EKS-MOD-00117

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00117

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	298.0	6.7E-89	41	310	270

Status

Unreviewed

Ensembl Protein

ENSMODP00000035012

UniProt Accession

F7CA71;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000005655	ENSMODP00000035012	ENSMODT00000036600

Organism

Monodelphis domestica

Functional Description

Protein Length

1329

Protein Sequence
(FASTA)

MSLLQSALDF LAGPGSLGGA ASRDHTDFVG QTVELGDLRL RIKRVIAEGG FAFVYEAQDL 60

GSGKDYALKR LLSNEEEKNK AIIQEVCFMK KLSGHPNIVQ FCSAASIGKE ESDTGQAEFL 120

LLTELCRGQL VEFLKKVESK GPLSCDTVLK IFYQTCRAVQ HMHKQKPPII HRDLKVHIAF 180

KNQRCENCQE EITSDLPFFS ISPYSAQPSL LMVKITRNTT PMYRTPEIID LYSNFPIGEK 240

QDIWALGCIL YLLCFRQHPF EDGAKLRIVN GKYSIPPNDT RYTVFHDLIR STLKVNPEER 300

LSITELVNQL QEIAAARNVN PKSPITELLE HNGGYGNNMQ PRGSLNSVPQ GTKAVGQLSN 360

VYSAGMTVAE CDQSYSGFFD ILRGGTERFF TNIKDTSSKV IQSVANYAKG DLDISYITSR 420

IAVMSFPAEG VESALKNNIE DVRLFLDSKH PGHYAVYNLS PRTYRPSRFH NRVSECGWPA 480

RRAPNLQNLY NICKNMHLWL KQDHKNVCIV HCIDGRAASA VVVCSFLCFC RLFTTAEAAV 540

YMFSMKRCPP GIWPSHKRYI EYMCDMMAEE PIIPHSKPIL IKAVLMTPVP LFSKQRNGCR 600

PFCEVYVGDE RVTTTSQEYD KMKDFKIEDG KAVIPLGITV QGDVLIVIYH ARSTLGGRLQ 660

AKMASMKMFQ IQFHTGFVPR NATTVKFAKY DLDACDIQEK YPDLFQVNLE VEVEPRDRPS 720

LETPPWDNLN MKGLNPKILF SSREEQQDIL SKFGKPELPR QPGSTAQYEA EASQQSPESV 780

PTESDSPQSN STETNNFFHT LDWQEGKVAE PGVENNFLKE NHVVLNEDRE GSELSDEESS 840

TFPGENKVIT IEEEKSSAPE KAEDENLLFD TDYEPSAQLQ EPQQEDSVDL LGLDSEAEPE 900

QSHASKEIQS SSSNADLLSN LFVAGATISE EPTGDLLGAG TDFFFGSPPP PSDNAQSTSQ 960

NVVLSSAADP FDPFTMASGS ETQSHSNPDL FEDFLNPSSA PASSNMFPST HSAPPPSSSS 1020

DFLHLGNLPT EQPTKMTTSA SHPDLLGGWD SWADSSSIGN ITSTQPAKSA CEGSTFSSGS 1080

QSSVTPGSSI SQTKPQNFDP FADLANLSSG IQGPSCGFSP GGFAPKAAQS SKGGSPWQTK 1140

PPNYGPSWPS QAKSQQTKSS PQTKPNYSVK FSVIGGREER GIRAPSFAQK PKVSENDFED 1200

LLPNQGFSSK SDKKGPKTIA EMRKQEMSKD MDPLKLKLLD WIEGKERNIR ALISTLHMVL 1260

WEGESRWKPV GMADLVTPEQ VKKYYRKAVL VVHPDKAAGQ PYEQYAKMIF MELNDAWSEF 1320

ENQGSKSLF 1329

Nucleotide Sequence
(FASTA)

