EKS-MOD-00258

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00258

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	422.3	7.7E-127	63	315	253

Status

Unreviewed

Ensembl Protein

ENSMODP00000008297

UniProt Accession

F7F258;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK1

Gene Synonyms/Alias

PLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000006693	ENSMODP00000008297	ENSMODT00000008463

Organism

Monodelphis domestica

Functional Description

Protein Length

614

Protein Sequence
(FASTA)

MSTAPVKLPL RQPGVGSSEP RGKPAGTGGG AGGGGGTAAA PPAAAPAKEI PEVLVDPRSR 60

RRYLRGRFLG KGGFAKCFEL SDLESKEVFA GKIVPKSLLL KPHQKEKMSM EINIHKSLVH 120

QHVVGFHGFF EDSDFVFVVL ELCRRRSLLE LHKRRKAVTE PEARYYLRQI VLGCQYLHQN 180

KVIHRDLKLG NLFLNDDMEV KIGDFGLATR VEYDGERKRT LCGTPNYIAP EVLSKKGHSF 240

EVDVWSIGCI MYTLLVGKPP FETSCLKETY IRIKKNEYSI PKHINPVAAS LIQKMLRSDP 300

ASRPTISELL NDEFFSSGYI PARLPTTCLT IPPRFSIAPN NVESGGRKPL TALNKGMDSP 360

APERPLEKEE VIVQEPNGPP DCYLSDMLQQ LLSVNAAKPS DRGLVRQEEA EDPACIPIFW 420

VSKWVDYSDK YGLGYQLCDN SVGVLFNDST RLILYNDGDS LQYIERDGSE SYLTVRSYPS 480

PLTKKITLLK YFRNYMSEHL LKAGANITPR EGDELARLPY LRTWFRTRSA IILHLSNGTV 540

QINFFQDHTK LILCPLMAAV TYIDEKRDFR TYKLSLLEEH GCCKELASRL RYARTMVDKL 600

LSSRSASARL KAST 614

Nucleotide Sequence
(FASTA)

