EKS-MOD-00031

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00031

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	318.3	4.9E-95	907	1175	269

Status

Unreviewed

Ensembl Protein

ENSMODP00000007046

UniProt Accession

F6V3I2;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

TYK2

Gene Synonyms/Alias

TYK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000005684	ENSMODP00000007046	ENSMODT00000007187
ENSMODG00000005684	ENSMODP00000039685	ENSMODT00000042791

Organism

Monodelphis domestica

Functional Description

Protein Length

1197

Protein Sequence
(FASTA)

MPLCHCAARH NDSDGDWVHP GSGLKVFLHW SNGGEQYVTY NQGTMTAEEV CIHIAKKVGI 60

TPLCYNLFAL YDTQAQIWLP PNHLFEVTKD TNLTLQFRIR YYFRNWHGLN TQEPAVYRSM 120

TRNIEVSEDK IQMEQGCALL DKASFEYLFE QGKFEFVNDV ASLWDLHSEA EIHHFKNESL 180

GMAVLHLSHL ALQRGIPLEE VVRKTSFKDC IPRSFSRQIQ QNNFLTKFRL RTVFQKFMRR 240

FHLQTVGPGH LSKQNIMFKY LATLEQLAPR FGAERFLALT LALPTEAERE LCYVNSSGQT 300

PAGPAGSTFS LDAQVPTHEV LVMGTNGIRW RLLQEKVSTY VSELEINRPK SSFGKKSKAQ 360

KAENQKLSQL PTEKKDPSWT YFCDFQEITH VVVKESNVSI HRQDNKCLEL TLPSPIVALS 420

LVSLIDGYFR LTADSSHYLC HEVAPPRLVM SIQNGIHGPL QESYVLSKLK REEVEDGLYL 480

IRWSSFDFHR LILTVARKDQ AQGLRYKQFR IEEQGRTFQL EGWDQTFSSV RELTTALQGC 540

TLRSSSGSGP GSSLESFTIS KCCLPRAGEI SNLIITRHRP KEGPKPLNLS QLSFYQIRKD 600

EITQLAHLGQ GTRTNIYEGL LHVGGGMEAE DEEEENIPSE PNNNHRELRV VLKVLDPSHR 660

DIALAFFETA SLMSQVSHIH LAFVHGVCVR GSENIMVAEY VEHGPLDVCL RREKGHVPVA 720

WKITVAQQLA SALSYLEDKN LVHGNVCAKN ILLARRGLGD GTQPFIKLSD PGVSVTALSR 780

EERVERIPWI APECVPSGTG LSTAADKWSF GTTLLEICFD GEAPLQGRTP SEKERFYEKK 840

HRLQEPSCKE LATLISQCLT YEANQRPSFR TILRDLTQLQ PQNLSDITTM SPEFPASDPT 900

VFQKRYLKKI RDLGEGHFGK VSLYCYDPTN DGTGEMVAVK SLKAGCSSQL LSSWQREIEI 960

LRTLYHDHIV KYKGCCSDQG EKIVQLIMEY VPLGSLRDYL PKHSLGLAQI LLFAQQICKG 1020

MSYLHSQHYI HRDLAARNVL LENDNIIKIG DFGLAKAVPE GRDYYCVRED GDSPVFWYAM 1080

ECLKESKFYY ASDVWSFGVT LYELLTRCDY NQSPPLKFIE MIGVTQGQMT VLRLIDLLER 1140

GQRLPCPKDC PSEIYALMKS CWESEASFRP TFEKLDPILK TFHEKYRSQA PSVFSVC 1197

Nucleotide Sequence
(FASTA)