ATGTCCCTGT TGCAGTCGGC GTTGGACTTC CTGGCCGGTC CGGGGTCCCT GGGCGGGGCC 60

GCCAGCCGCG ACCACACAGA CTTCGTGGGG CAGACAGTGG AGCTGGGCGA CCTGAGGCTG 120

CGGATCAAGC GGGTCATCGC CGAGGGTGGG TTTGCTTTTG TTTATGAAGC TCAAGATCTT 180

GGAAGTGGTA AAGATTATGC TTTAAAGAGA CTGCTGTCCA ATGAAGAGGA AAAGAACAAA 240

GCAATCATTC AAGAAGTTTG TTTTATGAAA AAACTTTCTG GACATCCTAA CATTGTCCAG 300

TTCTGCTCTG CTGCATCAAT AGGAAAAGAA GAGTCTGATA CTGGACAAGC TGAGTTTCTT 360

CTTCTCACTG AACTCTGCAG AGGGCAACTG GTCGAATTCT TAAAGAAAGT TGAATCCAAG 420

GGCCCTCTCT CCTGTGACAC GGTTTTGAAG ATATTTTATC AGACATGCAG AGCAGTACAA 480

CATATGCATA AACAGAAGCC CCCTATTATC CATCGGGATC TCAAGGTACA TATAGCATTT 540

AAAAATCAGA GATGCGAAAA TTGTCAGGAA GAAATAACAT CAGATCTGCC TTTCTTTTCC 600

ATCTCTCCTT ACTCAGCACA ACCAAGCCTT CTGATGGTCA AAATCACAAG GAATACAACA 660

CCGATGTACA GGACACCAGA AATAATTGAC TTATATTCAA ACTTTCCAAT TGGGGAAAAA 720

CAAGATATCT GGGCCTTGGG CTGTATCCTA TACCTCTTGT GCTTCAGGCA ACATCCTTTT 780

GAAGATGGAG CAAAACTTCG GATAGTTAAT GGAAAATACT CAATCCCACC AAATGACACA 840

AGATACACAG TTTTTCATGA TCTCATTCGT TCTACATTGA AGGTGAACCC AGAAGAAAGG 900

TTGTCAATCA CAGAACTTGT AAATCAGCTC CAGGAGATAG CAGCTGCTAG AAATGTAAAT 960

CCAAAGTCAC CTATAACAGA GCTTCTGGAA CACAATGGCG GTTATGGAAA TAATATGCAG 1020

CCTAGAGGTT CTCTCAATTC AGTGCCACAA GGTACTAAAG CTGTGGGGCA GCTCAGCAAT 1080

GTGTATAGTG CAGGCATGAC AGTTGCAGAG TGTGATCAGT CCTATAGTGG TTTCTTTGAC 1140

ATTCTTAGAG GAGGAACAGA AAGATTTTTT ACTAACATCA AAGACACTTC TTCCAAAGTT 1200

ATCCAGTCTG TTGCTAATTA TGCTAAAGGA GATTTGGATA TTTCTTACAT CACATCCAGA 1260

ATTGCTGTGA TGTCATTTCC AGCAGAAGGT GTAGAATCTG CTCTCAAAAA TAACATAGAA 1320

GATGTGCGGT TGTTTTTAGA CTCTAAGCAT CCTGGGCATT ATGCTGTTTA CAATCTTTCT 1380

CCAAGAACAT ACAGGCCTTC CAGATTTCAT AATCGGGTTT CAGAATGTGG TTGGCCAGCA 1440

AGACGAGCCC CAAACCTTCA AAACCTTTAT AACATCTGCA AGAATATGCA TTTATGGCTA 1500

AAACAAGACC ACAAAAATGT TTGCATCGTG CACTGCATTG ATGGAAGAGC CGCATCAGCT 1560

GTTGTTGTTT GCTCCTTTTT ATGTTTCTGT CGTCTTTTTA CCACTGCTGA GGCTGCAGTT 1620

TATATGTTTA GTATGAAACG CTGTCCACCT GGCATCTGGC CATCACATAA AAGGTATATA 1680

GAGTACATGT GTGACATGAT GGCAGAAGAG CCCATTATCC CCCATAGTAA ACCAATCCTT 1740

ATTAAAGCAG TCCTGATGAC ACCAGTGCCC CTGTTCAGCA AGCAGAGAAA TGGCTGTAGA 1800

CCCTTTTGTG AAGTTTATGT GGGAGATGAA CGAGTGACCA CAACATCTCA AGAGTATGAT 1860

AAAATGAAGG ATTTTAAAAT TGAGGATGGC AAAGCAGTAA TTCCATTGGG CATAACAGTC 1920

