EKS-MOD-00430

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00430

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	494.1	1.0E-148	77	343	267

Status

Unreviewed

Ensembl Protein

ENSMODP00000007747

UniProt Accession

F7FRV9;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPA

Gene Synonyms/Alias

CDC42BPA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000006246	ENSMODP00000007747	ENSMODT00000007902

Organism

Monodelphis domestica

Functional Description

Protein Length

1771

Protein Sequence
(FASTA)

MLYASSFSPH SSDHNRFSVM TNLLMMVLCL PHQTACCALP LQILSAVTPH CCLMRGRGST 60

KPFTSKVKQM RLHKEDFEIL KVIGRGAFGE VAVVKLKNAD KVFAMKILNK WEMLKRAETA 120

CFREERDVLV NGDNKWITTL HYAFQDDNYL YLVMDYYVGG DLLTLLSKFE DRLPEDMARF 180

YLAEMVIAID SVHQLHYVHR DIKPDNILMD MNGHIRLADF GSCLKLMEDG TVQSSVAVGT 240

PDYISPEILQ AMEDGKGKYG PECDWWSLGV CMYEMLYGET PFYAESLVET YGKIMNHKER 300

FQFPVQVTDV SESAKDLIRR LICSREHRLG QNGIDDFKNH PFFAGIDWEN IRNCEAPYIP 360

EVSSPTDTSN FDVDDDCLKN SETMPPPTHT AFSGHHLPFV GFTYTSSCVL SDRSCLRVTA 420

GPPSMDVDVS IQRTLEDSLA TEAYERRIRR LEQEKLELSR KLQESTQTVQ ALQYSTVDGP 480

LTANKDLEIK NLKEEIEKLR KQVTDSDHLE QQLEEASSMR RELDDASRQI KASEKQIKLL 540

KQEREDLNKE LVESSERLKS QTKELKDAHS QRKLAMQEFS EMNERLTDLH SQKQKLARQV 600

RDKEEEMELV MQKVESLRQE LRKTERAKKE LEVHVESVTA EASKDRKLRE RSEQYSKQLE 660

NELEGLKQKQ IGRSPGISSI EHQQEITKLK ADLEKKSIFY EEELSKRNVI HTNEIKNLKK 720

ELRDAEGQQL ALKKEIMILK DKLEKTRRES QNEREEFESE FKQKYEREKI LLTEENKKLS 780

NELDKLTAMF ERLSINNRQL EEEMRDLADK KESVAHWEAQ ITEIIQWVSD EKDARGYLQA 840

LASKMTEELE ALRNSSLGTR ATDMPWKMRR FAKLDMSARL ELQSALDAEI KAKQAIQEEL 900

NKVKALNIST ECKLQESEKK NLELLSEIEK LKKETEELKS EKGVKHQDSQ NSFLAFLNAP 960

TSALDQFERS PSCIPASKGR SIDSVENFTL SNPPSRDEEV KSHLQSRSRS PSTASDIEPI 1020

EITDHPPRSA HTPTMRSAYI GSGISAPKPK AHQLVVKSFN TPTKCNQCTS LMVGLIRQGC 1080

ACEVCGFSCH VTCADKAPAF CPIPPEQTKA PLGIDPQKGV GTAYEGHVRI PKPAGVKKGW 1140

QRALAVVCDF KLFLYDIAEG KTSQPSVIVS QVIDMRDEEF SVSSVLASDV IHASRKDIPC 1200

IFRVTASQLS ASSNKCSVLM LADSENEKSK WVCLLNELHR ILKKNKLKDR SVYIPKEAYD 1260

STLPLIKTTQ AAAIIDHERI ALGNEEGLFV VHVTKDEIIR VGDSKKVHQI ELIPNEQLIA 1320

VISGRNRHVR LFPMSALDGR ETEFFKLAET KGCQTIASGQ VRHGALTCLC VAMKRQVLCY 1380

ELNQSKTRHK KIKEIQVLGN VQWMSVFSER LCVGFQSGFL RYPLPGEGNP HSLLHPDDHT 1440

LSFIAQQPTD AICAVEISNK EFLLCFSSVG IYIDCQGRRS RQQELMWPAV PSSCCYNAPY 1500

LSVYSENAVD IFDVNSMEWI QTIPLKKVRP LNSEGSLNLL GLETIRLIYF KNKMAEGDEL 1560

VVPETSDNSR KQMVRNINNK RRYSFRVPEE ERMQQRREML RDPEMRNKLI SNPTNFNHIA 1620

HMGPGDGIQI LKDLPMNLRP QESRTMFSGS VSIPSITKSR PEPGRSMSAS SGLAARSSSQ 1680

NGSALRREFS GGSYGSKRQP MTSPSDGSLS SGGMDQGSDV PARDYDREDS DSPRHSTASN 1740

SSNLSSPPSP ISPHKTKSLS LESTDHVSWD T 1771

Nucleotide Sequence
(FASTA)