ATGCCACTAT GTCACTGTGC TGCAAGACAC AATGACTCCG ATGGAGACTG GGTCCACCCT 60

GGCAGTGGAC TCAAGGTTTT CCTCCATTGG AGCAATGGGG GTGAACAGTA TGTGACCTAC 120

AACCAAGGCA CCATGACCGC AGAGGAAGTC TGCATCCACA TTGCAAAGAA AGTGGGGATC 180

ACCCCACTCT GCTACAACCT TTTTGCATTA TATGATACCC AGGCCCAAAT CTGGCTGCCT 240

CCTAACCACC TTTTTGAGGT CACTAAGGAC ACCAACCTCA CCCTACAGTT TCGAATAAGG 300

TATTACTTCC GAAACTGGCA TGGTTTGAAC ACCCAGGAGC CAGCTGTGTA CCGAAGCATG 360

ACTAGAAATA TTGAGGTCTC TGAAGATAAG ATCCAAATGG AACAGGGGTG TGCTTTGCTG 420

GACAAAGCCT CCTTCGAGTA CCTCTTTGAA CAGGGGAAGT TCGAATTTGT CAATGATGTT 480

GCCTCACTTT GGGACCTACA CAGTGAAGCA GAGATACATC ACTTCAAGAA TGAGAGCCTT 540

GGCATGGCTG TGCTGCACCT TTCCCACCTT GCCCTGCAGC GTGGTATCCC TCTGGAAGAG 600

GTGGTAAGGA AGACCAGCTT CAAAGACTGC ATCCCACGGT CCTTCAGTCG ACAAATCCAA 660

CAGAACAATT TCCTGACTAA ATTCCGCCTG AGGACTGTCT TCCAGAAGTT TATGAGACGA 720

TTCCATCTAC AGACAGTGGG TCCAGGGCAT CTTAGTAAAC AGAACATTAT GTTCAAATAC 780

CTGGCTACTC TGGAGCAGCT AGCCCCACGA TTTGGTGCTG AGCGATTTCT TGCCCTAACT 840

TTAGCATTAC CTACAGAGGC CGAAAGGGAG TTGTGCTATG TTAACAGCAG TGGACAAACA 900

CCTGCTGGTC CAGCAGGATC CACTTTCTCT CTTGATGCTC AGGTTCCTAC CCATGAGGTT 960

CTAGTAATGG GTACAAATGG TATCCGTTGG AGGCTTCTTC AGGAGAAGGT GAGCACATAT 1020

GTCTCTGAAT TGGAAATTAA CCGCCCCAAA AGTTCCTTTG GTAAGAAGTC CAAAGCCCAG 1080

AAGGCAGAGA ACCAGAAGCT AAGCCAGCTG CCAACTGAAA AGAAAGACCC TTCCTGGACA 1140

TATTTTTGTG ACTTCCAAGA GATCACTCAT GTTGTGGTCA AGGAGAGCAA CGTCAGCATC 1200

CATCGTCAAG ACAACAAGTG CCTGGAACTG ACTCTCCCTT CACCTATCGT GGCTCTCTCC 1260

CTGGTATCCC TGATAGATGG CTATTTCAGG CTGACAGCAG ACTCTAGCCA CTACCTGTGC 1320

CATGAGGTGG CTCCCCCCAG ACTGGTGATG AGCATTCAGA ATGGCATCCA TGGACCCCTG 1380

CAGGAGAGTT ATGTACTGTC CAAACTGAAG AGGGAGGAAG TAGAAGATGG TCTCTACCTT 1440

ATTCGTTGGA GTTCCTTTGA CTTCCACCGC CTCATCCTGA CTGTGGCCCG GAAGGACCAG 1500

GCACAGGGTC TCCGTTACAA GCAGTTCCGT ATTGAAGAGC AGGGCCGGAC CTTCCAGCTG 1560

GAAGGCTGGG ATCAAACCTT TTCCAGTGTT CGTGAACTCA CAACTGCCTT GCAGGGCTGC 1620

ACACTTCGAT CCAGCTCTGG CTCTGGTCCT GGATCCAGTC TAGAAAGCTT CACCATCAGC 1680

AAATGTTGCC TGCCTCGAGC AGGAGAAATC TCCAACCTGA TCATCACTCG GCATCGTCCT 1740

AAGGAGGGCC CTAAACCACT CAACTTATCC CAGCTCAGCT TCTACCAAAT CCGAAAGGAT 1800

GAAATTACTC AGTTGGCTCA TCTGGGCCAG GGCACCCGGA CCAATATTTA TGAGGGACTT 1860

CTGCATGTGG GGGGTGGAAT GGAAGCTGAG GATGAGGAAG AAGAGAACAT TCCCTCAGAA 1920

CCCAACAACA ACCATCGGGA GCTTCGAGTA GTGCTGAAAG TGCTGGACCC AAGTCACCGT 1980

GATATTGCCC TGGCATTTTT TGAAACAGCC AGCCTAATGA GCCAGGTCTC CCACATCCAC 2040

CTGGCCTTCG TCCATGGTGT TTGTGTCCGG GGCTCTGAGA ATATCATGGT GGCAGAATAT 2100

GTAGAGCATG GACCACTGGA TGTATGTCTC CGCCGGGAGA AGGGCCATGT GCCTGTGGCC 2160

TGGAAGATTA CTGTGGCCCA GCAGCTTGCC AGTGCTCTCA GCTACCTAGA GGATAAGAAC 2220

CTGGTTCATG GTAATGTTTG TGCCAAGAAC ATCCTGTTGG CAAGGCGTGG CCTTGGGGAT 2280

GGCACTCAGC CCTTCATCAA GCTCAGTGAT CCTGGAGTCA GCGTCACTGC TCTCTCCAGG 2340

GAGGAAAGGG TAGAACGAAT TCCCTGGATT GCTCCTGAAT GTGTACCCAG TGGGACTGGT 2400

CTTAGCACAG CTGCTGACAA GTGGAGCTTT GGAACAACCC TCCTAGAGAT CTGCTTTGAT 2460

GGAGAAGCAC CCCTCCAGGG TCGTACCCCT TCTGAGAAGG AGCGCTTTTA TGAGAAGAAA 2520

CATCGGCTCC AGGAGCCCTC ATGCAAGGAA CTGGCCACAC TCATCAGCCA GTGCCTTACC 2580

