EKS-MOD-00060

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00060

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	374.3	3.8E-112	133	429	297

Status

Unreviewed

Ensembl Protein

ENSMODP00000006870

UniProt Accession

F7FH38;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK9

Gene Synonyms/Alias

CDK9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000005552	ENSMODP00000006870	ENSMODT00000007008
ENSMODG00000005552	ENSMODP00000040851	ENSMODT00000043959

Organism

Monodelphis domestica

Functional Description

Protein Length

487

Protein Sequence
(FASTA)

MQRDGPPRAP APIPGPRLPG PGGVGSVGGG SGGVGGGGGS TAPAAPVLPG TTSPRGPGGS 60

RRAEEAGPAP RGRKWPGRRK WRGRGGSWSA AAAGPGPGPA GAASGAAGGT GEATMAKQYD 120

TVECPFCDEV TKYEKLAKIG QGTFGEVFKA KHRQTGKKVA LKKVLMENEK EGFPITALRE 180

IKILQLLKHE NVVNLIEICR TKASPYNRCK GSIYLVFDFC EHDLAGLLSN AHVKFTLSEI 240

KKVMQMLLNG LYYIHRNKIL HRDMKAANVL ITRDGVLKLA DFGLARAFSL AKNSQPNRYT 300

NRVVTLWYRP PELLLGERDY GPPIDLWGGG CIMAEMWTRS PIMQGNTEQH QLALISQLCG 360

SITSEVWPNV DKYELYEKLE LPKGQKRKVK ERLKAYVKDP YALDLIDKLL VLDPTQRIDS 420

DDALNHDFFW SDPMPSDLKN MLSTHSTSMF EYLAPPRRRG GGHMPQQPAN QSRNPAATNQ 480

TEFDRVF 487

Nucleotide Sequence
(FASTA)