CAGGGTGATG TACTCATTGT CATTTATCAT GCAAGATCAA CATTGGGAGG AAGATTGCAA 1980

GCTAAGATGG CTTCAATGAA GATGTTTCAG ATTCAGTTCC ACACGGGATT TGTGCCCCGA 2040

AATGCTACAA CTGTGAAGTT TGCCAAGTAT GATCTGGATG CATGTGACAT TCAAGAGAAA 2100

TACCCTGATT TATTTCAAGT GAATCTTGAA GTAGAAGTGG AACCCAGAGA CAGGCCAAGT 2160

CTTGAGACTC CACCATGGGA TAACTTAAAT ATGAAGGGAC TGAATCCAAA AATTCTGTTC 2220

TCCAGCCGAG AGGAGCAACA AGATATTTTG TCTAAATTTG GTAAACCTGA GCTTCCTAGA 2280

CAGCCTGGAT CTACAGCCCA GTATGAGGCA GAAGCCTCCC AGCAGTCCCC TGAAAGTGTA 2340

CCCACAGAGT CAGACTCACC ACAGAGTAAT AGCACTGAGA CAAACAACTT TTTTCATACA 2400

TTGGACTGGC AAGAAGGAAA AGTAGCAGAA CCTGGAGTAG AAAATAACTT TCTTAAAGAA 2460

AACCATGTTG TTCTGAATGA AGACAGGGAA GGAAGTGAAT TGTCTGATGA AGAATCTTCT 2520

ACTTTCCCTG GGGAGAACAA AGTAATTACT ATTGAAGAAG AAAAGTCAAG TGCCCCTGAA 2580

AAAGCAGAAG ATGAAAATTT ACTTTTTGAT ACAGATTATG AACCCTCAGC CCAGCTGCAA 2640

GAGCCCCAGC AAGAAGACAG TGTTGATTTG CTAGGCCTGG ACTCTGAAGC TGAACCAGAG 2700

CAAAGCCATG CCTCCAAAGA AATTCAAAGT TCCTCTAGCA ATGCTGATTT GTTAAGCAAT 2760

CTGTTTGTTG CTGGTGCAAC CATTTCAGAA GAGCCTACAG GGGACTTGCT TGGGGCAGGG 2820

ACAGATTTCT TTTTCGGTAG TCCTCCTCCC CCTTCAGATA ATGCACAGAG TACTTCACAA 2880

AATGTAGTAC TCTCTTCAGC TGCTGATCCA TTTGATCCAT TCACGATGGC ATCTGGTTCC 2940

GAAACTCAGA GTCATTCCAA TCCTGATCTG TTTGAAGATT TTCTTAATCC CAGTTCTGCA 3000

CCAGCCTCAT CCAATATGTT TCCTTCTACA CACAGTGCAC CTCCTCCTTC TTCCAGCTCT 3060

GACTTTTTAC ATTTAGGAAA TTTGCCAACA GAGCAGCCTA CCAAGATGAC TACTTCTGCC 3120

AGCCACCCTG ATCTCTTGGG AGGATGGGAC TCCTGGGCTG ATTCCTCCAG TATTGGCAAT 3180

ATAACATCAA CACAGCCTGC CAAATCTGCA TGCGAAGGCT CAACTTTTTC TTCAGGAAGC 3240

CAGTCAAGTG TTACCCCTGG CTCATCTATC AGCCAAACTA AACCTCAGAA CTTTGATCCC 3300

TTTGCTGACC TTGCTAACCT CAGTTCAGGT ATTCAAGGTC CTTCTTGTGG ATTTTCTCCT 3360

GGTGGATTTG CTCCAAAAGC AGCTCAGTCT TCAAAAGGAG GGAGCCCATG GCAGACAAAG 3420

CCCCCAAACT ATGGTCCATC ATGGCCATCC CAGGCGAAAT CACAGCAAAC CAAATCCAGT 3480

CCACAGACAA AACCTAATTA TTCTGTGAAA TTCAGTGTTA TTGGAGGACG AGAAGAGAGG 3540

GGCATTAGAG CTCCCAGTTT TGCTCAAAAG CCAAAAGTTT CAGAAAATGA TTTTGAGGAT 3600

CTGTTACCCA ATCAAGGATT TTCATCGAAA TCAGATAAAA AAGGACCAAA GACAATTGCT 3660

GAGATGAGGA AGCAAGAGAT GTCTAAAGAT ATGGATCCTC TTAAGCTAAA GCTTCTTGAT 3720

TGGATCGAAG GAAAAGAGAG GAATATAAGA GCTCTGATTT CCACACTGCA CATGGTGCTT 3780