TATGAGGCCA ACCAGCGACC TTCCTTCCGA ACCATCCTTC GTGACCTCAC CCAGCTGCAG 2640

CCCCAAAATC TCTCTGACAT TACCACTATG AGCCCAGAGT TCCCAGCCTC AGACCCCACC 2700

GTTTTTCAGA AGCGCTACCT AAAGAAGATT CGAGACCTGG GAGAGGGCCA TTTTGGCAAA 2760

GTGAGCCTCT ATTGCTATGA CCCAACTAAT GATGGGACAG GTGAGATGGT GGCTGTGAAG 2820

TCTCTCAAGG CTGGCTGCAG TTCCCAACTC TTGAGCAGCT GGCAACGGGA GATTGAGATC 2880

CTTCGGACAC TCTACCATGA CCACATCGTC AAATACAAGG GCTGCTGCAG TGACCAAGGG 2940

GAGAAGATTG TCCAGCTGAT CATGGAGTAT GTGCCACTGG GCAGTTTGCG GGACTACCTG 3000

CCCAAACATA GTTTGGGGCT GGCCCAGATT CTGCTGTTTG CTCAGCAGAT CTGTAAGGGC 3060

ATGTCCTACC TCCATTCTCA ACACTACATC CATCGAGACC TGGCAGCCCG AAATGTCCTT 3120

CTGGAGAATG ACAACATTAT CAAGATTGGG GACTTTGGCC TGGCCAAGGC TGTGCCAGAG 3180

GGCCGTGATT ACTACTGTGT CCGGGAAGAT GGAGACAGCC CTGTCTTCTG GTATGCCATG 3240

GAGTGTCTCA AGGAATCTAA GTTCTACTAT GCTTCAGACG TCTGGTCCTT TGGGGTCACC 3300

CTCTATGAGC TGCTAACCCG CTGTGACTAC AATCAGAGTC CCCCCTTGAA ATTCATTGAA 3360

ATGATTGGGG TTACCCAGGG CCAGATGACT GTGCTAAGGC TTATTGACTT GCTAGAGAGA 3420

GGTCAGAGAC TGCCTTGTCC CAAGGATTGT CCCTCTGAGA TCTATGCCCT CATGAAGAGT 3480

TGCTGGGAAT CTGAAGCCTC CTTTCGCCCA ACCTTTGAGA AGCTTGATCC CATTCTCAAG 3540

ACATTCCATG AGAAGTACAG GAGTCAAGCG CCCTCCGTGT TTAGTGTATG CTGA 3594

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv ++++d+++d t+e+va+k Lk  ++ +  ++++re+eil++l+h

Q: 907   LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKSLKaGCSSQLLSSWQREIEILRTLYH  966

         6899*********************************99*********************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         +hivk+kg+c ++ge+  +l+meyv+ GsL++yL+k+  +l l++ l +a+q++k+m+YL

Q: 967   DHIVKYKGCCSDQGEKivQLIMEYVPLGSLRDYLPKH--SLGLAQILLFAQQICKGMSYL  1024

         ************************************9..9********************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         ++++++hrd+aarnvL+e+++       +k++d+glakav+++ +Yy vre++ds+++w+

Q: 1025  HSQHYIHRDLAARNVLLENDNI------IKIGDFGLAKAVPEGrDYYCVREDGDSPVFWY  1078

         *********************9......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         a ecl+e+k +++asdvWsFgvtlyellt c+ ++sp    +++++ +       r++ l

Q: 1079  AMECLKESK-FYYASDVWSFGVTLYELLTrCDYNQSPplkfIEMIGVTqgqmtvlRLIDL  1137

         *********.****************************77766666668899999*****

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrai  261

         le+++rlp+pk cp+e++ lm+ c++ e+s+rp+F+++

Q: 1138  LERGQRLPCPKdCPSEIYALMKSCWESEASFRPTFEKL  1175

         ***********************************997

Domain Sequence
(FASTA)

LKKIRDLGEG HFGKVSLYCY DPTNDGTGEM VAVKSLKAGC SSQLLSSWQR EIEILRTLYH 60

DHIVKYKGCC SDQGEKIVQL IMEYVPLGSL RDYLPKHSLG LAQILLFAQQ ICKGMSYLHS 120

QHYIHRDLAA RNVLLENDNI IKIGDFGLAK AVPEGRDYYC VREDGDSPVF WYAMECLKES 180

KFYYASDVWS FGVTLYELLT RCDYNQSPPL KFIEMIGVTQ GQMTVLRLID LLERGQRLPC 240

PKDCPSEIYA LMKSCWESEA SFRPTFEKL 269

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045	; Tyr_kinase_non-rcpt_TYK2_N.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR00109	; TYRKINASE.
PR01827	; YKINASETYK2.

Created Date

20-Feb-2013