ATGCAGCGGG ACGGGCCGCC CCGCGCCCCC GCCCCCATCC CGGGGCCCCG CCTTCCAGGC 60

CCCGGAGGTG TTGGTAGTGT CGGCGGCGGT AGTGGCGGTG TTGGCGGCGG TGGCGGCTCT 120

ACAGCCCCAG CAGCCCCCGT CCTCCCGGGA ACTACAAGTC CCAGGGGTCC CGGCGGCAGC 180

CGCAGGGCGG AAGAGGCGGG ACCGGCACCT CGGGGCCGGA AGTGGCCGGG GAGGCGGAAG 240

TGGCGGGGCC GAGGAGGGAG CTGGAGCGCA GCTGCAGCGG GACCCGGGCC CGGGCCAGCG 300

GGGGCAGCCA GTGGGGCGGC GGGAGGCACG GGCGAGGCCA CCATGGCCAA GCAGTACGAC 360

ACGGTGGAAT GCCCCTTCTG CGATGAGGTG ACCAAGTACG AGAAGCTGGC CAAGATCGGT 420

CAGGGCACCT TCGGTGAAGT CTTCAAGGCC AAACACAGAC AGACCGGCAA GAAGGTAGCC 480

CTGAAGAAAG TGCTGATGGA AAATGAAAAG GAGGGGTTTC CCATCACTGC CTTAAGGGAA 540

ATCAAGATCC TTCAGCTTCT CAAACATGAG AATGTGGTCA ACCTAATTGA GATCTGTAGG 600

ACCAAAGCCT CTCCCTACAA CCGCTGCAAA GGTAGCATCT ACCTGGTGTT TGATTTCTGT 660

GAACATGACC TTGCTGGCCT GCTGAGCAAT GCCCATGTCA AGTTCACTCT GTCGGAGATC 720

AAGAAGGTGA TGCAAATGTT GCTCAATGGC CTCTACTATA TCCATCGGAA TAAGATATTG 780

CATCGGGATA TGAAGGCTGC CAATGTGCTC ATCACCCGAG ATGGGGTCCT GAAGTTGGCT 840

GACTTTGGTT TGGCTCGAGC TTTCAGTCTT GCCAAGAATA GCCAGCCAAA CCGATACACT 900

AACAGAGTGG TGACCCTCTG GTACCGGCCC CCTGAACTGT TGCTTGGAGA GCGTGACTAT 960

GGCCCTCCAA TAGACCTTTG GGGTGGAGGC TGCATCATGG CAGAAATGTG GACCCGGAGC 1020

CCTATCATGC AGGGTAACAC GGAGCAGCAC CAGCTGGCCC TCATCAGTCA GCTCTGTGGC 1080

TCCATTACCT CAGAGGTGTG GCCCAATGTG GATAAATACG AGCTGTATGA GAAACTGGAA 1140

CTGCCTAAAG GACAGAAGCG GAAGGTAAAA GAGCGGCTTA AAGCCTATGT CAAGGACCCT 1200

TATGCACTGG ACCTGATTGA CAAACTGCTG GTGCTGGACC CTACCCAGCG TATTGACAGT 1260

GACGATGCCC TCAACCATGA CTTCTTCTGG TCAGACCCCA TGCCCTCAGA CCTCAAGAAT 1320

ATGCTTTCCA CTCACAGTAC TTCCATGTTT GAGTACCTGG CTCCACCCCG ACGGAGAGGC 1380

GGTGGGCACA TGCCCCAACA GCCAGCCAAT CAGAGCCGCA ACCCAGCAGC CACTAATCAG 1440

ACAGAGTTTG ACCGAGTATT C 1461

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         yekl+kig+Gt+g+v+kak+++tg++vAlKk+ +e+ekeg+pitalrEi++l+ lkh+n+

Q: 133   YEKLAKIGQGTFGEVFKAKHRQTGKKVALKKVLMENEKEGFPITALREIKILQLLKHENV  192

         99**********************************************************

S: 61    vkLlevva.......kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqllegl  113

         v+L+e++        + k ++yLvf+f+e+dL+ ll++ +  k++l+e+k+++++ll+gl

Q: 193   VNLIEICRtkaspynRCKGSIYLVFDFCEHDLAGLLSNAHV-KFTLSEIKKVMQMLLNGL  251

         ********99999988889********************99.******************

S: 114   aylHsnkilHRDlKpqNlLiskegklklaDfGlaraf....ssplktytkevvTlwYraP  169

          y+H+nkilHRD+K++N+Li+++g+lklaDfGlaraf    +s+ ++yt++vvTlwYr+P

Q: 252   YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFslakNSQPNRYTNRVVTLWYRPP  311

         *************************************7776555557*************

S: 170   elLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevs  229

         elLlg+++Y+  +D+W+ gci+ae++tr+p++qg++e++ql  i++l+g+++++vwp+v

Q: 312   ELLLGERDYGPPIDLWGGGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITSEVWPNVD  371

         ************************************************************

S: 230   klpeyk.ksfpkkkkkklkekvkklkek..aldllekllaldpkkRisakealqhkyf  284

         k++ y+  ++pk +k+k+ke++k++ ++  aldl++kll ldp++Ri++++al+h++f

Q: 372   KYELYEkLELPKGQKRKVKERLKAYVKDpyALDLIDKLLVLDPTQRIDSDDALNHDFF  429

         ******8899**9999******988766579*************************98

Domain Sequence
(FASTA)

YEKLAKIGQG TFGEVFKAKH RQTGKKVALK KVLMENEKEG FPITALREIK ILQLLKHENV 60

VNLIEICRTK ASPYNRCKGS IYLVFDFCEH DLAGLLSNAH VKFTLSEIKK VMQMLLNGLY 120

YIHRNKILHR DMKAANVLIT RDGVLKLADF GLARAFSLAK NSQPNRYTNR VVTLWYRPPE 180

LLLGERDYGP PIDLWGGGCI MAEMWTRSPI MQGNTEQHQL ALISQLCGSI TSEVWPNVDK 240

YELYEKLELP KGQKRKVKER LKAYVKDPYA LDLIDKLLVL DPTQRIDSDD ALNHDFF 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0016605	; C:PML body
GO:0005524	; F:ATP binding
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0017069	; F:snRNA binding
GO:0044212	; F:transcription regulatory region DNA binding
GO:0071345	; P:cellular response to cytokine stimulus
GO:0071157	; P:negative regulation of cell cycle arrest
GO:0006282	; P:regulation of DNA repair
GO:0031056	; P:regulation of histone modification
GO:0043111	; P:replication fork arrest

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013