ATGCTGTACG CATCTTCTTT CTCACCCCAT TCCTCTGACC ACAACAGGTT CTCAGTGATG 60

ACAAACCTTT TAATGATGGT GCTGTGCCTC CCCCACCAGA CTGCATGCTG TGCCCTGCCT 120

CTCCAGATAC TAAGTGCTGT AACCCCGCAC TGCTGCCTTA TGAGAGGGAG GGGAAGTACC 180

AAACCATTCA CTTCTAAGGT GAAACAGATG CGATTACATA AAGAAGACTT TGAAATATTA 240

AAGGTGATTG GTAGAGGAGC TTTTGGGGAG GTAGCTGTTG TAAAACTAAA AAATGCTGAT 300

AAAGTATTTG CTATGAAAAT ACTGAATAAA TGGGAAATGC TGAAAAGAGC AGAGACAGCA 360

TGTTTTCGAG AAGAGAGGGA TGTACTAGTG AATGGAGACA ATAAGTGGAT TACAACTTTG 420

CACTATGCCT TCCAGGATGA CAATTATTTA TACCTGGTTA TGGATTACTA TGTTGGTGGG 480

GATTTGCTTA CTCTTCTCAG CAAGTTTGAA GATAGACTAC CTGAGGATAT GGCTCGATTT 540

TACTTGGCTG AGATGGTCAT AGCCATTGAT TCAGTCCATC AACTACATTA TGTACACAGG 600

GATATTAAGC CTGATAATAT CCTAATGGAT ATGAATGGTC ACATTCGGTT AGCGGATTTT 660

GGTTCTTGCT TGAAACTCAT GGAAGATGGA ACAGTTCAGT CCTCTGTGGC TGTTGGTACT 720

CCAGACTATA TATCTCCAGA AATCCTTCAA GCCATGGAAG ATGGGAAAGG AAAATATGGA 780

CCAGAGTGTG ACTGGTGGTC TTTGGGTGTC TGCATGTATG AAATGCTCTA TGGAGAAACA 840

CCATTTTATG CTGAATCTCT GGTGGAAACC TACGGGAAAA TCATGAACCA CAAAGAGAGA 900

TTTCAGTTTC CAGTTCAAGT GACAGATGTC TCTGAAAGTG CTAAAGACCT TATTCGAAGG 960

CTTATTTGTA GCAGAGAACA TAGACTTGGA CAAAATGGCA TAGATGACTT TAAAAACCAC 1020

CCCTTTTTTG CTGGTATTGA CTGGGAAAAT ATTCGGAACT GTGAAGCACC TTATATCCCA 1080

GAAGTTAGTA GTCCTACAGA CACTTCCAAC TTTGATGTCG ACGATGATTG TTTAAAGAAT 1140

TCTGAAACAA TGCCCCCTCC AACCCACACT GCATTCTCTG GTCACCATCT GCCATTTGTT 1200

GGTTTTACAT ATACTAGTAG CTGTGTTCTT TCAGATCGGA GTTGTTTAAG AGTTACAGCT 1260

GGACCCCCAT CAATGGATGT TGATGTCAGT ATTCAGCGAA CTTTGGAGGA CAGCTTAGCA 1320

ACTGAAGCTT ATGAACGGAG AATAAGACGT CTTGAACAGG AAAAACTTGA ACTCAGTAGA 1380

AAGCTTCAAG AGTCAACACA GACAGTCCAG GCTCTGCAGT ATTCAACTGT AGATGGCCCA 1440

TTAACTGCAA ACAAAGATTT AGAAATAAAA AACTTAAAGG AAGAAATTGA GAAGTTGAGG 1500

AAACAAGTAA CAGATTCTGA TCATCTAGAA CAACAATTGG AAGAAGCTAG TTCAATGAGA 1560

CGAGAACTAG ATGATGCTTC TAGACAAATC AAGGCTTCTG AGAAACAAAT AAAATTGCTA 1620