TGGGAGGGAG AAAGCAGGTG GAAACCAGTT GGCATGGCAG ACCTGGTGAC TCCTGAGCAG 3840

GTGAAGAAGT ACTACCGAAA AGCTGTGCTG GTGGTTCATC CAGACAAGGC CGCCGGGCAG 3900

CCCTATGAGC AGTATGCCAA AATGATCTTC ATGGAGTTAA ATGATGCCTG GTCAGAGTTT 3960

GAAAATCAGG GATCCAAATC CCTTTTTTAA 3990

Domain Profile

S: 2     riekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghknivk  61

         ri++v+aeGGfa+vy a+d+ +g+ yalKr+l+neee++++i++E+++mkklsgh+niv+

Q: 41    RIKRVIAEGGFAFVYEAQDLGSGKDYALKRLLSNEEEKNKAIIQEVCFMKKLSGHPNIVQ  100

         89**********************************************************

S: 62    lv..dssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrav  119

         ++  +s  kee+d+g++e+lll+e+c+ g+lv++l+k ++kg ls++++lki+++++rav

Q: 101   FCsaASIGKEESDTGQAEFLLLTELCR-GQLVEFLKKVESKGPLSCDTVLKIFYQTCRAV  159

         **877888999***************9.8*******************************

S: 120   aalHalsvpliHRDlkveNillsdegelvlcDlGSattaileveskqelsalqeeieknt  179

         +++H++++p+iHRDlkv     +++ e     + S    +     + + s l  +i++nt

Q: 160   QHMHKQKPPIIHRDLKVHIAFKNQRCENCQEEITSDLPFFSISPYSAQPSLLMVKITRNT  219

         *****************8666666666666777776655544445788899999******

S: 180   tlsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiPens  239

         t++yr+PE+idlysn++i+ek+DiWaLGc+lY lcf+++Pfe+++kl+i+ngkysiP+n+

Q: 220   TPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPND  279

         ************************************************************

S: 240   ryseklkslikkmlevdpeeRptiaqvlell  270

         + ++ +++li++ l+v+peeR++i++++++l

Q: 280   TRYTVFHDLIRSTLKVNPEERLSITELVNQL  310

         ***************************9986

Domain Sequence
(FASTA)

RIKRVIAEGG FAFVYEAQDL GSGKDYALKR LLSNEEEKNK AIIQEVCFMK KLSGHPNIVQ 60

FCSAASIGKE ESDTGQAEFL LLTELCRGQL VEFLKKVESK GPLSCDTVLK IFYQTCRAVQ 120

HMHKQKPPII HRDLKVHIAF KNQRCENCQE EITSDLPFFS ISPYSAQPSL LMVKITRNTT 180

PMYRTPEIID LYSNFPIGEK QDIWALGCIL YLLCFRQHPF EDGAKLRIVN GKYSIPPNDT 240

RYTVFHDLIR STLKVNPEER LSITELVNQL 270

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00226	; DnaJ; 1.
PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

SM00271

; DnaJ; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS50076	; DNAJ_2; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013