCGTGAT AGAGAATGCC CTGGGGAGCC TCCGATACAA CTATCTCCTG 720
GATGTGCTAG AGCGCTCCCC CCACCGGCCC ATCCTGCAGG CTGGCCTGCC CGCCAACACC 780
ACAGCTGTGG TTGGCAGCGA TGTAGAGCTA CTGTGCAAAG TCTACAGCGA CGCCCAGCCC 840
CACATCCAGT GGCTGAAGCA CATCGAGGTC AACGGGAGCA GCTTTGGGGC GGACGGATTC 900
CCCTTCGTGC AGGTGCTCAA GACCGCTGAT ATCAACAGCT CAGAGGTAGA GGTCTTGTAC 960
TTACGTAATG TGTCATCAGA GGATGCAGGC GAATACACCT GCCTGGCTGG CAACTCCATT 1020
GGGCTCTCCT ACCAATCGGC CTGGCTCACG GTGCTGCCTG AGGAGAGGCT GGTATGGGAA 1080
GCTGCTGCCT CAGAGGTGAA GGCCACAGAC ATCATCATGT ACACGTCAGG CTCTGTGGCC 1140
ATCCTGGTGA TCCTGGTCAT TGCCGGGCTG TGCCGGGGGC AGGCGCTATC TAGCCGGCCG 1200
CCCCACCAGC CCCTTGCTGT GCAGAAGCTC TCACGCTTCC CTCTCATCAG ACAGTTCTCC 1260
CTGGAGTCAG GCTCATCAGG GAAGCTGAGT TCCTCCCTCG TTCGGGGTGG CCGCCTGTCC 1320
TCCAGCTGTA CCCCAATGCT CCCTGGCCTT GTGGAGCTGG ACCTGCCACT TGATGCCAAG 1380
TGGGAGTTTC CCCGGGATAG GCTGGTGCTA GGGAAGCCCC TTGGTGAAGG TTGTTTTGGG 1440
CAGGTGGTAT GGGCAGAGGC CTATGGAATG GACCCTCAAC AACCAGATGG AGCTGCCACG 1500
GTGGCCATCA AAATGCTCAA AGACAATGCT TCTGACAAAG ATCTGGCAGA CCTGATCTCT 1560
GAGATGGAAA TGATGAAGCT TATTGGTCGA CACAAGAATA TTATCAACCT GCTGGGTGTC 1620
TGCACCCAGG AAGGGCCCTT GTACGTGATC GTAGAATTTG CTGCTAAAGG CAACCTCCGG 1680
GAATACCTTC GGGCAAGAAG ACCACCTAGC CCTGACTACA CCTTGGAAGC ACCCAGGACC 1740
CCCGAGGAAC AGCTGTCATT CCAGGCCCTG GTCTCTTGTG CCTACCAAGT GGCCCGTGGC 1800
ATGGAATATC TGGAGTCTCG GAAGTGCATA CACAGGGACC TGGCTGCCCG GAATGTGCTG 1860
GTCACTGAGG ACAATGTGAT GAAGATTGCA GACTTTGGCC TGGCCAGGGG TGTTCATGAC 1920
ATCGACTACT ACAAAAAAAC CAGTAATGGC CGCCTGCCTG TCAAGTGGAT GGCACCTGAG 1980
GCCCTATTTG ACCGAGTCTA CACTCACCAG AGTGATGTGT GGTCCTTTGG GATCCTGCTG 2040
TGGGAGATCT TCACCCTGGG TGGCTCCCCT TACCCTGGCA TCCCTGTAGA AGAGCTATTC 2100
TCACTGCTGA GAGAAGGACA TCGTATGGAC CGGCCTTCCC ACTGCCCCCC AGAGCTGTAT 2160
ATGTTGATGC GTGAGTGCTG GCACGCTGTA CCCTCCCAGA GACCTACCTT CAAGCAGTTG 2220
GTTGAAGCCC TGAACAAGCT CTTGACTGCC ATCTCTGAGG AGTACCTGGA CCTCTCGATG 2280
CCCTTTGAGC AGTACTCCCC AGCCGCTGAG GACACCAGCA GCACCTGCTC TTCCAATGAC 2340
TCGGTTTTCA CCCATGAACC CCTGGCCCCC GGGGGCCTGA GCCCTAGCCC CTTCACTTAC 2400
CACAATGTAA GGACATAA 2418
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         lvlgk+lGeG+fGqvv aea g+d ++++ ++tva+kmlk++a+dkdladl+seme++kl
Q: 468   LVLGKPLGEGCFGQVVWAEAYGMDPQQPDGAATVAIKMLKDNASDKDLADLISEMEMMKL  527
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iG+hkniinllG+ctqeGplyvive+aakGnlre+lrarrp++ +++ ++++++eeql++
