EKS-MOD-00286

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00286

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	339.8	1.0E-101	774	1037	264

Status

Unreviewed

Ensembl Protein

ENSMODP00000028612

UniProt Accession

F6YWN3;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000006946	ENSMODP00000028612	ENSMODT00000030195

Organism

Monodelphis domestica

Functional Description

Protein Length

1069

Protein Sequence
(FASTA)

INFFSLFFRM FEAHLQSYRG DDPLDQWERY VQWTEENFAQ NTGHLSTLLE RLIKTFLDKK 60

KYHNDPRFIN SCVKFAEFNS EPCQFYEYIH SQGIGIGSSA LYLAWAQHLE IQGDLQRANA 120

VFLEGIQNKA EPIEILHQQY SLFQNRLTGT CLPAQVEAPE PLRNSQIVNQ MNTIRTLPGN 180

ADPACPPKSQ KNKMKSAVVN GCAIFLHFRE QRTVISKSGY SVQQSSLASR SDIKQVCMYC 240

KDKLICGDSE LSFEELRAQK HKQRKQKEWV NEDKEYLKRK EADAFEEQLL QQKMDELHKQ 300

LAEVMKTSQG NAATLQSRSE AHPICVRSSA GLPQEPSGPY QAKSQQPTVN IRDKQLMVSP 360

FEPISVKTTT NTTTTSLLPR LNQNVTYNYT FFPSIRYVNK NTYESNVYSG PKFKEASETP 420

SFFGASTSHV TPNTSAGMIQ ATPSRVQPSP TVHTKEALGF IMNMFQETSH PEVSVEEDKL 480

SSLNQSDDAF KDHSQKTIQP LGAWGVNDVP SVPPAFSIFE DGSKENAGLT QSKNKSMGTR 540

FFGERPSSRS TSKPNEGFQA AESLDDCTIW GVRCNKTLAP SPNSTRDFTS AAQLASTPFN 600

KISMDAWQAL EDKENMIGNN NVGMTYDSCK EKLMENSKNQ KLSTIQEHGI ENLVSVNVPS 660

LPFTQHVVSK VLTDGVEEGL VACKLTETEL AMEVEPPEVS VGHSANCTQS RPSENAHVQD 720

FIVENPWDED LIQKLLSRLS TPINAYPNAF EWECKLPNIK LKSEIQWGPW LLFVDSFLGE 780

GAFAHVYEAT QWNLNDTKIK QKVILKVQKP ANPWEFYIGT QLKERLPPSV RHLFIQFDAA 840

HFFHNGSVLV GDLYSYGTLL NAINLYKNTP EKVMPQALAI YFTIKILHMI EQLHSCEIIH 900

GDIKPDNFII GDRQISLFIY DLSHGLALID LGQSIDMTLF PKGTTFTARC ETSGFQCVEM 960

LSQKPWNYQT DYFGIAATAY CMLFGTYMKV KNDQGVWKPE GVFKRVPNSE IWSEFFHVLL 1020

NIPDCHHLPS LESLREKLKV LFQQSYVNKI KSFRSRLIVL LLEYKRSRK 1069

Nucleotide Sequence
(FASTA)

