EKS-MOD-00138

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00138

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/Akt	504.8	5.6E-152	148	405	258

Status

Unreviewed

Ensembl Protein

ENSMODP00000008221

UniProt Accession

F7GEK1;

Protein Name

Protein Synonyms/Alias

Gene Name

AKT3

Gene Synonyms/Alias

AKT3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000006626	ENSMODP00000008221	ENSMODT00000008386

Organism

Monodelphis domestica

Functional Description

Protein Length

479

Protein Sequence
(FASTA)

MSDVTIVKEG WVQKRGEYIK NWRPRYFLLK TDGSFIGYKE KPQDVDLPYP LNNFSVAKCQ 60

LMKTERPKPN TFIIRCLQWT TVIERTFHVD TPEEREEWTE AIQAVADRLQ RQEEERMNCS 120

PTSQIDNIGE EEMDASTTHH KRKTMNDFDY LKLLGKGTFG KVILVREKAS GKYYAMKILK 180

KEVIIAKDEV AHTLTESRVL KNTRHPFLTS LKYSFQTKDR LCFVMEYVNG GELFFHLSRE 240

RVFSEDRTRF YGAEIVSALD YLHSGKIVYR DLKLENLMLD KDGHIKITDF GLCKEGITDA 300

ATMKTFCGTP EYLAPEVLED NDYGRAVDWW GLGVVMYEMM CGRLPFYNQD HEKLFELILM 360

EDIKFPRTLS SDAKSLLSGL LIKDPNKRLG GGPDDAKEIM RHSFFVGVNW QDVYDKKLVP 420

PFKPQVTSET DTRYFDEEFT AQTITITPPE KYDEDGMDCM DNERRPHFPQ FSYSASGRE 479

Nucleotide Sequence
(FASTA)

ATGAGCGATG TTACCATTGT GAAAGAAGGT TGGGTTCAGA AGAGGGGAGA ATATATAAAA 60

AACTGGAGGC CAAGATACTT CCTTTTGAAG ACAGATGGCT CATTCATAGG ATATAAGGAG 120

AAACCTCAAG ATGTGGATTT ACCTTATCCC CTTAACAACT TTTCAGTGGC AAAATGCCAG 180

CTCATGAAAA CAGAACGACC AAAGCCAAAC ACATTTATTA TCAGATGCCT CCAGTGGACC 240

ACTGTTATAG AACGAACATT TCATGTGGAT ACTCCAGAGG AAAGGGAAGA ATGGACAGAA 300

GCTATCCAGG CTGTAGCAGA CAGACTTCAG AGGCAAGAAG AGGAAAGGAT GAACTGTAGT 360

CCAACTTCAC AAATTGACAA TATAGGAGAA GAGGAAATGG ATGCTTCTAC AACTCATCAT 420

AAAAGAAAGA CAATGAATGA CTTTGACTAT TTGAAATTAT TGGGTAAAGG CACTTTTGGG 480

AAAGTGATTT TGGTTCGAGA GAAGGCAAGT GGAAAATATT ATGCTATGAA GATTTTGAAG 540

AAAGAAGTAA TTATTGCAAA GGATGAAGTG GCACACACTC TAACAGAAAG CAGAGTATTA 600

AAAAACACTA GACATCCCTT TTTAACATCC TTGAAATATT CTTTCCAGAC AAAAGATCGT 660

TTGTGTTTTG TGATGGAGTA TGTTAATGGA GGAGAGCTGT TTTTCCATTT GTCGAGAGAG 720

CGGGTGTTCT CTGAGGACCG CACACGCTTC TATGGTGCAG AAATTGTCTC TGCTTTGGAC 780

TATCTACATT CTGGAAAGAT TGTGTATCGT GATCTCAAGT TGGAAAATTT GATGTTGGAT 840

AAAGATGGCC ACATAAAAAT TACAGATTTT GGACTTTGCA AAGAAGGGAT TACAGATGCA 900

GCTACAATGA AGACATTTTG TGGTACACCT GAATACCTTG CACCTGAGGT ATTAGAAGAT 960

AATGACTATG GCCGTGCAGT GGACTGGTGG GGTTTGGGGG TTGTCATGTA TGAAATGATG 1020

TGTGGGAGAT TACCATTCTA CAACCAGGAT CATGAGAAAC TTTTTGAGCT AATACTAATG 1080

GAGGACATTA AATTTCCTCG AACTCTTTCT TCTGATGCAA AATCCTTACT TTCAGGACTC 1140

TTAATAAAAG ATCCAAATAA ACGCCTTGGT GGAGGTCCGG ATGATGCAAA AGAAATTATG 1200

AGGCACAGTT TCTTTGTTGG AGTAAATTGG CAAGATGTAT ATGATAAAAA GCTGGTACCT 1260

CCTTTTAAGC CTCAAGTAAC GTCTGAGACA GATACCAGAT ATTTTGATGA AGAATTTACA 1320

GCTCAAACAA TTACAATAAC TCCACCTGAA AAATATGATG AAGATGGTAT GGACTGCATG 1380

GACAATGAGA GACGGCCACA TTTTCCACAG TTTTCCTACT CAGCAAGTGG ACGAGAATAA 1440

Domain Profile

S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60

         fd+lkllGkGtfGkvilvreka++k+ya+kilkkevi+akdevahtlte+rvlk+t+hpf

Q: 148   FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF  207

         9***********************************************************

S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120

         l++lkysfqtk++lc+v+eyvnGGelffhls+ervfsedr+rfygaeivsaldylhs ++

Q: 208   LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKI  267

         ************************************************************

S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180

         vyrdlklenl+ldkdGhikitdfGlcke+i+d++++ktfcGtpeylapevled+dyg+av

Q: 268   VYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV  327

         ************************************************************

S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240

         dwwglGvv+yem+cGrlpfyn+dheklfelil+e++kfpr+ls++aksllsGll kdp+k

Q: 328   DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNK  387

         ************************************************************

S: 241   rlGggkddakeireheff  258

         rlGgg+ddakei++h+ff

Q: 388   RLGGGPDDAKEIMRHSFF  405

         *****************9

Domain Sequence
(FASTA)

FDYLKLLGKG TFGKVILVRE KASGKYYAMK ILKKEVIIAK DEVAHTLTES RVLKNTRHPF 60

LTSLKYSFQT KDRLCFVMEY VNGGELFFHL SRERVFSEDR TRFYGAEIVS ALDYLHSGKI 120

VYRDLKLENL MLDKDGHIKI TDFGLCKEGI TDAATMKTFC GTPEYLAPEV LEDNDYGRAV 180

DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL ILMEDIKFPR TLSSDAKSLL SGLLIKDPNK 240

RLGGGPDDAK EIMRHSFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000002	; P:mitochondrial genome maintenance
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013