Q: 528   IGRHKNIINLLGVCTQEGPLYVIVEFAAKGNLREYLRARRPPSPDYTLEAPRTPEEQLSF  587
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         + lvs+ayqvarGmeyl+s+kcihrdlaarnvlvtednv+kiadfGlar+vh+idyykkt
Q: 588   QALVSCAYQVARGMEYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHDIDYYKKT  647
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         +nGrlpvkwmapealfdrvyt+qsdvwsfG+llwei+tlGgspypgi+veelf+ll+eGh
Q: 648   SNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH  707
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm++p++c+ ely+lmrecwha++s+rptfkqlve+l
Q: 708   RMDRPSHCPPELYMLMRECWHAVPSQRPTFKQLVEAL  744
         **********************************986
Domain Sequence
(FASTA)
LVLGKPLGEG CFGQVVWAEA YGMDPQQPDG AATVAIKMLK DNASDKDLAD LISEMEMMKL 60
IGRHKNIINL LGVCTQEGPL YVIVEFAAKG NLREYLRARR PPSPDYTLEA PRTPEEQLSF 120
QALVSCAYQV ARGMEYLESR KCIHRDLAAR NVLVTEDNVM KIADFGLARG VHDIDYYKKT 180
SNGRLPVKWM APEALFDRVY THQSDVWSFG ILLWEIFTLG GSPYPGIPVE ELFSLLREGH 240
RMDRPSHCPP ELYMLMRECW HAVPSQRPTF KQLVEAL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00141
EKS-ANC-00141
EKS-BOT-00149
EKS-CAF-00157
EKS-CAP-00150
EKS-DAR-00435
EKS-EQC-00148
EKS-FEC-00139
EKS-GAM-00077
EKS-GAA-00174
EKS-ICT-00143
EKS-LAC-00159
EKS-LOA-00148
EKS-MUM-00154
EKS-MUP-00154
EKS-MYL-00158
EKS-ORN-00184
EKS-ORC-00140
EKS-ORL-00172
EKS-PAT-00140
EKS-RAN-00148
EKS-SAH-00144
EKS-SUS-00130
EKS-TAG-00178
EKS-TAR-00193
EKS-TEN-00185
EKS-XET-00138
EKS-XIM-00178
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005783; C:endoplasmic reticulum
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008201; F:heparin binding
GO:0061144; P:alveolar secondary septum development
GO:0016477; P:cell migration
GO:0042593; P:glucose homeostasis
GO:0001759; P:organ induction
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0055062; P:phosphate ion homeostasis
GO:0008284; P:positive regulation of cell proliferation
GO:2000573; P:positive regulation of DNA biosynthetic process
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048554; P:positive regulation of metalloenzyme activity
GO:0045862; P:positive regulation of proteolysis
GO:0046777; P:protein autophosphorylation
GO:0070857; P:regulation of bile acid biosynthetic process
GO:2000188; P:regulation of cholesterol homeostasis
GO:0010715; P:regulation of extracellular matrix disassembly
KEGG
mdo:100031838;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013