ATGAGCACGG CTCCCGTGAA GCTGCCCCTG CGGCAGCCCG GCGTGGGCTC CTCAGAGCCC 60

CGGGGCAAGC CGGCTGGCAC CGGCGGCGGG GCCGGAGGAG GCGGCGGGAC TGCAGCCGCA 120

CCACCTGCGG CTGCCCCGGC CAAGGAGATC CCGGAGGTGC TGGTGGACCC GCGCAGCAGA 180

CGGCGCTATC TGCGGGGCCG TTTTCTGGGC AAGGGCGGCT TCGCCAAATG CTTCGAGCTC 240

TCGGACCTGG AGAGCAAGGA GGTGTTTGCG GGCAAGATCG TGCCCAAGTC GCTGCTGCTG 300

AAGCCGCATC AGAAGGAGAA GATGTCCATG GAGATCAATA TCCACAAGAG CCTAGTCCAC 360

CAGCACGTCG TCGGTTTCCA CGGCTTCTTC GAAGATAGCG ACTTCGTTTT CGTGGTACTG 420

GAGCTGTGCC GGAGGCGGTC TCTACTGGAG TTACATAAAA GAAGGAAAGC TGTGACTGAG 480

CCTGAGGCCA GGTATTACCT GCGGCAGATT GTCCTGGGCT GTCAGTATCT CCATCAAAAT 540

AAAGTTATTC ACAGAGACCT CAAGTTGGGT AACCTCTTCC TCAATGATGA CATGGAAGTG 600

AAGATCGGGG ACTTTGGATT AGCAACCAGA GTAGAATATG ATGGTGAGCG GAAGAGGACC 660

CTCTGCGGAA CACCCAACTA CATAGCCCCT GAGGTGCTAA GTAAGAAGGG TCACAGCTTT 720

GAGGTGGATG TCTGGTCCAT TGGGTGTATC ATGTATACTT TATTGGTAGG CAAACCACCC 780

TTTGAAACCT CTTGCTTAAA GGAGACCTAC ATCAGAATCA AGAAAAATGA ATACAGCATT 840

CCCAAGCACA TCAACCCTGT GGCTGCCTCC CTCATCCAGA AGATGCTTCG CTCCGACCCT 900

GCCTCCCGCC CCACCATTAG TGAACTTCTT AATGACGAGT TTTTTTCTTC CGGCTACATC 960

CCCGCTCGGC TTCCCACGAC CTGTCTCACC ATCCCGCCGA GATTCTCCAT TGCCCCCAAC 1020

AATGTGGAAT CTGGAGGCCG GAAGCCTCTC ACAGCTCTCA ATAAAGGAAT GGATAGCCCT 1080

GCCCCTGAGC GCCCCCTTGA AAAGGAAGAA GTGATAGTAC AGGAACCAAA TGGACCCCCT 1140

GACTGCTACC TCTCTGACAT GCTTCAGCAA CTCCTCAGTG TCAATGCGGC AAAGCCTTCT 1200

GATCGAGGAT TGGTGAGACA AGAGGAGGCA GAGGACCCTG CCTGCATTCC CATTTTCTGG 1260

GTCAGTAAAT GGGTGGACTA CTCAGACAAG TATGGCCTTG GATACCAGCT CTGTGACAAC 1320

AGCGTGGGAG TGCTGTTCAA CGACTCCACT CGGCTCATTC TGTATAACGA CGGGGACAGT 1380

TTGCAGTACA TCGAGCGAGA TGGCTCCGAG TCCTACCTCA CCGTGCGTTC CTATCCTTCA 1440

CCGCTGACCA AAAAGATTAC TCTCCTCAAG TACTTCCGCA ATTACATGAG TGAGCACTTG 1500

CTGAAGGCTG GGGCTAACAT TACTCCGAGA GAAGGGGATG AGCTGGCTCG CCTTCCCTAC 1560

CTGCGAACCT GGTTCCGCAC ACGTAGTGCC ATTATTCTAC ACCTCAGCAA TGGCACTGTA 1620

CAAATCAACT TCTTCCAGGA CCACACGAAG CTGATATTGT GCCCCTTGAT GGCCGCTGTG 1680

ACTTACATTG ATGAGAAGCG GGACTTCCGA ACGTACAAGC TCAGCCTCCT GGAAGAGCAC 1740

GGCTGCTGCA AGGAGCTGGC TAGCCGCCTG CGCTATGCGC GTACCATGGT GGACAAATTG 1800

CTCAGTTCCA GGTCAGCCTC AGCCCGCCTC AAGGCCTCCA CGTAG 1845

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y rg++lGkGgfakc+el+dle+kevfa k+vpksll k++q+ek+++ei+ih+sl h++

Q: 63    YLRGRFLGKGGFAKCFELSDLESKEVFAGKIVPKSLLLKPHQKEKMSMEINIHKSLVHQH  122

         889*********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v ++ ffed+++v++vlelc+rrsl el+krrka+tepe+ryylrqiv g++ylh++++

Q: 123   VVGFHGFFEDSDFVFVVLELCRRRSLLELHKRRKAVTEPEARYYLRQIVLGCQYLHQNKV  182

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         +hrdlklgnlfln+++evkigdfGlatr+e+++erk+tlcGtPnyiaPevlskkghs+ev

Q: 183   IHRDLKLGNLFLNDDMEVKIGDFGLATRVEYDGERKRTLCGTPNYIAPEVLSKKGHSFEV  242

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+Ws+Gci+ytllvGkPPfet++lkety +ikk+eys+P+++++ a+sli+k+l+++P++

Q: 243   DVWSIGCIMYTLLVGKPPFETSCLKETYIRIKKNEYSIPKHINPVAASLIQKMLRSDPAS  302

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp+++e+l+def+

Q: 303   RPTISELLNDEFF  315

         ************8

Domain Sequence
(FASTA)

YLRGRFLGKG GFAKCFELSD LESKEVFAGK IVPKSLLLKP HQKEKMSMEI NIHKSLVHQH 60

VVGFHGFFED SDFVFVVLEL CRRRSLLELH KRRKAVTEPE ARYYLRQIVL GCQYLHQNKV 120

IHRDLKLGNL FLNDDMEVKI GDFGLATRVE YDGERKRTLC GTPNYIAPEV LSKKGHSFEV 180

DVWSIGCIMY TLLVGKPPFE TSCLKETYIR IKKNEYSIPK HINPVAASLI QKMLRSDPAS 240

RPTISELLND EFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0000942	; C:condensed nuclear chromosome outer kinetochore
GO:0030496	; C:midbody
GO:0005876	; C:spindle microtubule
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007092	; P:activation of mitotic anaphase-promoting complex activity
GO:0051297	; P:centrosome organization
GO:0000910	; P:cytokinesis
GO:0031572	; P:G2/M transition DNA damage checkpoint
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0001578	; P:microtubule bundle formation
GO:0043066	; P:negative regulation of apoptotic process
GO:0045736	; P:negative regulation of cyclin-dependent protein kinase activity
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0010800	; P:positive regulation of peptidyl-threonine phosphorylation
GO:0031648	; P:protein destabilization
GO:0071168	; P:protein localization to chromatin
GO:0016567	; P:protein ubiquitination
GO:0090007	; P:regulation of mitotic anaphase
GO:0043393	; P:regulation of protein binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013