AAACAAGAAA GAGAAGACCT CAATAAGGAA TTAGTTGAGT CTAGTGAGCG ATTAAAATCC 1680

CAAACCAAAG AACTGAAAGA TGCACACAGC CAGCGGAAAC TGGCCATGCA AGAGTTCTCA 1740

GAAATGAATG AGCGGCTGAC AGACTTGCAC TCCCAGAAAC AGAAACTTGC TCGCCAAGTA 1800

CGAGATAAAG AAGAGGAGAT GGAACTGGTA ATGCAAAAGG TTGAAAGCTT AAGGCAAGAA 1860

CTGCGCAAAA CAGAACGAGC CAAAAAAGAG CTGGAAGTCC ATGTAGAATC TGTAACTGCA 1920

GAAGCATCTA AGGACAGGAA ACTACGTGAA CGGAGTGAAC AGTATTCTAA ACAGCTGGAG 1980

AATGAATTGG AGGGATTAAA GCAAAAACAG ATTGGTCGCT CACCAGGAAT AAGTAGCATA 2040

GAACACCAGC AAGAGATAAC CAAATTAAAG GCTGACTTGG AAAAGAAAAG TATCTTTTAT 2100

GAAGAGGAAT TATCCAAAAG GAATGTAATA CACACAAATG AAATTAAAAA TCTAAAGAAA 2160

GAACTGCGTG ATGCAGAAGG CCAACAGCTT GCCCTTAAGA AGGAGATAAT GATTTTAAAA 2220

GACAAATTAG AAAAGACCAG GAGAGAGAGC CAAAATGAAA GGGAAGAATT TGAAAGTGAA 2280

TTTAAACAAA AGTATGAACG AGAAAAGATT CTGTTGACTG AAGAAAATAA AAAACTTTCA 2340

AATGAGCTTG ATAAGCTAAC TGCTATGTTT GAGAGACTAA GCATAAACAA CCGACAGCTA 2400

GAAGAAGAGA TGAGAGATCT AGCAGACAAA AAGGAATCAG TTGCACATTG GGAAGCCCAA 2460

ATCACAGAAA TTATTCAGTG GGTAAGTGAT GAAAAGGATG CACGAGGGTA TCTTCAGGCA 2520

TTGGCCTCTA AAATGACAGA GGAATTGGAG GCATTGAGAA ATTCCAGCCT TGGTACAAGA 2580

GCAACAGACA TGCCTTGGAA GATGCGCCGT TTTGCAAAAC TGGATATGTC AGCTCGATTG 2640

GAATTACAGT CAGCTCTGGA TGCAGAAATC AAAGCCAAAC AGGCCATCCA AGAAGAACTT 2700

AATAAAGTCA AAGCACTGAA CATCTCAACA GAATGCAAAC TGCAAGAGTC AGAGAAGAAG 2760

AACTTGGAAC TGCTATCAGA AATTGAAAAA CTGAAAAAGG AAACTGAGGA ACTTAAATCT 2820

GAAAAGGGTG TAAAGCACCA AGATTCACAG AATTCTTTCT TGGCATTTTT GAATGCGCCT 2880

ACCTCTGCTC TGGATCAATT TGAACGCTCT CCATCCTGTA TTCCAGCTAG CAAAGGCAGA 2940

AGTATTGATT CAGTTGAGAA CTTTACGTTG TCTAACCCTC CTTCACGGGA TGAGGAGGTC 3000

AAGTCTCACC TCCAGTCAAG GTCCAGGTCT CCTTCCACAG CTAGTGACAT TGAACCAATT 3060

GAGATTACAG ACCACCCTCC ACGTTCAGCT CACACACCAA CAATGAGATC TGCATATATT 3120

GGTTCTGGCA TCTCTGCGCC AAAGCCAAAG GCCCACCAGT TAGTTGTAAA ATCATTTAAC 3180

ACTCCTACAA AATGTAATCA GTGCACATCT CTGATGGTTG GTTTGATAAG ACAAGGCTGT 3240