ATAAATTTTT TTTCATTATT TTTTAGAATG TTTGAAGCTC ATTTACAAAG CTACAGGGGA 60

GATGATCCAC TTGATCAGTG GGAAAGATAT GTACAGTGGA CAGAAGAAAA TTTTGCCCAA 120

AATACAGGAC ATTTGTCAAC ACTCTTAGAA CGATTAATCA AGACATTTTT GGATAAGAAG 180

AAGTACCACA ATGATCCAAG GTTCATTAAT AGCTGTGTAA AATTTGCTGA ATTTAACAGT 240

GAACCTTGTC AGTTTTATGA ATATATACAC AGTCAAGGGA TTGGCATTGG GTCATCAGCT 300

CTGTATTTAG CTTGGGCTCA GCACCTTGAA ATCCAAGGAG ATCTACAACG TGCCAATGCT 360

GTTTTTCTTG AAGGAATTCA AAACAAGGCA GAACCTATAG AAATATTGCA TCAACAGTAC 420

AGTTTATTCC AGAACCGACT TACTGGAACA TGTTTACCAG CTCAAGTTGA AGCCCCAGAA 480

CCCCTTCGCA ATTCTCAAAT TGTAAATCAA ATGAACACAA TAAGAACACT TCCAGGAAAT 540

GCTGACCCAG CTTGCCCTCC TAAAAGTCAG AAGAACAAGA TGAAGTCTGC AGTAGTAAAT 600

GGATGTGCCA TTTTTCTTCA TTTCAGAGAA CAACGAACGG TCATTTCCAA ATCAGGTTAT 660

TCAGTCCAGC AATCTTCTTT GGCATCCAGA AGTGATATCA AGCAAGTCTG TATGTACTGC 720

AAGGACAAGC TCATTTGTGG AGATTCTGAA TTATCCTTTG AGGAACTGAG AGCTCAGAAG 780

CACAAGCAGA GAAAACAAAA AGAATGGGTG AATGAAGATA AAGAATATTT AAAAAGGAAA 840

GAAGCTGATG CTTTTGAGGA GCAGCTTTTA CAACAGAAAA TGGATGAACT TCACAAGCAG 900

TTGGCTGAAG TGATGAAGAC TTCTCAGGGA AATGCAGCTA CTCTCCAGAG TAGATCTGAG 960

GCTCATCCTA TATGTGTGAG GTCGAGTGCA GGCTTGCCAC AAGAACCATC TGGACCATAT 1020

CAAGCCAAAA GTCAACAGCC CACAGTTAAT ATAAGAGACA AGCAGCTAAT GGTGTCTCCT 1080

TTTGAACCAA TCTCAGTGAA GACTACTACC AATACTACCA CCACCTCATT GTTACCAAGG 1140

TTAAACCAAA ATGTTACCTA TAACTATACA TTTTTTCCTT CCATTAGATA TGTGAATAAA 1200

AATACTTACG AATCAAATGT GTATTCTGGA CCAAAATTTA AAGAAGCATC TGAAACACCT 1260

TCATTCTTTG GTGCAAGTAC TTCTCATGTA ACACCCAACA CATCAGCAGG AATGATACAA 1320

GCCACCCCAT CAAGAGTCCA GCCTTCACCC ACAGTTCACA CCAAAGAAGC ACTAGGTTTC 1380

ATAATGAATA TGTTTCAGGA AACTTCACAT CCTGAAGTTT CTGTTGAAGA AGATAAACTT 1440

TCCTCCCTGA ATCAAAGTGA TGATGCATTT AAGGACCATT CCCAAAAGAC CATACAACCC 1500

CTTGGAGCTT GGGGAGTTAA TGATGTTCCA TCTGTGCCAC CTGCTTTTTC CATCTTTGAA 1560

GATGGAAGTA AAGAGAATGC TGGATTAACA CAGTCTAAAA ACAAAAGCAT GGGAACCAGA 1620

TTCTTTGGTG AACGACCTTC AAGCAGATCT ACTTCAAAAC CAAATGAAGG GTTTCAGGCA 1680

GCAGAGTCCT TGGATGATTG TACTATATGG GGTGTACGCT GTAATAAAAC TTTGGCACCT 1740

AGTCCTAACA GTACAAGAGA TTTTACATCT GCTGCACAAC TTGCTTCTAC ACCATTTAAC 1800

AAAATTTCCA TGGATGCATG GCAAGCCCTA GAGGATAAAG AAAATATGAT TGGAAATAAT 1860

AATGTTGGTA TGACTTATGA TTCCTGTAAG GAAAAACTTA TGGAGAACTC AAAAAACCAA 1920

AAGCTAAGTA CAATTCAAGA ACATGGCATA GAGAACCTCG TATCAGTCAA TGTGCCGTCG 1980

CTCCCGTTCA CTCAGCATGT AGTGTCCAAA GTTCTTACTG ATGGTGTTGA AGAGGGCCTT 2040

GTTGCGTGTA AACTCACTGA AACCGAACTC GCGATGGAAG TGGAACCACC AGAAGTCAGT 2100

GTTGGACACT CAGCCAACTG CACACAGAGT AGACCATCTG AAAATGCACA TGTTCAAGAT 2160

TTCATTGTGG AGAATCCATG GGATGAAGAC TTGATTCAGA AGCTTTTATC AAGATTATCT 2220

ACACCAATAA ATGCTTATCC CAATGCTTTT GAATGGGAAT GTAAACTTCC AAACATCAAG 2280

CTAAAATCTG AAATCCAGTG GGGTCCTTGG CTGCTCTTTG TTGATTCCTT TCTTGGAGAG 2340

GGGGCTTTTG CCCACGTTTA CGAAGCCACA CAGTGGAATC TAAATGACAC CAAAATCAAG 2400

CAGAAAGTCA TATTAAAGGT TCAAAAGCCT GCCAACCCCT GGGAATTCTA TATAGGAACC 2460