GCTTGTGAAG TTTGTGGATT CTCATGTCAT GTTACCTGTG CAGACAAAGC TCCAGCATTT 3300

TGCCCAATTC CTCCTGAACA AACAAAAGCC CCTCTGGGTA TAGACCCACA AAAAGGAGTT 3360

GGAACAGCAT ATGAAGGCCA TGTGAGGATC CCTAAGCCAG CTGGAGTGAA GAAAGGCTGG 3420

CAGCGAGCAT TGGCTGTGGT TTGTGATTTC AAACTCTTCC TTTATGACAT AGCTGAAGGA 3480

AAAACATCCC AACCCAGTGT CATCGTCAGT CAAGTCATTG ATATGAGGGA TGAAGAGTTT 3540

TCCGTGAGTT CAGTTTTGGC TTCTGATGTT ATTCATGCAA GCCGAAAGGA TATCCCTTGT 3600

ATCTTTAGAG TAACAGCTTC TCAGCTTTCT GCATCAAGTA ACAAATGTTC AGTCCTGATG 3660

TTAGCAGATA GTGAGAATGA GAAGAGCAAA TGGGTGTGCT TACTGAATGA ACTGCACAGG 3720

ATTTTGAAGA AGAATAAACT TAAGGACCGT TCAGTCTATA TCCCCAAAGA GGCCTATGAC 3780

AGCACTCTCC CTCTCATTAA AACGACCCAA GCAGCAGCCA TCATAGATCA TGAAAGGATT 3840

GCTCTGGGAA ATGAAGAAGG ATTATTTGTT GTTCATGTCA CAAAAGATGA GATCATTCGT 3900

GTTGGTGACA GCAAAAAGGT TCATCAGATT GAACTCATCC CAAATGAACA GCTCATTGCT 3960

GTGATCTCAG GACGAAACCG CCATGTGCGA CTTTTCCCCA TGTCAGCTTT GGATGGACGA 4020

GAGACTGAAT TTTTTAAGTT AGCAGAGACT AAAGGTTGCC AAACTATAGC TTCCGGACAG 4080

GTGCGCCATG GAGCTCTTAC ATGCCTATGT GTGGCTATGA AAAGGCAGGT CCTCTGTTAT 4140

GAACTAAATC AAAGCAAGAC CCGTCACAAA AAGATTAAGG AGATCCAAGT CTTGGGTAAT 4200

GTCCAGTGGA TGTCAGTCTT CAGTGAACGA CTCTGTGTGG GATTTCAGTC AGGATTCCTC 4260

AGATATCCCC TGCCTGGAGA AGGGAATCCA CACAGCTTGC TCCATCCAGA CGACCATACA 4320

CTGTCATTTA TTGCACAACA GCCCACTGAT GCAATCTGCG CAGTTGAGAT CTCCAATAAA 4380

GAGTTTCTGC TGTGTTTTAG CAGCGTTGGA ATATATATTG ATTGCCAGGG CAGAAGGTCA 4440

AGACAACAAG AACTTATGTG GCCTGCAGTA CCATCCTCTT GCTGTTACAA TGCACCATAC 4500

CTCTCAGTGT ATAGTGAAAA TGCAGTAGAT ATATTTGATG TCAATTCCAT GGAATGGATT 4560

CAGACAATCC CCCTCAAGAA GGTGCGACCC TTGAACTCAG AAGGATCGTT AAACCTTTTA 4620

GGGCTGGAGA CAATTAGATT AATATATTTC AAAAATAAGA TGGCAGAGGG GGATGAGCTC 4680

GTAGTCCCTG AAACATCAGA TAATAGTCGG AAACAAATGG TTCGAAACAT AAATAATAAA 4740

CGGCGTTACT CCTTCAGAGT CCCAGAAGAG GAAAGGATGC AACAGAGGAG GGAGATGCTA 4800

CGAGATCCAG AAATGAGAAA TAAATTAATT TCTAACCCAA CTAATTTTAA CCACATAGCA 4860

CACATGGGTC CAGGAGATGG AATACAAATC CTGAAAGACT TGCCCATGAA CCTTAGGCCT 4920

CAGGAAAGTC GGACAATGTT CAGCGGCTCT GTCAGTATTC CATCCATCAC CAAATCACGT 4980

CCTGAGCCAG GACGTTCCAT GAGTGCTAGC AGTGGGCTAG CAGCAAGGTC ATCTTCACAA 5040

AATGGTAGTG CATTAAGGAG GGAATTCTCA GGAGGAAGTT ACGGGTCAAA ACGGCAACCT 5100

ATGACCTCTC CCTCGGATGG TTCATTGTCT TCTGGAGGTA TGGACCAAGG AAGTGATGTG 5160

CCAGCAAGGG ACTATGACCG AGAGGACTCT GATTCTCCAA GGCATTCTAC AGCTTCCAAC 5220

AGCTCCAACC TCAGCAGCCC TCCCAGCCCC ATTTCTCCTC ACAAGACCAA GAGCCTCTCT 5280

CTGGAGAGCA CTGACCACGT GAGTTGGGAC ACATGA 5316

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         feilkviGrGafgevavv+ k+++kv+amkil+k+e+lkrae+a+freerdvlv++d++w

Q: 77    FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKW  136

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqd++ylylvm+y+vGGdlltllsk+ed+lpe++arfylae+v+a+dsvh+l+

Q: 137   ITTLHYAFQDDNYLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLH  196

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrdikpdnil+d++Ghi+ladfGsclkl+edgtv+ssvavGtpdyispe+l+a+e+gk

Q: 197   YVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGK  256

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nhke+++fp ++ +vse+akd

Q: 257   GKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPVQVtDVSESAKD  316

         ************************************************9998********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++l++sre+rlg++gi+d+k+hpff

Q: 317   LIRRLICSREHRLGQNGIDDFKNHPFF  343

         **************************9

Domain Sequence
(FASTA)

FEILKVIGRG AFGEVAVVKL KNADKVFAMK ILNKWEMLKR AETACFREER DVLVNGDNKW 60

ITTLHYAFQD DNYLYLVMDY YVGGDLLTLL SKFEDRLPED MARFYLAEMV IAIDSVHQLH 120

YVHRDIKPDN ILMDMNGHIR LADFGSCLKL MEDGTVQSSV AVGTPDYISP EILQAMEDGK 180

GKYGPECDWW SLGVCMYEML YGETPFYAES LVETYGKIMN HKERFQFPVQ VTDVSESAKD 240

LIRRLICSRE HRLGQNGIDD FKNHPFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013