CAGCTGAAAG AGAGACTCCC TCCCAGCGTG CGCCACCTGT TTATCCAGTT TGACGCAGCG 2520

CATTTCTTCC ATAATGGCAG TGTGCTGGTT GGCGATCTCT ACAGTTATGG AACATTACTA 2580

AATGCTATTA ATCTTTACAA AAACACTCCT GAAAAAGTGA TGCCACAAGC ACTGGCCATC 2640

TATTTTACAA TAAAAATTCT CCACATGATA GAACAACTTC ATAGCTGTGA GATCATTCAT 2700

GGGGACATTA AACCTGACAA TTTTATAATT GGAGACAGGC AAATCTCTCT ATTTATCTAT 2760

GACTTATCTC ATGGATTGGC TTTAATTGAC TTGGGTCAGA GTATAGATAT GACCCTTTTC 2820

CCTAAAGGAA CAACATTTAC AGCAAGATGT GAAACCTCTG GTTTTCAGTG TGTTGAAATG 2880

CTCAGCCAAA AACCTTGGAA CTATCAGACC GATTACTTTG GAATTGCTGC AACAGCGTAC 2940

TGCATGCTCT TTGGCACCTA CATGAAAGTG AAAAATGACC AGGGAGTCTG GAAGCCTGAA 3000

GGAGTTTTCA AAAGGGTTCC TAATTCTGAA ATATGGAGTG AATTTTTTCA TGTCCTGCTG 3060

AACATACCAG ACTGTCACCA TCTGCCTTCT CTGGAATCCT TACGGGAAAA ATTGAAAGTT 3120

TTATTTCAGC AGTCTTATGT AAACAAGATC AAATCCTTCC GCAGCCGGCT AATTGTGTTA 3180

CTTTTGGAAT ACAAACGTTC ACGAAAATAA 3210

Domain Profile

S: 3     iekeigeGayakvykaeh....dsksgelvalKvekpansWefYIclqlkeRlkeeellk  58

         ++  +geGa+a+vy+a++    d+k +++v+lKv+kpan+WefYI +qlkeRl  +++ +

Q: 774   VDSFLGEGAFAHVYEATQwnlnDTKIKQKVILKVQKPANPWEFYIGTQLKERLP-PSVRH  832

         7889*****************9*******************************9.77***

S: 59    siieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkivek  118

          +i++ +a+ f+++s+lv +++sygtll++in++k++ +kvm+++l +++++++l+++e+

Q: 833   LFIQFDAAHFFHNGSVLVGDLYSYGTLLNAINLYKNTPEKVMPQALAIYFTIKILHMIEQ  892

         ************************************************************

S: 119   lHeveIiHgDlkPdnfllgnrimdkadkdkeekglkliDfgrsiDmkllpdgtkfkgkak  178

         lH++eIiHgD+kPdnf++g r        + ++gl+liD+g+siDm+l+p+gt+f+++++

Q: 893   LHSCEIIHGDIKPDNFIIGDRQISLFI-YDLSHGLALIDLGQSIDMTLFPKGTTFTARCE  951

         ******************999887776.5689****************************

S: 179   tdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikrllkkel  238

         t++f+c+eml+ k+w+Yq+D+fg+aa+++++lfg+y++v++++g wk++  +kr +++e+

Q: 952   TSGFQCVEMLSQKPWNYQTDYFGIAATAYCMLFGTYMKVKNDQGVWKPEGVFKRVPNSEI  1011

         ************************************************************

S: 239   wekiferlLNisdastlpsleelveek  265

         w ++f++lLNi+d+++lpsle l+e k

Q: 1012  WSEFFHVLLNIPDCHHLPSLESLRE-K  1037

         ***********************96.4

Domain Sequence
(FASTA)

VDSFLGEGAF AHVYEATQWN LNDTKIKQKV ILKVQKPANP WEFYIGTQLK ERLPPSVRHL 60

FIQFDAAHFF HNGSVLVGDL YSYGTLLNAI NLYKNTPEKV MPQALAIYFT IKILHMIEQL 120

HSCEIIHGDI KPDNFIIGDR QISLFIYDLS HGLALIDLGQ SIDMTLFPKG TTFTARCETS 180

GFQCVEMLSQ KPWNYQTDYF GIAATAYCML FGTYMKVKND QGVWKPEGVF KRVPNSEIWS 240

EFFHVLLNIP DCHHLPSLES LREK 264

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000777	; C:condensed chromosome kinetochore
GO:0000780	; C:condensed nuclear chromosome, centromeric region
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007063	; P:regulation of sister chromatid cohesion
GO:0071173	; P:spindle assembly checkpoint

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013